# L: Lobe location: 2-72.0. phenotype: Variable reduction in eye size of heterozygotes and homozygotes as well as in homozygous viability, depending on allele. Most extreme allele, L2, exhibits reduced eyes in heterozygote and tiny eyes and poor viability in homozygote; classifiable in single dose in triploids (Schultz, 1934, DIS 1: 55). L1/+ have slightly reduced eyes with nick in ante- rior edge and the lower half of eye reduced more than upper; overlaps wild type; eyes of homozygote much smaller and less variable; bipartite eyes occasionally formed. Lr shows weakest expression, with the heterozygote indistinguishable from wild type and the homozygote with small kidney-shaped eyes at 25, but overlapping wild type at 19. Tested alleles (L4, LB, Ld, Lr) exhibit reduced expression at 19 compared to 25. Expres- sion enhanced (L1, L2, L4) in combination with Minutes [M(2)58F, M(3)69E, M(3)95A] (Dunn and Coyne, 1935, Biol. Zentr. 55: 385-89). Reduced numbers of cells enter into for- mation of eye disks (L2, L4, L5, Steinberg, 1944, Proc. Nat. Acad. Sci. USA 30: 5-13); reduced size of cephalic complex detectable in 24-hr larva, but subsequent growth rate is simi- lar to wild type (L4, Medvedev, 1935, Z. Indukt. Abstamm. Vererbungsl. 70: 55-72; Tr. Inst. Genet. Akad. Nauk. SSSR 10: 119-51). alleles: allele origin discoverer synonym ref ( phenotype | _________________________________________________________________________________ L1 spont Bridges, 18i24 2, 10 L2 spont Mohr, 20b2 2, 9, 10 *L3 spont Bridges, 24d10 2, 10 L1 > L3 > Lr L4 spont Sturtevant, 23f L / 2 L2 > L4 > L1 L5 Mohr, 31k26 2, 3 L1 > L5 > Lr L34 spont Glass, 1934 2, 4 L2 > L34 > L4 L52 spont Nakayama, 52c 2, 11 = L1 LB / Becker 1a, 2 L2 > LB > L1 *Ld spont Kodani 2, 12 = L1 *Ldq spont Kadel & dq 2, 5, 6 = Lr Jenkins, 55g 2 LK spont Krivshenko, 1957 2, 7 L2 > LK > L1 Lr spont L. V. Morgan, 29h23 2 Lrm spont 2a strong allele, outgrowths at anterior edge of eye Lro Ultraviolet Edmondson, 49k 2, 8 L2 > Lro > L4 Lrv1 X ray 1 cytology normal Lrv3 X ray 1 heterochromatic rearrangement Lrv5 X ray 1 In(2LR)26F;51B5C2 Lsi spont Morgan, 1932 L1 > Lsi > Lr ( 1 = Baker and Ridge, 1980, Genetics 94: 383-423; 1a = Becker, Z. Indukt. Abstamm. Vererbungsl. 88: 333-73 (fig.); 2 = CP627; 2a = Craymer, 1980, DIS 55: 197-206; 3 = Dunn, 1935, DIS 4: 14; 4 = Glass, 1939, DIS 12: 47; 5 = Kadel, 1956, DIS 30: 73-74; 6 = Kadel, 1957, DIS 31: 83; 7 = Krivshenko, 1958, DIS 32: 81; 8 = Meyer, Edmondson, Byers, and Erickson, 1950, DIS 24: 60; 9 = Mohr, 1924, Z. Indukt. Abstamm. Vererbungsl. 32: 216; 10 = Mor- gan, Bridges, and Sturtevant, 1925, Bibliog. Genet. 2: 230 (fig.); 11 = Nakayama, 1953, DIS 37: 59; 12 = Zimm, 1951, J. Exp. Zool. 116: 289-319 (fig.). | Strength of phenotypic expression, graded with respect to standard phenotypes L1, L2, and Lr. / In In(2L+2R)Cy, therefore only heterozygote testable. Sec- tors of ommatidia replaced by chitin and bristles; lower half of head also reduced at 25. Lower half of eye apparently produced from fewer than the normal nine or ten presumptive ommatidium-producing cells. Temperature- sensititve period for ommatidium formation first and second instars; third instar as well for head reduction. cytology: Placed in 51A2-B1 based on its inclusion in Df(2L)L4 = Df(2L)51A2;51A12-B1 (Baker and Ridge, 1980, Genetics 94: 383-423). # l: lethal Some gene functions are dispensable to survival of flies in culture, whereas others are vital to survival such that amorphic alleles are lethal. Intermediate degrees of dispen- sability and hypomorphic alleles lead to intermediate situa- tions. Whether a vital locus is named according to the pheno- type of a hypomorphic allele or an escaper from a usually lethal genotype, or as a lethal is largely an accident of cir- cumstance. Add to this uncertainty the recent practice of naming lethal mutants according to their lethal phenotype rather than as lethals, and the inconsistencies of nomencla- tural usage become severe. In this revision, when a specific phenotype, either in the adult or an immature stage, can be associated with a mutation, that phenotype is used in its designation; otherwise, more general terms such as "lethal" are applied. In this regard, stage of death is not neces- sarily considered a specific phenotype. In this revision an attempt is made to generate some order in the nomenclature for lethal alleles, which have heretofore been designated in a most capricious manner. Inasmuch as the cytological map has developed into such an exquisite instru- ment for gene localization, the method of indicating lethal loci currently used by Wright for the lethals in regions 37B and C has been adopted insofar as possible to the entire genome. Lethals are named according to the lettered subdivi- sion of the polytene map that they occupy; separate loci are differentiated by lower case letters, e.g., l(1)1Aa, and l(1)1Ab, etc. for lethals in region 1A; in case a lettered subdivision has more that 26 lethal complementation groups, l(1)Az will be followed by l(1)Aaa, l(1)Abb, etc. Since cyto- genetic mapping is imperfect, this system of nomenclature can- not be expected to be perfect; there are bound to be instances where the lethal name misidentifies the position of the locus, being slightly off in most cases, but seriously so in a few. The order in which loci within a subdivision are named is arbitrary, although when the linear order is known, it may be reflected in the locus designations; however, alphabetical order is not a reliable indication of map order! Where the cytological information is available, lethal loci in a let- tered subdivision are tabulated in bold face according to let- tered subdivision and their alternative designation(s) indi- cated in body type. Lethal mutations named according to their more specific phenotypes are tabulated according to lettered subdivision in body type and their current designation in bold face in the column headed "synonym", e.g., l(1)1Aa = l(1)EC1 and l(1)1Ae = ewg. Tabulations of loci in a lettered subdivi- sion are generally followed by tabulations of the known alleles at each locus. Lethals named according to their more specific phenotypes are described and their alleles listed under the more specific name and not with the lethals. Where the cytological locations are unavailable, lethals are listed as in "Genetic Variations of Drosophila melanogaster", but where possible, groups of lethals with some aspect in common are designated alike and tabulated. As cytological determina- tions and complementation tests are made, additional lethals can be renamed according to cytological conventions and non- complementing lethals listed under the same locus symbol. The column designated "comments" contains a variety of informa- tion. The notations represented by upper case letters indi- cate the lethal phase: E = embryonic; L1, L2, L3 = larval instars; EP = early pupa; LP = late pupa; A = adult; PP = polyphasic. In the case of X-chromosome lethals, notations with a slash bar are from Perrimon (e.g. Perrimon, Engstrom, and Mahowald, 1984, Dev. Biol. 105: 404-14; 1989, Genetics 121: 333-52). The letters preceeding the slash bar indicate the lethal phase; the letters following the slash bar indicate the behavior of homozygous oogenic clones in otherwise hetero- zygous females: NME = no maternal effect, i.e, the lethal phenotype of males produced by homozygous germ-line clones is indistinguishable from that of males produced by heterozygous mother; ME = maternal effect; MER = maternal effect partially rescued by paternal +; VME = variable maternal expression; AO = abnormal oogenesis; L = lethal. Rearrangements listed as associated with lethals are described under the appropriate rearrangement type, usually with breakpoints indicated. For those numbered divisions in which saturation mutagenesis has been carried out, the lethal tabulations are followed by tables of the deficiency mapping results for the region. Cytological localizations of deficiency breakpoints are presented even though some are at variance with the genetic data. The orders indicated cannot be completely accurate, since all lethals have not been tested with all indicated deficiencies. # l(1) Lethal mutations on the X chromosome are among the easiest to recover and the least convenient to characterize geneti- cally. Accordingly they comprise the most represented and least characterized subset of lethal mutations. There are doubtlessly numerous instances of undetected allelism and therefore, in the following treatment, the number of named loci must substantially exceed the number actually represented. #*l(1)1: lethal (1) 1 location: 1-1.1. origin: Spontaneous. discoverer: Rawls, 12b. references: 1913, Biol. Bull. 24: 115-24. Morgan and Bridges, 1916, Carnegie Inst. Washington Publ. No. 237: 31. other information: First recessive lethal found in D. melano- gaster. # l(1)1A Eight lethally mutable loci tentatively identified in region 1A; these include the former l(1)J1 of Jacobs-Muller, pch, cin, ewg, and arth. Order established by deficiency mapping by Fleming, Schalet, Lim, and White; Complementation tests between mutants described by Maddern and the remainder not carried out; allelic relations arbitrarily assigned. genetic cytological locus location location included in excluded from synonym _________________________________________________________________________ l(1)1Aa 1-0.0 Df(1)SJ1b Df(1)y75e dmd, l(1)EC1, pch l(1)1Ac 1-0.0 1A6 Df(1)y75e Df(1)cin-arth l(1)J1 l(1)1Ad 1-0.0 1A5 Df(1)SJ1d Df(1)SJ1b l(1)EC2 l(1)1Ae 1-0.0 1A7 Df(1)SJ1a Df(1)SJ1d cin l(1)1Af 1-0.0 1A7-8 l(1)1Ag 1-0.0 1A8 Df(1)SJ1a Df(1)SJ1d ewg, l(1)EC3 Df(1)sc19 l(1)1Ah 1-0.0 Df(1)sc19 Df(1)SJ1a arth allele origin discoverer synonym ref ( comments ____________________________________________________________________ l(1)1Ac1 X ray Jacobs- l(1)J1 1 In(1)scJ4 Muller l(1)1Ac2 X ray Meyer l(1)HM1 l(1)1Ac3 X ray Meyer l(1)HM2 l(1)1Ac4 EMS Lim l(1)J11 l(1)1Ac5 EMS Lim l(1)J169 l(1)1Ac6 EMS Lim l(1)J171 l(1)1Ac7 EMS Lim l(1)J189 l(1)1Ac8 EMS Lim l(1)J196 l(1)1Ac9 EMS Lim l(1)J1115 l(1)1Ac10 EMS Lim l(1)J1129 l(1)1Ac11 MMS Lim l(1)J1M7 l(1)1Ac12 X ray Lefevre l(1)RF17 2 l(1)G11 *l(1)1Ac13 X ray Lefevre l(1)L61 2 T(1;2)1A5;32F1-2 l(1)G1 *l(1)1Ac14 X ray Lefevre l(1)HA35 2 complex aberration *l(1)1Ac15 X ray Lefevre l(1)JC56 2 T(1;3)1A5;66C1 *l(1)1Ac16 X ray Lefevre l(1)HF341 2 complex aberration l(1)1Ac17 EMS Lefevre l(1)EA106 3 L/NME l(1)1Ac18 spont Schalet l(1)19-30DP 5 l(1)1Ac19 spont Schalet l(1)20-97 5 l(1)1Ac20 EMS White l(1)1Ac21 EMS White l(1)1Ac22 EMS White l(1)1Ac23 EMS White l(1)1Ac24 EMS White l(1)1Ac25 EMS White l(1)1Ac26 X ray White l(1)1Ad1 spont Maddern l(1)2804 4 l(1)1Ad2 EMS Lim l(1)EC257 2 l(1)1Ad3 EMS Lefevre l(1)VE619 3 l(1)1Ad4 EMS Lefevre l(1)VE899 3 L3/L l(1)1Ad5 EMS White *l(1)1Af1 X ray Lefevre l(1)HC107 2 complex aberration ( 1 = CP627; 2 = Lefevre, 1981, Genetics 99: 461-80; 3 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 4 = Maddern, 1977, DIS 52: 82; 5 = Schalet, 1986, Mutat. Res. 163: 115-44. | From DNA-injected egg. # l(1)1B Eleven lethally mutable loci identified in region 1B includ- ing named loci sc, svr, elav, vnd, and M(1)Bld. genetic cytological locus location location included in excluded from synonym ____________________________________________________________________ l(1)1Ba 1-0.0 1B4 In(1)sc4 In(1)sc9 l(1)sc l(1)1Bb 1-0.0 Df(1)260.1 Df(1)sc19 l(1)EC4 l(1)1Bc 1-0.0 Df(1)yT6-151 Df(1)260.1 l(1)EC5 l(1)1Bd 1-0.0 1B5-6 Df(1)yT6-151 Df(1)260.1 svr l(1)1Be 1-0.0 1B4-9 Df(1)yT7-155 Df(1)yT6-151 elav, l(1)EC7 l(1)1Bf 1-0.0 1B9 Df(1)yT8-184 Df(1)yT7-155 vnd, l(1)EC6 l(1)1Bg 1-0.0 1B10-11 Df(1)su(s)E2 Df(1)svr Df(1)su(s)83 l(1)1Bh 1-0.0 Df(1)y74k10.1 Df(1)yT9-7 l(1)1Bi 1-0.0 Df(1)y74k24.1 Df(1)y74k10.1 l(1)1Bj 1-0.0 1B11-12 Df(1)y74k24.1 Df(1)y74k10.1 M(1)Bld l(1)1Bk 1-0.0 Df(1)yT14-546 Df(1)yT13-464 # l(1)1Bb phenotype: Homozygous clones in eyes display swelling and vacu- olization of pigment cells (alleles designated MM2 and TE10). Deletion for l(1)1Bb enhances central-nervous-system and eye effects of ASC deficiencies (Jimenez and Campos-Ortega, 1987, J. Neurogenet. 4: 179-200; Gonzalez, Romani, Cubas, Modolell, and Campuzano, 1989, EMBO J. 8: 3553-62). allele origin ( discoverer synonym ref | comments __________________________________________________________________________ l(1)1Bb1 EMS Lim l(1)EC44 3 l(1)1Bb2 EMS Lim l(1)EC46 l(1)1Bb3 EMS Lim l(1)EC48 l(1)1Bb4 EMS Lim l(1)EC4011 l(1)1Bb5 EMS Lim l(1)EC4013 l(1)1Bb6 EMS Lim l(1)EC4021 l(1)1Bb7 EMS Lim l(1)EC454 l(1)1Bb8 EMS Lim l(1)EC465 l(1)1Bb9 EMS Lim l(1)EC481 l(1)1Bb10 EMS Lim l(1)EC486 l(1)1Bb11 EMS Lim l(1)EC4120 l(1)1Bb12 MMS Lim l(1)EC4M20 *l(1)1Bb13 X ray Lefevre l(1)JA7 3 *l(1)1Bb14 X ray Lefevre l(1)C84 3 l(1)G4 l(1)1Bb15 X ray Lefevre l(1)C35 3 l(1)1Bb16 EMS Lefevre l(1)DC724 4 l(1)1Bb17 EMS Lefevre l(1)VA265 4 l(1)1Bb18 EMS Lefevre l(1)VE637 4 l(1)1Bb19 EMS Lefevre l(1)VE859 4 P/NME l(1)1Bb20 spont Schalet l(1)11-53 l(1)1Bb21 EMS White l(1)EC4mmz l(1)1Bb22 EMS White l(1)EC4TE10 l(1)1Bb23 EMS White l(1)1Bb24 EMS White l(1)1Bb25 EMS White l(1)1Bb26 EMS White l(1)1Bb27 EMS White l(1)1Bb28 ENU Voelker l(1)A74V l(1)1Bb29 ENU Voelker l(1)A84 l(1)1Bb30 ENU Voelker l(1)A91 l(1)1Bb31 ENU Voelker l(1)A112 l(1)1Bb32 ENU Voelker l(1)A133 l(1)1Bb33 HMS l(1)HM439 2 l(1)1Bc1 EMS Lim l(1)EC5017 l(1)1Bc2 EMS Lim l(1)EC542 l(1)1Bc3 EMS Lim l(1)EC558 l(1)1Bc4 EMS Lim l(1)EC5119 l(1)1Bc5 EMS Lim l(1)EC5126 l(1)1Bc6 EMS Lim l(1)EC5143 l(1)1Bc7 TEM Lim l(1)EC5T001 l(1)1Bc8 TEM Lim l(1)EC5T006 l(1)1Bc9 TEM Lim l(1)EC5T007 *l(1)1Bc10 X ray Lefevre l(1)RC10 3 l(1)1Bc11 X ray Lefevre l(1)HA81 3 l(1)1Bc12 EMS Lefevre l(1)EC209 4 l(1)1Bc13 EMS Lefevre l(1)EC288 4 l(1)1Bc14 EMS Lefevre l(1)VA76 4 L3/NME l(1)1Bc15 EMS Lefevre l(1)VE648 4 l(1)1Bc16 spont Schalet l(1) 6-4 l(1)1Bc17 EMS White l(1)1Bc18 EMS White l(1)1Bc19 EMS White l(1)1Bc20 ENU Voelker l(1)A8 l(1)1Bc21 ENU Voelker l(1)A72 l(1)1Bc22 ENU Voelker l(1)A113 l(1)1Bc23 ENU Voelker l(1)A137 l(1)1Bg1 X ray Lefevre l(1)C244 3 complex aberration l(1)1Bg2 X ray Lefevre l(1)HC147 3 l(1)1Bg3 X ray Lefevre l(1)HF379 3 T(1;3)1B11;67B + 69A; heterochromatin *l(1)1Bh1 X ray Lefevre l(1)C22 3 complex aberration l(1)1Bh2 X ray Lefevre l(1)C73 3 *l(1)1Bh3 X ray Lefevre l(1)RF16 3 l(1)1Bh4 EMS Lefevre l(1)EF406 4 PP/L l(1)1Bh5 EMS White l(1)PB3 l(1)1Bh6 EMS White l(1)PBTE6 l(1)1Bh7 EMS White l(1)PBLP9 l(1)1Bh8 ENU Voelker l(1)A90 1 P l(1)1Bh9 ENU Voelker l(1)B21 semilethal; adults with short thin bristles l(1)1Bh10 ENU Voelker l(1)B24 l(1)1Bh11 ENU Voelker l(1)B28 l(1)1Bh12 ENU Voelker l(1)B31 l(1)1Bh13 ENU Voelker l(1)B33 l(1)1Bh14 ENU Voelker l(1)B34 l(1)1Bh15 ENU Voelker l(1)B35 l(1)1Bh16 ENU Voelker l(1)B40 l(1)1Bh17 EMS Voelker l(1)C3 l(1)1Bh18 DEB Voelker l(1)DB1 l(1)1Bi1 EMS Lefevre l(1)DC703 4 l(1)1Bi2 EMS White l(1)D65 l(1)1Bi3 HMS Kramers l(1)HM52 2 l(1)1Bi4 HMS Kramers l(1)HM419 2 l(1)1Bi6 ENU Voelker l(1)A7 1 L1-2 l(1)1Bi7 ENU Voelker l(1)A43 l(1)1Bi8 ENU Voelker l(1)A99 l(1)1Bi9 ENU Voelker l(1)A105 l(1)1Bi10 ENU Voelker l(1)B4 l(1)1Bi11 ENU Voelker l(1)B10 l(1)1Bi12 ENU Voelker l(1)B30 l(1)1Bi13 ENU Voelker l(1)B36 l(1)1Bi14 ENU Voelker l(1)B38 l(1)1Bi15 ENU Voelker l(1)B48 semilethal l(1)1Bk1 EMS Lefevre l(1)DF979 4 l(1)1Bk2 HMS Kramers l(1)HM441 1 E-L1 l(1)1Bk3 ENU Voelker l(1)A24 l(1)1Bk4 ENU Voelker l(1)B3 l(1)1Bk5 DEB Voelker l(1)DB2 ( Lethals in Voelker's B series were induced in Dp(1;3)E1. | 1 = Eberl, Hilliker, and Voelker, 1988, DIS 67: 36; 2 = Kramers, Schalet, Paradi, and Huiser-Hoogteyling, 1983, Mutat. Res. 107: 187-201; 3 = Lefevre, 1981, Genetics 99: 461-80; 4 = Lefevre and Watkins, 1986, Genetics 113: 869-95. # l(1)1C Two lethally mutable loci recognized, one of which is mul. locus included in excluded from synonym _________________________________________________ l(1)1Ca Df(1)yT15-5 Df(1)yT14-546 l(1)1Cb Df(1)yT16-14 Df(1)yT15-5 mul allele | origin discoverer synonym ref ( comments ______________________________________________________________ *l(1)1Ca1 X ray Lefevre l(1)HA34 2 *l(1)1Ca2 X ray Lefevre l(1)HC111 2 *l(1)1Ca3 X ray Lefevre l(1)RC7 2 *l(1)1Ca4 EMS Lefevre l(1)EA148 3 l(1)1Ca5 ENU Voelker l(1)A19 1 P l(1)1Ca6 EMS Voelker l(1)C4 l(1)1Ca7 EMS Voelker l(1)C5 ( 1 = Eberl, Hilliker, and Voelker, 1988, DIS 67: 36; 2 = Lefevre, 1981, Genetics 99: 461-80; 3 = Lefevre and Watkins, 1986, Genetics 113: 869-95. | Lefevre's and Voelker's mutants have arbitrarily been declared alleles, since all of Lefevre's are lost and the alternative is to postulate two loci, one of which Lefevre sampled four times and the other of which Voelker mutated three times. # l(1)1D Region 1D contains three lethally mutable loci, one of which is brc. locus included in excluded from synonym __________________________________________________ l(1)1Da Df(1)yT18-319 Df(1)yT17-600 l(1)1Db Df(1)yT19-16 Df(1)yT18-319 brc l(1)1Dc Df(1)yT19-16 Df(1)pn7b allele origin discoverer synonym ref ( comments _____________________________________________________________________________ l(1)1Da1 HMS Kramers l(1)HM454 1, 2 L1-2 l(1)1Da2 ENU Voelker l(1)A29 1 L1-2 l(1)1Da3 ENU Voelker l(1)A32 l(1)1Da4 ENU Voelker l(1)A139 *l(1)1Dc1 X ray Lefevre l(1)A118 3 *l(1)1Dc2 X ray Lefevre l(1)A146 3 l(1)1Dc3 X ray Lefevre l(1)GA39 3 l(1)1Dc4 X ray Lefevre l(1)GF326 3 T(1;2)1D4;36C; fails to complement Df(1)su(s)83 l(1)1Dc5 X ray Lefevre l(1)JC45 3 l(1)1Dc6 EMS Lefevre l(1)DF917 4 complex T(1;?)1D4;het l(1)1Dc7 EMS Lefevre l(1)VE846 4 L/L ( 1 = Eberl, Hilliker, and Voelker, 1988, DIS 67: 36; 2 = Kramers, Schalet, Paradi, and Huiser-Hoogteyling, 1983, Mutat. Res. 107: 187-201; 3 = Lefevre, 1981, Genetics 99: 461-80; 4 = Lefevre and Watkins, 1986, Genetics 113: 869-95. # l(1)1E Six lethally mutable loci, mostly identified by Lefevre. cytological locus location included in excluded from __________________________________________________________ l(1)1Ea 1E2 Df(1)S39 Df(1)A94 l(1)1Eb 1E3 Df(1)S39 Df(1)A94 l(1)1Ec 1E4 Df(1)A94 l(1)1Ed 1E5 Df(1)A94 l(1)1Ee l(1)1Ef allele origin discoverer synonym ref ( comments ________________________________________________________________________ l(1)1Ea1 EMS Lefevre l(1)EA48 4 L3-P/L l(1)1Ea2 EMS Lefevre l(1)VE737 4 l(1)1Eb1 X ray Lefevre l(1)N3 3 T(1;3)1E1;71C1 + complex other l(1)1Eb2 EMS Lefevre l(1)DA565 4 L2-3/L l(1)1Eb3 EMS Lefevre l(1)DA681 4 l(1)1Eb4 EMS Lefevre l(1)VA209 4 L1-2/L l(1)1Eb5 HMS l(1)HM14 2 l(1)1Ec1 X ray Lefevre l(1)A102 3 L/NME *l(1)1Ec2 X ray Lefevre l(1)RC66 3 T(1;2)1E4;58E l(1)1Ec3 X ray Lefevre l(1)GA77 3 L/ l(1)1Ec4 X ray Lefevre l(1)GA119 3 T(1;3)1E1;93A l(1)1Ec5 EMS Lefevre l(1)DA553 3 l(1)1Ec6 EMS Lefevre l(1)DC755 4 l(1)1Ec7 EMS Lefevre l(1)EA1 4 l(1)1Ec8 EMS Lefevre l(1)VE606 4 l(1)1Ec9 HMS l(1)HM20 2 l(1)1Ec10 HMS l(1)HM53 2 l(1)1Ec11 MR l(1)28/6A 1 *l(1)1Ed1 X ray Lefevre l(1)HF358 3 *l(1)1Ed2 X ray Lefevre l(1)RC47 3 l(1)1Ed2 X ray Lefevre l(1)RC66 3 T(1;2)1E4;58E l(1)1Ee1 X ray Lefevre l(1)HF308 3 Tp(1;3)1E4;12A;81 l(1)1Ef1 X ray Lefevre l(1)C24 3 E/NME l(1)1Ef2 X ray Lefevre l(1)GA91 3 T(1;3)1F4;99A l(1)1Ef3 X ray Lefevre l(1)GE241 3 E/NME l(1)1Ef4 X ray Lefevre l(1)HA29 3 l(1)1Ef5 EMS Lefevre l(1)DC836 4 l(1)1Ef6 EMS Lefevre l(1)VE625 4 l(1)1Ef7 EMS Lefevre l(1)VE811 4 ( 1 = Eeken, Sobels, Hyland, and Schalet, 1985, Mutation Res. 150: 261-75; 2 = Kramers, Schalet, Paradi, and Huiser- Hoogteyling, 1983, Mutat. Res. 107: 187-201; 3 = Lefevre, 1981, Genetics 99: 461-80; 4 = Lefevre and Watkins, 1986, Genetics 113: 869-95. # l(1)EF Ten loci placed in 1E3-2A3 by Belyaeva and Aizenzon on the basis of their mapping to the region common to Df(1)AT127 and Df(1)RA19. Not tested for allelism with l(1)1E or l(1)1F mutations of Lefevre. locus synonym ____________________ l(1)1EFa l(1)BA1 l(1)1EFb l(1)BA2 l(1)1EFc l(1)BA3 l(1)1EFd l(1)BA4 l(1)1EFe l(1)BA5 l(1)1EFf l(1)BA6 l(1)1EFg l(1)BA7 l(1)1EFh l(1)BA8 l(1)1EFi l(1)BA9 l(1)1EFj l(1)BA10 allele origin synonym comments _____________________________________________________ l(1)1EFa1 EMS l(1)t44 l(1)1EFa2 EMS l(1)t70 l(1)1EFa3 EMS l(1)t156 l(1)1EFa4 EMS l(1)t348 l(1)1EFa5 EMS l(1)t373 l(1)1EFb1 EMS l(1)t11 l(1)1EFb2 EMS l(1)t34 l(1)1EFb3 EMS l(1)t130 l(1)1EFb4 EMS l(1)t155 l(1)1EFb5 EMS l(1)t170 l(1)1EFb6 EMS l(1)t192 l(1)1EFc1 EMS l(1)t6 l(1)1EFc2 EMS l(1)t7 l(1)1EFc3 EMS l(1)t37 l(1)1EFc4 EMS l(1)t381 l(1)1EFc5 EMS l(1)t402 l(1)1EFd1 EMS l(1)t9 l(1)1EFd2 EMS l(1)t49 l(1)1EFd3 EMS l(1)t153 l(1)1EFd4 EMS l(1)t163 l(1)1EFd5 EMS l(1)t242 l(1)1EFe1 EMS l(1)t16 l(1)1EFe2 EMS l(1)t40 l(1)1EFe3 EMS l(1)t46 l(1)1EFe4 EMS l(1)t214 l(1)1EFe5 EMS l(1)t233 l(1)1EFe6 EMS l(1)t341 l(1)1EFf1 EMS l(1)t42 l(1)1EFf2 EMS l(1)t101 l(1)1EFf3 EMS l(1)t186 complements l(l)EFf4 l(1)1EFf4 EMS l(1)t55 complements l(1)EFf3 l(1)1EFg1 EMS l(1)t29 l(1)1EFg2 EMS l(1)t485 l(1)1EFh1 X ray l(1)R1 l(1)1EFi1 EMS l(1)t69 l(1)1EFj1 EMS l(1)t147 ( 1 = Belyaeva, Aizenzon, Kiss, Gorelova, Pak, Umbetova, Kra- mers, and Zhimulev, 1982, DIS 58: 184-90. # l(1)1F Six lethally mutable loci identified by Lefevre. cytological locus location included in excluded from ___________________________________________________________ l(1)1Fa Df(1)A94 Df(1)1F2-2B7 l(1)1Fb Df(1)1F2-2B7 l(1)1Fc l(1)1Fd 1F4 y2Y59k9.4 l(1)1Fe Df(1)GA120 l(1)1Ff allele origin discoverer synonym ref ( comments ___________________________________________________________________ l(1)1Fa1 X ray Lefevre l(1)RA8 1 l(1)1Fb1 X ray Lefevre l(1)HF331 1 l(1)1Fb2 EMS Lefevre l(1)DC793 2 L3/L l(1)1Fb3 spont Schalet l(1)6-62 l(1)1Fc1 X ray Lefevre l(1)HA78 1 L3-P/NME l(1)1Fc2 X ray Lefevre l(1)JA29 1 T(1;3)1E5;85A l(1)1Fc3 EMS Lefevre l(1)EF506 2 l(1)1Fc4 EMS Lefevre l(1)VA180 2 l(1)1Fc5 EMS Lefevre l(1)VA189 2 l(1)1Fc6 EMS Lefevre l(1)VE676 2 L/L l(1)1Fd1 X ray Lefevre l(1)HC156 1 l(1)1Fd2 X ray Lefevre l(1)HC191 1 l(1)1Fd3 X ray Lefevre l(1)KA16 1 P/ME l(1)1Fe1 EMS Lefevre l(1)VA92 2 L-P/NME l(1)1Fe2 EMS Lefevre l(1)VE809 2 l(1)1Ff1 EMS Lefevre l(1)VE804 2 L-P/ME ( 1 = Lefevre, 1981, Genetics 99: 461-80; 2 = Lefevre and Watkins, 1986, Genetics 113: 869-95. # DEFICIENCY MAP OF REGION 1 side breakpoint variant DNA coordinates ( _______________________________________________________________ left 1A1-3 Df(1)SJ1a left 1A1-3 Df(1)SJ1b left 1A1-3 Df(1)SJ1c left 1A1-3 Df(1)SJ1d 1A4 l(1)1Aa 1A5 dmd left Df(1)y75e 1A6 l(1)1Ac left Df(1)cin-arth right Df(1)5-13 right Df(1)17-8 right Df(1)259 right Df(1)403 right 1A6-7 Df(1)SJ1b right 1A6-7 Df(1)SJ1c 1A6-B1 l(1)1Ad right Df(1)05-22-1 right 1A6-B1 Df(1)SJ1d 1A7 cin T(1;4)cin 140-151 1A7-8 l(1)1Af 1A8 ewg right 1A8-B1 Df(1)SJ1a left Df(1)arth 119 to 121 left Df(1)sc19 100-103 left lJ1+Y 100-103 right Df(1)1-96 136-140 right Df(1)B428 121-133 T(1;4)ewgP 109-118 arth y2 left 1B1-2 In(1)y3P 73.7 to 72.3 Df(1)yT1a-394 72.3 to 71.6 Df(1)yT1a-473 72.3 to 71.6 Df(1)yT1a-653 72.3 to 71.6 -5 T6 left 1A8-B1 In(1)y4 71.6 to 70.6 1B1 y Df(1)yT1a-276 71.5 to 69.5 Df(1)yT1a-741 71.5 to 69.5 Df(1)yT1b-627 69.5 to 68.7 Df(1)yT1b-733 68.6 to 67.8 Df(1)yT1b-81 67.8 to 67.7 3 T6 Df(1)yT1b-94 67.7 to 67.2 Df(1)yT1b-303 67.2 to 66.3 Df(1)yT1b-628 67.2 to 66.3 Df(1)yT1b-689 67.2 to 66.3 Df(1)yT1b-497 65.6 to 65.3 Df(1)yT1b-625 65.3 to 64.8 Df(1)yT1b-488 64.2 to 63.2 Df(1)yT1b-589 62.9 to 62.4 Df(1)yT1b-195 62.4 to 61.8 Df(1)yT1b-633 62.4 to 61.8 Df(1)yT1b-659 62.4 to 61.8 Df(1)yT1b-242 61.2 to 60.3 Df(1)yT1b-331 61.2 to 60.3 Df(1)yT1b-739 60.3 to 59.9 Df(1)yT1b-691 59.9 to 59.7 Df(1)yT1b-626 59.7 to 58.9 left 1B2-3 In(1)ac3 59.6 to 58.8 Df(1)yT1b-688 Df(1)yT1b-96 3 1B2-3 ac Df(1)yT2-398 58.9 to 58.2 Df(1)yT2-558 58.9 to 58.2 5 1B2-3 ac Df(1)yT2-293 57.6 to 56.6 Df(1)yT2-212 56.8 to 56.3 Df(1)yT2-655 55.8 to 54.3 Df(1)yT2-97 55.8 to 54.3 left 1B2-3 In(1)scV2 55.8 to 54.3 Df(1)yT2-503 54.3 to 53.2 Df(1)yT2-624 54.3 to 53.2 Df(1)yT2-95 54.3 to 53.2 Df(1)yT2-701 53.2 to 52.4 Df(1)yT2-84 53.2 to 52.4 Df(1)yT2-86 53.2 to 52.4 Df(1)yT2-216 52.4 to 50.6 Df(1)yT2-356 52.4 to 50.6 Df(1)yT2-520 52.4 to 50.6 Df(1)yT2-590 52.4 to 50.6 Df(1)yT2-90 52.4 to 50.2 Df(1)yT2-438 50.6 to 49.4 Df(1)yT2-92 50.6 to 49.4 Df(1)yT2-83 50.2 to 49.4 Df(1)yT2-637 49.4 to 47.9 Df(1)yT2-730 49.4 to 47.9 Df(1)yT2-93 49.4 to 47.9 Df(1)yT2-336 47.9 to 46.8 Df(1)yT2-351 47.9 to 46.8 Df(1)yT2-742 47.9 to 46.8 left 1B2-3 In(1)sc8 47.9 to 46.8 Df(1)yT2-288 46.0 to 45.4 Df(1)yT2-643 46.0 to 45.4 Df(1)yT2-85 46.0 to 45.4 Df(1)yT2-89 46.0 to 45.4 Df(1)yT1b-685 45.4 to 43.9 Df(1)yT2-165 45.4 to 43.9 Df(1)yT2-623 45.4 to 44.4; 36.7 to 34.4 Df(1)yT2-630 45.4 to 43.9 Df(1)yT2-304 44.4 to 43.9 Df(1)yT2-29 42.3 to 39.5 Df(1)yT2-524 42.3 to 42.1 Df(1)yT2-551 42.3 to 39.5 Df(1)yT2-629 42.3 to 39.5 Df(1)yT2-103 42.1 to 41.5 Df(1)yT2-252 42.1 to 41.5 Df(1)yT2-618 39.1 to 37.1 Df(1)yT2-233 38.4 to 36.3 Df(1)yT2-748 38.4 to 36.3 Df(1)yT2-631 37.1 to 35.5 Df(1)yT2-650 37.1 to 35.5 Df(1)yT2-343 36.3 to 33.8 Df(1)yT2-26 Df(1)yT2-634 Df(1)yT2-695 Df(1)yT2-696 complex Df(1)yT2-734 Df(1)yT2-735 Df(1)yT2-738 Df(1)yT2-744 Df(1)yT2-749 Df(1)yT2-99 1B3-4 sc sis-b Df(1)yT3-150 33.8 to 33.4 Df(1)yT3-214 33.4 to 32.7 left 1B3-4 In(1)scL8 30.9 to 28.8 left 1B3-4 In(1)scS1 28.2 to 26.9 left In(1)sc4 25.8 to 24.0 Df(1)yT3-15 Df(1)yT3-22 Df(1)yT3-24 Df(1)yT3-55 l(1)Bb 1B4-8 su(b) Df(1)yT4-8 Df(1)yT4-19 Df(1)yT4-20 Df(1)yT4-25 l(1)1Bc 1B5-6 svr Df(1)yT6-151 Df(1)yT6-188 Df(1)yT6-244 Df(1)yT6-291 Df(1)yT6-522 Df(1)yT6-544 Df(1)yT6-506 -17 to -14 Df(1)yT6-450 -10 to -8 1B4-9 elav Df(1)yT7-263 -1 to +4 Df(1)yT7-437 -1 to +4 Df(1)yT7-191 +4 to +14 Df(1)yT7-107 +15 to +23 Df(1)yT7-104 Df(1)yT7-108 Df(1)yT7-109 Df(1)yT7-114 Df(1)yT7-115 Df(1)yT7-129 Df(1)yT7-130 Df(1)yT7-155 Df(1)yT7-157 Df(1)yT7-178 Df(1)yT7-194 Df(1)yT7-208 Df(1)yT7-218 Df(1)yT7-229 Df(1)yT7-234 Df(1)yT7-250 Df(1)yT7-284 Df(1)yT7-292 Df(1)yT7-296 Df(1)yT7-301 Df(1)yT7-311 Df(1)yT7-329 Df(1)yT7-341 Df(1)yT7-348 Df(1)yT7-358 Df(1)yT7-366 Df(1)yT7-371 Df(1)yT7-376 Df(1)yT7-377 Df(1)yT7-400 Df(1)yT7-401 Df(1)yT7-404 Df(1)yT7-406 Df(1)yT7-435 Df(1)yT7-446 Df(1)yT7-448 Df(1)yT7-458 Df(1)yT7-518 Df(1)yT7-525 Df(1)yT7-532 Df(1)yT7-547 1B9 vnd left Df(1)su(s)E2 Df(1)yT8-9 Df(1)yT8-12 Df(1)yT8-18 Df(1)yT8-101 Df(1)yT8-124 Df(1)yT8-128 Df(1)yT8-143 Df(1)yT8-148 Df(1)yT8-158 Df(1)yT8-184 Df(1)yT8-185 Df(1)yT8-197 Df(1)yT8-206 Df(1)yT8-241 Df(1)yT8-271 Df(1)yT8-361 Df(1)yT8-362 Df(1)yT8-368 Df(1)yT8-369 Df(1)yT8-385 Df(1)yT8-409 Df(1)yT8-420 Df(1)yT8-500 Df(1)yT8-530 1B10-11 l(1)1Bg left 1B10 Df(1)su(s)83 Df(1)yT9-7 1B10-12 Df(1)yT9-21 Df(1)yT9-220 Df(1)yT9-275 l(1)1Bh 1B5-6 Df(1)y74k10.1 1B9-10 Df(1)svr Df(1)yT10-102 Df(1)yT10-106 Df(1)yT10-581 Df(1)yT10-665 Df(1)yT10-673 Df(1)yT10-677 l(1)1Bi 1B11-12 M(1)Bld right 1B9-10 Df(1)y74k24.1 Df(1)yT12-173 Df(1)yT12-187 Df(1)yT12-200 Df(1)yT12-206 Df(1)yT12-246 Df(1)yT12-667 right 1B14 y2Y61l su(s) Df(1)yT13-423 Df(1)yT13-464 l(1)1Bk right Df(1)su(s)E2 Df(1)yT14-546 Df(1)yT14-576 l(1)1Ca Df(1)yT15-5 Df(1)yT15-6 Df(1)yT15-28 Df(1)yT15-56 Df(1)yT15-105 Df(1)yT15-158b Df(1)yT15-161 Df(1)yT15-177 Df(1)yT15-183 Df(1)yT15-189 Df(1)yT15-219 Df(1)yT15-222 Df(1)yT15-270 Df(1)yT15-274 Df(1)yT15-286 Df(1)yT15-300 Df(1)yT15-318 Df(1)yT15-325 Df(1)yT15-327 Df(1)yT15-334 Df(1)yT15-364 Df(1)yT15-365 Df(1)yT15-383 Df(1)yT15-390 Df(1)yT15-392 Df(1)yT15-405 Df(1)yT15-408 Df(1)yT15-410 Df(1)yT15-412 Df(1)yT15-433 Df(1)yT15-449 Df(1)yT15-460 Df(1)yT15-468 Df(1)yT15-502 Df(1)yT15-509 Df(1)yT15-511 Df(1)yT15-517 Df(1)yT15-533 Df(1)yT15-543 Df(1)yT15-548 Df(1)yT15-552 Df(1)yT15-564 Df(1)yT15-568 Df(1)yT15-575 Df(1)yT15-586 Df(1)yT15-597 Df(1)yT15-599 mul Df(1)yT16-14 Df(1)yT16-171 Df(1)yT16-411 Df(1)yT16-499 Df(1)yT16-534 Df(1)yT16-554 tw Df(1)yT17-570 Df(1)yT17-600 l(1)1Da Df(1)yT18-319 brc Df(1)yT19-16 Df(1)yT19-253 right 1D6-E1 Df(1)su(s)83 l(1)1Dc left Df(1;f)3 left 1E1-2 Df(1)pn7b left 1E1-2 Df(1)S39 left 1E1-2 Df(1)sta 1E2 l(1)1Ea 1E3 l(1)1Eb left 1E3-4 Df(1)A94 left 1E3-4 Df(1)AT127 left 1E3-4 Df(1)dor1T left 1E3-4 Df(1)RA19 right 1E3-4 Dp(1;Y)y+sc 1E4 l(1)1Ec right 1E4-F1 Dp(1;f)18 right 1E4-F1 Dp(1;f)112 1E5 l(1)1Ed l(l)EFa l(l)EFb l(l)EFc l(l)EFd l(l)EFe l(l)EFf l(l)EFg l(l)EFh l(l)EFi l(l)EFj l(1)1Fa l(1)1Fb left 1F2 Df(1)1F2-2B7 l(1)1Fc l(1)1Fd right y2Y59k9.4 right 2A2-3 Df(1)A127 ( For coordinates in the y to sc region, (1) see Fleming, DeSimone, and White (1989, Mol. Cell Biol. 9: 719-25) when values are > 100, (2) see Ruiz-Gomez and Modolell (1987, Genes Dev. 1: 1238-46), when values are < 100. 0 is defined as the more distal EcoR1 site within the scS2 molec- ular deficiency; positive values extend to the left. For coordinates in the elav region, see Campos, Rosen, Robinow and White (1987, EMBO J. 6: 425-31). 0 is defined as the BamHI site closest to the proximal breakpoint of In(1)elav4; positive values extend to the right. The Df(1)yT series comprises terminal deficiencies that were induced in a mu2 background; such deficiencies are unstable and lose about 75 terminal nucleotides per generation (Biessman and Mason, 1988, EMBO J. 7: 1081-86); hence the above determinations represent the situation prior to 1987. # l(1)2A At least six lethally mutable loci, including sta. Two loci identified by Belyaeva and Aizenzon; their l(1)BA11 arbi- trarily assigned to l(1)2Ac, but complementation tests not performed; when these are done the locus designation is likely to change. Their l(1)BA12 assigned to the l(1)2Ad locus on the basis of its localization to the right of Dp(1;f)101 and to the left of sta. These lethals placed between 2A2 and 2B4 by Aizenzon and Belyaeva. Schalet records spontaneous lethals at two loci within Df(1)HA18, l(1)13-80 and l(1)4-134, and Kra- mers et al. record an HMS-induced allele of the latter l(1)HM31; allelism tests of these mutants to known alleles of l(1)2Ab, l(1)2Ac, and l(1)2Ad have not been carried out. cytological locus location included in excluded from synonym _______________________________________________________________ l(1)2Aa 2A1 Df(1)A127 Df(1)HA18 l(1)2Ab 2A1 Df(1)A127 Df(1)HA18 l(1)2Ac 2A2 Df(1)HA18 Dp(1;f)101 l(1)2Ad 2A2-3 Df(1)HA18 Dp(1;f)101 l(1)BA11 l(1)2Ae Df(1)HA18 Dp(1;f)101 l(1)BA12 l(1)2Af 2A3-5 Df(1)sta sta allele origin discoverer synonym ref ( comments _______________________________________________________________________ l(1)2Aa1 EMS Lefevre l(1)VA185 4 L/L l(1)2Ab1 EMS Lefevre l(1)EA97 E/NME l(1)2Ab2 EMS Lefevre l(1)VE896 4 E/NME l(1)2Ac1 X ray Lefevre l(1)A70 3 *l(1)2Ac2 X ray Lefevre l(1)HC278 3 *l(1)2Ac3 X ray Lefevre l(1)RF51 3 l(1)2Ac5 EMS Lefevre l(1)VE721 4 l(1)2Ac6 EMS Lefevre l(1)VA305 4 L3/L l(1)2Ad1 X ray Lefevre l(1)A60 3 L1/L *l(1)2Ad2 X ray Lefevre l(1)RC32 3 l(1)2Ad3 EMS Lefevre l(1)VE795 4 l(1)2Ad4 EMS l(1)t5 1, 2 l(1)2Ad5 EMS l(1)t23 1, 2 l(1)2Ad6 EMS l(1)t62 1, 2 l(1)2Ad7 EMS l(1)t185 1, 2 l(1)2Ad8 EMS l(1)t416 1, 2 l(1)2Ae1 X ray Lefevre l(1)C220 3 sta mutant l(1)2Ae2 X ray Lefevre l(1)C229 3 *l(1)2Ae3 X ray Lefevre l(1)HA93 3 l(1)2Ae4 X ray Lefevre l(1)HC206 3 In(1)1E1-2;2A1-2 l(1)2Ae5 X ray Lefevre l(1)JC53 3 l(1)2Ae6 EMS Lefevre l(1)EC223 4 l(1)2Ae7 EMS Lefevre l(1)VA326 4 l(1)2Ae8 X ray l(1)R4 1, 2 l(1)2Ae9 EMS l(1)t12 1, 2 l(1)2Ae10 EMS l(1)t27 1, 2 l(1)2Ae11 EMS l(1)t224 1, 2 ( 1 = Aizenzon and Belyaeva, 1982, DIS 58: 3-7; 2 = Belyaeva, Aizenzon, Kiss, Gorelova, Pak, Umbetova, Kramers, and Zhimu- lev, 1982, DIS 58: 184-90; 3 = Lefevre, 1981, Genetics 99: 461-80; 4 = Lefevre and Watkins, 1986, Genetics 113: 869-95. # l(1)2B Two collections of lethals in region 2B (Lefevre; Belyaeva et al.) have been complementation tested inter se, but have not been tested against each other. Lefevre identifies eleven complementing groups, whereas Belyaeva et al. identify nine plus two or three others that are identified here as alleles of l(1)2A loci but could lie in 2B. Where a single lethal complementation group from each series occupies the same region as defined by deficiency mapping, they are treated as a single locus. Lethal alleles of br and dor are included in both collections. Belyaeva et al. identify a complex of com- plementing lethals (designated o.c.c. = overlapping complemen- tation complex) that includes the lethal alleles of br, and which is not recognized by Lefevre. These are tabulated below as l(1)2Ba to l(1)2Bd; l(1)2Bad alleles fail to complement four mutually complementing lethals and l(1)2Bab fails to com- plement l(1)2Ba and l(1)2Bb. The loci identified by Lefevre in the br-dor region and which he places in 2B4-12 have been equated arbitrarily to the complementing complex, which Belyaeva et al. place in 2B3-8; future crosses will determine the rectitude of this assignment. These lethals are described with the broad complex (BRC). In addition, Schalet (1983, DIS 59: 107) describes three complementation groups between the breakpoints of y2Y67g19.1 and Dp(1;3)wvco; not tested against l(1)2Bj through l(1)2Bt. arm, selected by Wieschaus, Nusslein-Volhard and Jurgens, has not been tested in combina- tion with any of the others. genetic cytological locus location location included in excluded from synonym _________________________________________________________________________________ l(1)2Ba 1-0.3 2B4-5 Df(1)S39 Df(1)sta br 2B7 Df(1)Sz280 l(1)2Bab 2B4-5 Df(1)S39 Df(1)sta Df(1)Sz280 l(1)2Bad 2B4-5 Df(1)S39 Df(1)sta npr Df(1)Sz280 l(1)2Bb 2B4-5 Df(1)S39 Df(1)sta rbp 2B8 Df(1)Sz280 l(1)2Bc 2B4-5 Df(1)S39 Df(1)sta l(1)pp1 2B9 Df(1)Sz280 l(1)2Bd 2B4-5 Df(1)S39 Df(1)sta l(1)pp2 2B10 Df(1)Sz280 l(1)2Be 1-0.4 2B6-7 y2Y67g24.2 Df(1)S39 dor 2B11-12 l(1)2Bf 2B6-7 y2Y67g24.2 Df(1)S39 hfw, swi 2B11-1 l(1)2Bg 2B12-14 Dp(1;Y)2E Df(1)RA19 l(1)2Bh 2B12-14 Dp(1;Y)2E Df(1)RA19 l(1)2Bi 1-{0.5} 2B15 y2Y67g19.1 Dp(1;Y)2E tlc l(1)2Bj y2Y67g19.1 Df(1)A94 l(1)2Bk y2Y67g19.1 Df(1)A94 l(1)2Bl y2Y67g19.1 Df(1)A94 l(1)2Bm y2Y67g19.1 Df(1)A94 l(1)2Bn y2Y67g19.1 Df(1)A94 l(1)2Bo y2Y67g19.1 Df(1)A94 l(1)2Bp y2Y67g19.1 Df(1)A94 l(1)2Bq y2Y67g19.1 Df(1)A94 l(1)2Br y2Y67g19.1 Df(1)A94 l(1)2Bs y2Y67g19.1 Df(1)A94 l(1)2Bt y2Y67g19.1 Df(1)A94 l(1)2Bu y2Y67g19.1 l(1)2Bv 1-1.2 2B15 y2Y67g19.1 Df(1)svr arm allele origin discoverer synonym ref ( comments _______________________________________________________________________ l(1)2Bg1 HMS Kramers l(1)HM38 1, 2 l(1)2Bg2 | EMS Lefevre l(1)DA681 4 l(1)2Bh1 HMS Kramers l(1)HM40 1, 2 l(1)2Bj1 X ray Lefevre l(1)A68 3 l(1)2Bj2 X ray Lefevre l(1)GA29 3 l(1)2Bj3 X ray Lefevre l(1)HC192 3 l(1)2Bj4 X ray Lefevre l(1)HF347 3 T(1;3)2B;91 (complex) l(1)2Bj5 EMS Lefevre l(1)DA641 4 l(1)2Bj6 EMS Lefevre l(1)DF902 4 l(1)2Bj7 EMS Lefevre l(1)VE792 4 PP l(1)2Bj8 EMS Geer l(1)y23 l(1)2Bk1 EMS Lefevre l(1)VE810 4 L2/L l(1)2Bk2 EMS Lefevre l(1)VE831 4 l(1)2Bl1 EMS Lefevre l(1)EC293 4 l(1)2Bl2 EMS Lefevre l(1)VA177 4 P/NME l(1)2Bm1 X ray Lefevre l(1)HC225 4 l(1)2Bm2 EMS Lefevre l(1)VA341 4 l(1)2Bm3 EMS Lefevre l(1)VA355 4 E/L l(1)2Bn1 X ray Lefevre l(1)C143 3 l(1)2Bn2 X ray Lefevre l(1)HC126 3 l(1)2Bn3 EMS Lefevre l(1)DC831 4 l(1)2Bn4 EMS Lefevre l(1)EF490 4 l(1)2Bn5 EMS Lefevre l(1)VE672 4 L2/L l(1)2Bn6 spont Schalet l(1)17-114 l(1)2Bo1 EMS Lefevre l(1)VA143 4 l(1)2Bp1 EMS Lefevre l(1)DC836 4 l(1)2Bq1 X ray Lefevre l(1)HC180 3 l(1)2Br1 EMS Lefevre l(1)VA130 4 L/L l(1)2Bs1 X ray Lefevre l(1)A106 3 l(1)2Bt1 EMS Lefevre l(1)DF949 4 l(1)2Bu1 spont Schalet l(1)10-153-2 ( 1 = Aizenzon and Belyaeva, 1982, DIS 58: 3-7; 2 = Belyaeva, Aizenzon, Kiss, Gorelova, Pak, Umbetova, Kramers, and Zhimu- lev, 1982, DIS 58: 184-90; 3 = Lefevre, 1981, Genetics 99: 461-80; 4 = Lefevre and Watkins, 1986, Genetics 113: 869-95. | Three mutants in the same region; the two HMS-induced alleles shown not to complement; l(1)2Bg2 arbitrarily assigned to l(1)2Bg, but could equally be allelic to l(1)Bh. # l(1)2C Six lethally mutable loci including Actn and usp. genetic cytological locus location location included in excluded from synonym _________________________________________________________________ l(1)2Ca 2C1 y2Y67g19.1 Dp(1;3)wvco l(1)2Cb 1-1.0 2C3 Dp(1;3)wvco Dp(1;Y)w+303 fliA Actn l(1)2Cc 2B17-D2 Dp(1;3)wvco Dp(1;Y)w+303 l(1)2Cd 2C9 l(1)2Ce 2B17-D2 Dp(1;3)wvco Dp(1;Y)w+303 l(1)2Cf 2C9 Dp(1;3)wvco Dp(1;Y)w+303 usp allele origin discoverer synonym ref ( comments _____________________________________________________________________ l(1)2Ca1 X ray Lefevre l(1)HC282 2 T(1;2)2C1-2;32B l(1)2Ca2 spont Schalet l(1)6-62 # l(1)2Cc phenotype: l(1)2Cc12 larval lethal; l(1)2Cc3 polyphasic; l(1)2Cc1 carries independent lethal and cannot be tested in l/Dp males. Germ line clones in females exhibit nurse-cell degeneration; therefore the normal allele required for normal oogenesis (Perrimon, Engstrom, and Mahowald, l985, Genetics 111: 23-41). allele origin discoverer synonym ref ( comments ______________________________________________________________ l(1)2Cc1 EMS Lefevre l(1)VA56 3, 4 L l(1)2Cc2 EMS Lefevre l(1)VE651 3, 4 L2-3/AO l(1)2Cc3 EMS Lefevre l(1)VE782 3, 4 PP l(1)2Cd1 X ray Lefevre l(1)C134 l(1)2Ce1 X ray Lefevre l(1)GA55 2, 4 L/NME l(1)2Ce2 X ray Lefevre l(1)GF316 2, 4 E l(1)2Ce3 EMS Lefevre l(1)DF943 3, 4 PP ( 1 = Kramers, Schalet, Paradi, and Huiser-Hoogteyling, 1983, Mutation Res. 107: 187-201; 2 = Lefevre, 1981, Genetics 99: 461-80; 3 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 4 = Perrimon, Engstrom, and Mahowald, 1985, Genetics 111: 23-41. # l(1)2D Four lethally mutable loci, three of which have specific names: csw, Pgd, and wapl. genetic cytological locus location location included in excluded from synonym __________________________________________________________________________ l(1)2Da 2D1-2 Dp(1;Y)w+303 Df(1)pn38 l(1)2Db 2D1-2 Dp(1)JA52 Df(1)pn38 l(1)107 l(1)2Dc 2D1-2 Dp(1)JA52 Df(1)pn38 l(1)405 l(1)2Dd 2D3-4 Df(1)pn38 Df(1)Pgd-kz csw l(1)2De 1-0.6 2D4-6 Df(1)Pgd-kz Df(1)64c18 Pgd l(1)2Df 1-0.65 2D4-6 Df(1)Pgd-kz Df(1)64c18 wapl l(1)2Dg l(1)2Dh l(1)2Di # l(1)2Da phenotype: Larval lethal; also cell lethal in female germ line. allele origin discoverer synonym ref ( comments __________________________________________________________________ l(1)2Da1 X ray Lefevre l(1)RC38 3 l(1)2Da2 EMS Lefevre l(1)DF967 4, 5 l(1)2Da3 EMS 2 l(1)2Da4 EMS 2 l(1)2Da5 EMS 2 l(1)2Da6 EMS 2 l(1)2Da7 EMS 2 l(1)2Da8 EMS 2 l(1)2Da9 EMS 2 semilethal l(1)2Db1 EMS 2 l(1)2Db2 EMS 2 l(1)2Db3 X ray 2 l(1)2Dc1 X ray 2 l(1)2Dg1 EMS Gvozdev l(1)N390 1 l(1)2Dg2 X ray Lefevre l(1)A7 3 T(1;A)2E-F;? *l(1)2Dh1 EMS Gvozdev l(1)N572 1 *l(1)2Di1 EMS Gvozdev l(1)N627 1 ( 1 = Alatortsev and Tolchkov, 1985, DIS 61: 24; 1 = Dura, Randsholt, Deatrick, Erk, Santamaria, Freeman, Freeman, Weddell, and Brock, 1987, Cell 51: 829-39; 3 = Lefevre, 1981, Genetics 99: 461-80; 4 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 5 = Perrimon, Engstrom, and Mahowald, 1985, Genetics 111: 23-41. Gvozdev and colleagues recovered three complementing lethals between wapl and l(1)2Ea, two of which are lost; Lefevre reports one. Allelism of Lefevre's mutant arbitrarily assigned. # l(1)2E Two lethally mutable loci, one of which is kz. genetic cytological locus location location included in excluded from synonym _______________________________________________________________________ l(1)2Ea 2E2 Df(1)64c18 Df(1)278B-4-1a l(1)2Eb 1-0.9 2E3 Df(1)278B-4-1a Df(1)2F1-3A4 kz allele origin discoverer synonym ref ( comments ____________________________________________________________________________ l(1)2Ea1 X ray Lefevre l(1)C99 2 In(1)2E3;20; fails to complement pn l(1)2Ea2 X ray Lefevre l(1)JA127 2, 4 l(1)2Ea3 X ray Lefevre l(1)JC105 2, 4 Fails to complement pn and l(1)2Cd2; L1-2/L l(1)2Ea4 X ray Lefevre l(1)RF4 2 l(1)2Ea5 EMS Lefevre l(1)EC205 3, 4 l(1)2Ea6 EMS Lefevre l(1)VA70 3 l(1)2Ea7 EMS Lefevre l(1)VA283 3 l(1)2Ea8 EMS Lefevre l(1)VE712 3 *l(1)2Ea9 NMU Gvozdev l(1)N769 1 l(1)2Ea10 NMU Gvozdev l(1)N770 1 l(1)2Ea11 EMS Gvozdev l(1)N781 1 l(1)2Ea12 gamma Gvozdev l(1)N7107 1 ( 1 = Gvozdev, Gerasimova, Kovalev, and Ananiev, 1977, DIS 52: 67-68; 2 = Lefevre, 1981, Genetics 99: 461-80; 3 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 4 = Perrimon, Engstrom, and Mahowald, 1984, Genetics 108: 559-72. Kramers, Schalet, Paradi, and Huiser-Hoogteyling (1983, Mutation Res. 107: 187-201) place pn and l(1)2Ea10 between the left breakpoints of Df(1)TEM304 on the left and Df(1)TEM1 and Df(1)TEM501 on the right; Lefevre places his alleles adja- cent to pn, either to the left or right; no complementation tests between Lefevre's and Gvozdev's series. # l(1)2Fd Five lethally mutable loci detected by both Gvozdev et al. and Lefevre, complementation relations among the two collec- tions of mutants not fully worked out. genetic cytological locus location location included in excluded from synonym ___________________________________________________________________________ l(1)2Fa 1-{0.95} 2F1 Df(1)278.4B.1 Df(1)2F1-3A4 crn l(1)2Fb 2F1-3 Df(1)2F1-3A4 Df(1)JC19 l(1)2Fc 2F1-3 Df(1)2F1-3A4 Df(1)JC19 l(1)2Fd 2F1-3 Df(1)2F1-3A4 Df(1)JC19 l(1)2Fe 2F6 Df(1)JC19 Df(1)62g18 phl # l(1)2Fb phenotype: l(1)2Fb1, l(1)2Fb3, and l(1)2Fb5 die as second- or third-instar larvae; germ-line clones of l(1)2Fb1 and l(1)2Fb3, but not l(1)2Fb5 are cell lethal. allele origin discoverer synonym ref ( comments _____________________________________________________________________ l(1)2Fb1 X ray Lefevre l(1)JC155 3, 5 l(1)2Fb2 X ray Lefevre l(1)GA1 3 T(1;2)2E-F;41; also rx? l(1)2Fb3 EMS Lefevre l(1)DC798 4, 5 l(1)2Fb4 EMS Lefevre l(1)DC807 4 l(1)2Fb5 EMS Lefevre l(1)VA172 4, 5 L3/NME l(1)2Fb6 EMS Lefevre l(1)VA353 4 l(1)2Fb7 EMS Gvozdev l(1)N916 1 l(1)2Fb8 EMS Gvozdev l(1)N918 1 l(1)2Fb9 EMS Gvozdev l(1)N922 1 l(1)2Fb10 EMS Gvozdev l(1)N924 1 l(1)2Fb11 EMS Gvozdev l(1)N928 1 l(1)2Fb12 EMS Gvozdev l(1)N957 1 l(1)2Fb13 EMS Gvozdev l(1)N958 1 l(1)2Fb14 EMS Gvozdev l(1)N968 1 l(1)2Fb15 EMS Gvozdev l(1)N978 1 l(1)2Fb16 EMS Gvozdev l(1)N982 1 l(1)2Fb17 EMS Gvozdev l(1)N996 1 l(1)2Fb18 EMS Gvozdev l(1)N999 1 l(1)2Fb19 EMS Gvozdev l(1)N9102 1 l(1)2Fb20 EMS Gvozdev l(1)N9108 1 l(1)2Fb21 HMS l(1)HM401 2 l(1)2Fb14 fails to complement l(1)2Fb21; Gvozdev's alleles arbitrarily assigned to this locus although complementation with Lefevre's alleles not tested; could equally well be allelic to l(1)2Fd. # l(1)2Fc phenotype: Lethal phase second or third larval instars; few eggs produced by homozygous germ-line clones in young l(1)2Fc1/+ but not l(1)2Fc2/+ females; clones in older females of both genotypes exhibit previtellogenic arrest. allele origin discoverer synonym ref ( ____________________________________________________ l(1)2Fc1 X ray Lefevre l(1)HF311 3, 5 l(1)2Fc2 X ray Lefevre l(1)HF330 3, 5 l(1)2Fc3 EMS Lefevre l(1)EF420 4 l(1)2Fc4 NMU Gvozdev l(1)N121 1 l(1)2Fc5 EMS Gvozdev l(1)N1246 1 l(1)2Fc6 EMS Gvozdev l(1)N1254 1 l(1)2Fc7 EMS Gvozdev l(1)N1262 1 l(1)2Fc8 EMS Gvozdev l(1)N1275 1 l(1)2Fc9 EMS Gvozdev l(1)N1289 1 l(1)2Fc10 EMS Gvozdev l(1)N1298 1 l(1)2Fc11 HMS l(1)HM438 2 ( 1 = Gvozdev, Gerasimova, Kovalev, and Ananiev, 1977, DIS 52: 67-68; 2 = Kramers, Schalet, Paradi, and Huiser- Hoogteyling, 1983, Mutation Res. 107: 187-201; 3 = Lefevre, 1981, Genetics 99: 461-80; 4 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 5 = Perrimon, Engstrom, and Mahowald, 1985, Genetics 111: 23-41. Failure of l(1)2Fc11 to complement either l(1)2Fc2 or l(1)2Fc5 establishes allelism between the two series. # l(1)2Fd phenotype: Hemizygotes die during second or third instar; homo- zygous germ-line clones for all alleles tested are cell lethal. allele origin discoverer synonym ref ( _____________________________________________________ l(1)2Fd1 EMS Lefevre l(1)EC226 4, 5 l(1)2Fd2 EMS Lefevre l(1)EF462 4, 5 l(1)2Fd3 EMS Lefevre l(1)VA99 4 l(1)2Fd4 EMS Lefevre l(1)VA196 4 l(1)2Fd5 EMS Gvozdev l(1)N1114 2 l(1)2Fd6 EMS Gvozdev l(1)N1115 2 l(1)2Fd7 EMS Gvozdev l(1)N1119 2 l(1)2Fd8 EMS Gvozdev l(1)N1120 2 l(1)2Fd9 EMS Gvozdev l(1)N1123 2 l(1)2Fd10 EMS Gvozdev l(1)N1126 2 l(1)2Fd11 EMS Gvozdev l(1)N1131 2 l(1)2Fd12 EMS Gvozdev l(1)N1142 2 l(1)2Fd13 EMS Gvozdev l(1)N1143 2 l(1)2Fd14 EMS Gvozdev l(1)N1153 2 l(1)2Fd15 EMS Gvozdev l(1)N1160 2 l(1)2Fd16 EMS Gvozdev l(1)N1184 2 l(1)2Fd17 EMS Gvozdev l(1)N11103 2 l(1)2Fd18 EMS Gvozdev l(1)N11105 2 l(1)2Fd19 MR Sobels l(1)D62 1, 5 l(1)2Fd19 MR Sobels l(1)D72 1, 5 l(1)2Fd20 MR Sobels l(1)D82 1, 5 l(1)2Fd21 HMS l(1)HM28 3 l(1)2Fd22 HMS l(1)HM450 3 ( 1 = Eekens, Sobels, Hyland, and Schalet, 1985, Mut. Res. 150: 261-75; 2 = Gvozdev, Gerasimova, Kovalev, and Ananiev, 1977, DIS 52: 67-68; 3 = Kramers, Schalet, Paradi, and Huiser-Hoogteyling, 1983, Mutation Res. 107: 187-201; 4 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 5 = Perrimon, Engstrom, and Mahowald, 1985, Genetics 111: 23-41. Allelism established between HMS-induced mutants and l(1)2Fd10. Arbitrarily assigned to l(1)2Fd, but could equally well be l(1)2Fb alleles. # DEFICIENCY MAP OF REGION 2 side breakpoint variant coordinates ( ________________________________________________________________ right 2A1-4 Df(1)At127 l(1)2Aa left 2B1-2 Df(1)HA18 l(1)2Ab l(1)2Ac left Dp(1;f)101 l(1)2Ad sta right 2B1-2 Df(1)HA18 right 2B1-2 Dp(1)dorY21T right 2B3-4 Df(1)sta 94 to 98.5 kb left BRC br rdp l(1)2Bc l(1)2Bd right BRC 2B3-6 Cp70 right 2B3-4 Df(1)br-R1 125.5 to 129 kb right 2B5-6 Df(1)pn7b 144.5 to 147 kb left 2B4-5 Df(1)P154 174 to 176 kb right 2B5-6 Df(1)ST469 181 to 183 kb right 2B5-6 Df(1)S39 208 to 213 kb left 2B6-8 Df(1)ST472 210.1 to 214.5 kb right 2B5-6 Df(1)P154 214 to 216 kb left 2B6-8 Df(1)dor2T dor Df(1)HF333 hfw right 2B6-8 y2Y67g24.2 right 2B6-8 y2Y21T right 2B6-8 y2Y53T fmf right 2B9-10 y2Y22T right 2B9-10 Dp(1;Y)dor13T right 2B9-11 y2Y40T right 2B11-12 Df(1)ST472 right 2B11-12 Df(1)RA19 right 2B11-12 Df(1)A94 l(1)2Bg l(1)2Bh right Dp(1;f)A1 right 2B12-13 Dp(1;Y)2E right 2B17-18 Df(1)dor1T tlc right 2B17-18 y2Y67g19.1 right 2B17-18 Dp(1;Y)Sz78/4 right 2B17-18 Dp(1;Y)Sz170 right 2B17-18 Dp(1;Y)Sz303 right 2C1-2 Dp(1;Y)dor1T right 2C1-2 Dp(1;Y)dor10T right 2C1-2 Dp(1;Y)dor17T right 2C1-2 Dp(1;Y)Sz71/4 l(1)2Ca left Dp(1;3)wvco Actn l(1)2Cc l(1)2Cd l(1)2Ce usp right 2C10-D1 Df(1)T34 2C12 Dp(1;Y)Sz280 right 2D1-2 Dp(1;Y)dorY18T left 2D1-2 w+Y left 2D1-2 Dp(1;Y)w+303 left 2D3 Df(1)JA52 l(1)2Da 2D1-4 l(1)2Db 2D1-4 l(1)2Dc left 2D3-4 Df(1)pn38 2D2 csw ph left 2D3-4 Df(1)Pgd-kz inferred lethal right Df(1)JA52 left 2D4 Dp(1;Y)y2sc l(1)2Dg 2D3-6 Pgd left Df(1)JC105 2D3-6 wapl left Df(1)l24 right 2E1-2 Df(1)dor2T right 2E1-2 Dp(1)dorY3T right 2E1-2 Dp(1)y2Y43T left 2E1 Df(1)pn7a left 2E1-2 Df(1)64c18 left 2E1-2 Df(1)c99-wm4 left 2E2-F1 Df(1)TEM304 (Perrimon) right 2E1-2 Dp(1;Y)dorY3T 2E1 pn l(1)2Ea Df(1)TEM501 (Schalet) Df(1)TEM1 (Schalet) right 2D6 Df(1)JC105 right Df(1)124 left 2E3-F3 Df(1)278.4B.1a 5.5 to 9.0 kb right 2E2-4 y2Y43T right 2E2-F1 Df(1)Pgd35 right 2E4-F1 Dp(1;f)18 right 2E1-2 Df(1)dor2T 2E pcx right 2E3 Df(1)pn38 left Df(1)L271 55 kb 2E3 kz fs(1)k10 right Df(1)L271 61 kb 2F1 crn 65 to 70 kb left Df(1)2F1-3A4 73.5 to 75.0 kb l(1)2Fb l(1)2Fc l(1)2Fd right 2F5 Df(1)Pgd-kz left Df(1)JC19 left Df(1)X12 phl left Df(1)62g18 left Df(1)TEM75 gt right 3A4 Dp(1;Y)y2sc ( Coordinates in 2B from Chao and Guild (1986, EMBO J. 5: 143-50); coordinates in 2E-F from Haenlin, Steller, Pir- rotta, and Mohier (1985, Cell 40: 827-37). genetic cytological locus location location included in excluded from synonym ________________________________________________________________________ l(1)3Aa 1-0.95 3A2 Df(l)62g18 Df(1)w-rJ1 gt l(1)3Ab 1-0.99 3A2-3 Df(1)w-rJ1 Df(1)64c4 tko l(1)3Ac 1-1.04 3A4 Df(1)K95 Dp(1;3)w67k27 l(1)zw1 l(1)3Ad 1-1.15 3A6 Dp(1;2)w67k27 Dp(1;3)w+70h31 l(1)zw8 l(1)3Ae 1-1.16 3A7 Dp(1;2)w67k27 Dp(1;3)w+70h31 l(1)zw4 l(1)3Af 1-1.17 3A8 Dp(1;3)w+70h31 Df(1)w-rJ2 mit(1)15, l(1)zw10 l(1)3Ag 1-1.26 3A9 l(1)zw13 l(1)3Ah 1-1.29 3A9 Df(1)w-rJ2 Df(1)64f1 l(1)zw2 # l(1)3Ac phenotype: Tight alleles [l(1)3Ac9, l(1)3Ac12, l(1)3Ac23, l(1)3Ac33] are polyphasic, dying during L2, L3, and post puparial stages; cell viable. Semilethal alleles [l(1)3Ac2 and l(1)3Ac6] die as pupae; escapers have rough eyes, shriv- eled or blistered wings, and crippled metathoracic legs; phenotype of X0 more extreme that that of XY males. XY escapers fertile but females sterile [l(1)3Ac2/l(1)3Ac2 and l(1)3Ac2/l(1)3Ac6] or nearly so [l(1)3Ac6/l(1)3A6]. The latter females sterile in crosses to l(1)3Ac6 males, but pro- duce heterozygous daughters when outcrossed (Shannon, Kaufman, Shen, and Judd, 1975, Genetics 72: 615-38). In line freed of l(1)3Ba4 (Robbins), l(1)3Ac14 survives as epidermal clones and as oogenic clones, which produce lethal zygotes (Garcia- Bellido and Robbins, 1983, Genetics 103: 235-47). molecular biology: Likely included in the chromosome walk of Mariani, Pirrotta, and Manet (1985, EMBO J. 4: 2045-52). allele origin discoverer synonym ref ( comments | _________________________________________________________________________ l(1)3Ac1 NNG Kaufman l(1)zw15x 1 l(1)3Ac2 NNG Kaufman l(1)zw17w 1 l(1)3Ac3 NNG Kaufman l(1)zw115j 1 l(1)3Ac4 NNG Kaufman l(1)zw116x 1 l(1)3Ac5 NNG Kaufman l(1)zw128e 1 l(1)3Ac6 NNG Kaufman l(1)zw132i 1 l(1)3Ac7 NNG Kaufman l(1)zw143v 1 l(1)3Ac8 NNG Kaufman l(1)zw145a 1 l(1)3Ac9 X ray Abrahamson l(1)zw1a1 1 l(1)3Ac10 X ray Abrahamson l(1)zw1a2 1 l(1)3Ac11 X ray Judd l(1)zw1a17 1 l(1)3Ac12 X ray Elequin l(1)zw1b16 1 l(1)3Ac13 X ray Judd l(1)zw1b22 1 no MZI l(1)3Ac14 X ray Judd l(1)zw1d8 1 l(1)3Ac15 X ray Judd l(1)zw1d13 1 with l(1)3Ba4, MZI l(1)3Ac16 EMS Judd l(1)zw1E1 1 l(1)3Ac17 EMS Judd l(1)zw1E2 1 l(1)3Ac18 EMS Judd l(1)zw1E3 1 l(1)3Ac19 X ray Judd l(1)zw1e6 1 l(1)3Ac20 X ray Abrahamson l(1)zw1f2 1 l(1)3Ac21 X ray Abrahamson l(1)zw1f5 1 l(1)3Ac22 X ray Judd l(1)zw1g9 1 l(1)3Ac23 X ray Judd l(1)zw1g17 1 l(1)3Ac24 X ray Judd l(1)zw1g19 1 l(1)3Ac25 X ray Judd l(1)zw1g26 1 l(1)3Ac26 X ray Alexander l(1)zw1g30 1 l(1)3Ac27 X ray Judd l(1)zw1g31 1 In(1)3A3-4;6B2-3, MZI l(1)3Ac28 X ray Alexander l(1)zw1i13 1 + EI l(1)3Ac29 X ray Alexander l(1)zw1j20 1 l(1)3Ac30 X ray Alexander l(1)zw1j28 1 l(1)3Ac31 X ray Alexander l(1)zw1k4 1 l(1)3Ac32 X ray Judd l(1)zw1k5 1 l(1)3Ac33 X ray Judd l(1)zw1k6 1 l(1)3Ac34 X ray Judd l(1)zw1k26 1 l(1)3Ac35 EMS l(1)zw1e2 5 l(1)3Ac36 EMS l(1)zw1e4 5 l(1)3Ac37 EMS l(1)zw1e9 5 l(1)3Ac38 EMS l(1)zw1e10 5 l(1)3Ac39 EMS l(1)zw1e15 5 l(1)3Ac40 EMS l(1)zw1e16 5 l(1)3Ac41 EMS l(1)zw1e18 5 l(1)3Ac42 EMS l(1)zw1e24 5 l(1)3Ac43 EMS l(1)zw1e25 5 l(1)3Ac44 EMS l(1)zw1e33 5 l(1)3Ac45 EMS l(1)zw1e34 5 l(1)3Ac46 EMS l(1)zw1e40 5 l(1)3Ac47 EMS l(1)zw1e49 5 l(1)3Ac48 EMS l(1)zw1e52 5 l(1)3Ac49 EMS l(1)zw1e54 5 l(1)3Ac50 EMS l(1)zw1e67 5 l(1)3Ac51 EMS l(1)zw1e70 5 l(1)3Ac52 EMS l(1)zw1e76 5 l(1)3Ac53 EMS l(1)zw1e83 5 l(1)3Ac54 EMS l(1)zw1e84 5 l(1)3Ac55 EMS l(1)zw1e89 5 l(1)3Ac56 EMS l(1)zw1e94 5 l(1)3Ac57 EMS l(1)zw1e95 5 l(1)3Ac58 TEM l(1)zw12 5 l(1)3Ac59 TEM l(1)zw1214 5 T(1;3)3Ac59 l(1)3Ac60 TEM l(1)zw1301 5 l(1)3Ac61 TEM l(1)zw1401 5 l(1)3Ac62 TEM l(1)zw1e411 5 l(1)3Ac63 MMS l(1)zw1m7 6 l(1)3Ac64 MMS l(1)zw1m13 6 l(1)3Ac65 MMS l(1)zw1m14 6 l(1)3Ac66 MMS l(1)zw1m18 6 l(1)3Ac67 MMS l(1)zw1m22 6 l(1)3Ac68 MMS l(1)zw1m23 6 l(1)3Ac69 MMS l(1)zw1m34 6 l(1)3Ac70 MMS l(1)zw1m50 6 l(1)3Ac71 MMS l(1)zw1m51 6 l(1)3Ac72 MMS l(1)zw1m53 6 l(1)3Ac73 MMS l(1)zw1m71 6 l(1)3Ac74 MMS l(1)zw1m76 6 l(1)3Ac75 MMS l(1)zw1m82 6 l(1)3Ac76 MMS l(1)zw1m83 6 l(1)3Ac78 MMS l(1)zw1m86 6 l(1)3Ac79 MMS l(1)zw1m105 6 l(1)3Ac80 MMS l(1)zw1m106 6 l(1)3Ac81 X ray Lefevre l(1)C44 3 l(1)3Ac82 X ray Lefevre l(1)GA3 3 l(1)3Ac83 X ray Lefevre l(1)GE224 3 In(1)3A;20F l(1)3Ac84 X ray Lefevre l(1)HA18 3 also lethal in 2A l(1)3Ac85 X ray Lefevre l(1)HA37 3 T(1;2)3A4;32A1-2 l(1)3Ac86 X ray Lefevre l(1)HF318 3 Tp(3;1)3A3-4;66D-E;80 l(1)3Ac87 X ray Lefevre l(1)HF407 3 l(1)3Ac88 X ray Lefevre l(1)JC31 3 In(1)1E5;3A1-2 l(1)3Ac89 X ray Lefevre l(1)JC46 3 In(1)3A4;4E1 l(1)3Ac91 X ray Lefevre l(1)N4 3 T(1;2)3A5;55A l(1)3Ac92 X ray Lefevre l(1)RF43 3 T(1;4)3A2-3 (complex) l(1)3Ac93 X ray Lefevre l(1)RC45 3 T(1;2)3A;3C1;59D l(1)3Ac94 X ray Lefevre l(1)RC59 3 l(1)3Ac95 X ray Lefevre l(1)S76 3 T(1;2)3A2-3;42A l(1)3Ac96 EMS Lefevre l(1)DC827 4 l(1)3Ac97 EMS Lefevre l(1)DF941 4 l(1)3Ac98 EMS Lefevre l(1)EA31 4 l(1)3Ac99 EMS Lefevre l(1)EA94 4 l(1)3Ac100 EMS Lefevre l(1)EC276 4 l(1)3Ac101 EMS Lefevre l(1)EF418 4 l(1)3Ac102 EMS Lefevre l(1)VA31 4 l(1)3Ac103 EMS Lefevre l(1)VA259 4 l(1)3Ac104 mei-9 / Schalet l(1)9-96 l(1)zw1S1 l(1)3Ac105 mei-9 Schalet l(1)zw1S2M l(1)3Ac106 mei-9 Schalet l(1)zw1S3M l(1)3Ac107 mei-9 Schalet l(1)zw1S4M l(1)3Ac108 HMS l(1)HM34 2 l(1)3Ac109 HMS l(1)HM413 2 l(1)3Ac110 HMS l(1)HM429 2 l(1)3Ac111 HMS l(1)HM432 2 ( 1 = Judd, Shen, and Kaufman, 1972, Genetics 71: 139-56; 2 = Kramers, Schalet, Paradi, and Huiser-Hoogteyling, 1983, Mutat. Res. 107: 187-201; 3 = Lefevre, 1981, Genetics 99: 461-80; 4 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 5 = Lim and Snyder, 1974, Genet. Res. 24: 1- 10; 6 = Liu and Lim, 1975, Genetics 79: 601-11. | MZI = maternal-zygotic interaction; demonstrated in males carrying mutant allele from heterozygous mother and variegating allele in a paternally derived duplication (Rob- bins, 1983, Genetics 103: 633-48). / Spontaneous in the paternal X chromosome of a cross between wild-type males and mei-9 females, such that the F1 females were l(1)3Ac/mei-9. # l(1)3Ad l(1)3Ad6 lethal in epidermal and female germ-line clones (Garcia-Bellido and Robbins, 1983, Genetics 103: 235-47). allele origin discoverer synonym ref ( comments | ____________________________________________________________________________ l(1)3Ad1 NNG Kaufman l(1)zw86b 1 t.s. semilethal, MZI l(1)3Ad2 NNG Kaufman l(1)zw820m 1 l(1)3Ad3 NNG Kaufman l(1)zw828y 1 l(1)3Ad4 NNG Kaufman l(1)zw833o 1 l(1)3Ad5 NNG Kaufman l(1)zw844j 1 t.s. semilethal, MZI l(1)3Ad6 X ray Judd l(1)zw8g10 1 MZI l(1)3Ad7 X ray Judd l(1)zw8g28 1 MZI l(1)3Ad8 EMS l(1)zw8e5 5 l(1)3Ad9 EMS l(1)zw8e17 5 l(1)3Ad10 EMS l(1)zw8e35 5 l(1)3Ad11 EMS l(1)zw8e45 5 l(1)3Ad12 EMS l(1)zw8e65 5 l(1)3Ad13 EMS l(1)zw8e78 5 l(1)3Ad14 EMS l(1)zw8e88 5 l(1)3Ad15 MMS l(1)zw8m1 6 l(1)3Ad16 MMS l(1)zw8m42 6 l(1)3Ad17 MMS l(1)zw8m44 6 l(1)3Ad18 MMS l(1)zw8m48 6 l(1)3Ad19 MMS l(1)zw8m61 6 l(1)3Ad20 MMS l(1)zw8m64 6 l(1)3Ad21 MMS l(1)zw8m79 6 l(1)3Ad22 MMS l(1)zw8m89 6 l(1)3Ad23 MMS l(1)zw8m92 6 l(1)3Ad24 MMS l(1)zw8m107 6 l(1)3Ad25 MMS l(1)zw8m114 6 l(1)3Ad26 X ray Lefevre l(1)RC2 3 l(1)3Ad27 X ray Lefevre l(1)RF15 3 l(1)3Ad28 EMS Lefevre l(1)EC204 4 l(1)3Ad29 EMS Lefevre l(1)VA4 4 l(1)3Ad30 EMS Lefevre l(1)VA19 4 l(1)3Ad31 EMS Lefevre l(1)VA50 4 l(1)3Ad32 EMS Lefevre l(1)VE664 4 l(1)3Ad33 EMS Lefevre l(1)VE667 4 l(1)3Ad34 EMS Lefevre l(1)VE815 4 l(1)3Ad35 spont Schalet l(1)16-94 l(1)zw8S1 l(1)3Ad36 HMS l(1)HM6 2 l(1)3Ad37 HMS l(1)HM458 2 ( 1 = Judd, Shen, and Kaufman, 1972, Genetics 71: 139-56; 2 = Kramers, Schalet, Paradi, and Huiser-Hoogteyling, 1983, Mutat. Res. 107: 187-201; 3 = Lefevre, 1981, Genetics 99: 461-80; 4 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 5 = Lim and Snyder, 1974, Genet. Res. 24: 1- 10; 6 = Liu and Lim, 1975, Genetics 79: 601-11. | MZI = maternal-zygotic interaction; demonstrated in males carrying mutant allele from heterozygous mother and variegating allele in a paternally derived duplication (Rob- bins, 1983, Genetics 103: 633-48). # l(1)3Ae phenotype: Alleles tested [l(1)Ae2, l(1)Ae3, l(1)Ae6, l(1)Ae8, l(1)Ae10, l(1)Ae11] die in post puparial stage, but growth slowing starts at various earlier stages; tested alleles sur- vive in hemizygous condition in gynandromorphs; hemizygous eyes rough. Pharate adults dissected from l(1)3Ae1 and l(1)Ae5 pupae show rough eyes, sparse microchaetae, and incom- plete dorsal midline; XY but not XO males of both rescued by Dp(1;4)wm65g, exhibiting phenotype of dissected pharate adults described above (Shannon, Kaufman, Shen, and Judd, l972, Genetics 72: 615-38). allele origin discoverer synonym ref ( comments | _______________________________________________________________________ l(1)3Ae1 NNG Kaufman l(1)zw429l 1 l(1)3Ae2 X ray Judd l(1)zw4d28 1 no MZI l(1)3Ae3 X ray Judd l(1)zw4e4 1 no MZI l(1)3Ae4 X ray + EI Alexander l(1)zw4g8 1 l(1)3Ae5 spont Lefevre l(1)zw4g11 1 l(1)3Ae6 X ray Judd l(1)zw4g24 1 semilethal, no MZI l(1)3Ae7 X ray + EI Alexander l(1)zw4h6 1 l(1)3Ae8 X ray + EI Alexander l(1)zw4i24 1 no MZI l(1)3Ae9 EI Alexander l(1)zw4j6 1 l(1)3Ae10 X ray Alexander l(1)zw4j27 1 l(1)3Ae11 EI Alexander l(1)zw4k16 1 MZI l(1)3Ae12 EI Alexander l(1)zw4k27 1 l(1)3Ae13 EMS l(1)zw4e11 4 l(1)3Ae14 EMS l(1)zw4e48 4 l(1)3Ae15 EMS l(1)zw4e57 4 l(1)3Ae16 EMS l(1)zw4e82 4 l(1)3Ae17 EMS l(1)zw4e85 l(1)3Ae18 MMS l(1)zw4m5 5 l(1)3Ae19 MMS l(1)zw4m11 5 l(1)3Ae21 MMS l(1)zw4m15 5 l(1)3Ae22 MMS l(1)zw4m20 5 l(1)3Ae23 MMS l(1)zw4m68 5 l(1)3Ae24 MMS l(1)zw4m101 5 l(1)3Ae25 X ray Lefevre l(1)GA107 2 l(1)3Ae26 X ray Lefevre l(1)GE240 2 l(1)3Ae27 EMS Lefevre l(1)DF944 3 l(1)3Ae28 EMS Lefevre l(1)EC241 3 l(1)3Ae29 EMS Lefevre l(1)EC270 3 l(1)3Ae30 EMS Lefevre l(1)EF442 3 ( 1 = Judd, Shen, and Kaufman, 1972, Genetics 71: 139-56; 2 = Lefevre, 1981, Genetics 99: 461-80; 3 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 4 = Lim and Snyder, 1974, Genet. Res. 24: 1-10; 5 = Liu and Lim, 1975, Genetics 79: 601-11. | MZI = maternal-zygotic interaction; demonstrated in males carrying mutant allele from heterozygous mother and variegating allele in a paternally derived duplication (Rob- bins, 1983, Genetics 103: 633-48). # l(1)3Ag allele origin synonym ref ( comments | _____________________________________________________ l(1)3Ag1 EMS l(1)zw13e50 1 MZI l(1)3Ag2 EMS l(1)zw13e77 1 l(1)3Ag3 TEM l(1)zw1313 1 MZI l(1)3Ag4 MMS l(1)zw13m2 2 l(1)3Ag5 MMS l(1)zw13m6 2 l(1)3Ag6 MMS l(1)zw13m115 2 ( 1 = Lim and Snyder, 1974, Genet. Res. 24: 1-10; 2 = Liu and Lim, 1975, Genetics 79: 601-11. | MZI = maternal-zygotic interaction; demonstrated in males carrying mutant allele from heterozygous mother and variegating allele in a paternally derived duplication (Rob- bins, 1983, Genetics 103: 633-48). Survival of duplication-bearing males cold sensitive; l(1)3Ag/w+Y males yield frequent meiotic nondisjunction. # l(1)3Ah phenotype: Lethal alleles [l(1)3Ah7, l(1)3Ah9, l(1)3Ah11] die at the egg-larval boundary; l(1)3Ah16 and l(1)3Ah12 die shortly after hatching. Cell viable, but gynandromorphs show reduced survival. l(1)3Ah6 semilethal with biphasic lethal expression in early larval and imago stages; escapers have rough eyes and are male fertile; inviable in combination with deficiency or lethal alleles (Shannon, Kaufman, Shen, and Judd, l972, Genetics 72: 615-38). l(1)3Ah13 viable in epi- dermal but not female germ-line clones (Garcia-Bellido and Robbins, 1983, Genetics 103: 235-47). allele origin discoverer synonym ref ( comments | ____________________________________________________________________ l(1)3Ah1 NNG Reichert l(1)zw21f 1 l(1)3Ah2 NNG Kaufman l(1)zw21u 1 l(1)3Ah3 NNG Kaufman l(1)zw21x 1 l(1)3Ah5 NNG Kaufman l(1)zw23g 1 l(1)3Ah6 NNG Kaufman l(1)zw26p 1 l(1)3Ah7 NNG Kaufman l(1)zw220f 1 l(1)3Ah8 NNG Kaufman l(1)zw228c 1 l(1)3Ah9 NNG Kaufman l(1)zw239p 1 l(1)3Ah10 X ray Abrahamson l(1)zw2a3 1 l(1)3Ah11 Le Fever l(1)zw2b11 1 MZI l(1)3Ah12 X ray Judd l(1)zw2b26 1 l(1)3Ah13 X ray Judd l(1)zw2c21 1 MZI l(1)3Ah14 X ray Judd l(1)zw2c28 1 l(1)3Ah15 X ray Abrahamson l(1)zw2f3 1 l(1)3Ah16 X ray Lefevre l(1)zw2g4 1 l(1)3Ah17 X ray Lefevre l(1)zw2g6 1 l(1)3Ah18 EMS Kaufman l(1)zw2g12 1 l(1)3Ah19 X ray + EI Alexander l(1)zw2h5 1 l(1)3Ah20 X ray + EI Alexander l(1)zw2l20 1 l(1)3Ah21 X ray Alexander l(1)zw2l23 1 MZI l(1)3Ah22 EMS l(1)zw2e1 5 l(1)3Ah23 EMS l(1)zw2e3 5 l(1)3Ah24 EMS l(1)zw2e7 5 l(1)3Ah25 EMS l(1)zw2e8 5 l(1)3Ah26 EMS l(1)zw2e14 5 l(1)3Ah27 EMS l(1)zw2e20 5 l(1)3Ah28 EMS l(1)zw2e27 5 l(1)3Ah29 EMS l(1)zw2e31 5 l(1)3Ah30 EMS l(1)zw2e37 5 l(1)3Ah31 EMS l(1)zw2e41 5 l(1)3Ah32 EMS l(1)zw2e43 5 l(1)3Ah33 EMS l(1)zw2e44 5 l(1)3Ah34 EMS l(1)zw2e46 5 l(1)3Ah35 EMS l(1)zw2e47 5 l(1)3Ah36 EMS l(1)zw2e53 5 l(1)3Ah37 EMS l(1)zw2e59 5 l(1)3Ah38 EMS l(1)zw2e61 5 l(1)3Ah39 EMS l(1)zw2e66 5 l(1)3Ah40 EMS l(1)zw2e68 5 l(1)3Ah41 TEM l(1)zw28 5 l(1)3Ah42 TEM l(1)zw29 5 l(1)3Ah43 TEM l(1)zw214 5 l(1)3Ah44 TEM l(1)zw2109 5 l(1)3Ah45 TEM l(1)zw2201 5 l(1)3Ah46 TEM l(1)zw2303 5 l(1)3Ah47 TEM l(1)zw2305 5 l(1)3Ah48 TEM l(1)zw2402 5 l(1)3Ah49 TEM l(1)zw2405 5 l(1)3Ah51 TEM l(1)zw2406 5 l(1)3Ah52 TEM l(1)zw2412 5 l(1)3Ah53 TEM l(1)zw2413 5 l(1)3Ah54 MMS l(1)zw2m3 6 l(1)3Ah55 MMS l(1)zw2m8 6 l(1)3Ah56 MMS l(1)zw2m26 6 l(1)3Ah57 MMS l(1)zw2m30 6 l(1)3Ah58 MMS l(1)zw2m37 6 l(1)3Ah59 MMS l(1)zw2m38 6 l(1)3Ah60 MMS l(1)zw2m43 6 l(1)3Ah61 MMS l(1)zw2m46 6 l(1)3Ah62 MMS l(1)zw2m59 6 l(1)3Ah63 MMS l(1)zw2m60 6 l(1)3Ah64 MMS l(1)zw2m67 6 l(1)3Ah65 MMS l(1)zw2m69 6 with l(1)3Ba20 l(1)3Ah66 MMS l(1)zw2m70 6 l(1)3Ah67 MMS l(1)zw2m74 6 l(1)3Ah68 MMS l(1)zw2m75 6 l(1)3Ah69 MMS l(1)zw2m95 6 l(1)3Ah70 MMS l(1)zw2m99 6 l(1)3Ah71 MMS l(1)zw2m104 6 l(1)3Ah72 MMS l(1)zw2m108 6 l(1)3Ah73 MMS l(1)zw2m109 6 l(1)3Ah74 MMS l(1)zw2m110 6 l(1)3Ah75 MMS l(1)zw2m113 6 l(1)3Ah76 X ray Lefevre l(1)C208 3 l(1)3Ah77 X ray Lefevre l(1)HC114 3 l(1)3Ah78 X ray Lefevre l(1)JC109 3 l(1)3Ah79 X ray Lefevre l(1)RA43 3 l(1)3Ah80 X ray Lefevre l(1)RF33 3 l(1)3Ah81 EMS Lefevre l(1)DC716 4 l(1)3Ah82 EMS Lefevre l(1)DF921 4 l(1)3Ah83 EMS Lefevre l(1)EA12 4 l(1)3Ah84 EMS Lefevre l(1)EA96 4 l(1)3Ah85 EMS Lefevre l(1)EC216 4 l(1)3Ah86 EMS Lefevre l(1)EF440 4 l(1)3Ah87 EMS Lefevre l(1)VA329 4 l(1)3Ah88 EMS Lefevre l(1)VA359 4 l(1)3Ah89 EMS Lefevre l(1)VE616 4 l(1)3Ah90 EMS Lefevre l(1)VE722 4 l(1)3Ah91 spont Schalet l(1)17-59 l(1)zw2S1 l(1)3Ah92 mei-9 / Schalet l(1)zw2S2M l(1)3Ah93 HMS l(1)HM434 2 ( 1 = Judd, Shen, and Kaufman, 1972, Genetics 71: 139-56; 2 = Kramers, Schalet, Paradi, and Huiser-Hoogteyling, 1983, Mutat. Res. 107: 187-201; 3 = Lefevre, 1981, Genetics 99: 461-80; 4 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 5 = Lim and Snyder, 1974, Genet. Res. 24: 1- 10; 6 = Liu and Lim, 1975, Genetics 79: 601-11. | MZI = maternal-zygotic interaction; demonstrated in males carrying mutant allele from heterozygous mother and variegating allele in a paternally derived duplication (Rob- bins, 1983, Genetics 103: 633-48). / Spontaneous in the paternal X chromosome of a cross between wild-type males and mei-9 females, such that the F1 females were l(1)3Ah/mei-9. genetic cytological locus location location included in excluded from synonym _________________________________________________________________________ l(1)3Ba 1-1.32 3B1 Df(1)64f1 Df(1)62d18 sgg; l(1)zw3 l(1)3Bb 1-1.41 3B2 Df(1)62d18 Df(1)w258-45 l(1)zw6 l(1)3Bc 1-1.43 3B3 Df(1)w258-45 Dp(1;3)N264-58a l(1)zw12 l(1)3Bd 1-1.43 3B4 Dp(1;3)N264-58a l(1)zw7 Df(1)X12 l(1)3Be 1-1.47 3B5 Dp(1;3)N264-58a dwg Df(1)X12 l(1)zw5 l(1)3Bf 1-1.48 3B6 Dp(1;3)N264-58a l(1)zw11 Df(1)X12 # l(1)3Bb phenotype: Tested alleles die without growth in first larval instar [l(1)3Bb4, l(1)3Bb6, l(1)3Bb7] or grow slightly [l(1)3Bb1, l(1)3Bb5]. Few reach second instar but fail to grow further. All survive as XY but not as XO males in pres- ence of either Dp(1;4)wm65g or Dp(1;3)wm49a. Survive as gynandromorphs when only tergites and occasionally wing tissue mutant; mutant tissue etched, lacks bristles, and deformed in the case of wing tissue (Shannon, Kaufman, Shen, and Judd, l972, Genetics 72: 615-38). l(1)3Bb1 and l(1)3Bb4 viable in epidermal clones; only l(1)3Bb1 survives in oogenic clones, and they produced viable zygotes (Garcia-Bellido and Robbins, 1983, Genetics 103: 235-47). allele origin discoverer synonym ref ( comments | _____________________________________________________________________ l(1)3Bb1 ICR170 Hochman l(1)zw6a25 1 l(1)3Bb2 X ray Elequin l(1)zw6b17 1 l(1)3Bb3 X ray Judd l(1)zw6b23 1 MZI l(1)3Bb4 X ray Judd l(1)zw6e5 1 l(1)3Bb5 X ray Judd l(1)zw6e13 1 l(1)3Bb6 X ray Alexander l(1)zw6g7 1 l(1)3Bb7 X ray Judd l(1)zw6l12 1 l(1)3Bb8 EMS l(1)zw6e12 4 l(1)3Bb9 EMS l(1)zw6e72 4 l(1)3Bb10 EMS l(1)zw6e80 4 l(1)3Bb11 TEM l(1)zw6403 4 l(1)3Bb12 MMS l(1)zw6m31 5 l(1)3Bb13 MMS l(1)zw6m47 5 l(1)3Bb14 MMS l(1)zw6m57 5 l(1)3Bb15 MMS l(1)zw6m58 5 l(1)3Bb16 MMS l(1)zw6m66 5 l(1)3Bb17 X ray Lefevre l(1)A14 2 In(1)3B1-2;4E1 l(1)3Bb18 X ray Lefevre l(1)HC222 2 l(1)3Bb19 EMS Lefevre l(1)EC287 3 l(1)3Bb20 EMS Lefevre l(1)VE734 3 l(1)3Bb21 P / l(1)zw6P1 6 l(1)3Bb22 P / l(1)zw6P2 6 ( 1 = Judd, Shen, and Kaufman, 1972, Genetics 71: 139-56; 2 = Lefevre, 1981, Genetics 99: 461-80; 3 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 4 = Lim and Snyder, 1974, Genet. Res. 24: 1-10; 5 = Liu and Lim, 1975, Genetics 79: 601-11. 6 = Reddy, Zehring, Wheeler, Pirrotta, Had- field, Hall, and Rosbash, 1984, Cell 38: 701-10. | MZI = maternal-zygotic interaction; demonstrated in males carrying mutant allele from heterozygous mother and variegating allele in a paternally derived duplication (Rob- bins, 1983, Genetics 103: 633-48). / No P-derived sequences detectable; possibly deletion gen- erated by P excision. # l(1)3Bc phenotype: Die as first instar larvae. XY but not XO males survive in combination with Dp(1;4)wm65g and Dp(1;3)wm49a. Mutant tissue survives and is phenotypically normal in gynan- dromorphs (Shannon, Kaufman, Shen, and Judd, l972, Genetics 72: 615-38). Germ-line clones in females don't survive (Garcia-Bellido and Robbins, 1983, Genetics 103: 235-47). allele origin discoverer synonym ref ( comments | _________________________________________________________ l(1)3Bc1 NNG Kaufman l(1)zw1235n 1 l(1)3Bc2 X ray Alexander l(1)zw12k1 1 MZI l(1)3Bc3 X ray Alexander l(1)zw12k3 1 l(1)3Bc4 X ray + Alexander l(1)zw12k9 1 DMSO l(1)3Bc5 l(1)zw12e34 5 l(1)3Bc6 MMS l(1)zw12m19 6 l(1)3Bc7 MMS l(1)zw12m28 6 l(1)3Bc8 MMS l(1)zw12m32 6 l(1)3Bc9 MMS l(1)zw12m40 6 l(1)3Bc10 MMS l(1)zw12m56 6 l(1)3Bc11 MMS l(1)zw12m65 6 l(1)3Bc12 X ray Lefevre l(1)A117 3 l(1)3Bc13 X ray Lefevre l(1)C130 3 l(1)3Bc14 X ray Lefevre l(1)HC102 3 l(1)3Bc15 X ray Lefevre l(1)RC53 3 l(1)3Bc16 EMS Lefevre l(1)VE658 4 l(1)3Bc17 HMS l(1)HM16 2 l(1)3Bc18 HMS l(1)HM402 2 ( 1 = Judd, Shen, and Kaufman, 1972, Genetics 71: 139-56; 2 = Kramers, Schalet, Paradi, and Huiser-Hoogteyling, 1983, Mutat. Res. 107: 187-201; 3 = Lefevre, 1981, Genetics 99: 461-80; 4 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 5 = Lim and Snyder, 1974, Genet. Res. 24: 1- 10; 6 = Liu and Lim, 1975, Genetics 79: 601-11. | MZI = maternal-zygotic interaction; demonstrated in males carrying mutant allele from heterozygous mother and variegating allele in a paternally derived duplication (Rob- bins, 1983, Genetics 103: 633-48). # l(1)3Bd phenotype: l(1)3Bd1 males die either without growth in L1 or following protracted growth to full sized L2 stage. l(1)3Bd3 males die as full-size L1 or variable-size L2 stage. XY but not XO males survive with slightly rough eyes and are fertile in presence of Dp(1;4)wm65g, Dp(1;3)wm49a, and Dp(1;3)N264- 58a. Mutant tissue does not survive in gynandromorphs (Shan- non, Kaufman, Shen, and Judd, l972, Genetics 72: 615-38), nor in epidermal or female germ-line clones (Garcia-Bellido and Robbins, 1983, Genetics 103: 235-47). allele origin discoverer synonym ref ( comments | ___________________________________________________________________ l(1)3Bd1 NNG Kaufman l(1)zw731x 1 MZI l(1)3Bd2 X ray Judd l(1)zw7e3 1 MZI l(1)3Bd3 X ray Judd l(1)zw7g20 1 MZI l(1)3Bd4 EMS l(1)zw7e13 4 l(1)3Bd5 EMS l(1)zw7e30 4 l(1)3Bd6 EMS l(1)zw7e42 4 l(1)3Bd7 EMS l(1)zw7e92 4 l(1)3Bd8 TEM l(1)zw710 4 l(1)3Bd9 TEM l(1)zw7302 4 l(1)3Bd10 TEM l(1)zw7407 4 l(1)3Bd11 MMS l(1)zw7m12 5 l(1)3Bd12 X ray Lefevre l(1)C26 2 l(1)3Bd13 X ray Lefevre l(1)GE203 2 l(1)3Bd14 EMS Lefevre l(1)VE698 3 l(1)3Bd15 mei-9 / Schalet l(1)zw7S1M ( 1 = Judd, Shen, and Kaufman, 1972, Genetics 71: 139-56; 2 = Lefevre, 1981, Genetics 99: 461-80; 3 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 4 = Lim and Snyder, 1974, Genet. Res. 24: 1-10; 5 = Liu and Lim, 1975, Genetics 79: 601-11. | MZI = maternal-zygotic interaction; demonstrated in males carrying mutant allele from heterozygous mother and variegating allele in a paternally derived duplication (Rob- bins, 1983, Genetics 103: 633-48). / Spontaneous in the paternal X chromosome of a cross between wild-type males and mei-9 females, such that the F1 females were l(1)3Bd/mei-9. # l(1)3Bf phenotype: Most mutant larvae survive to L2 stage; L2 survivors grow slowly and reach half normal size before dying. XY but not XO males survive in combination with Dp(1;4)wm65g, Dp(1;3)wm49a, and Dp(1;3)N264-58a; lack varying numbers of orbital, ocellar, and vertical bristles; occasionally wing veins thickened; fertile. Mutant tissue [l(1)3Bf5, l(1)3Bf6, l(1)3Bf7] does not survive in gynandromorphs (Shannon, Kauf- man, Shen, and Judd, l972, Genetics 72: 615-38). l(1)Bf5 lethal in both epidermal and oogenic clones (Garcia-Bellido and Robbins, 1983, Genetics 103: 235-47). allele origin discoverer synonym ref ( ______________________________________________________ l(1)3Bf1 NNG Kaufman l(1)zw113w 1 l(1)3Bf2 NNG Kaufman l(1)zw1114e 1 l(1)3Bf3 NNG Kaufman l(1)zw1120t 1 l(1)3Bf4 NNG Kaufman l(1)zw1125f 1 l(1)3Bf5 ICR170 Hochman l(1)zw11a5 1 l(1)3Bf6 X ray Elequin l(1)zw11b18 1 l(1)3Bf7 X ray Judd l(1)zw11g3 1 l(1)3Bf8 EMS l(1)zw11e22 3 l(1)3Bf9 TEM l(1)zw1111 3 l(1)3Bf10 TEM l(1)zw11404 3 l(1)3Bf11 MMS l(1)zw11m4 4 l(1)3Bf12 MMS l(1)zw11m39 4 l(1)3Bf13 MMS l(1)zw11m85 4 l(1)3Bf14 MMS l(1)zw11m97 4 l(1)3Bf15 MMS l(1)zw11m111 4 l(1)3Bf16 EMS Lefevre l(1)EF525 2 l(1)3Bf17 EMS Lefevre l(1)VE725 2 ( 1 = Judd, Shen, and Kaufman, 1972, Genetics 71: 139-56; 2 = Lefevre, 1981, Genetics 99: 461-80; 3 = Lim and Snyder, 1974, Genet. Res. 24: 1-10; 4 = Liu and Lim, 1975, Genetics 79: 601-11. # l(1)3C3 location: 1-1.6 (between w and rst). origin: Synthetic. discoverer: Lefevre and Wilkins. references: 1964, Genetics 50: 264. phenotype: Male lethal. l(1)3C3/w is normal. RK2. cytology: The consequence of deleting 3C3 through 3C6, a region postulated to contain duplicated loci (Lefevre and Green, 1972, Chromosoma 36: 391-412). Originally associated with the deficiency for band 3C3 alone obtained as a single recombinant carrying the left end of T(1;4)wmJ = T(1;4)3C2-3;20;102C and the right end of In(1)rst3 = In(1)3C3-5;20B. That result attributed to the combined effects of the deficiency for 3C3 and a positon effect on 3C5-6, neither of which is lethal by itself (Lefevre and Green). # l(1)3C-D 3C contains two named lethally mutable loci, crm and N. 3D contains one lethally mutable locus. genetic cytological locus location location included in excluded from synonym _______________________________________________________________________________ l(1)3Ca 1-1.49 3C1 Df(1)w-rJ1 Df(1)X12 crm, l(1)zw9 l(1)3Cb 1-3.0 3C7 Df(1)T30 Df(1)dm75e19 N l(1)3Da 3D6 Df(1)JA53 Df(1)GA113 allele origin discoverer synonym ref ( comments | _____________________________________________________________________ l(1)3Da1 X ray Lefevre l(1)GE204 1 T(1;2)3D3-4;41, also dm l(1)3Da2 X ray Lefevre l(1)GE246 1 also dm; In(1)3B3;20F l(1)3Da3 X ray Lefevre l(1)JA53 1 T(1;A)3D5;4B5;?; complex, also dm l(1)3Da4 X ray Lefevre l(1)JC9 1 not dm l(1)3Da5 X ray Lefevre l(1)RA55 1 also dm; EL1-2/L l(1)3Da6 X ray Lefevre l(1)RF29 1 also dm; T(1;2;3)3D3-6;7D;41; 93F-94A1 l(1)3Da7 EMS Lefevre l(1)EC238 2 also dm; rearranged ( 1 = Lefevre, 1981, Genetics 99: 461-80; 2 = Lefevre and Watkins, 1986, Genetics 113: 869-95. | dm effects considered to result from rearrangements; lethal- ity considered not to be at the dm locus. # l(1)3E Five lethally mutable loci recorded by Lefevre. genetic cytological locus location location included in excluded from synonym _______________________________________________________________ l(1)3Ea 1-3.6 3E1 Df(1)N8 Df(1)GBM207 slc l(1)3Eb 3E2 Dp(1;3)w49a Df(1)N-8 l(1)3Ec 3E3 Df(1)dm75e19 Dp(1;3)w49a l(1)3Ed 3E4-6 Df(1)WC159 Df(1)dm75e19 l(1)3Ee 3E7 Df(1)WC159 Df(1)HF366 allele origin discoverer synonym ref ( comments ___________________________________________________________ l(1)3Eb1 X ray Lefevre l(1)GF332 1 T(1;A)3E5; het l(1)3Eb2 X ray Lefevre l(1)RF52 1 T(1;A)3E1-2;? l(1)3Eb3 EMS Lefevre l(1)DA564 2 l(1)3Eb4 EMS Lefevre l(1)DA618 2 l(1)3Eb5 EMS Lefevre l(1)DC805 2 l(1)3Eb6 EMS Lefevre l(1)DF957 2 l(1)3Eb7 EMS Lefevre l(1)VA44 2 l(1)3Eb8 EMS Lefevre l(1)VA148 2 EL/AO l(1)3Eb9 EMS Lefevre l(1)VE619 2 l(1)3Ec1 X ray Lefevre l(1)HF345 1 T(1;2)3C7;27E l(1)3Ec2 X ray Lefevre l(1)RF53 1 T(1;3)3E1;80 l(1)3Ec3 X ray Lefevre l(1)VE880 1 P/NME l(1)3Ed1 X ray Lefevre l(1)GA2 = 1 In(1)3C5;3E-F; l(1)GA58 18A1-2 l(1)3Ed2 X ray Lefevre l(1)GE210 1 l(1)3Ed3 X ray Lefevre l(1)JC43 1 T(1;4)3A10;3E5; 102C l(1)3Ee1 X ray Lefevre l(1)L56 1 l(1)3Ee2 EMS Lefevre l(1)EC245 2 l(1)3Ee3 EMS Lefevre l(1)EF423 2 ( 1 = Lefevre, 1981, Genetics 99: 461-80; 2 = Lefevre and Watkins, 1986, Genetics 113: 869-95. # DEFICIENCY MAP OF REGION 3 side breakpoint variant DNA coordinates ( ___________________________________________________________ left 2F5-3A1 Df(1)TEM75 left 2F6-3A1 Df(1)X12 left 3A1 Df(1)TEM6 left 3A1-2 Df(1)62g18 left 3A1-2 Df(1)62j26 3A3 gt left 3A1-2 Df(1)w-rJ1 3A2-3 tko right 3A3 Df(1)TEM6 left 3A3 Df(1)TEM7 right 3A3 Df(1)TEM304 left 3A3-4 Df(1)64c4 left 3A3-4 Df(1)K95 left 3A3-4 Df(1)w258-11 right 3A4 Df(1)2F1-3A4 3A4 l(1)3Ac right 3A4 Df(1)pn7a right 3A4-6 Df(1)62g18 right 3A4-6 Df(1)62j26 right 3A4-6 Df(1)TEM304 left 3A4-6 Df(1)w258-42 left 3A4-6 Df(1)w-N71a left 3A4-6 Dp(1;3)w67k27 right 3A5-B4 Df(1)278.4B.1a 3A6 l(1)3Ad 3A7 l(1)3Ae left 3A6-8 Dp(1;2)w+70h31 3A8 l(1)3Af left 3A8-9 Df(1)64j4 left 3A8-9 Df(1)w-rJ2 3A9 l(1)3Ag left 3A9 Df(1)mm69 3A9 l(1)3Ah left 3A9-B1 Df(1)64f1 left 3A9-B2 Dp(1;3)w49a right 3B Df(1)TEM1 3B1 l(1)3Ba right 3B1 l(1)mm69 left 3B1-2 Df(1)62d18 0 to 1.0 kb left 3B2 Df(1)TEM202 5.5 to 6.6 kb left 3B1-2 per T(1;4)JC43 13.3 to 13.7 kb right per right 3B1-2 Df(1)64j4 16.9 to 19.2 kb ~-97 kb right 3B1-2 Df(1)K95 left 3B1-2 Df(1)w64d 22.9 to 24.5 kb left 3B1-2 Dp(1;4)wm65g 3B2 l(1)3Bb left 3B2-3 Df(1)w258-45 ~-87 kb 3B3 l(1)3Bc left 3B2-4 Dp(1;3)N-264-58a right 3B3 Df(1)TEM7 right 3B3-4 Df(1)64f1 ~-83 kb 3B4 l(1)3Bd 3B5 dwg 3B6 l(1)3Bf right 3B5-C1 Df(1)X12 3C1 crm left 3C1-2 Df(1)N-8 left 3C1-2 Dp(1;3)w+51b 3C2 w 0 kb left 3C1-2 Df(1)w67c23.2 1.5 to 3.5 kb right 3C2-3 Dp(1;2)w+70h ~29 kb right 3C1-3 Df(1)TEM501 right 3C2 Df(1)64c18 right 3C2-3 Df(1)64c4 left 3C2-3 Df(1)N-64i16 left 3C2-3 Df(1)N-64j15 right 3C2-3 Df(1)w64d right 3C2-3 Df(1)w258-45 ~65 kb right 3C2-3 Df(1)w-rJl right 3C2-3 Df(1)w-rJ2 right 3C2-3 Dp(1;2)w+70h31 right 3C2-4 Df(1)TEM75 right 3C3 Df(1)TEM75 right 3C3-5 Df(1)TEM202 right 3C3-5 Df(1)w258-11 right 3C3-5 Df(1)w258-42? right 3C3-5 Dp(1;4)wm65g right 3C3-5 Dp(1;3)wvco right 3C5 Df(1)JC19 right 3C5-6 Df(1)w258-42? right 3C6-7 Df(1)62d18 ~65 kb left 3C6-7 Df(1)T30 left 3C7 N right 3C6-7 Df(1)N-68f19 -26.2 to -24.7 kb left 3C7 Df(1)N-62b1 -19.3 to -18.6 kb left Df(1)N-76b8 -2.2 to -1.3 kb right 3C6-7 Df(1)N-66i25 0.8 to 2.7 kb right 3C7 N right 3C8-9 Df(1)T30 right 3C10-11 Df(1)w-N71a left 3C11-12 Df(1)dm75e19 right 3D2-3 w+Y right 3D3-4 Df(1)N-64j15 -2 to 0 kb right 3D3-4 Dp(1;Y)w+303 3D4 dnc left 3D4-5 Df(1)GA102 left 3D4-5 Df(1)JA53 right Df(1)N-74h 34 to 42 kb right 3D4-5 Df(1)N-64i16 50 to 58 kb 3D5 dm 3D6 l(1)3Da left 3D6-E1 Df(1)GA113 right 3D6-E1 Df(1)GBM207 right 3D6-E1 Dp(1;3)w+51b right 3D5-7 Dp(1;3)N-264-58a 3E1 slc right 3E1-2 Df(1)N-8 3E2 l(1)3Eb right 3E2-3 Dp(1;3)w49a 3E3 l(1)3Ec right 3E3-4 Df(1)dm75e19 right 3E3-4 Df(1)W-N14A1-b4-1 3E4-6 l(1)3Ed left 3E6-7 Df(1)WC159 3E7 l(1)3Ee left 3E7-8 Df(1)HF366 right 3E8-F2 Dp(1;3)w67k27 ( Coordinates in 3B1-2 from Bargiello and Young (1984, Proc. Nat. Acad. Sci. USA 81: 2142-46); coordinates in 3B1-2 to 3C2-3 from Pirrotta, Hadfield, and Pretorius (1983, EMBO J. 2: 927-34); coordinates in 3C2-7 from Kidd, Lockett, and Young (1983, Cell 34: 421-33); and coordinates in 3D from Davis and Davidson (1986, Mol. Cell Biol. 6: 1464-70). # l(1)5CDa location: 1-15.1 (Voelker and Wisely, 1982, DIS 58: 150-51). origin: Induced by ethyl methanesulfonate. synonym: l(1)E12 (or l(1)E7 by label mixup?). references: Suzuki, Piternick, Hayashi, Tarasoff, Baillie, and Erasmus, 1967, Proc. Nat. Acad. Sci. USA 57: 907-12. Tarasoff and Suzuki, 1970, Dev. Biol. 23: 492-509. phenotype: Development protracted and adults sterile when reared at 22; protracted even more but adults fertile when reared at 17. Sensitive to 29 at all stages of development. Lethality in midpupal stage. Shift down prior to lethal phase improves survival. cytology: Placed in 5C5-D6 on the basis of its inclusion in Df(1)N73 = Df(1)5C2;5D56 but not in Df(1)C149 = Df(1)5A8- 9;5C5-6. other information: l(1)E12 mapped to 35.4 by Tarasoff and Suzuki and to 15.1 by Voelker and Wisely. Could Voelker and Wisely have received a mislabeled stock of l(1)E7 (1-15.2) from Vancouver? #*l(1)6 location: 1-0.4. origin: Spontaneous. discoverer: Bridges, 14d9. references: 1916, Genetics 1: 149. phenotype: Rare survivors interpreted as recombinants led Bridges to place l(1)6 0.4 unit to the left of y. # l(1)6D Eight lethally mutable loci identified, but not ordered by Lefevre. locus included in excluded from synonym ___________________________________________________ l(1)6Da Dp(1;3)sn13a1 Df(1)ct-J6 l(1)6Db Dp(1;3)sn13a1 Df(1)ct-J6 l(1)EM24 l(1)6Dc Dp(1;3)sn13a1 Df(1)ct-J6 l(1)6Dd Dp(1;3)sn13a1 Df(1)ct-J6 l(1)6De Dp(1;3)sn13a1 Df(1)ct-J6 l(1)EM25 l(1)6Df Dp(1;3)sn13a1 Df(1)ct-J6 l(1)6Dg Dp(1;3)sn13a1 Df(1)ct-J6 l(1)6Dh Dp(1;3)sn13a1 Df(1)ct-J6 allele origin discoverer synonym ref ( comments _______________________________________________________________________ l(1)6Da1 X ray Lefevre l(1)C214 1, 3 L-P/VME l(1)6Db1 EMS Lefevre l(1)DC785 2 l(1)6Db2 EMS Lefevre l(1)EC224 2 l(1)EM24 l(1)6Db3 EMS Lefevre l(1)VA251 2 l(1)6Dc1 X ray Lefevre l(1)HC245 1 l(1)6Dc2 X ray Lefevre l(1)GA31 1 l(1)6Dc3 EMS Lefevre l(1)EA42 2, 3 E-L/AO l(1)EM25 l(1)6Dd1 X ray Lefevre l(1)HC233 1 l(1)6Dd2 EMS Lefevre l(1)DF919 2 l(1)6Dd3 EMS Lefevre l(1)EF455 2 l(1)6Dd4 EMS Lefevre l(1)EF461 2 l(1)6Dd5 EMS Lefevre l(1)VE636 2 l(1)6Dd6 EMS Lefevre l(1)VE735 2 l(1)6Dd7 EMS Lefevre l(1)VE921 2, 3 L-P/NME l(1)6De1 EMS Lefevre l(1)DF962 2, 3 L-P/VME *l(1)6Df1 X ray Lefevre l(1)S41 1 In(1)5D7-8;6D7-8 l(1)6Df2 EMS Lefevre l(1)VA179 2, 3 P/VME l(1)6Dg1 EMS Lefevre l(1)VA234 2, 3 P/AO l(1)6Dh1 X ray Lefevre l(1)RA52 1 ( 1 = Lefevre, 1981, Genetics 99: 461-80; 2 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 3 = Perrimon, Engstrom, and Mahowald, 1984, Dev. Biol. 105: 404-14. # l(1)6E This region plus 6F and 7A subjected to saturation mutagenesis by Nicklas and Cline (1983, Genetics 103: 617-31) and sampled extensively by Lefevre and Watkins (1986, Genetics 99: 869-95). Where alleles still existed, Nicklas and Cline tested their mutants against those of Lefevre. genetic cytological excluded locus location location included in from synonym _________________________________________________________________________ l(1)6Ea 1-18.3 6E1-2 Df(1)ct-J6 Df(1)Sxl-bt l(1)jnL4 l(1)6Eb 1-18.3-.8 6E4 Df(1)Sxl-bt Df(1)HA32 l(1)jnLX l(1)6Ec 1-18.8 6E1-5 Df(1)Sxl-bt Df(1)HA32 ogre, l(1)jnL3 l(1)6Ed 1-18.8 6E1-5 Df(1)Sxl-bt Df(1)HA32 l(1)jnL2 l(1)6Ee 1-18.9 6E5-6 Df(1)HA32 Df(1)Sxl-ra l(1)jnL1 allele origin discoverer synonym ref ( comments _______________________________________________________________________ *l(1)6Ea1 X ray Lefevre l(1)N84 1 In(1)6E1-2;8B4-7 l(1)6Ea2 EMS Lefevre l(1)DC737 2, 4 E/NME l(1)6Ea3 to EMS Nicklas 3 E-L l(1)6Ea9 l(1)6Eb1 X ray Lefevre l(1)HC217 1 l(1)6Eb2 EMS Nicklas l(1)jnLX 3, 4 P-A/VME l(1)6Ed1 to EMS Nicklas l(1)jnL2 3, 4 E/NME l(1)6Ed9 l(1)6Ee1 X ray Lefevre l(1)KC26 1 l(1)6Ee2 EMS Lefevre l(1)EA22 2 l(1)6Ee3 EMS Lefevre l(1)EC251 2 l(1)6Ee4 to EMS Nicklas l(1)jnL1 3, 4 E/NME l(1)6Ee18 ( 1 = Lefevre, 1981, Genetics 99: 461-80; 2 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 3 = Nicklas and Cline, 1983, Genetics 103: 617-31; 4 = Perrimon, Engstrom, and Mahowald, 1984, Dev. Biol. 105: 404-14. # l(1)6F Three lethally mutable loci, one of which is Sxl; the single alleles of l(1)6Fb and l(1)6Fc lost before they could be tested against Niklas' and Cline's lethals. cytological locus location included in excluded from synonym ______________________________________________________ l(1)6Fa 6F5 Df(1)Sxl-ra Df(1)cm Sxl l(1)6Fb 6F5 Df(1)HA32 Df(1)cm l(1)6Fc 6F7 allele origin discoverer synonym ref ( comments __________________________________________________________ *l(1)6Fb1 X ray Lefevre l(1)HC290 1 T(1;2)6F;40-41 *l(1)6Fc1 X ray Lefevre l(1)HA68 l In(1)6F;10B2; semilethal ( 1 = Lefevre, 1981, Genetics 99: 461-80; # l(1)7: see dorl # l(1)7A Five mutable loci, including one named locus, adl-1. genetic cytological locus location location included in excluded from synonym __________________________________________________________________ l(1)7Aa 1-19.4 7A3 Df(1)ct-j4 Df(1)RF19 l(1)jnR1 l(1)7Ab 1-19.6 7A6-8 Df(1)RF19 Df(1)HA32 l(1)jnR2 Df(1)GA34 Dp(1;2)sn+72d l(1)7Ac 1-19.8 7A6 Df(1)RF19 Df(1)HA32 l(1)jnR3 Df(1)GA34 Dp(1;2)sn+72d l(1)7Ad 1-19.9 7A8 Dp(1;2)sn+72d l(1)jnR4 Df(1)Sxl-ra allele origin discoverer synonym ref ( comments _________________________________________________________________ l(1)7Aa1 X ray Lefevre l(1)C62 1 In(1)6F9;12F l(1)7Aa2 X ray Lefevre l(1)JA9 1 In(1)7A3;20F; L/NME l(1)7Aa3 X ray Lefevre l(1)GA75 1 T(1;3)7A3;83E l(1)7Aa4 X ray Lefevre l(1)GA83 1 In(1)7A1-7B3 l(1)7Aa5 X ray Lefevre l(1)KC13 1 l(1)7Aa6 X ray Lefevre l(1)RA49 1 T(1;3)7A1-2;80 l(1)7Aa7 X ray Lefevre l(1)RA62 1 l(1)7Aa8 X ray Lefevre l(1)RC35 1 T(1;2)7A3;49A1-5 l(1)7Aa9 X ray Lefevre l(1)RF27 1 l(1)7Aa10 X ray Lefevre l(1)RF42 1 complex aberration l(1)7Aa11 X ray Lefevre l(1)RF46 1 T(1;3)7A1;80-81 l(1)7Aa12 EMS Lefevre l(1)EA54 2 l(1)7Aa13 EMS Lefevre l(1)VE758 2 l(1)7Aa14 to EMS Nicklas 2 E-L l(1)7Aa51 l(1)7Ab1 to EMS Nicklas 3 L l(1)7Ab22 l(1)7Ab23 spont Schalet l(1)13-95 l(1)7Ac1 X ray Lefevre l(1)HC141 1 l(1)7Ac2 X ray Lefevre l(1)HF302 1 In(1)7A6-8;12E; noncomplementing l(1)7Ac3 X ray Lefevre l(1)JA59 1 noncomplementing l(1)7Ac4 X ray Lefevre l(1)JE53 1 T(1;3)5A7;7A6;86D l(1)7Ac5 X ray Lefevre l(1)RC57 1 l(1)7Ac6 X ray Lefevre l(1)RC61 1 complements l(1)7Ac8 and l(1)7Ac9; EL/L l(1)7Ac7 EMS Lefevre l(1)EF465 2 complements l(1)7Ac8 and l(1)7Ac9 l(1)7Ac8 EMS Lefevre l(1)VE852 2 complements l(1)7Ac6 and l(1)7Ac7; EL/L l(1)7Ac9 to EMS Nicklas 3 E l(1)7Ac27 l(1)7Ac28 spont Schalet l(1)14-4 l(1)7Ad1 to EMS Nicklas 3 P-A l(1)7Ad10 ( 1 = Lefevre, 1981, Genetics 99: 461-80; 2 = Lefevre and Watkins, 1986, Genetics 113: 869-95. 3 = Nicklas and Cline, 1983, Genetics 103: 617-31. 4 = Perrimon, Engstrom, and Mahowald, 1984, Dev. Biol. 105: 404-14. # l(1)7B Six lethally mutable loci including kf and ct, both part of the cut complex. genetic cytological locus location location included in excluded from synonym _________________________________________________________________________ l(1)7Ba 20.0 7B1 Df(1)RF19 Df(1)HA32 kf l(1)7Bb 20.0 7B3 Df(1)GA34 Df(1)RF19 ct l(1)7Bc 7B5 Df(1)GA34 l(1)7Bd l(1)7Be l(1)7Bf allele origin discoverer synonym ref ( comments ______________________________________________________________ l(1)7Bc1 EMS Lefevre l(1)EA68 2, 3 LP/NME l(1)7Bc2 EMS Lefevre l(1)VE890 2 l(1)7Bd1 X ray Lefevre l(1)N63 1 l(1)7Bd2 X ray Lefevre l(1)RC21 1 l(1)7Bd3 EMS Lefevre l(1)VA156 2, 3 LP/NME l(1)7Be1 EMS Lefevre l(1)DC829 2 l(1)7Bf1 X ray Lefevre l(1)GF320 1 ( 1 = Lefevre, 1981, Genetics 99: 461-80; 2 = Lefevre and Watkins, 1986, Genetics 113: 869-95. 3 = Perrimon, Engstrom, and Mahowald, 1984, Dev. Biol. 105: 404-14. # L(1)7C: Dominant Lethal in 7C location: 1-{22}. origin: Inferred from the haploinviability of deficiencies for 7C. synonym: Hiv. references: Lefevre and Johnson, 1973, Genetics 74: 633-45. cytology: Placed in 7C5-9 on the basis of the failure to recover ct sn deficiencies and on the failure of deficiencies for ct to extend to the right beyond 7C4 and of a sn defi- ciency to extend to the left beyond 7D1. # l(1)7C Eight lethally mutable loci, only one of which has more than a single allele, identified by Lefevre. cytological locus location included in excluded from ______________________________________________________ l(1)7Ca 7C1 ct+Yy+ Df(1)ct4b1 l(1)7Cb 7C2 ct+Yy+ Df(1)ct4b1 l(1)7Cc 7C4 Dp(1;2)sn+72d ct+Yy+ l(1)7Cd 7C5 l(1)7Ce l(1)7Cf l(1)7Cg l(1)7Ch 7C8 allele origin discoverer synonym ref ( comments _________________________________________________________________________ l(1)7Ca1 EMS Lefevre l(1)VA175 2, 3 L/VME l(1)7Cb1 EMS Lefevre l(1)VA276 2, 3 L3/L l(1)7Cc1 X ray Lefevre l(1)HC187 1 l(1)7Cc2 X ray Lefevre l(1)JC107 1 In(1)6A1-2;7C6-7 l(1)7Cc3 EMS Lefevre l(1)EC271 2 l(1)7Cc4 EMS Lefevre l(1)VA354 2 l(1)7Cd1 X ray Lefevre l(1)C85 1 In(1)4C13-14;7C6-7 l(1)7Ce1 X ray Lefevre l(1)GE219 1 In(1)7C6;18A l(1)7Cf1 EMS Lefevre l(1)EA24 2, 3 L/MER l(1)7Cg1 X ray Lefevre l(1)GA41 1 T(1;3)7C;95A;98E-F; E/L l(1)7Ch1 EMS Lefevre l(1)DF948 2, 3 LP/VME ( 1 = Lefevre, 1981, Genetics 99: 461-80; 2 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 3 = Perrimon, Engstrom, and Mahowald, 1984, Dev. Biol. 105: 404-14. # l(1)7D Thirteen lethally mutable loci recognized by Lefevre; order poorly understood. l(1)ad1 also in 7D; maybe allelic to mutants at one of the other loci. genetic cytological locus location location included in excluded from synonym _____________________________________________________________________ l(1)7Da 7D Df(1)C128 Dp(1;3)sn13a1 fs(1)h l(1)7Db 1-23 7D1-6 Df(1)C128 mys; l(1)EM28 l(1)7Dc l(1)7Dd l(1)7De l(1)7Df Df(1)RA2 l(1)7Dg Df(1)RA2 Df(1)GE202 l(1)EM29 l(1)7Dh 7D1 l(1)7Di l(1)7Dj 7D12 Df(1)GE202 Df(1)HA11 l(1)7Dk Df(1)HA11 l(1)7Dl l(1)7Dm 7D22 l(1)7Dn 1-21.3 7D11-22 Df(1)HA11 l(1)adl1 allele origin discoverer synonym ref ( comments ____________________________________________________________________ l(1)7Dd1 X ray Lefevre l(1)HC120 1 l(1)7Dd2 X ray Lefevre l(1)HC261 1 l(1)7Dd3 X ray Lefevre l(1)RC65 1 l(1)7Dd4 EMS Lefevre l(1)DC704 2 L/L l(1)7Dd5 EMS Lefevre l(1)DF914 2 l(1)7Dd6 EMS Lefevre l(1)VA107 2 l(1)7De1 X ray Lefevre l(1)HF375 1 l(1)7De2 EMS Lefevre l(1)DC768 2 l(1)7De3 EMS Lefevre l(1)EA30 2 l(1)7Df1 X ray Lefevre l(1)KC29 1 l(1)7Df2 X ray Lefevre l(1)KC30 1 l(1)7Df3 EMS Lefevre l(1)VA313 2 l(1)7Df4 EMS Lefevre l(1)VE607 2 L3/L l(1)7Df5 EMS Lefevre l(1)VE753 2 l(1)7Dg1 EMS Lefevre l(1)VA334 2 E-L/L l(1)7Dh1 EMS Lefevre l(1)EF430 2 l(1)7Dh2 EMS Lefevre l(1)VA113 2, 3 E-L/NME l(1)7Di1 X ray Lefevre l(1)JA67 1 l(1)7Di2 EMS Lefevre l(1)DA602 2 l(1)7Di3 EMS Lefevre l(1)DA679 2 l(1)7Di4 EMS Lefevre l(1)DC710 2 l(1)7Di5 EMS Lefevre l(1)DF956 2 l(1)7Di6 EMS Lefevre l(1)EF421 2 E-L/NME l(1)7Di7 EMS Lefevre l(1)VA174 2 l(1)7Dj1 X ray Lefevre l(1)C113 1 T(1;2)7D18-19;41 l(1)7Dj2 EMS Lefevre l(1)DA563 2 l(1)7Dj3 EMS Lefevre l(1)DA572 2, 3 E/NME l(1)7Dj4 EMS Lefevre l(1)VA302 2 l(1)7Dk1 X ray Lefevre l(1)HC241 1 l(1)7Dk2 X ray Lefevre l(1)RA63 1 l(1)7Dk3 EMS Lefevre l(1)DA511 2 l(1)7Dk4 EMS Lefevre l(1)DA512 2 l(1)7Dk5 EMS Lefevre l(1)DC720 2 l(1)7Dk6 EMS Lefevre l(1)EC204 2 l(1)7Dk7 EMS Lefevre l(1)EF494 2 l(1)7Dk8 EMS Lefevre l(1)VA86 2, 3 E/L l(1)7Dk9 EMS Lefevre l(1)VA184 2 l(1)7Dl1 EMS Lefevre l(1)VA40 2, 3 L3/AO l(1)7Dl2 EMS Lefevre l(1)VE662 2 l(1)7Dm1 X ray Lefevre l(1)A28 1 T(1;4)1F3;7D12;102 l(1)7Dm2 X ray Lefevre l(1)GA50 1 Tp(1;2)3C1;7D22;26A; complex l(1)7Dm3 X ray Lefevre l(1)HA8 1 T(1;2)7E;57A l(1)7Dm4 X ray Lefevre l(1)HA25 1 l(1)7Dm5 X ray Lefevre l(1)HC110 1 l(1)7Dm6 X ray Lefevre l(1)JC27 1 In(1)7D18-21;20 l(1)7Dm7 X ray Lefevre l(1)RA5 1 In(1)7D14-15;11E13 l(1)7Dm8 EMS Lefevre l(1)DA583 2 l(1)7Dm9 EMS Lefevre l(1)DC770 2 l(1)7Dm10 EMS Lefevre l(1)VA114 2 l(1)7Dm11 EMS Lefevre l(1)VA154 2 l(1)7Dm12 EMS Lefevre l(1)VA162 2 l(1)7Dm13 EMS Lefevre l(1)VA221 2 l(1)7Dm14 EMS Lefevre l(1)VE616 2 ( 1 = Lefevre, 1981, Genetics 99: 461-80; 2 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 3 = Perrimon, Engstrom, and Mahowald, 1984, Dev. Biol. 105: 404-14. # l(1)7e: see l(1)1Aa # l(1)7E Five lethally mutable loci including std. cytological locus location included in excluded from synonym ______________________________________________________________ l(1)7Ea Df(1)VE624 Df(1)GE202 l(1)7Eb 7E4 Df(1)VE624 Df(1)KA14 l(1)7Ec 7E6 Df(1)VE624 Df(1)KA14 l(1)7Ed Df(1)VE624 Df(1)KA14 l(1)7Ee Df(1)VE624 Df(1)KA14 l(1)7Ef 7D10-F2 Df(1)VE624 Df(1)KA14 std allele origin discoverer synonym ref ( comments ______________________________________________________________________ l(1)7Ea1 X ray Lefevre l(1)G262 1 l(1)7Ea2 X ray Lefevre l(1)HF382 1 In(1)7E-F1;20 l(1)7Ea3 EMS Lefevre l(1)DC771 2 l(1)7Ea4 EMS Lefevre l(1)EC240 2 l(1)7Ea5 EMS Lefevre l(1)EF520 2, 3 EL/L l(1)7Eb1 X ray Lefevre l(1)GF329 1 l(1)7Eb2 X ray Lefevre l(1)HA57 1 l(1)7Eb3 X ray Lefevre l(1)JA4 1 l(1)7Eb4 X ray Lefevre l(1)KC40 1 l(1)7Eb5 EMS Lefevre l(1)VA293 2, 3 L3-P/L l(1)7Eb6 EMS Lefevre l(1)VE911 2 l(1)7Eb7 spont Schalet l(1)14-160 l(1)7Ec1 X ray Lefevre l(1)JA11 1 In(1)7B;7E5 lethal at both breakpoints l(1)7Ed1 EMS Lefevre l(1)DF980 1, 3 L/L l(1)7Ee1 X ray Lefevre l(1)HF348 1 l(1)7Ee2 X ray Lefevre l(1)KA4 1 l(1)7Ee3 X ray Lefevre l(1)RF2 1 l(1)7Ee4 EMS Lefevre l(1)EC222 2 ( 1 = Lefevre, 1981, Genetics 99: 461-80; 2 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 3 = Perrimon, Engstrom, and Mahowald, 1984, Dev. Biol. 105: 404-14. # l(1)7F Six lethally mutable loci including pt, gg, and otd. genetic cytological locus location location included in synonym ____________________________________________________________ l(1)7Fa 1-23.6 7F1 Df(1)KA14 Nrg l(1)7Fb 1-23.1 Df(1)KA14 pt l(1)7Fc 7F3-4 Df(1)KA14 l(1)7Fd Df(1)KA14 l(1)7Fe 1-23.1 7F10 Df(1)KA14 gg l(1)7Ff 7F1-8A5 Df(1)KA14 otd allele origin discoverer synonym ref ( comments __________________________________________________________________ l(1)7Fc1 X ray Lefevre l(1)GE208 1 T(1;2)7F; 41 l(1)7Fc2 X ray Lefevre l(1)HC230 1 l(1)7Fc3 X ray Lefevre l(1)JC18 1 l(1)7Fc4 EMS Lefevre l(1)EC242 2 l(1)7Fc5 EMS Lefevre l(1)DA610 2 l(1)7Fc6 EMS Lefevre l(1)VE727 2 LP/VME l(1)7Fd1 X ray Lefevre l(1)KA26 1 l(1)7Fd2 EMS Lefevre l(1)VA67 2 l(1)7Fd3 EMS Lefevre l(1)VA195 2 L3-P/L l(1)7Fd4 EMS Lefevre l(1)VA205 2 ( 1 = Lefevre, 1981, Genetics 99: 461-80; 2 = Lefevre and Watkins, 1986, Genetics 113: 869-95. #*l(1)8 location: 1-21.3 (19.0 to 23.6). discoverer: Sobels. references: Gloor, 1962, Rev. Suisse Zool. 69: 409-63 (fig.). phenotype: Larvae lethal in third instar, survive up to 10 days. Testes and lymph glands degenerate. Imaginal disks develop normally after transplantation. Protein metabolism disturbed; free amino acids and peptides abnormally high. RK2. # l(1)8A Four lethally mutable loci including oc. l(1)8Aab of Schalet fails to complement both l(1)8Aa and l(1)8Ab. genetic cytological locus location location included in synonym _________________________________________________________ l(1)8Aa 8A1 Df(1)KA14 l(1)8Ab 8A2 Df(1)KA14 l(1)8Ac 1-23.1 8A1-2 Df(1)KA14 oc l(1)8Ad 8A4 Df(1)KA14 allele origin discoverer synonym ref ( comments ____________________________________________________________________________ l(1)8Aa1 X ray Lefevre l(1)GA19 1 l(1)8Aa2 X ray Lefevre l(1)GA28 1 l(1)8Aa3 X ray Lefevre l(1)GF319 1 Tp(1;2)8A1;9A3;10A;2L l(1)8Aa4 X ray Lefevre l(1)HC179 1 l(1)8Aa5 X ray Lefevre l(1)JC68 1 T(1;2)8A4-5;41 l(1)8Aa6 EMS Lefevre l(1)DF901 2 l(1)8Aa7 EMS Lefevre l(1)VE661 2, 3 L2-3/AO l(1)8Aa8 EMS Lefevre l(1)VE709 2 l(1)8Aab1 spont Schalet l(1)7-07 l(1)8Ab1 X ray Lefevre l(1)HF383 1 l(1)8Ab2 X ray Lefevre l(1)JA18 1, 3 L/L l(1)8Ab3 X ray Lefevre l(1)JA62 1 T(1;2)8A3;41E l(1)8Ad1 X ray Lefevre l(1)A86 1 T(1;2)8A3-5;34B ( 1 = Lefevre, 1981, Genetics 99: 461-80; 2 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 3 = Perrimon, Engstrom, and Mahowald, 1984, Dev. Biol. 105: 404-14. # DEFICIENCY MAP OF REGION 6D TO 8A side breakpoint variant __________________________________ l(1)6Da l(1)6Db l(1)6Dc l(1)6Dd l(1)6De l(1)6Df l(1)6Dg l(1)6Dh l(1)6Di left 6D1 Dp(1;3)ct+ 6D8 l(1)6Dg left 6D8-E1 Df(1)ct-j6 l(1)6Ea left y+Yct+ left 6E2 Df(1)Sxl-bt l(1)6Eb ogre l(1)6Ed left 6E4-5 Df(1)HA32 6E5 cm 6E6 l(1)6Ee l(1)6Fa Df(1)cm? left 6F5 Df(1)Sxl-ra 6F5 Sxl l(1)6Fc left 7A2-3 Df(1)ct-j4 l(1)7Aa left 7A4-5 Df(1)RF19 right 7A6 Df(1)Sxl-bt right 7A6 Df(1)HA32 l(1)7Ab l(1)7Ac left Dp(1;2)sn+72d l(1)7Ad right 7B1-2 Df(1)Sxl-ra kf right 7B1-2 Df(1)RF19 left 7B2-4 Df(1)ct4b1 right 7B7-8 Df(1)ct-j6 ct right Df(1)GA34 l(1)7Bc l(1)7Bd l(1)7Be right 7B8C1 Df(1)ct-j4 right 7C3 Df(1)ct4b1 l(1)7Ca l(1)7Cb ct+Yy+ left Dp(1;?)FN107 l(1)7Cc right 7D1-2 Dp(1;3)sn13a1 l(1)7Cd l(1)7Ce l(1)7Cf l(1)7Cg l(1)7Ch left 7D1 Df(1)C128 sn l(1)7Da fs(1)M122 fs(1)h mys right 7D5-6 Df(1)C128 l(1)7Dc l(1)7Dd l(1)7De l(1)7Df left 7D10 Df(1)RA2 l(1)7Dg left Df(1)GE202 l(1)7Dh l(1)7Di l(1)7Dj left Df(1)HA11 l(1)7Dk right Df(1)GE202 l(1)7Dl l(1)7Dm mys l(1)7Ea l(1)7Eb l(1)7Ec l(1)7Ed l(1)7Ee l(1)7Ef l(1)7Eg std left 7F1-2 Df(1)KA14 Nrg pt l(1)7Fd l(1)7Fe gg otd l(1)8Aa l(1)8Ab oc l(1)8Ad right 8C6 Df(1)KA14 # l(1)9A, l(1)9E Four complementation groups between 9E1 and 9E8 identified by Janca, Woloshyn, and Nash, (1986, Genetics 112: 43-64); three identified by Lefevre (Lefevre and Watkins, 1986, Genet- ics 113: 869-95); complementation studies by Janca et al. show that only ras and l(1)9Ed identified by both studies. genetic cytological locus location location included in excluded from synonym _______________________________________________________________ l(1)9Aa 9A2-B2 Df(1)sbr9 Df(1)sbr8 mus109 l(1)9Ea 9E1-2 l(1)EM32 l(1)9Eb 1-32.35 9E3-4 Df(1)v-P14 Df(1)v64f29 ras l(1)9Ec 9E3-4 Df(1)203 Df(1)v64f l(1)9Ed 9E7-8 Df(1)v64f l(1)EM31 Df(1)217 l(1)9Ee 9E7-8 Df(1)v64f Df(1)217 allele origin discoverer synonym ref ( comments __________________________________________________________ l(1)9Ea1 l(1)EM32 2 l(1)DA665 l(1)9Ec1 EMS l(1)B13 1 l(1)9Ec2 EMS l(1)E20 1 l(1)9Ec3 EMS l(1)G4 1 l(1)9Ed1 EMS l(1)A17 1 l(1)9Ed2 EMS l(1)G16 1 haplospecific | l(1)9Ed3 EMS l(1)H22 1 l(1)9Ed4 EMS l(1)M27 1 haplospecific l(1)9Ed5 EMS l(1)Q10 1 haplospecific l(1)9Ed6 EMS Lefevre l(1)EM31 2 L1-2/AO l(1)DC701 l(1)9Ed7 EMS Lefevre l(1)DF935 2 l(1)9Ed8 EMS Lefevre l(1)DF981 2 l(1)9Ee1 EMS l(1)Q21 1 ( 1 = Janca, Woloshyn, and Nash, l986, Genetics 112: 43-64; 2 = Lefevre and Watkins, 1986, Genetics 113: 869-95. | Haplospecific alleles survive as males or homozygous females, but die in heterozygous combination with a deficiency for the locus. # l(1)9F Alleles recovered and characterized by three groups: allel- ism between mutants from the different collections partially carried out by Zhimulev, Pokholkova, Bgatov, Umbetova, Solovjeva, Khudyakov, and Belyaeva (1987, Biol. Zentralbl. 106: 699-720). As many as seven lethally mutable loci, including sesB, fliK, and sbr, identified. Deficiency map based largely on the work of Zhimulev et al. Presumptive loci originally identified by Zhimulev et al. are labeled l(1)BP after Belyaeva and Pokholkova; those identified by Geer et al. are labeled l(1)G; the remainder were identified by Lefevre. Janca, Woloshyn, and Nash isolated three mutants in different complementation groups in 9E7-9F11 and four in two complemen- tation groups in 9F10-10A2, but no complementation tests car- ried out with other lethal mutations in 9F and therefore not included in tabulations. genetic cytological locus location location included in excluded from synonym _________________________________________________________________ l(1)9Fa 1-32.53 9F1 Df(1)ras-P14 sesB Df(1)v64f l(1)9Fc 9F4-8 Df(1)ras-P14 fliK Df(1)v-L4 l(1)9Fd 1-32.6 9F5-11 Df(1)v-L4 Df(1)v-L3 sbr l(1)9Fe 1-32.78 9F9-12 Df(1)v-L3 Df(1)M6 l(1)BP1 l(1)9Ff 9F9-12 Df(1)v-L3 Dp(1;2)v+65 l(1)G3 l(1)9Fg 1-32.96 9F13-10A1 Df(1)v-L2 Df(1)v-L1 l(1)BP3 l(1)9Fh 1-32.96 9F13-10A1 Df(1)v-L2 Df(1)v-L1 l(1)EF433 # l(1)9Fe alleles: All alleles lethal except l(1)9Fe12, which is viable and of normal phenotype in both homozygous and heterozygous condition. However, flies heterozygous for l(1)9Fe12 and any lethal allele except l(1)9Fe1 or for a deficiency for l(1)9Fe show irregularly missing bristles, especially humerals; l(1)9Fe1 complements l(1)9Fe12. allele origin discoverer synonym ref ( comments ____________________________________________________________ l(1)9Fe1 ICR170 Carlson l(1)Q54 2 l(1)9Fe2 X ray Lefevre l(1)A62 2 l(1)9Fe3 X ray Lefevre l(1)A89 2 l(1)9Fe4 X ray Lefevre l(1)HA13 2 euchab l(1)9Fe5 X ray Lefevre l(1)JE2 2 hetab l(1)9Fe6 EMS Lefevre l(1)EA86 3 l(1)9Fe7 EMS Lefevre l(1)VE881 3 l(1)9Fe8 EMS Belyaeva l(1)191 4, 5 l(1)9Fe9 EMS Pokholkova l(1)171 4, 5 l(1)9Fe10 EMS Pokholkova l(1)G101 4, 5 l(1)9Fe11 EMS Pokholkova l(1)G98 4, 5 l(1)9Fe12 EMS Fomina bir336 4, 5 l(1)9Fe13Y EMS Bgatov l(1)dpS42 4, 5 on v+Yy+ l(1)9Fe14 EMS l(1)v126 1 pupal l(1)9Fe15Y EMS l(1)v348 1 on v+BS-Yy+ l(1)9Ff1 EMS l(1)v350 1 larval-pupal l(1)9Fg1 EMS Pokholkova l(1)163 4, 5 l(1)9Fg2 EMS Belyaeva l(1)167 4, 5 l(1)9Fg3 EMS Pokholkova l(1)183 4, 5 l(1)9Fg4Y EMS Bgatov l(1)dpS22 4, 5 on v+Yy+ l(1)9Fg5 Pokholkova l(1)F6 6 l(1)9Fg6 EMS l(2)v5 1 l(1)9Fg7 EMS l(2)v40 1 l(1)9Fg8 EMS l(2)v103 1 l(1)9Fg9 EMS l(2)v172 1 l(1)9Fg10 EMS l(2)v205 1 l(1)9Fg11 EMS l(2)v207 1 l(1)9Fg12Y EMS l(2)v363 1 on v+BS-Yy+ l(1)9Fh EMS Lefevre l(1)EF433 3 possible allele of l(1)9Ff ( 1 = Geer, Lischwe, and Murphy, 1983, J. Exp. Zool. 225: 107-18; 2 = Lefevre, 1981, Genetics 99: 461-80; 3 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 4 = Zhimu- lev, Belyaeva, Pokholkova, Kotchneva, Fomina, Bgatov, Khu- dyakov, Patzevich, Semeshin, Baritcheva, Aizenzon, Kramers, and Eeken, 1981, DIS 56: 192-96; 5 = Zhimulev, Pokholkova, Bgatov, Semeshin, and Belyaeva, 1981, Chromosoma 82: 25-40; 6 = Zhimulev and Pokholkova, l981, 8th European Drosophila Research Conference. # DEFICIENCY MAP OF REGION 9 side breakpoint variant _____________________________________ left 9A Df(1)ras59 left 9A Df(1)ras217 left 9A2 Dp(1;2)v+75d left 9A2-4 Df(1)sbr10 left 9A2-4 Df(1)sbr9 9A2-5 mus109 left 9B1-2 Df(1)sbr8 left 9B9-10 Df(1)sbr1 left 9D1-2 Df(1)ras-v17Cc8 left 9D1-2 Df(1)v-P5 left 9D3 Df(1)v-M1 left 9D3 Df(1)v-M7 left 9E1 Dp(1;2)v+63i left 9E1-2 Df(1)ras203 left 9E1-2 Df(1)ras-P14 9E2-8 ras 9E1-8 l(1)19Ec left 9E3-4 Dp(1;3)v+74c left 9E7-8 Df(1)v64f 9E7-8 l(1)9Ed 9E7-8 l(1)9Ee l(1)9Ea sesB right 9F3-4 Df(1)ras-P14 right 9E7-8 Df(1)ras217 left 9F4 v+BS-Yy+ left 9F4 v+Yy+ fliK right Df(1)HC133 left 9F5-6 Df(1)v-L4 9F5-11 sbr left 9F10-12 Df(1)v-L3 fliG fs(1)BP 9F9-12 l(1)9Fe 9F9-12 l(1)9Ff left 9F11-12 Df(1)v-M6 right 9F12-13 Df(1)ras59 left 9F12-13 Dp(1;2)v+65b left 9F12-13 Df(1)v65b left 9F13 Df(1)v-L2 right 9F13 Df(1)ras203 9F13-10A1 l(1)9Fh 9F13-10A1 l(1)9Fg left 9F13 Df(1)v-L1 left 9F13-10A1 Df(1)v-M5 left 10A1 Df(1)P22 right 9F13-10A1 Df(1)sbr1 right 9F13-10A1 Df(1)sbr10 # l(1)10A Four independent mutation searches have been carried out in this region. Most mutants have been tested against the first group of three loci identified by Lefevre (1971, Genetics 67: 497-513), but there are indications of as many as five additional loci as inferred from the results of within-search complementation tests. In general mutants recovered in dif- ferent searches have not been tested against one another. rtv has not been tested for complementation by other mutants in region 10A. Presumptive loci originally identified by Zhimu- lev et al. are labeled l(1)BP after Belyaeva and Pokholkova; those identified by Geer et al. are labeled l(1)G; the remainder were identified by Lefevre. genetic cytological locus location location included in excluded from synonym _________________________________________________________________________________ l(1)10Aa 1-33.05 10A1 Df(1)v-L2 csk, l(1)BP4, l(1)G6 Df(1)v-L1 l(1)10Ac 1-33.51 10A3-5 Df(1)v-L1 Df(1)v-L2 l(1)L12, l(1)BP5, l(1)G8 l(1)10Ad 1-33.55 10A6-7 Df(1)RA37 l(1)BP8 Df(1)v-L3 l(1)10Ae 1-33.56 10A6-7 Df(1)RA37 l(1)L8, l(1)BP7, l(1)G10 Df(1)v-L3 l(1)10Af 1-33.56 10A8 Df(1)v-L3 l(1)G11, l(1)EM16 Df(1)K7 l(1)10Ag 1-33.68 10A9-12 Df(1)KA7 Df(1)GA112 rtv, l(1)L1, l(1)G13 l(1)10Ah 1-{33} 10A9-12 Df(1)KA7 Df(1)GA112 l(1)G12 l(1)10Ai 1-{33} 10A9-12 Df(1)KA7 Df(1)GA112 l(1)10Aj 1-{33} 10A11-? Df(1)GA112 # l(1)10Ac alleles: Complementation relations among complementing alleles complex and vary according to temperature of rearing, some combinations being heat sensitive and others cold sensitive. Allelism to l(1)10Ac1 established for the Russian alleles by Zhimulev et al. and for the G8 alleles by Geer et al. allele origin discoverer synonym ref ( comments _________________________________________________________________________________ l(1)10Ac1 X ray Lefevre l(1)L12 3, 6 larval lethal complementing allele l(1)10Ac2 EMS Belyaeva l(1)E54 8, 9, 11 l(1)10Ac3 EMS Belyaeva l(1)E112 8, 9, 11 l(1)10Ac4 EMS Belyaeva l(1)E114 8, 9, 11 l(1)10Ac5 EMS Belyaeva l(1)E120 8, 9, 11 l(1)10Ac6 EMS Belyaeva l(1)164 8, 9, 11 complementing allele l(1)10Ac7 EMS Belyaeva l(1)169 8, 9, 11 l(1)10Ac8 EMS Belyaeva l(1)187 8, 9, 11 l(1)10Ac9 EMS Belyaeva l(1)193 8, 9, 11 l(1)10Ac10 Pokholkova l(1)F230 10, 11 haplospecific heat- sensitive allele l(1)10Ac11 EMS l(1)F409 11 l(1)10Ac12 EMS l(1)F437 11 l(1)10Ac13 EMS l(1)F439 11 haplospecific heat- sensitive allele l(1)10Ac14 EMS Pokholkova l(1)G62 2, 8, 9, 11 l(1)10Ac15 EMS Pokholkova l(1)G67 8, 9, 11 l(1)10Ac16 EMS Pokholkova l(1)G76 8, 9, 11 complementing allele l(1)10Ac17 EMS Pokholkova l(1)G93 8, 9, 11 l(1)10Ac18 EMS Pokholkova l(1)G95 8, 9, 11 l(1)10Ac19 EMS Pokholkova l(1)G96 8, 9, 11 complementing allele l(1)10Ac20 EMS Pokholkova l(1)G105 8, 9, 11 l(1)10Ac21 EMS Pokholkova l(1)G139 8, 9, 11 l(1)10Ac22 EMS Khudyakov l(1)J21 8, 9, 11 complementing allele l(1)10Ac23Y EMS Fomina l(1)dpO25 8, 9, 11 on v+Yy+ l(1)10Ac24Y EMS Biyasheva l(1)dpZ4 8, 9, 11 on v+Yy+ l(1)10Ac25Y EMS Bgatov l(1)dpS145 8, 9, 11 on v+Yy+ l(1)10Ac26 X ray Lefevre l(1)A114 4 l(1)10Ac27 X ray Lefevre l(1)C202 4 In(1)7A2;10A3-4 l(1)10Ac28 X ray Lefevre l(1)GF319 4 T(1;2)7F-8A;9A3;10A;32B | l(1)10Ac29 X ray Lefevre l(1)RA75 4 T(1;2;3)10A;41;100 / l(1)10Ac30 EMS Lefevre l(1)DA514 5 PP/L l(1)10Ac31 EMS Lefevre l(1)VA160 5 l(1)10Ac32 EMS Lefevre l(1)VA244 5 l(1)10Ac33 EMS Lefevre l(1)VA275 5 l(1)10Ac34 EMS Lefevre l(1)VA312 5 l(1)10Ac35 EMS Lefevre l(1)VE666 5 l(1)10Ac36 EMS Lefevre l(1)VE727 5 l(1)10Ac37 EMS Lefevre l(1)VE772 5 L2/NME l(1)10Ac38 EMS Lefevre l(1)VE815 5 l(1)10Ac39 EMS l(1)v201 1 l(1)10Ac40 EMS l(1)v202 1 l(1)10Ac41Y EMS l(1)v361 1 on v+BS-Yy+ l(1)10Ac42Y EMS l(1)v372 1 on v+BS-Yy+ l(1)10Ac43 EMS Mayoh l(1)HM21 7 cold-sensitive allele; females surviving 17 sterile; 25 fertile ( 1 = Geer, Lischwe, and Murphy, 1983, J. Exp. Zool. 225: 107-18; 2 = Kramers, Schalet, Paradi, and Huiser- Hoosteyling, 1983, Mutat. Res. 107: 187-201; 3 = Lefevre, 1971, Genetics 67: 497-513; 4 = Lefevre, 1981, Genetics 99: 461-80; 5 = Lefevre and Watkins, 1986 Genetics 113: 869-95; 6 = Lefevre and Wiedenheft, 1974, DIS 51: 83; 7 = Mayoh and Suzuki, 1973, Can. J. Genet. Cytol. 15: 237- 54; 8 = Zhimulev, Belyaeva, Pokholkova, Kotchneva, Fomina, Bgatov, Khudyakov, Patzevich, Semeshin, Baritcheva, Aizen- zon, Kramers, and Eeken, 1981, DIS 56: 192-96; 9 = Zhimu- lev, Pokholkova, Bgatov, Semeshin, and Belyaeva, 1981, Chro- mosoma 82: 25-40; 10 = Zhimulev and Pokholkova, 1981, 8th European Drosophila Research Conference; 11 = Zhimulev, Pokholkova, Bgatov, Umbetova, Solovjeva, Khudyakov, and Belyaeva, 1987, Biol. Zentralbl. 106: 699-720. | Tentative new order: 1A-7F|9A3-10A|8A-9A3|32B-60F;21A- 32B|10A- 20. / Tentative new order: 1A-10A|41-21;60-41|100-61;20-10A|100. # l(1)10Ad One of two loci in the region of overlap between Df(1)RA37 and Df(1)v-l3. Allelism of l(1)10Ad1 with Russian alleles and with HMS-induced alleles established by Zhimulev et al. l(1)10Ad23 and l(1)10Ad24 designated alleles on basis of defi- ciency mapping and complementation of l(1)10Ae1. l(1)10Ae20 fails to complement the Russian alleles, but according to Geer et al. does complement l(1)10Ad21 and l(1)10Ad22Y, which are not mentioned in the Russian papers. allele origin discoverer synonym ref ( comments _______________________________________________________________________ l(1)10Ad1 ICR170 Carlson l(1)Q66 l(1)10Ad2 EMS Belyaeva l(1)E62 4, 5, 6 l(1)10Ad3 EMS Belyaeva l(1)E72 4, 5, 6 l(1)10Ad4 EMS Belyaeva l(1)153 4, 5, 6 l(1)10Ad5 EMS Belyaeva l(1)173 4, 5, 6 l(1)10Ad6 EMS Belyaeva l(1)174 4, 5, 6 l(1)10Ad7 EMS Belyaeva l(1)175 4, 5, 6 l(1)10Ad8 EMS Belyaeva l(1)194 4, 5, 6 l(1)10Ad9 Pokholkova l(1)F59 6 haplospecific cold- sensitive allele l(1)10Ad10 Pokholkova l(1)F79 6 l(1)10Ad11 l(1)F99 6 l(1)10Ad12 l(1)F431 6 haplospecific cold- sensitive allele l(1)10Ad13 EMS Pokholkova l(1)G97 4, 5, 6 l(1)10Ad14Y EMS Fomina l(1)dpO5 4, 5, 6 on v+Yy+ l(1)10Ad15Y EMS Fomina l(1)dpO24 4, 5, 6 on v+Yy+ l(1)10Ad16Y EMS Biyasheva l(1)dpZ3 4, 5, 6 on v+Yy+ l(1)10Ad17 HMS Kramers l(1)HM4 2, 4, 5, 6 l(1)10Ad18 HMS Kramers l(1)HM26 2, 4, 5, 6 l(1)10Ad19 HMS Kramers l(1)HM445 2, 4, 5, 6 l(1)10Ad20 EMS l(1)v145 1 l(1)10Ad21 EMS l(1)v200 1 l(1)10Ad22Y EMS l(1)v353 1 on v+BS-Yy+ larval lethal l(1)10Ad23 EMS Lefevre l(1)VE704 3 l(1)10Ad24 EMS Lefevre l(1)VE774 3 E-L2/MER ( 1 = Geer, Lischwe, and Murphy, 1983, J. Exp. Zool. 225: 107-18; 2 = Kramers, Schalet, Paradi, and Huiser- Hoosteyling, 1983, Mutat. Res. 107: 187-201; 3 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 4 = Zhimulev, Belyaeva, Pokholkova, Kotchneva, Fomina, Bgatov, Khudyakov, Patzevich, Semeshin, Baritcheva, Aizenzon, Kramers, and Eeken, 1981, DIS 56: 192-96; 5 = Zhimulev, Pokholkova, Bga- tov, Semeshin, and Belyaeva, 1981, Chromosoma 82: 25-40; 6 = Zhimulev, Pokholkova, Bgatov, Umbetova, Solovjeva, Khu- dyakov, and Belyaeva, 1987, Biol. Zentralbl. 106: 699-720. # l(1)10Ae Allelism of l(1)10Ae1 with Russian alleles and l(1)10Ae17 determined by Zhimulev et al.; allelism with l(1)10Ae16 deter- mined by Geer et al. allele origin discoverer synonym ref ( comments _______________________________________________________________ l(1)10Ae1 X ray Lefevre l(1)L8 3 l(1)10Ae2 X ray Lefevre l(1)HC166 4 l(1)10Ae3 X ray Lefevre l(1)L57 4 l(1)10Ae4 EMS Lefevre l(1)DC812 5 L1-2/NME l(1)10Ae5 EMS Belyaeva l(1)E66 6, 7, 8 l(1)10Ae6 EMS Belyaeva l(1)E67 6, 7, 8 l(1)10Ae7 EMS Belyaeva l(1)E142 6, 7, 8 l(1)10Ae8 EMS Belyaeva l(1)TE108 6, 7, 8 l(1)10Ae9 EMS Belyaeva l(1)170 6, 7, 8 l(1)10Ae10 Pokholkova l(1)F60 8 l(1)10Ae11 Pokholkova l(1)F100 8 l(1)10Ae12 l(1)F313 8 l(1)10Ae13 l(1)F342 8 l(1)10Ae14 EMS Pokholkova l(1)G52 6, 7, 8 l(1)10Ae15 EMS Pokholkova l(1)G65f 6, 7, 8 l(1)10Ae16 EMS l(1)v153 2, 8 larval lethal l(1)10Ae17 MR l(1)D41 1, 8 ( 1 = Eeken, Sobels, Hyland, and Schalet, 1985, Mutat. Res. 150: 261-75; 2 = Geer, Lischwe, and Murphy, 1983, J. Exp. Zool. 225: 107-18; 3 = Lefevre, 1971, Genetics 67: 497- 513; 4 = Lefevre, 1981, Genetics 99: 461-80; 5 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 6 = Zhimulev, Belyaeva, Pokholkova, Kotchneva, Fomina, Bgatov, Khudyakov, Patzevich, Semeshin, Baritcheva, Aizenzon, Kramers, and Eeken, 1981, DIS 56: 192-96; 7 = Zhimulev, Pokholkova, Bga- tov, Semeshin, and Belyaeva, 1981, Chromosoma 82: 25-40; 8 = Zhimulev, Pokholkova, Bgatov, Umbetova, Solovjeva, Khu- dyakov, and Belyaeva, 1987, Biol. Zentralbl. 106: 699-720. # l(1)10Af Allelism of l(1)10Af5 with other alleles not tested; allel- ism inferred from similarity of deficiency mapping positions at 10A8. allele origin discoverer synonym ref ( comments _______________________________________________________________ l(1)10Af1 EMS Lefevre l(1)EF444 2 L/VME l(1)EM16 l(1)10Af2 EMS Lefevre l(1)EF501 2 l(1)10Af3 EMS Lefevre l(1)VE651 2 l(1)10Af4 EMS Lefevre l(1)VE937 2 l(1)10Af5 EMS l(1)v147 1 embryonic-larval lethal ( 1 = Geer, Lischwe, and Murphy, 1983, J. Exp. Zool. 225: 107-18; 2 = Lefevre and Watkins, 1986, Genetics 113: 869-95. allele origin discoverer synonym ref ( comments ________________________________________________________________________ l(1)10Ah1 X ray Lefevre l(1)JE57 1 complex T(1;2;3) | l(1)10Ai1 EMS Lefevre l(1)VE821 2 E/L l(1)10Aj1 X ray Lefevre l(1)JF6 1 E/L; complex aberration / ( 1 = Lefevre, 1981, Genetics 99: 161-80; 2 = Lefevre and Watkins, 1986, Genetics 113: 869-95. | Tentative order: 1-5C|73F-77A|22A-60;20-14B|13B-14B|10A- 13B|10A-5D|77A-61;21-22A|73F-100. / Segment from 3C12 to 20A4 highly rearranged and inserted into 3L at 64B; additional breaks recorded in 9D-E, 10B7-12, 11A7, and 15B-C. # l(1)10B Complementation and deficiency mapping of the lethals in 10B have been carried out by Sponaugle, who determined relations among mutant alleles produced by Lefevre, Geer et al., and Voelker. genetic cytological locus location location included in excluded from synonym _______________________________________________________________________________ l(1)10Ba 1-{34} 10B4-9 Df(1)GA112 Df(1)N71 l(1)G16 l(1)10Bb 1-34.28 10B4-9 Df(1)N71 Df(1)DA622 l(1)G14 l(1)10Bc 1-34.39 10B4-9 Df(1)N71 Df(1)DA622 l(1)G15 l(1)10Bd 1-34.50 10B4-9 Df(1)N71 Df(1)DA622 dsh, l(1)G17 l(1)10Be 1-34.61 10B4-9 Df(1)N71 Df(1)DA622 hop, l(1)L4, l(1)G18 l(1)10Bf 1-34.82 10B8-9 Df(1)DA622 Df(1)M13 dlg, l(1)L11, l(1)G19, l(1)bwn, l(1)d.lg-1, l(1)l.pr-2 l(1)10Bg 1-35.08 10B8-15 Df(1)M13 l(1)G20 Df(1)RA37 l(1)10Bh 1-35.31 10B8-15 Df(1)M13 l(1)G21 Df(1)RA37 l(1)10Bi 1-{35} 10B8-15 Df(1)M13 l(1)G22 Df(1)RA37 l(1)10Bj 1-{35} 10B8-15 Df(1)M13 l(1)G23 Df(1)RA37 l(1)10Bk 1-{35} 10B17-C2 Df(1)GA112 Df(1)RA37 l(1)10Bl 1-{35} 10B8-15 Df(1)M13 Df(1)RA37 l(1)10Bm 1-{35} 10B8-15 Df(1)M13 l(1)L9 Df(1)RA37 l(1)10Bn 1-{35} 10B8-15 Df(1)M13 Df(1)RA37 l(1)10Bo 1-{35} 10B17-C2 Df(1)GA112 Df(1)RA37 allele origin discoverer synonym ref ( comments _________________________________________________________________________ l(1)10Ba1 EMS l(1)v4 1 larval-pupal lethal l(1)10Ba2 EMS Lefevre l(1)VA273 4 l(1)10Ba3 EMS Lefevre l(1)VE663 4 l(1)10Ba4 EMS Lefevre l(1)VE731 4 l(1)10Ba5 EMS Lefevre l(1)VE874 4, 6 PP/NME l(1)10Ba6 ENU Voelker l(1)M26 l(1)10Ba7 ENU Voelker l(1)M64 l(1)10Bb1 EMS l(1)v7 1 embryonic-larval lethal l(1)10Bb2 X ray Lefevre l(1)GE255 3 In(1) + T(1;2) | l(1)10Bb3 EMS Lefevre l(1)DF961 4 l(1)10Bb4 EMS Lefevre l(1)EC230 4, 6 L1-2/L l(1)10Bc1 EMS l(1)v16 1 l(1)10Bc2 EMS l(1)v17 1 l(1)10Bc3 EMS l(1)v18 1 l(1)10Bc4 EMS l(1)v22 1 l(1)10Bc5 EMS l(1)v64 1 l(1)10Bc6 EMS l(1)v149 1 l(1)10Bc7 EMS l(1)v212 1 l(1)10Bc8 X ray Lefevre l(1)C9 3 l(1)10Bc9 X ray Lefevre l(1)GA118 3 T(1;2)10B4;11A;37A / l(1)10Bc10 EMS Lefevre l(1)EA126 4 l(1)10Bc11 EMS Lefevre l(1)EF416 4 l(1)10Bc12 EMS Lefevre l(1)VA178 4, 6 L3/AO l(1)10Bc13 EMS Lefevre l(1)VE626 4 l(1)10Bc14 EMS Lefevre l(1)VE643 4 l(1)10Bc15 EMS Lefevre l(1)VE658 4 l(1)10Bc16 ENU Voelker l(1)M5 l(1)10Bc17 ENU Voelker l(1)M6 l(1)10Bc18 ENU Voelker l(1)M22 l(1)10Bc19 ENU Voelker l(1)M33 l(1)10Bc20 ENU Voelker l(1)M34 l(1)10Bg1 EMS l(1)v21 1 larval lethal l(1)10Bg2 X ray Lefevre l(1)GA110 3 complex rearrangement l(1)10Bg3 EMS Lefevre l(1)EF476 4 escapers -> thin bristles l(1)10Bg4 EMS Lefevre l(1)DC705 4, 6 L/AO l(1)10Bg5 ENU Voelker l(1)M2 l(1)10Bg6 ENU Voelker l(1)M30 l(1)10Bg7 ENU Voelker l(1)M40 l(1)10Bg8 ENU Voelker l(1)M53 l(1)10Bh1 EMS l(1)v73 1 pupal lethal l(1)10Bh2ms EMS MSV12 1 viable, male sterile l(1)10Bh3ms EMS MSV22 1 viable, male sterile l(1)10Bi1 EMS l(1)v28 1 l(1)10Bj1 EMS l(1)v127 1 larval lethal l(1)10Bj2 ENU l(1)M44 7 leaky; phenotype normal l(1)10Bk1 X ray Lefevre l(1)L3 2, 6 PP/L l(1)10Bk2 X ray Lefevre l(1)HC157 3 l(1)10Bk3 EMS Lefevre l(1)EC236 4 l(1)10Bk4 EMS Voelker l(1)K10 7 l(1)10Bk5 EMS Voelker l(1)K19 7 l(1)10Bk6 EMS Voelker l(1)K22 7 l(1)10Bk7 ENU Voelker l(1)M19 7 l(1)10Bk8 ENU Voelker l(1)M46 7 l(1)10Bk9 EMS l(1)v217 7 l(1)10Bl1 ENU Voelker l(1)M23 7 leaky l(1)10Bl2 ENU Voelker l(1)M27 7 leaky l(1)10Bl3 ENU Voelker l(1)M31 7 leaky l(1)10Bm1 X ray Lefevre l(1)L9 2, 6 L3-P/AO l(1)10Bn1 X ray Lefevre l(1)L19 5, 6 E-L/VME l(1)C248 l(1)10Bo1 EMS Lefevre l(1)VA188 4, 6 L-P/AO l(1)10Bo2 EMS Lefevre l(1)VA328 4 l(1)10Bo3 EMS Lefevre l(1)VE916 4 ( 1 = Geer, Lischwe, and Murphy, 198l, J. Exp. Zool. 225: 107- 18; 2 = Lefevre, 1971, Genetics 67: 497-513; 3 = Lefevre, 1981, Genetics 99: 461-80; 4 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 5 = Mortin and Lefevre, 1981, Chromo- soma 82: 237-47; 6 = Perrimon, Engstrom, and Mahowald, 1984, Dev. Biol. 105: 404-14; 7 = Voelker, Wisely, Huang, and Gyur- kovics, 1985, Mol. Gen. Genet. 201: 437-45. | Tentative order: 1-7F|20-10A4|50B-21;20|8A-10A|50B-60. / Tentative order: 1-10B4|37A-60;20-11A|10B4-11A|37-21. # l(1)10C Searches of Lefevre, of Geer et al., and of Voelker et al. extend into this region. 10C is subdivided into two regions by the Df(1)v-N48 breakpoint. Of four lethally mutable loci in the more distal region, 10C1-5, RpII215 is 0.02 map units to the left of l(1)10Cc (5X2/63,658) other pairs of loci have not been separated by recombination: RpII215-tyl (0/8,606), tyl-l(1)10Cc (0/81,402), and l(1)10Cc-l(1)10Cd (0/144,897); the fifth locus, nod, was tested for complementation, but not by recombination (Voelker, Wisely, Huang, and Gyurkovics, l985, Mol. Gen. Genet. 201: 437-45). genetic cytological locus location location included in excluded from synonym ________________________________________________________________________ l(1)10Ca 1-35.66 10C1-5 Df(1)v-N48 Df(1)GA112 RpII215, l(1)L5 l(1)10Cb 1-{36} 10C1-5 Df(1)v-N48 Df(1)GA112 tyl l(1)10Cc 1-35.68 10C1-5 Df(1)v-N48 Df(1)GA112 l(1)L20 l(1)10Cd 1-{36} 10C1-5 Df(1)v-N48 Df(1)GA112 l(1)10Ce 1-35.9 10C3-D5 Df(1)N71 Df(1)v-N48 l(1)L16 l(1)10Cf 1-{36} 10C3-D5 Df(1)N71 Df(1)v-N48 dsl l(1)10Cg 1-{35} 10B17-C2 Df(1)GA112 l(1)10Ch 1-{36} l(1)10Ci 1-{36} 10C1-5 Df(1)v-N48 Df(1)GA112 allele origin discoverer synonym ref ( comments ________________________________________________________ l(1)10Cc1 X ray Lefevre l(1)L20 2, 4 l(1)GA47 l(1)10Cc2 X ray Lefevre l(1)HA10 4, 5 L1-2/L l(1)10Cc3 EMS Voelker l(1)K5 6 l(1)10Cc4 HD Voelker l(1)32/65A 6 l(1)10Cd1 EMS Voelker l(1)M39 6 l(1)10Ce1 X ray Lefevre l(1)L16 1 l(1)10Ce2 X ray Lefevre l(1)RA6 2 l(1)10Ce3 X ray Lefevre l(1)RA60 2 l(1)10Ce4 X ray Lefevre l(1)S51 2 l(1)10Ce5 EMS Lefevre l(1)DC833 3, 5 L1-2/VME l(1)10Ce6 EMS Lefevre l(1)EF464 3 l(1)10Ce7 EMS Lefevre l(1)VA270 3 l(1)10Ce8 EMS Lefevre l(1)VE710 3 l(1)10Ce9 EMS Lefevre l(1)VE912 3 l(1)10Ce10 EMS Lefevre l(1)VE914 3 l(1)10Ce11 EMS Voelker l(1)K29 6 l(1)10Ce12 ENU Voelker l(1)M9 6 l(1)10Ce13 ENU Voelker l(1)M7 6 l(1)10Ce14 ENU Voelker l(1)M16 6 l(1)10Ce15 ENU Voelker l(1)M29 6 l(1)10Ce16 ENU Voelker l(1)M41 6 l(1)10Cg1 X ray Lefevre l(1)JC13 2 l(1)10Ch1 X ray Lefevre l(1)JC36 2 l(1)10Ci1 EMS Lefevre l(1)VE623 3, 5 EL/L ( 1 = Lefevre, 1971, Genetics 67: 497-513; 2 = Lefevre, 1981, Genetics 99: 461-80; 3 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 4 = Mortin and Lefevre, 1981, Chromosoma 82: 237-47; 5 = Perrimon, Engstrom, and Mahowald, 1984, Dev. Biol. 105: 404-14; 6 = Voelker, Wisely, Huang, and Gyurko- vics, 1985, Mol. Gen. Genet. 201: 437-45. # l(1)10D and E genetic cytological locus location location included in excluded from _________________________________________________________ l(1)10Da 1-{36} 10D4-E1 Df(1)m259-4 Df(1)N71 l(1)10Db 1-{36} 10D4-E1 Df(1)m259-4 Df(1)N71 l(1)10Dc 1-{36} 10D4-E1 Df(1)m259-4 Df(1)N71 l(1)10Dd 1-{36} 10D2-4 Df(1)N71 Df(1)DA622 l(1)10Ea 1-{36} 10E1-F1 Df(1)KA6 Df(1)RA47 l(1)10Eb 1-{36} 10E1-F1 Df(1)KA6 Df(1)RA47 allele origin discoverer synonym ref ( comments _________________________________________________________________ l(1)10Da1 X ray Lefevre l(1)GF303 1 semilethal allele l(1)10Da2 EMS Lefevre l(1)VE742 2, 3 L-P/ME l(1)10Db1 EMS Szidonya l(1)878ts 4 l(1)10Dc1 EMS Voelker l(1)A1 4 l(1)10Dd1 EMS Lefevre l(1)EA18 2 l(1)10Ea1 X ray Lefevre l(1)GA82 1 l(1)10Ea2 EMS Lefevre l(1)DC727 2 l(1)10Ea3 EMS Lefevre l(1)DF916 2 l(1)10Ea4 | EMS Lefevre l(1)VE817 2 l(1)10Ea5 EMS Lefevre l(1)VE897 2 l(1)10Eb1 EMS Lefevre l(1)DF939 2, 3 L1-2/L l(1)10Eb2 EMS Lefevre l(1)DC751 2 l(1)10Eb3 EMS Lefevre l(1)DC757 2 ( 1 = Lefevre, 1981, Genetics 99: 461-80; 2 = Lefevre and Wat- kins, 1986, Genetics 113: 869-95; 3 = Perrimon, Engstrom, and Mahowald, 1984, Dev. Biol. 105: 404-14; 4 = Voelker, Wisely, Huang, and Gyurkovics, 1985, Mol. Gen. Genet. 201: 437-45. | l(1)10Ea4 fails to complement both l(1)10Ea and l(1)10Eb alleles; possibly a small deficiency. # l(1)10F With the exception of qs, mutants in 10F adequately tested for complementation. qs not tested against any other mutants in region. genetic cytological locus location location included in excluded from synonym ________________________________________________________________ l(1)10Fa 1-{37} 10F1-6 Df(1)RA47 l(1)L6 Df(1)KA7 l(1)10Fb 1-{37} 10F1-6 Df(1)RA47 Df(1)KA7 l(1)10Fc 1-{37} 10F1-6 Df(1)RA47 Df(1)KA7 l(1)10Fd 1-{37} 10F1-6 Df(1)RA47 l(1)L10 Df(1)KA7 l(1)10Fe 1-{37} 10F1-6 Df(1)RA47 l(1)L17 Df(1)KA7 l(1)10Ff 1-{37} 10F6-8 Df(1)HA85 Df(1)KA7 l(1)10Fg 1-{37} 10F6-8 Df(1)HA85 Df(1)KA7 l(1)L18 l(1)10Fh 1-{37} 10F9 Df(1)RA47 Df(1)HA85 l(1)10Fi 1-{37} 10F9 Df(1)RA47 Df(1)HA85 l(1)10Fj 1-{37} 10F10-11 Df(1)KA6 Df(1)RA47 l(1)10Fk 1-{37} 10F10-11 Df(1)KA6 Df(1)RA47 l(1)10Fl 1-39.5 10F1-10 Df(1)RA47 qs allele origin discoverer synonym ref ( comments _______________________________________________________________________ l(1)10Fa1 X ray Lefevre l(1)L6 2 l(1)10Fa2 X ray Lefevre l(1)A119 3 l(1)10Fa3 X ray Lefevre l(1)A20 3 l(1)10Fa4 X ray Lefevre l(1)GA44 3 l(1)10Fa5 EMS Lefevre l(1)EA10 4 l(1)10Fa6 EMS Lefevre l(1)DF978 4, 5 L1-2/NME l(1)10Fa7 spont Schalet l(1)1-38 6 l(1)10Fa8 spont Schalet l(1)L6S1 l(1)10Fa9 spont Schalet l(1)L6S2 l(1)10Fb1 EMS Lefevre l(1)VE603 3, 5 L1-2/AO l(1)10Fc1 EMS Lefevre l(1)VE754 3 l(1)10Fd1 X ray Lefevre l(1)L10 2 l(1)10Fd2 X ray Lefevre l(1)C228 3 l(1)10Fd3 X ray Lefevre l(1)GA5 3 l(1)10Fd4 X ray Lefevre l(1)GF305 3 l(1)10Fd5 EMS Lefevre l(1)DA513 4 l(1)10Fd6 EMS Lefevre l(1)EA17 4, 5 P-A/NME l(1)10Fd7 EMS Lefevre l(1)EA21 4 l(1)10Fd8 EMS Lefevre l(1)EC210 4 l(1)10Fd9 EMS Lefevre l(1)EC237 4 l(1)10Fd10 EMS Lefevre l(1)VA132 4 l(1)10Fe1 X ray Lefevre l(1)L17 1, 2 l(1)10Fe2 X ray Lefevre l(1)RA11 3 l(1)10Fe3 X ray Lefevre l(1)HC132 3 l(1)10Fe4 X ray Lefevre l(1)HC106 3 l(1)10Fe5 EMS Lefevre l(1)VA154 4 l(1)10Fe6 EMS Lefevre l(1)VA222 4 l(1)10Fe7 EMS Lefevre l(1)VE620 4 l(1)10Fe8 EMS Lefevre l(1)VE755 4, 5 L3-P/MER l(1)10Ff1 EMS Lefevre l(1)EF421 4 l(1)10Ff2 EMS Lefevre l(1)VA171 1, 4 l(1)10Ff3 EMS Lefevre l(1)VE615 4 l(1)10Fg1 X ray Lefevre l(1)L18 1, 2 l(1)10Fg2 X ray Lefevre l(1)HF364 3 l(1)10Fg3 X ray Lefevre l(1)RA15 3 l(1)10Fg4 EMS Lefevre l(1)EA35 4 l(1)10Fg5 EMS Lefevre l(1)VA331 4 l(1)10Fh1 EMS Lefevre l(1)VE694 1, 4 l(1)10Fi1 EMS Lefevre l(1)VA147 1, 4, 5 PP/L l(1)10Fj1 X ray Lefevre l(1)A29 1, 3, 5 PP/L; T(1;2)10F9;21E3 l(1)10Fk1 X ray Lefevre l(1)RF6 1, 3 ( 1 = Kulkarni and Hall, 1987, Genetics 115: 461-75; 2 = Lefevre, 1971, Genetics 67: 497-513; 3 = Lefevre, 1981, Genetics 99: 461-80; 4 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 5 = Perrimon, Engstrom, and Mahowald, 1984, Dev. Biol. 105: 404-14; 6 = Schalet, 1986, Mutat. Res. 163: 115- 44. # DEFICIENCY MAP OF REGION 10 side breakpoint variant DNA coordinates ( ________________________________________________________________ right 9F13-10A2 Df(1)sbr1 right 10A1 Df(1)sbr10 v 10A1 csk right 10A1 Df(1)ras-v-P26 right 10A1 Df(1)v-L2 right 10A1-2 Df(1)sbr-K8 right 10A1-2 Df(1)sbr-K9 right 10A1-2 Df(1)v-B151 right 10A1-2 Df(1)v-L4 right 10A1-2 Df(1)v-L7 right 10A1-2 Df(1)v-L11 right 10A1-2 Df(1)v-L15 right 10A1-2 Df(1)v-M1 right 10A1-2 Df(1)v-M5 right 10A1-2 Df(1)v-M6 right 10A1-2 Df(1)v-M7 right 10A1-2 Df(1)v-P5 right 10A2 Df(1)v64f sev right 10A2 Df(1)ras-v17 ms(1)10A slm l(1)10Ac right 10A4-5 Df(1)v-L1 left 10A8 Df(1)RA37 10A6-7 l(1)10Ad 10A6-7 l(1)10Ae right 10A7-8 Df(1)v-L3 10A8 l(1)10Af left 10A9 Df(1)KA7 10A7-11 rtv 10A8-11 l(1)10Ah l(1)10Ai right 10A11 Dp(1;2)v+63i tu-Sz left 10A11-B1 Df(1)GA112 l(1)10Aj 10B4-8 l(1)10Ba left 10B4-5 Df(1)N71 10B4-8 sisA 10B4-8 l(1)10Bb 10B4-8 dsh 10B4-8 hop 10B4-8 l(1)10Bc 10B4-8 ny left 10B8 Df(1)DA622 48 to 47 kb 10B8-9 dlg 36 to 11 kb left Df(1)M-13 0 kb 10B8-15 l(1)10Bg 10B8-15 l(1)10Bh 10B17-C2 l(1)10Bi 10B17-C2 l(1)10Bj 10B17-C2 l(1)10Bl 10B17-C2 l(1)10Bm 10B17-C2 l(1)10Bn right 10B17 Df(1)RA37 10B17-C2 l(1)10Bk 10B17-C2 l(1)10Bo l(1)10Cg right 10C1-2 v+Yy+ right 10C1-2 Df(1)GA112 left 10C1-2 Df(1)HA85 right 10C2 Dp(1;2)v+75d left 10C2-3 Df(1)m259 RpII215 -7.2 to 0.2 kb tyl 0.5 to 1.3 kb (tentative) l(1)10Cc 1.5 to 2.6 kb (tentative) l(1)10Cd l(1)10Ch l(1)10Ci nod right 10C3-5 Df(1)v-N48 l(1)10Ce dsl right 10D2 Df(1)DA622 l(1)10Dd right 10D4 Df(1)N71 right 10D4 Df(1)HM456 l(1)10Da left 10E1 Df(1)KA6 10E l(1)10Ea 10E l(1)10Eb right 10E1-2 Df(1)m259-4 10E1-2 m right 10E3-4 v+BS-Yy+ dy left 10F1 Df(1)RA47 10F l(1)10Fa 10F l(1)10Fb 10F l(1)10Fc 10F l(1)10Fd 10F l(1)10Fe right 10F10 Df(1)KA7 10F l(1)10Fg 10F l(1)10Ff right 11A1-2 Df(1)HA85 10F l(1)10Fh 10F1-10 l(1)10Fi right 10F11 Df(1)RA47 l(1)10Fj l(1)10Fk right 11A7 Df(1)KA6 ( Region 10B coordinates by Woods and Bryant (1989, Dev. Biol. 134: 222-35); region 10C by Biggs, Searles, and Greenleaf (1985, Cell 42: 611-21). # l(1)11A Nine lethally mutable loci including tsg and agn. genetic cytological locus location location included in excluded from synonym ________________________________________________________________ l(1)11Aa 1-36.66 11A2 Df(1)RC29 Df(1)RA47 l(1)L13 l(1)11Ab 1-36.79 11A2 Df(1)RC29 tsg l(1)11Ac l(1)11Ad Df(1)KA10 Df(1)RC29 Df(1)HF368 l(1)11Ae 1-37.0 11A6 Df(1)m13 Df(1)RC29 l(1)L2 l(1)11Af 1-38.9 11A7-9 Df(1)v65b Df(1)KA10 agn Df(1)HF368 l(1)11Ag Df(1)HF368 Df(1)KA10 l(1)11Ah Df(1)HF368 Df(1)KA10 l(1)11Ai Df(1)HF368 Df(1)KA10 allele origin discoverer synonym ref ( comments ___________________________________________________________________________ l(1)11Aa1 X ray Lefevre l(1)L13 1 l(1)11Aa2 X ray Lefevre l(1)A78 2 In(1)10F-11A;20 l(1)11Aa3 X ray Lefevre l(1)A97 2 In(1)1E1-2;11A2 l(1)11Aa4 X ray Lefevre l(1)A101 2 In(1)11A1-2;12E1-2; 18B11 l(1)11Aa5 X ray Lefevre l(1)C155 2 l(1)11Aa6 X ray Lefevre l(1)HC129 2 l(1)11Aa7 X ray Lefevre l(1)HC146 2 In(1)11A7;12A1 l(1)11Aa8 X ray Lefevre l(1)HC268 2 l(1)11Aa9 X ray Lefevre l(1)N66 2 In(1)7A7-8;11A4 l(1)11Aa10 X ray Lefevre l(1)RF23 2 l(1)11Aa11 X ray Lefevre l(1)RF56 2 complex breaks in 11A6, 15B, 34A, 38C, 69C-D, 77E-F, 81, 88E-F l(1)11Aa12 EMS Lefevre l(1)L135-8 3 l(1)11Aa13 EMS Lefevre l(1)L1320-3 3 l(1)11Aa14 EMS Lefevre l(1)L13325 3 l(1)11Aa15 EMS Lefevre l(1)EA80 3 l(1)11Aa16 EMS Lefevre l(1)EA121 3 l(1)11Aa17 EMS Lefevre l(1)EC252 3 l(1)11Aa18 EMS Lefevre l(1)EC276 3 l(1)11Aa19 EMS Lefevre l(1)DA600 3 l(1)11Aa20 EMS Lefevre l(1)DC752 3 l(1)11Aa21 EMS Lefevre l(1)VA47 3 l(1)11Aa22 EMS Lefevre l(1)VA226 3 l(1)11Aa23 EMS Lefevre l(1)VE870 3 l(1)11Aa24 spont Schalet l(1)4-92 4 l(1)11Aa25 spont Schalet l(1)9-78 4 l(1)11Aa26 spont Schalet l(1)20-195 4 l(1)11Ac1 X ray Lefevre l(1)HA77 2 l(1)11Ac2 X ray Lefevre l(1)KC23 2 l(1)11Ac3 X ray Lefevre l(1)RF32 2 l(1)11Ad1 X ray Lefevre l(1)A4 2 l(1)11Ad2 X ray Lefevre l(1)HC281 2 l(1)11Ad3 EMS Lefevre l(1)DC816 3 l(1)11Ad4 EMS Lefevre l(1)VA213 3 l(1)11Ae1 X ray Lefevre l(1)L2 1 l(1)11Ae2 X ray Lefevre l(1)A92 2 T(1;2)11A5-6;37B + T(1;3)5A7;100 l(1)11Ae3 X ray Lefevre l(1)C221 2 l(1)11Ae4 X ray Lefevre l(1)C227 2 l(1)11Ae5 X ray Lefevre l(1)HA2 2 l(1)11Ae6 X ray Lefevre l(1)JC79 2 complex; T(1;2)11A5-6; 83C-D l(1)11Ae7 X ray Lefevre l(1)JC101 2 l(1)11Ae8 X ray Lefevre l(1)KC15 2 l(1)11Ae9 EMS Lefevre l(1)EA15 3 l(1)11Ae10 EMS Lefevre l(1)EA55 3 l(1)11Ae11 EMS Lefevre l(1)EC232 3 l(1)11Ae12 EMS Lefevre l(1)VA342 3 l(1)11Ae13 EMS Lefevre l(1)VE634 3 l(1)11Ae14 EMS Lefevre l(1)VE886 3 l(1)11Ae15 EMS Geer l(1)v44 l(1)11Ae16 EMS Voelker l(1)A100 l(1)11Ag1 X ray Lefevre l(1)HF303 2 also l(1)11Ah l(1)11Ag2 X ray Lefevre l(1)HF388 2 l(1)11Ag3 EMS Lefevre l(1)EC260 3 l(1)11Ag4 EMS Lefevre l(1)EC267 3 l(1)11Ag5 EMS Lefevre l(1)EF429 3 l(1)11Ag6 EMS Lefevre l(1)DC799 3 l(1)11Ag7 EMS Lefevre l(1)VA266 3 l(1)11Ag8 EMS Lefevre l(1)VA262 3 l(1)11Ah1 X ray Lefevre l(1)HF303 2 also l(1)11Ag l(1)11Ah2 X ray Lefevre l(1)MGM147 2 l(1)11Ah3 X ray Lefevre l(1)MGM194 2 l(1)11Ah4 EMS Lefevre l(1)DC837 3 l(1)11Ah5 EMS Lefevre l(1)VE759 3 l(1)11Ah6 neutrons Munoz l(1)17-58 3 l(1)11Ai1 EMS Lefevre l(1)DC799 3 l(1)11Ai2 EMS Lefevre l(1)DC837 3 l(1)11Ai3 EMS Lefevre l(1)EC262 3 l(1)11Ai4 EMS Lefevre l(1)EF429 3 ( 1 = Lefevre, 1971, Genetics 67: 497-513; 2 = Lefevre, 1981, Genetics 99: 461-80; 3 = Lefevre and Watkins, 1986, Genet- ics 113: 869-95; 4 = Schalet, 1986, Mutat. Res. 163: 115- 44. # l(1)11D-F The product of saturation mutagenesis and deficiency mapping in the region encompassed by Df(1)C246 carried out by N. Scott (1987, Ph.D. thesis, University of California, San Diego). genetic cytological locus location location included in __________________________________________ l(1)11Da 1-{41} 11D1-E Df(1)C246 Df(1)JA26 l(1)11Db 1-{41} 11D1-E Df(1)C246 Df(1)JA26 l(1)11Dc 1-{41} 11D1-E Df(1)C246 Df(1)JA26 allele origin discoverer ref ( comments ___________________________________________________ l(1)11Da1 ENU N. Scott 1, 2 L-P/L l(1)11Db1 ENU N. Scott 1, 2 L-P/AO l(1)11Dc1 ENU N. Scott 1, 2 P-A/L ( 1 = Perrimon, Engstrom, and Mahowald, 1989, Genetics 212: 333-52; 2 = Scott, 1987, Ph.D. thesis, University of California, San Diego. genetic cytological locus location location included in excluded from synonym ________________________________________________________________ l(1)11Ea 1-41.4 11D-E10 Df(1)wy26 Df(1)JA26 sno l(1)11Eb 1-{41} 11D-E10 Df(1)wy26 Df(1)JA26 l(1)11Ec 1-{41} 11D-E10 Df(1)wy26 Df(1)JA26 l(1)11Ed 1-{41} 11D-E10 Df(1)wy26 Df(1)JA26 l(1)11Ee 1-{41} 11D-E10 Df(1)wy26 Df(1)JA26 l(1)11Ef 1-{41} 11D-E10 Df(1)wy26 Df(1)JA26 allele origin discoverer ref ( comments _________________________________________________________________ l(1)11Eb1 ENU N. Scott 2 l(1)11Eb2 ENU N. Scott 2 l(1)11Eb3 ENU N. Scott 2 l(1)11Eb4 ENU N. Scott 2 l(1)11Eb5 ENU N. Scott 2 l(1)11Eb6 ENU N. Scott 2 l(1)11Eb7 ENU N. Scott 1, 2 L/L; partially comple- menting allele l(1)11Ec1 ENU N. Scott 1, 2 P/NME l(1)11Ed1 ENU N. Scott 1, 2 L-P/L l(1)11Ed2 ENU N. Scott 2 l(1)11Ee1 ENU N. Scott 2 l(1)11Ef1 ENU N. Scott 2 ( 1 = Perrimon, Engstrom, and Mahowald, 1989, Genetics 212: 333-52; 2 = Scott, 1987, Ph.D. thesis, University of California, San Diego. genetic cytological locus location location included in excluded from ________________________________________________________ l(1)11Fa 1-{42} 11F2-12A2 Df(1)C246 Df(1)wy2 l(1)11Fb 1-{42} 11F2-12A2 Df(1)C246 Df(1)wy2 allele origin discoverer ref ( comments ___________________________________________________ l(1)11Fa1 ENU N. Scott 1, 2 E-L/L l(1)11Fb1 ENU N. Scott 2 l(1)11Fb2 ENU N. Scott 1, 2 E-L/L ( 1 = Perrimon, Engstrom, and Mahowald, 1989, Genetics 212: 333-52; 2 = Scott, 1987, Ph.D. thesis, University of California, San Diego. # DEFICIENCY MAP OF REGION 11 side breakpoint variant __________________________________ left 11A1 Df(1)JA26 left 11A1 Df(1)KA10 left 11A1 Df(1)N105 left 11A1 Df(1)RC29 left 11A2 Df(1)HF368 11A2 cac 11A2 l(1)11Aa 11A2 nbA 11A2 gd 11A2 tsg 11A2 fw right 11A2 Df(1)RC29 right 11A1-2 Df(1)HA85 l(1)11Ae right 11A4-5 Df(1)m13 right 11A7 Df(1)KA10 right 11A7 Df(1)KA6 right 11A7 Dp(1;2)v+65b 11A7-9 agn right 11A8-9 Df(1)v65b right 11B9 Df(1)HF368 right 11B12 Dp(1;3)v+74c right 11C4-D1 Df(1)N105 left 11D1-2 Df(1)C246 left 11D1-2 Df(1)N12 l(1)11Da l(1)11Db l(1)11Dc right 11D-E Df(1)JA26 sno l(1)11Eb l(1)11Ec l(1)11Ed l(1)11Ee l(1)11Ef wy right 11E9-10 Df(1)wy26 right 11F1-2 Df(1)N12 right 11F2-4 Df(1)wy2 l(1)11Fa l(1)11Fb crt s right 12A1-2 Df(1)C246 # l(1)14-l(1)15 Two studies using lethal mutations in this region have been reported; neither was interested in the lethals per se, and the mutants reported in one study were never tested against those in the other, and no case of allelism was reported in either study. para is the only genetic landmark common to the two studies. Recent studies by Steller (unpublished) provide more information on relative positions of loci in 14B-C. Embryonic lethal mutations baz and exd map to this region, but allelism with the lethals tabulated not tested. references: Falk, Roselli, Curtiss, Halladay, and Klufas, 1984, Mutat. Res. 126: 25-34. Ganetzky, 1984, Genetics 108: 897-911. genetic cytological locus location location included in excluded from synonym ____________________________________________________________________ l(1)14Aa Dp(1;4)r+ Df(1)80e19a l(1)h26a l(1)14Ab Df(1)80e19a Df(1)80e27a l(1)h5c l(1)14Ca 14C1-2 Dp(1;2)r+75c Df(1)81k21e l(1)i19e l(1)14Cb Df(1)81l12h Df(1)80f18c l(1)k17a l(1)14Cc 14C1-2 Dp(1;2)r+75c Df(1)81k21e l(1)9-21 l(1)14Da 1-53.9 Df(1)r19 Df(1)82c19i para l(1)14DEa 1-53.9 14C7-F1 Df(1)D7 l(1)lD17 l(1)14DEb 1-53.9 14C7-F1 Df(1)D7 l(1)lD23 l(1)14DEc 1-53.9 14C7-F1 Df(1)D7 l(1)lD30 l(1)14Ea Df(1)80f3c Df(1)82c3k l(1)k22a l(1)14Fa Df(1)81j29i Df(1)80fb8 l(1)l6f l(1)15Aa Df(1)80f18c Df(1)81l8g l(1)i15b l(1)15Ab Df(1)81k21e Df(1)81f12a l(1)k27e l(1)15Ba Dp(1;4)r+ Df(1)81k9b l(1)g27a # l(1)15Aa location: 1-53.0 (1.5 units to the left of r). origin: Induced by ICR170. synonym: l7. references: Naguib and Jarry, 1981, Genet. Res. 37: 199-207. cytology: Placed in 14D1-15A1 based on its inclusion in Df(1)r9 = Df(1)14D1;15D1 and Df(1)r-D = Df(1)14B6-15A2 but not Df(1)r7 = Df(1)15A1;15A5. # DEFICIENCY MAP OF REGION 14-15 side breakpoint study 1 ( study 2 | DNA coordinates / _____________________________________________________________________ left 14A1 Df(1)80f3c left 14A1 Df(1)80f8b left 14A1 Df(1)81j16f left 14A1 Df(1)81l17h left 14B5-18 Df(1)81l19i left 14A1 Df(1)82c25g l(1)14Aa left 14A1 Df(1)80e19a l(1)14Ab left 14A1 Df(1)80e27a left 14A1 Df(1)80f25a left 14A1 Df(1)82c19i left 14B3-4 Df(1)80g12a Df(1)80g12a left 14B3-4 Df(1)81i21c left 14B3-4 Df(1)82c3k Df(1)82c3k 14B3-4 disco left 14B3-4 Df(1)80g7d Df(1)80g7d left 14B5-18 Df(1)80e3d left 14B5-18 Df(1)80f15f left 14B5-18 Df(1)81f20a left 14B5-18 Df(1)81f20e left 14B5-18 Df(1)81g1i left 14B5-18 Df(1)81i25b left 14B5-18 Df(1)81j6c left 14B5-18 Df(1)81j6e left 14B5-18 Df(1)81j29i left 14B5-18 Df(1)81j23a left 14B5-18 Df(1)81k19b left 14B5-18 Df(1)81k23b left 14B5-18 Df(1)81l1b left 14B5-18 Df(1)81l28f left 14B5-18 Df(1)82a2z left 14B5-18 Df(1)82b6w left 14B5-18 Df(1)82c5b left 14B5-18 Df(1)82d7e 14B5-18 eas left 14B5-18 Df(1)81h24b Df(1)81h24b ca 36 14B5-18 Df(1)E150 ca 43 left 14B5-18 Df(1)80f29d Df(1)80f29d ca 60 left 14B13 Dp(1;2)r+75c ca 64 14C1-2 l(1)14Cc 67.1 to 76.2 14C1-2 l(1)14Ca l(1)14Ca 72.0 to 76.2 14C1-2 nonA 72.0 to 80.9 left 14C1-2 Df(1)81k21e Df(1)81k21e ca 84 left 14B5-18 Df(1)81l12h Df(1)81l12h bss l(1)14Cb l(1)14Cb 14C3-6 mei-41 left 14C4-5 Df(1)80f18c left 14C5-6 Df(1)r-D left 14B5-18 Df(1)82a2y left 14B5-18 Df(1)81f12a left 14C6-8 Df(1)81l8g left 14C6-8 Df(1)82b10w left 14C6-8 Df(1)82b26c left 14C7-D1 Df(1)D7 left 14D1 Df(1)r19 14C6-8 para para l(1)14DEb l(1)14DEc l(1)14DEd right 14C6-8 Df(1)81i21c right 14D3-4 Df(1)82c19i right 14D3-4 Df(1)82d7e right 14E Df(1)81h24b right 14E Df(1)82b6w right 14E Df(1)82c3k l(1)14Ea right 14E Df(1)80f3c -1 to +20 right 14E3-F1 Df(1)D7 right 14F Df(1)80f8b -1 to +20 left 14F1-2 Df(1)D34 right 14F6 Df(1)D34 left 14F6 Df(1)4-D17 r l(1)14Fa right 15A1-2 Df(1)81l19i -1 to +20 right 15A1-2 Df(1)81j29i +20 to +37 right 15A1-2 Df(1)81l17h +37 to +43 right 15A3-4 Df(1)81l8g +37 to +43 l(1)a5Aa right 15A3-4 Df(1)82c5b +37 to +43 right 15A3-4 Df(1)80f18c right 15A3-4 Df(1)81f20a right 15A3-4 Df(1)81k23b +63 to +74 right 15A3-4 Df(1)81l1b +63 to +74 right 15A3-4 Df(1)82c25g +63 to +74 right 15A3-4 Df(1)82a2y right 15A3-4 Df(1)82a2z right 15A3-4 Df(1)82b10w right 15A3-4 Df(1)82b26c right 15A6-11 Df(1)81f12a 15A5 l(1)15Ab right 15A5 Df(1)81k21e right 15A6 Df(1)r-D17 right 15A6-11 Df(1)80e3d right 15A6-11 Df(1)80e19a right 15A6-11 Df(1)80e27a right 15A6-11 Df(1)80f15f right 15A6-11 Df(1)80f25a right 15A6-11 Df(1)80f29d right 15A6-11 Df(1)80g12a right 15A6-11 Df(1)81f20e right 15A6-11 Df(1)81g1i right 15A6-11 Df(1)81i25b right 15A6-11 Df(1)81j6c right 15A6-11 Df(1)81j6e right 15A6-11 Df(1)81j16f right 15A6-11 Df(1)81j23a right 15A6-11 Df(1)81l12h right 15A6-11 Df(1)81l28f right 15A9 Dp(1;2)r+75c right 15B Df(1)81k19b 15B l(1)15Ba right 15D1 Df(1)r19 ( Falk, Roselli, Curtiss, Halladay, and Klufas, 1984, Mutat. Res. 126: 25-34; | Data from 14B-C provided by Steller and updated from Jones and Rubin (1990, Neuron 4: 711-23); data from 14D-15 taken from Ganetzky (1984, Genetics 108: 897-911). / Molecular coordinates in 14C from Jones and Rubin; in 14F- 15A from D. Falk using probes from a 90-kb walk in the r region (Segraves, Christos, Schedl, and Jarry, 1983, Mol. Gen. Genet. 189: 34-40); origin not defined. # l(1)16F A series of lethal mutations in the vicinity of Sh isolated by Ferrus. The order of loci in 16F1-4 is as given; that of loci in 16F4-8 not determined? genetic cytological locus location location included in excluded from _______________________________________________________ l(1)16Fa 1-{59} 16F1-4 XP3DJC153 XPYDW32 l(1)16Fb 1-{59} 16F1-4 XP3DJC153 XPYDW32 l(1)16Fc 1-{59} 16F1-4 XP3DJC153 XPYDW32 l(1)16Fd 1-{59} 16F4-8 XPYDW32 XP3DV7 l(1)16Fe 1-{59} 16F4-8 XPYDW32 XP3DV7 allele origin synonym __________________________ l(1)16Fa1 EMS l(1)305 l(1)16Fa2 EMS l(1)579 l(1)16Fb1 EMS l(1)359 l(1)16Fb2 EMS l(1)62 l(1)16Fc1 EMS l(1)387 l(1)16Fc2 EMS l(1)581 l(1)16Fc3 EMS l(1)583 l(1)16Fc4 EMS l(1)598 l(1)16Fd1 EMS l(1)174 l(1)16Fe1 EMS l(1)1614 # l(1)16Fa phenotype: Major lethal phase in early pupae. Cell lethal in somatic mosaics in the hypoderm of the adult; also lethal in female germ-line mosaics. # l(1)16Fb phenotype: Major lethal phase in late pupae. Somatic clones of homozygous tissue in adult hypoderm show small bristles, slightly disoriented, unpigmented cuticle, and plexate veins. Gynandromorphs show vibrating appendages in the mutant terri- tory. Germ-line mosaics show a maternal effect since the eggs produced by mutant ovarioles never develop beyond the gastrula stage, irrespective of the zygotic genotype. # l(1)16Fc phenotype: Major lethal phase in the first larval instar. Somatic mosaics in the adult hypoderm show normal differentia- tion. Gynandromorphs show vibrating appendages in the mutant territory; also uncoordinated movement on the mutant side. Germ-line mosaics show a maternal effect since the eggs pro- duced by mutant ovarioles never develop beyond the gastrula stage, irrespective of the zygotic genotype. # l(1)16Fd phenotype: Major lethal phase in early pupae. Somatic mosaics in the adult hypoderm show fewer and smaller bristles and smooth ommatidia. Lethal in germ-line mosaics. # l(1)16Fe phenotype: Major lethal phase in second larval instar. Somatic mosaics in the adult hypoderm show normal cuticle. Gynandro- morphs exhibit vibrating appendages and abnormal wing position in the mutant side. Germ-line clones normal. # l(1)18F-19A Five lethally mutable loci including ot. cytological locus location included in excluded from synonym _______________________________________________________________ l(1)18Fa l(1)19Aa Df(1)mal11 Df(1)mal10 l(1)EM18 l(1)19Ab 19A3-4 Df(1)mal10 Df(1)T2-4a ot l(1)19Ac l(1)EM19 l(1)19Ad allele origin discoverer synonym ref ( comments ______________________________________________________________ l(1)18Fa1 X ray Lefevre l(1)HC223 1 l(1)18Fa2 EMS Lefevre l(1)VA197 2, 3 L1-2/L l(1)19Aa1 X ray Lefevre l(1)GA84 1 l(1)19Aa2 EMS Lefevre l(1)DA587 2 l(1)19Ac1 X ray Lefevre l(1)C68 1 l(1)19Ac2 X ray Lefevre l(1)HA64 2 l(1)19Ad1 X ray Lefevre l(1)C5 1 l(1)19Ad2 X ray Lefevre l(1)HA48 1 ( 1 = Lefevre, 1981, Genetics 99: 461-80; 2 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 3 = Perrimon, Engstrom, and Mahowald, 1984, Dev. Biol. 105: 404-14; # l(1)19B Two lethally mutable loci, one of which is sw. cytological locus location included in excluded from synonym ______________________________________________________ l(1)19Ba 19B1 Df(1)mal10 Df(1)T2-4a l(1)19Bb 19B3 Df(1)T2-4a Df(1)mal22 sw allele origin discoverer synonym ref ( comments ______________________________________________________________ l(1)19Ba1 X ray Lefevre l(1)A96 1 In(1)18F-19A;19B1-2 l(1)19Ba2 X ray Lefevre l(1)A149 1 T(1;2;3)19B1-2;20F; 48F;81 ( 1 = Lefevre, 1981, Genetics 99: 461-80; # l(1)19C-D Four lethally mutable loci identified by Schalet and Lefevre [1976, The Genetics and Biology of Drosophila (Ashburner and Novitski, eds.). Academic Press, London, New York, San Fran- cisco, vol. 1b, pp. 847-902]. Three lethally mutable loci identified in an independently derived sample (Lefevre and Watkins, 1986, Genetics 99: 869-95). Complementation tests between the two sets of mutants not performed; allelism between lethals in the two groups arbitrarily assigned. cytological locus location included in excluded from ______________________________________________ l(1)19Ca 19C1 Df(1)T2-4a Df(1)mal22 l(1)19Cb 19C4 Df(1)mal22 Df(1)T2-4a Df(1)16-3-22 l(1)19Cc 19C6 l(1)19Da allele origin discoverer synonym ref ( comments _____________________________________________________________________ l(1)19Ca1 neutron Munoz l(1)16-127 3 l(1)19Ca2 neutron Munoz l(1)17-238 3 l(1)19Ca3 neutron Munoz l(1)17-457 3 l(1)19Ca4 spont Schalet l(1)12-3 l(1)19Cb1 neutron Munoz l(1)16-398 3 l(1)19Cb2 X ray Lefevre l(1)C157 1 l(1)19Cb3 EMS Lefevre l(1)VA264 2 E-L1/NME l(1)19Cc1 X ray Singer l(1)25C4 3 semilethal l(1)19Cc2 EMS Singer l(1)ElC1 3, 4 l(1)19Cc3 X ray Lefevre l(1)A99 1 In(1)6A1-2;7C; 9A3;19C-D l(1)19Cc4 X ray Lefevre l(1)GA74 1 l(1)19Cc5 X ray Lefevre l(1)L20 1 l(1)19Cc6 X ray Lefevre l(1)N14 1 l(1)19Cc7 X ray Lefevre l(1)N60 1 l(1)19Cc8 EMS Lefevre l(1)DA588 2 l(1)19Cc9 EMS Lefevre l(1)EF489 2 l(1)19Cc10 mei-9 | Schalet l(1)01/7-1 l(1)19Cc11 mei-9 Schalet l(1)18-2 l(1)19Da1 X ray Lefevre l(1)C238 1 T(1;2)19E1-2;35A-B ( 1 = Lefevre, 1981, Genetics 99: 461-80; 2 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 3 = Schalet and Lefevre, 1976, The Genetics and Biology of Drosophila (Ash- burner and Novitski, eds.). Academic Press, London, New York, San Francisco, Vol. 1b, pp. 847-902; 4 = Schalet and Singer, 1971, DIS 46: 131-32. | Spontaneous in the paternal X chromosome of a cross between wild-type males and mei-9 females, such that the F1 females were l(1)3Ac/mei-9. # l(1)19E Six lethally mutable loci including four named loci: run, shakB, lf, and unc. cytological locus location included in excluded from synonym ___________________________________________________________ l(1)19Ea 19E1-2 Df(1)B57 Df(1)LB6 run, leg l(1)19Eb 19E4 Df(1)LB6 Df(1)A118 shakB, Pas l(1)19Ec 19E6 Df(1)A118 Df(1)A53 l(1)19Ed 19E4-5 Df(1)A53 Df(1)Q539 l(1)19Ee 19E5-6 Df(1)A53 Df(1)Q539 lf l(1)19Ef 19E8 Df(1)Q539 Df(1)DCB1-35b unc # l(1)19Ec phenotype: Mutant embryos from heterozygous females exhibit no defects in central or peripheral nervous systems; l(1)19Ec1 and l(1)19Ec18 are lethal in germ-line clones, whereas l(1)19Ec8 and l(1)19Ec25 germ-line clones exhibit a paternally rescuable maternal effect. Embryonic phenotype includes head and dorsal-closure defects, and most embryos are twisted (Per- rimon, Smouse, and Miklos, 1989, Genetics 121: 313-31). alleles: allele origin discoverer synonym ref ( comments __________________________________________________________________ l(1)19Ec1 Novitski l(1)151 2, 4, 7, 8 L/L l(1)19Ec2 l(1)J2 5 l(1)19Ec3 l(1)J9 5 l(1)19Ec4 spont Himoe l(1)N5 l(1)19Ec5 EMS Lifschytz l(1)P464 4 l(1)19Ec6 EMS Lifschytz l(1)Q256 4 l(1)19Ec7 EMS Lifschytz l(1)R-9-2 4 l(1)19Ec8 EMS Lifschytz l(1)R-9-28 4, 8 L/MER l(1)19Ec9 EMS Lifschytz l(1)YT6 5 l(1)19Ec10 X ray Lefevre l(1)GA71 2 l(1)19Ec11 X ray Lefevre l(1)HC279 2 mutant or deficient for l(1)19Ed l(1)19Ec12 X ray Lefevre l(1)HF417 2 l(1)19Ec13 X ray Lefevre l(1)JC8 2 l(1)19Ec14 X ray Lefevre l(1)KA12 2 l(1)19Ec15 X ray Lefevre l(1)L39 2 l(1)19Ec16 EMS Lefevre l(1)DA507 3 l(1)19Ec17 EMS Lefevre l(1)DA536 3 l(1)19Ec18 EMS Lefevre l(1)EC242 3, 6 L1-2/L l(1)19Ec19 EMS Lefevre l(1)VE863 3 l(1)19Ec20 EMS Lefevre l(1)VE866 3 l(1)19Ec21 EMS Lefevre l(1)VE926 3 l(1)19Ec22 mei-9 | Schalet l(1)4-2 l(1)19Ec23 l(1)17-457 8 l(1)19Ec24 l(1)AF2/19 6 l(1)19Ec25 l(1)LB2 6 L/MER ( 1 = Eeken, Sobels, Hyland, and Schalet, 1985, Mutat. Res. 150: 261-75; 2 = Lefevre, 1981, Genetics 99: 461-80; 3 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 4 = Lifschytz and Falk, 1969, Mut. Res. 8: 147-55 10; 5 = Lifschytz and Yakobovitz, 1978, Mol. Gen. Genet. 161: 275-84; 6 = Schalet and Lefevre, 1973, Chromosoma 44: 183-202; 7 = Perrimon, Smouse, and Miklos, 1989, Genet- ics 121: 313-31; 8 = Schalet and Lefevre, 1976, The Genet- ics and Biology of Drosophila (Ashburner and Novitski, eds.). Academic Press, London, New York, San Francisco, Vol. 1b, pp. 847-902; 9 = Zusman, Coulter, and Gergen, 1985, DIS 61: 217-18. | Spontaneous in the paternal X chromosome of a cross between wild-type males and mei-9 females, such that the F1 females were l(1)3Ac/mei-9. # l(1)19Ed phenotype: Mutant embryos have normal central nervous systems (CNS) and peripheral nervous systems (PNS); germ-line clones are lethal (Perrimon, Smouse, and Miklos, 1989, Genetics 121: 313-31). alleles: allele origin discoverer synonym ref ( comments __________________________________________________________ l(1)19Ed1 X ray Lefevre l(1)HC279 2 mutant or deficient for l(1)19Ec l(1)19Ed2 EMS Lefevre l(1)EC235 3 L1/L l(1)19Ed3 EMS Lefevre l(1)VE909 3 l(1)19Ed4 P Gergen l(1)5-7 9 l(1)19Ed5 P Gergen l(1)7-2 9 l(1)19Ed6 P Gergen l(1)24A 9 l(1)19Ed7 P Gergen l(1)26A 9 l(1)19Ed8 P Gergen l(1)31B(C) 9 l(1)19Ed9 P Gergen l(1)40A 9 l(1)19Ed10 P Gergen l(1)48-1 9 l(1)19Ed11 P Gergen l(1)BH9 9 l(1)19Ed12 P Gergen l(1)HT1 9 l(1)19Ed13 P Gergen l(1)PC7 9 l(1)19Ed14 P Gergen l(1)PG7 9 l(1)19Ed15 P Gergen l(1)PU1 9 l(1)19Ed16 l(1)11/27 6 l(1)19Ed17 MR l(1)D76 1, 6 l(1)19Ed18 MR l(1)D83 1, 6 l(1)19Ed19 HMS Kramers l(1)HM435 6 ( 1 = Eeken, Sobels, Hyland, and Schalet, 1985, Mutat. Res. 150: 261-75; 2 = Lefevre, 1981, Genetics 99: 461-80; 3 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 4 = Lifschytz and Falk, 1969, Mutat. Res. 8: 147-55 10; 5 = Lifschytz and Yakobovitz, 1978, Mol. Gen. Genet. 161: 275-84; 6 = Schalet and Lefevre, 1973, Chromosoma 44: 183-202; 7 = Perrimon, Smouse, and Miklos, 1989, Genet- ics 121: 313-31; 8 = Schalet and Lefevre, 1976, The Genet- ics and Biology of Drosophila (Ashburner and Novitski, eds.). Academic Press, London, New York, San Francisco, Vol. 1b, pp. 847-902; 9 = Zusman, Coulter, and Gergen, 1985, DIS 61: 217-18. Three mutants designated D83, D76, and HM46 placed between right breakpoints of Df(1)16-3-35 and Df(1)A118; complementa- tion of l(1)19Ec, l(1)19Ed, or lf not tested (Kramers, Schalet, Paradi, Huiser-Hoogteyling, 1983, Mutat. Res. 107: 187-201). # l(1)19F Seven lethally mutable loci identified, including lfl and fliI; l(1)l9Fc found only once, on mal+Y but not on the X in several large screens. genetic cytological locus location location included in excluded from synonym _________________________________________________________________ l(1)19Fa Df(1)DCB1-35b Df(1)17-257 lfl l(1)19Fb 19F2 Df(1)DCB1-35b Df(1)17-257 l(1)19Fc l(1)19Fd 19F3-4 Df(1)17-257 fliI Df(1)16-129 l(1)19Fe 19F4 Df(1)18-80 Df(1)16-129 l(1)19Ff 19F5 Df(1)HM44 Df(1)18-80 l(1)19Fg 19F6 Df(1)17-351 Df(1)HM44 # l(1)19Fb phenotype: Pupal lethal; embryonic central nervous system (CNS) and peripheral nervous system (PNS) normal. Eggs derived from homozygous germ-line clones have variably defective chorions. The few embryos that develop are U-shaped owing to defective germ-band retraction; have severe head defects (Perrimon, Smouse, and Miklos, 1989, Genetics 121: 313-31). alleles: allele origin discoverer synonym ref ( comments ___________________________________________________________________ l(1)19Fb1 X ray Lifschytz l(1)B214 1, 3, 4, 5, 9 l(1)19Fb2 l(1)B214-1 9 l(1)19Fb3 EMS Lifschytz l(1)YT16 5 on mal+Y l(1)19Fb4 EMS Lefevre l(1)DA689 2 P/AO l(1)19Fcut1 EMS Lifschytz l(1)YT57 5 on mal+Y l(1)19Fe1 l(1)M136 5 on y+Ymal+ l(1)19Fe2 l(1)NY20 5 l(1)19Fe3 l(1)P329 4, 5 l(1)19Fe4 EMS Lifschytz l(1)W4 1, 3, 4, 5, 9 l(1)19Fe5 l(1)YT28 5 on mal+Y l(1)19Fe6 l(1)YT31 5 on mal+Y ( 1 = Lefevre, 1981, Genetics 99: 461-80; 2 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 3 = Lifschytz and Falk, 1968, Mut. Res. 6: 235-44; 4 = Lifschytz and Falk, 1969, Mut. Res. 8: 147-55; 5 = Lifschytz and Yakobovitz, 1978, Mol. Gen. Genet. 161: 275-84; 6 = Perrimon, Smouse, and Miklos, 1989, Genetics 121: 313-31; 7 = Schalet, 1986, Mutat. Res. 163: 115-44; 8 = Schalet and Lefevre, 1971, Chromosoma 44: 183-202; 9 = Schalet and Lefevre, 1976, The Genetics and Biology of Drosophila (Ashburner and Novitski, eds.). Academic Press, London, New York, San Francisco, Vol. 1b, pp. 847-902; 10 = Schalet and Singer, 1972, DIS 46: 131-32. # l(1)19Ff phenotype: Mutant embryos have no obvious defects of central nervous system (CNS), peripheral nervous system (PNS), or cuticle. Germ line clones lethal (Perrimon, Smouse, and Mik- los, 1989, Genetics 121: 313-31). alleles: allele origin discoverer synonym ref ( comments __________________________________________________________________ l(1)19Ff1 X ray Singer l(1)11P1 7, 9, 10 l(1)19Ff2 X ray Lifschytz l(1)A112 1, 5, 6, 9, 10 L/L l(1)19Ff3 EMS Lifschytz l(1)P252 l(1)19Ff4 EMS Lifschytz l(1)R-9-26 4 l(1)19Ff5 EMS Lifschytz l(1)M173 5 on mal+Y l(1)19Ff6 X ray Lefevre l(1)GF314 1, 6 E-L/L l(1)19Ff7 spont Schalet l(1)8-1 6, 7 L/L l(1)S-19F6 l(1)19Ff8 l(1)17-62 6 E-L/L l(1)19Fg1 EMS Baldwin l(1)LB14 5, 8, 9 l(1)19Fg2 EMS Baldwin l(1)LB20 1, 6, 8, 9 L-P/L l(1)19Fg3 X ray Lefevre l(1)C27 1, 6 P/L l(1)19Fg4 X ray Lefevre l(1)KC14 1 l(1)19Fg5 X ray Lefevre l(1)RF42 1 T(1;2)7A1-2; 19F5-6,2L (complex) l(1)19Fg6 EMS Lefevre l(1)DA618 2, 6 L-P/L ( 1 = Lefevre, 1981, Genetics 99: 461-80; 2 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 3 = Lifschytz and Falk, 1968, Mutat. Res. 6: 235-44; 4 = Lifschytz and Falk, 1969, Mutat. Res. 8: 147-55; 5 = Lifschytz and Yakobovitz, 1978, Mol. Gen. Genet. 161: 275-84; 6 = Perrimon, Smouse, and Miklos, 1989, Genetics 121: 313-31; 7 = Schalet, 1986, Mutat. Res. 163: 115-44; 8 = Schalet and Lefevre, 1971, Chromosoma 44: 183-202; 9 = Schalet and Lefevre, 1976, The Genetics and Biology of Drosophila (Ashburner and Novitski, eds.). Academic Press, London, New York, San Francisco, Vol. 1b, pp. 847-902; 10 = Schalet and Singer, 1972, DIS 46: 131-32. # DEFICIENCY MAP OF REGION 19 side breakpoint variant ___________________________________ left 18F4-5 Df(1)mal8 left 19A1 Df(1)mal12 amn left 19A2-3 Df(1)mal11 l(1)19Aa left 19A2-3 Df(1)mal3 left 19A2-3 Df(1)mal17 left 19A5 Df(1)16-2-19 left 19A5-6 Df(1)mal10 19A3-5 ot 19B1 l(1)19Ba left 19B Df(1)HM44 left 19B3 Df(1)T2-4A 19B3 sw l(1)19Ca 19C2-3 mel left 19C3 Df(1)mal22 left 19C3 Df(1)mal6 right 19C4 Df(1)T2-4A l(1)19Cb l(1)19Cc l(1)19Cd left 19D1 Df(1)16-3-22 left 19D2-3 Df(1)16-3-35 19D3-E1 mal left 19E2-3 Df(1)N77 right 19E1 Df(1)mal17 mell left 19E1 Df(1)B12 left 19E1-2 Df(1)B57 left 19E Df(1)GA37 left 19E Df(1)GA40 right 19D3 Df(1)16-2-19 right 19E1 Df(1)mal8 right 19E1 Df(1)mal10 right 19E1 Df(1)mal11 right 19E1 Df(1)mal22 left y+Ymal102 run left 19E4 Df(1)LB6 left y+Ymal171 l(1)19Eb shakB left 19E Df(1)17-351 left 19F Df(1)26B left 19E4-5 Df(1)A118 left Df(1)HC279 left 19E4 Df(1)LB7 right 19E3-4 Df(1)16-3-35 19E4-5 l(1)19Ec left Df(1)17-489 left 19E5 Df(1)A53 left 19E5-6 Df(1)T2-14A l(1)19Ed 19E6-7 lf left 19E6-7 Df(1)LB23 left 19E6 Df(1)Q539 right Df(1)HM435 19E7-8 vao left 19E8 Df(1)D43L1 left 19F Df(1)GA33 left 19E8 Df(1)S54 right 19E8 Df(1)A118 right Df(1)HC279 right Df(1)run1112 right 19E7-8 Df(1)T2-14A 19E8-F1 unc left 19F1 Df(1)16-129 left 19E8-F1 Df(1)54 left 19F1 Df(1)C74 left 19F1-2 Df(1)DCB1-35b left 19F1 Df(1)VE969 right 19F1 Df(1)B57 lfl l(1)19Fb left 19F Df(1)2/19B left 19F3 Df(1)17-257 left Df(1)18-80 left 19F Df(1)GA104 left 19F1-2 Df(1)GE263 fliI right 19F3 Df(1)16-129 l(1)19Fe sol slg left 19F5 Df(1)17-59 left 19F Df(1)JC77 left 19F Df(1)JA117 right Df(1)18-80 l(1)19Ff right 19F5-6 Df(1)HM44 l(1)19Fg right 19F Df(1)2/19B right 20A2 Df(1)16.3.22 right 19F Df(1)17-351 right 19F Df(1)GA37 right 19F Df(1)GA104 right 19F Df(1)JA117 right 19F6 Df(1)Q539 tuh left 20A Df(1)17-137 left 20A1 Df(1)JC4 left Df(1)R19 left Df(1)R29 left Df(1)R37 left Df(1)R45 left Df(1)R48 left 19F6-20A1 y+Ymal126 # l(1)20A Five lethally mutable loci identified, including named loci eo, wap, intro, and uncl. cytological locus location included in excluded from synonym ________________________________________________________ l(1)20Aa 20A1-2 Df(1)B12 Df(1)Q539 eo l(1)20Ab 20A3 Df(1)DCB1.35c Df(1)B12 wap l(1)20Ac 20A Df(1)DCB1.35c Df(1)B12 intro l(1)20Ad 20A l(1)20Ae 20A Df(1)16.2.13 Df(1)DCB1.35c uncl Df(1)EA113 allele origin discoverer synonym ref ( comments __________________________________________________ l(1)20Ad1 EMS Lifschytz l(1)YT1 1 on mal+Y ( 1 = Lifschytz and Yakobovitz, 1978, Mol. Gen. Genet. 161: 275-84. # l(1)20B - l(1)20F Nine lethally mutable loci identified, including fog in 20A, stn in 20B, sph and su(f) in 20E, and bb arbitrarily assigned to 20F. genetic cytological locus location location included in excluded from synonym _________________________________________________________________________ l(1)20Ba 1-65 20A5-B Df(1)JA27 Df(1)HF359 fog l(1)20Bb 1-68.5 20A-B Df(1)17-439 Df(1)17-466 l(1)20Bc Df(1)HF359 stn Df(1)17-439 l(1)20Ca 20B Df(1)17-252 Df(1)17-439 Df(1)17-148 l(1)20Cb 20C-D Df(1)17-48 Df(1)17-252 Df(1)GA131 l(1)20Ea 20D-E Df(1)GA131 Df(1)16-185 sph l(1)20Eb 1-65.9 20E Df(1)16-185 su(f) Df(1)13C3 l(1)20Fa 1-66.0 20F Df(1)yX15 Df(1)16-185 bb Df(1)13C3 allele origin discoverer synonym ref ( comments ____________________________________________________ l(1)20Bb1 X ray Lefevre l(1)A72 2 L/L l(1)20Bb2 EMS Lefevre l(1)EA41 3 L/L l(1)20Bb3 HMS Kramers l(1)HM1 1 l(1)20Bb4 HMS Kramers l(1)HM410 1 l(1)20Bb5 HMS Kramers l(1)HM425 1 ( 1 = Kramers, Schalet, Paradi, and Huiser-Hoogteyling, 1983, Mut. Res. 107: 187-201; 2 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 3 = Lefevre, 1981, Genetics 99: 461-80. # l(1)20Ca phenotype: Embryonic-larval lethal with no cuticular, central nervous system (CNS), or peripheral nervous system (PNS) defects discernable in mutant embryos. l(1)20Ca1 exhibits no maternal effect, whereas homozygous germ-line clones of l(1)20Ca8 produce lethal embryos with slight rescue by pater- nally supplied normal X; head involution and segmentation defective in such embryos (Perrimon, Smouse, and Miklos, 1989, Genetics 121: 313-31). alleles: allele origin discoverer synonym ref ( comments _________________________________________________________ l(1)20Ca1 X ray Singer l(1)13E3 2, 4, 5, 7 E/NME l(1)20Ca2 EMS Lifschytz l(1)P19 4, 5, 7, 8 l(1)20Ca3 EMS Lifschytz l(1)P431 4 l(1)20Ca4 EMS Lifschytz l(1)YT65 5 on mal+Y l(1)20Ca5 X ray Lefevre l(1)GE201 2 l(1)20Ca6 X ray Lefevre l(1)HC137 2 l(1)20Ca7 X ray Lefevre l(1)N138 2 l(1)20Ca8 X ray Lefevre l(1)S60 2 E-L1/MER ( 1 = Kramers, Schalet, Paradi, and Huiser-Hoogteyling, 1983, Mut. Res. 107: 187-201; 2 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 3 = Lefevre, 1981, Genetics 99: 461-80; 4 = Lifschytz and Falk, 1969, Mut. Res. 8: 147-55; 5 = Lifschytz and Yakobovitz, 1978, Mol. Gen. Genet. 161: 275-84; 6 = Schalet and Finnerty, 1968, DIS 3: 128; 7 = Schalet and Lefevre, 1973, Chromosoma 44: 183-202; 8 = Schalet and Lefevre, 1976, The Genetics and Biology of Drosophila (Ashburner and Novitski, eds.). Academic Press, London, New York, San Francisco, Vol. 1b, pp. 847-902; 9 = Schalet and Singer, 1971, DIS 46: 131-32. # l(1)20Cb phenotype: l(1)20Cb2 is larval and the weaker l(1)20Cb13 is a polyphasic lethal; central nervous system (CNS) and peripheral nervous system (PNS) development appears normal. The stronger allele is lethal in homozygous germ-line clones; the weaker allele is not (Perrimon, Smouse, and Miklos, 1989, Genetics 121: 313-31). alleles: allele origin discoverer synonym ref ( comments ____________________________________________________________ l(1)20Cb1 neutron Munoz l(1)17-347 8 l(1)20Cb2 X ray Schalet l(1)20 2, 7, 8, 9 L/L l(1)20Cb3 Singer l(1)26E1 8 l(1)20Cb4 Novitski l(1)97 6 l(1)20Cb5 Novitski l(1)137 6 l(1)20Cb6 EMS Lifschytz l(1)Q463 4, 5, 7, 8 l(1)20Cb7 EMS Lifschytz l(1)R-9-14 5 l(1)20Cb8 EMS Lifschytz l(1)YT47 5 on mal+Y l(1)20Cb9 X ray Lefevre l(1)JA57 2 l(1)20Cb10 EMS Lefevre l(1)DA565 3 l(1)20Cb11 EMS Lefevre l(1)DC791 3 l(1)20Cb12 EMS Lefevre l(1)EA9 3 l(1)20Cb13 EMS Lefevre l(1)VA97 3 L3-A/NME l(1)20Cb14 EMS Lefevre l(1)VA151 3 l(1)20Cb15 EMS Lefevre l(1)VE641 3 l(1)20Cb16 HMS Kramers l(1)HM24 1 ( 1 = Kramers, Schalet, Paradi, and Huiser-Hoogteyling, 1983, Mut. Res. 107: 187-201; 2 = Lefevre and Watkins, 1986, Genetics 113: 869-95; 3 = Lefevre, 1981, Genetics 99: 461-80; 4 = Lifschytz and Falk, 1969, Mut. Res. 8: 147-55; 5 = Lifschytz and Yakobovitz, 1978, Mol. Gen. Genet. 161: 275-84; 6 = Schalet and Finnerty, 1968, DIS 3: 128; 7 = Schalet and Lefevre, 1973, Chromosoma 44: 183-202; 8 = Schalet and Lefevre, 1976, The Genetics and Biology of Drosophila (Ashburner and Novitski, eds.). Academic Press, London, New York, San Francisco, Vol. 1b, pp. 847-902; 9 = Schalet and Singer, 1971, DIS 46: 131-32. # DEFICIENCY MAP OF REGION 20 side breakpoint variant ___________________________________ right 19F Df(1)2/19B right 19F Df(1)17-351 right 19F Df(1)GA37 right 19F Df(1)GA104 right 19F Df(1)JA117 right 19F6 Df(1)Q539 tuh left 20A Df(1)17-137 left 20A1 Df(1)JC4 left Df(1)JC12 left Df(1)R19 left Df(1)R29 left Df(1)R37 left Df(1)R45 left Df(1)R48 left 19F6-20A1 y+Ymal126 20A1-2 eo left 20A3 Df(1)13C3 left 20A1-2 Df(1)16-2-13 left 20A Df(1)17-439 left 20A Df(1)17-466 left Df(1)A122 left Df(1)DCB1-35c left Df(1)GA22 left Df(1)HM455 left Df(1)R3 left Df(1)R13 left Df(1)R14 left Df(1)R15 left Df(1)R20 left Df(1)R21 left Df(1)R22 left Df(1)R24 left Df(1)R27 left Df(1)R28 left Df(1)R31 left Df(1)R32 left Df(1)R33 left Df(1)R35 left Df(1)R38 left Df(1)R40 left Df(1)R41 left Df(1)R44 left Df(1)R47 left Dp(1;f)3 right 20A2 Df(1)16-3-22 right 20A1-2 Df(1)17-257 right Df(1)26B right 20A1-2 Df(1)B12 right 20A1-2 Df(1)GE263 right Df(1)JC77 right 20A2-3 Df(1)LB6 right 20A2 Df(1)S54 right 20A2 Df(1)mal6 right 20A1-2 Df(1)A53 wap intro left 20A Df(1)17-408 left 20A Df(1)A209 left 20A Df(1)EA113 left Df(1)R12 left Df(1)R25 left Df(1)R26 left Df(1)R46 right Df(1)A122 right 20A4 Df(1)C74 right Df(1)DCB1-35c uncl left 20B Df(1)17-252 left 20B1 Df(1)GA42 left 20A-B Df(1)HM430 left Df(1)JA27 left Df(1)R2 left Df(1)R7 left Df(1)R10 left Df(1)R23 left Df(1)R30 left Df(1)R36 left Df(1)R42 left Df(1)R43 left 20A4-5 Df(1)yX5 right 20A4 Df(1)16-2-13 right Df(1)GA33 fog left BSY left 20A-B Df(1)HF359 left 20A3 Df(1)su(f)5A right 20B Df(1)17-466 l(1)20Bb stn right 20B Df(1)17-439 right 20B-D Df(1)54 l(1)20Ca left 20C Df(1)GA90 left Df(1)K5 left Df(1)R6 left Df(1)R8A right 20B-C Df(1)17-148 right 20C Df(1)17-252 l(1)20Cb left Df(1)GA131 left Df(1)R17 left 20D1-2 Df(1)yX15 left 20D-F Df(1)X1 right 20C-D Df(1)HM430 sph left 20D-E Df(1)17-87 left 20E Df(1)16-185 left Df(1)R8 left Df(1)R16 left Df(1)R18 su(f) right BSY right 20E-F Df(1)13C3 right 20F Df(1)16-185 right 20E-F Df(1)17-59 right 20E-F Df(1)17-137 right 20E-F Df(1)17-148 right 20E-F Df(1)17-408 right Df(1)17-489 right 20E-F Df(1)D43L1 right 20E-F Df(1)DCB1-35b right 20E-F Df(1)EA113 right 20E-F Df(1)GA22 right 20E-F Df(1)GA40 right Df(1)GA131 right 20E-F Df(1)HF359 right Df(1)JA27 right 20E-F Df(1)JC4 right Df(1)JC12 right Df(1)LB7 right 20E-F Df(1)LB23 right 20E-F Df(1)mal3 right 20E-F Df(1)mal12 right Df(1)N77 right 20E-F Df(1)su(f)5A right Df(1)R2 right Df(1)R3 right Df(1)R6 right Df(1)R7 right Df(1)R8 right Df(1)R12 right Df(1)R13 right Df(1)R14 right Df(1)R15 right Df(1)R16 right Df(1)R17 right Df(1)R18 right Df(1)R19 right Df(1)R23 right Df(1)R26 right Df(1)R28 right Df(1)R29 right Df(1)R31 right Df(1)R32 right Df(1)R33 right Df(1)R37 right Df(1)R38 right Df(1)R41 right Df(1)R44 right Df(1)R45 bb right Df(1)R46 right Df(1)R22 right 20F Df(1)17-87 right 20F Df(1)A209 right 20F Df(1)GA42 right 20F Df(1)GA90 right Df(1)K5 right Df(1)R1 right Df(1)R8A right Df(1)R10 right Df(1)R20 right Df(1)R21 right Df(1)R24 right Df(1)R25 right Df(1)R27 right Df(1)R30 right Df(1)R35 right Df(1)R36 right Df(1)R40 right Df(1)R42 right Df(1)R43 right Df(1)R47 right Df(1)R48 right 20F Df(1)VE696 right 20F Df(1)X1 right 20F Df(1)yX15 right 20F Df(1)yX5 # l(1)48j: see mys #*l(1)52 location: 1- (to the right of B). discoverer: Sobels. references: Gloor, 1962, Rev. Suisse Zool. 69: 409-63 (fig.). phenotype: Larvae die in second instar. Growth retarded. His- tology of nervous system, testes, and imaginal disks abnormal. Number of nuclei in salivary glands increased. Amino acids and peptides increased. Transplanted testes and imaginal disks autonomously lethal. RK2. # l(1)55 location: 1-0. discoverer: Burdick, 55a. references: 1956, DIS 30: 69. 1957, DIS 31: 86. phenotype: Rare surviving males misinterpreted by Burdick as crossovers to the left of y leading him to place l(1)55 at -0.6. Heterozygote claimed to have viability about 1.5 times normal. Not allelic to l(1)1Ac1. RK2. # l(1)55a location: 1-5.5. origin: Induced by ethyl methanesulfonate. references: Lifschytz, 1978, Dev. Biol. 66: 571-78 (fig.). phenotype: Temperature-sensitive lethal; few l(1)55-bearing males develop at 27; lethal-bearing males surviving either temperature regime display arrest of spermatogenesis. At 18- 22 a variable number of cysts continues to support gonial proliferation producing giant cysts with hundreds of spermato- genia, most of which degenerate. # l(1)63 location: 1-0.3. origin: Induced by ethyl methanesulfonate. references: Lifschytz, 1978, Dev. Biol. 66: 571-78 (fig.). phenotype: Temperature-sensitive lethal. Surviving l(1)63- bearing males raised under permissive conditions exhibit precocious spermatocyte maturation in some cysts of four and eight cells; other cysts produce sixteen primary spermato- cytes. Shifting such males to 27 causes mitotic arrest lead- ing to disappearance of gonial cells within two or three days and of primary spermatocytes after four or five days. Homozy- gous females raised at 18 phenotypically normal but sterile. Mutant tergites found in gynandromorphs raised at 27; half- and-half gynandromorphs formed from embryos shifted from per- missive to restrictive conditions 48 hr after oviposition; facet number in mutant eyes and bristles in mutant tissue reduced, indicating mitotic arrest. # l(1)76: see dorl2 #*l(1)184 location: 1- (rearrangement). origin: X ray induced. discoverer: Lindsley, Edington, and Von Halle. references: 1960, Genetics 45: 1649-70. phenotype: Almost completely lethal. The few survivors have dark, rough eyes. RK2A. cytology: Associated with T(1;3)l-184 = T(1;3)18A;81. #*l(1)272-13 location: 1- (rearrangement). origin: X ray induced. discoverer: Demerec, 1940. references: Sutton, 1943, Genetics 28: 210-217. phenotype: Lethal. l(1)272-13/sc is scute. RK2A. cytology: Associated with In(1)l-272-13 = In(1)1A6-B1;11A7- 8;11F2-12A1;18A4-B1. # l(1)1074ts location: 1-16.3. origin: Induced by ethyl methanesulfonate. references: Datson and Brink, 1978, Aust. J. Biol. Sci. 31: 73-91. Brink, 1979, Aust. J. Biol. Sci. 32: 597-606. phenotype: Temperature-sensitive mutant of a gene whose product is required several times during development. The temperature-sensitive periods are towards the end of oogenesis in homozygous females, from the sixth to twelfth hour of embryogenesis and again during larval and early pupal develop- ment in mutant offspring. Embryological abnormalities first evident during gastrulation and eventually result in the breakdown of organogenesis and the absence of normal muscular contractions. Fragments of mutant gastrulae transplanted into larvae fail to show evidence of the cuticular differentiation seen in transplanted wild-type fragments. X-ray-induced mutant clones formed normally in abdominal histoblasts, but didn't survive in imaginal discs. # l(1)2269 location: 1-unmapped. origin: Induced by ethyl methanesulfonate. references: Gateff, 1978, Biol. Rev. 53: 123-68. 1978, Science 200: 1448-59. phenotype: Causes malignant neuroblastoma of the adult optic neuroblasts and ganglion mother cells; also displays inter- mediate imaginal disc neoplasm with compact mode of growth. # l(1)3063 location: 1-0.8 (0/569 recombinants with pn). origin: X ray induced. references: Imaizumi, 1967, DIS 42: 78. phenotype: Embryonic lethal; dies in second half of embryo- genesis. # l(1)Ab: see r # l(1)Ac1 origin: X ray induced simultaneously with scJ1. discoverer: Jacobs-Muller. references: Muller, 1932, Proc. Intern. Congr. Genet., 6th., Vol. 1: 225. Muller, 1935, Genetica 17: 237-52. phenotype: Lethal. Not cell lethal (Ephrussi, 1934, Proc. Nat. Acad. Sci. USA 20: 420-22). One recorded surviving male had rough eyes and was sterile. RK2A. cytology: Probably in 1A6. Associated with In(1)scJ1 = In(1)1A4-5;1B4-5 (Muller, Prokofyeva, and Raffel, 1935, Nature 135: 253-55). # l(1)adl: lethal (1) adult A series of ethyl-methanesulfonate-induced mutants identi- fied by virtue of their reduced life span upon being shifted from their developmental temperature of 22 to 29 shortly after eclosion. Most are temperature-sensitive lethals with preima- ginal as well as adult lethal phases; as such they identify a subset of lethally mutable genes whose functions are required both during development and for the maintenance of adult via- bility; in general, they have not been tested for allelism with unconditional lethals nearby. Others are unconditionally lethal in the adult stage and are either completely viable during development or are semilethal during development at one or both temperatures. genetic preimaginal adult time of | locus location synonym ref ( phenotype phenotype death at 29 ___________________________________________________________________________________ l(1)adl1 1-21.3 addA 2, 3, 4, 6 ts E ts paralysis .25-.75 J1649 l(1)adl2 1-0.0 addB 2, 3, 4 + hypoactivity 3-7 l(1)adl3 y-cv 3, 5 ts L2-3 ts female sterile 6-8 l(1)adl4 cv-v 3, 5 ts semilethal 4-7 l(1)adl5 cv-v 3 ts P stress sensitive 7-21 l(1)adl6 cv-v 3 ts semilethal sc-like, rough eyes 3-28 l(1)adl7 v-f 3 + female sterile 2-12 l(1)adl8 v-f 3 ts semilethal 3-6 l(1)adl9 v-f 3 ts semilethal 2-10 l(1)adl10 v-f 3 ts semilethal ts stress sensitive 6-11 female sterile l(1)adl11 v-f 3 ts L1 stress sensitive 1-4 l(1)adl12 f-car 3 ts semilethal 2-10 l(1)adl13 car-sfa 3, 5 ts L2-P stress sensitive 4-8 l(1)adl14 car-sfa 3, 5 ts L1-2 ts 3-4 l(1)adl15 car-sfa 3 ts semilethal ts 16-29 l(1)adl16 1-50.8 flrdI 3, 5 ts E-L3 ts swollen abdomen 2-20 proboscis extended flight reduced ( 1 = Homyk and Sheppard, 1977, Genetics 87: 95-104; 2 = Homyk, Sinclair, Wong, and Suzuki, 1979, Genetics 91: s49- 50; 3 = Homyk, Sinclair, Wong, and Grigliatti, 1986, Genet- ics 113: 367-89; 4 = Homyk, Szidonia, and Suzuki, 1980, Mol. Gen. Genet. 177: 553-65; 5 = Laffelaar and Grigliatti, 1984, Dev. Genet. 4: 199-210; 6 = Shellenbarger and Cross, 1979, Dev. Biol. 71: 308-22. | The period during which adults die in days after eclosion at 29; control flies survive well beyond 25 days at that tem- perature. # l(1)adl1 phenotype: Temperature shift and pulse experiments delineate two major temperature sensitive periods, one during the second half of embryogenesis and the other at the time of pupation. Fate mapping revealed separate mesodermal foci for leg paralysis, and examination of embryos developing at 29 indi- cated abnormalities in muscle development (Homyk, Sinclair, Wong, and Grigliatti, 1986, Genetics 113: 367-89). cytology: Located in 7D11-22 based on its inclusion in Df(1)HA11 (Lefevre). # l(1)adl2 phenotype: Fate mapping suggests presence of bilateral dom- ineering foci located in or near the subesophageal ganglion responsible for both hypoactivity and lethality at 29 (Homyk, Sinclair, Wong, and Grigliatti, 1986, Genetics 113: 367-89). # l(1)adl3 phenotype: Severely debilitated in phototaxis and geotaxis shortly after shift of adults raised at 22 to 29 (Laffelaar and Grigliatti, 1984, Dev. Genet. 4: 199-210). # l(1)adl4 phenotype: Gradual loss of phototaxis and geotatic abilities during three days following shift of adults raised at 22 to 29 (Laffelaar and Grigliatti, 1984, Dev. Genet. 4: 199-210). # l(1)adl13 phenotype: Motor, geotatic, and phototatic behavior severely debilitated at 22, but lifespan shortened only when shifted to 29 (Laffelaar and Grigliatti, 1984, Dev. Genet. 4: 199-210). # l(1)adl16 phenotype: The normal pattern of behavioral loss associated with aging in Drosophila was contracted exactly in parallel with the contraction of the life span in l(1)adl161 flies, suggesting that mutations at this locus accelerate aging (Laf- felaar and Grigliatti, 1984, Dev. Genet. 4: 199-210). l(1)adl163 (formerly flrdI) adults show weak flight, general activity and reduced life span at 25. alleles: preimaginal adult time of | allele origin synonym ref ( phenotype phenotype death __________________________________________________________________________ l(1)adl161 EMS DC836 2, 3 ts E-L2 ts swollen abdomen 5-8 proboscis extended l(1)adl162 EMS DC359 2, 3 ts L2-3 2-3 l(1)adl163 EMS flrdI 1, 2 ts L2-3 ts swollen abdomen 10-20 proboscis extended; flight reduced ( 1 = Homyk and Sheppard, 1977, Genetics 87: 95-104; 2 = Homyk, Sinclair, Wong, and Grigliatti, 1986, Genetics 113: 367-89; 3 = Shellenbarger and Cross, 1979, Dev. Biol. 71: 308-22. | The period during which adults die in days after eclosion at 29; control flies survive well beyond 25 days at that tem- perature. # l(1)AL: lethal (1) Adult Lifespan X-ray-induced mutations at three different loci (by comple- mentation testing), which have not been mapped (Gould and Clark, 1977, J. Exp. Gerontol. 12: 107-12). mean lifespan (days) ________________________ locus males females _________________________________ l(1)AL1 34.9 _ 1.2 30.1 _ 1.4 l(1)AL2 12.7 _ 0.2 14.5 _ 0.3 l(1)AL3 28.7 _ 0.4 24.4 _ 0.4 + 68.5 _ 2.2 64.2 _ 2.1 # l(1)br: see br # l(1)C location: 1-6 (between ec and bi). origin: Spontaneous in sc t2 v sl B chromosome. discoverer: Muller, 20j. references: 1928, Genetics 13: 279-357. phenotype: Dies as late embryo or, more commonly, as first- instar larva (Brehme, 1937, Am. Naturalist 71: 567). RK2A. cytology: Associated with the left breakpoint of In(1)Cl = In(1)4A5-B1;17A6-B1. # l(1)carot: lethal(1) carnation to outheld location: A series of lethally mutable loci between car and ot. Some are likely to be alleles of l(1)18Fa or l(1)19Aa. references: Schalet, 1968, DIS 42: 64. Schalet and Finnerty, 1968, DIS 42: 128-29. genetic locus location origin discoverer synonym ____________________________________________________________________ l(1)carot1 l(1)1 l(1)carot2 car-l(1)carot3 Schalet, 1961 l(1)5 l(1)carot3 M(1)n-ot Schalet, 1961 l(1)34 l(1)carot4 l(1)77 l(1)carot5 l(1)106 l(1)carot6 l(1)412 l(1)carot7 Kaplan l(1)A11 l(1)carot8 Kaplan l(1)A12 l(1)carot9 Kaplan l(1)B4 l(1)carot10 Himoe l(1)D43l3 l(1)carot11 Kaplan l(1)DCB2-35b l(1)carot12 Novitski l(1)EN10 l(1)carot13 1-62.7 spont Bridges, 1923 M(1)18C l(1)carot14 1-63.8 EMS Wright l(1)TW5 allele origin discoverer synonym ref ( ________________________________________________________ l(1)carot14cs1 EMS Wright l(1)TW5cs 1, 3 l(1)carot14cs2 EMS Mayoh l(1)HM5 2 l(1)carot14cs3 EMS Mayoh l(1)HM6 2 l(1)carot14cs4 EMS Mayoh l(1)HM15 2 ( 1 = Falke and Wright, 1975, Genetics 81: 655-82; 2 = Mayoh and Suzuki, 1973, Can. J. Genet. Cytol. 151: 237-54; 3 = Wright, 1973, Mol. Gen. Genet. 122: 101-18. # l(1)crn: see crn # l(1)DC: lethal (1) of David Cross Twelve complementing heat-sensitive lethals which develop at 22 but not at 29; phenotypic information available on three. discoverer: Cross. references: Shellenbarger and Cross, 1979, Dev. Biol. 71: 308-22. # l(1)DC371 phenotype: Males raised at 22 fertile, but become sterile after eight days at 28. Sterile males have motile sperm, which are not transmitted to females. # l(1)DC836 phenotype: Males raised at 22 survive, but die when held at 28 following eclosion. # l(1)DC1112 phenotype: Males raised at 22 eclose but die prematurely at either permissive or restrictive temperature. # l(1)dd: lethal (1) discs degenerate A group of late larval-early pupal lethals that exhibit degeneration of imaginal discs at the normal time of pupation. None of those tested is able to survive in male tissue in gynandromorphs (all but dd10 and dd11 tested). All have been found by Baker, Smith, and Gatti to be mitotic mutants; they argue that the maternal genotype supports cell division in the embryo, and that disc proliferation represents the first instance of zygotically controlled cell division; thus the defects in these mutants do not affect phenotype until late in development (Baker, Smith, and Gatti, 1982, Proc. Nat. Acad. Sci. USA 79: 1205-09; Gatti, Pimpinelli, Bove, Baker, Smith, Carpenter, and Ripoll, Proc. Int. Cong. Genet. 15th, 1983, Vol. 3, pp. 193-204; Gatti and Baker, 1989, Genes Dev. 3: 438-53). lethal mitotic locus location synonym ref ( phase phenotype ________________________________________________________________________________________ l(1)dd1 1-13.7 mus105 1, 2, 3, 6 LP chromosome aberrations, l(1)d.deg.-1 euchromatic breaks and exchanges l(1)dd2 1-25.7 l(1)d.deg.-2 5 LP l(1)dd3 | 1-27.5 l(1)d.deg.-3 1, 2, 3, 6 P hypercontracted chromosomes, no anaphase, polyploid cells l(1)dd4 | 1-44.4 l(1)d.deg.-4 1, 2, 3, 6 P metaphase block, colchicine- like metaphases, polyploid cells l(1)dd9 | 1-29.7 l(1)d.deg.-9 1, 2, 3, 4 LP condensation abnormal, chromosomes swollen l(1)dd10 | 1-46.7 l(1)d.deg.-10 1, 2, 3, 4 LP hypercontracted chromosomes, no anaphase, polyploid cells l(1)dd11 | 1-27.2 l(1)d.deg.-11 1, 2, 3, 4 LP highly polyploid cells, many anaphases, some multipolar l(1)dd12 | 1-65.8 l(1)d.deg.-12 1, 2, 3, 4, 5 L irregular condensation of chromosomes, polyploids ( 1 = Baker, Smith, and Gatti, 1982, Proc. Nat. Acad. Sci. USA 79: 1205-09; 2 = Gatti and Baker, 1989, Genes Dev. 3: 438-53; 3 = Gatti, Pimpinelli, Bove, Baker, Smith, Car- penter, and Ripoll, Proc. Int. Cong. Genet. 15th, 1983, Vol. 3, pp. 193-204; 4 = Kiss, Bencze, Fekete, Fodor, Gausz, Maroy, Szabad, and Szidonya, 1976, Theor. Appl. Genet. 48: 217-226; 5 = Kiss, Szabad, and Major, 1978, Mol. Gen. Genet. 164: 77-83; 6 = Stewart, Murphy, and Fristrom, 1972, Dev. Biol. 27: 71-83. | Fuller discussion follows. # l(1)dd3 phenotype: Discs missing or degenerate; mitotic index of larval ganglion cells three times that of controls; chromosomes highly condensed as seen in colchicine-treated cells; 20% of metaphases polyploid; chromosome fragmentation common; no ana- phase figures seen (Gatti and Baker, 1989, Genes Dev. 3: 438-53). Homozygous cells in ovary lethal (Perrimon, Engstrom, and Mahowald, 1984, Dev. Biol. 105: 404-14). # l(1)dd4 phenotype: Discs missing or degenerate; mitotic index of larval ganglion cells three times that of controls; 20% of metaphases polyploid; very few anaphase figures seen. No maternal effect of homozygosis in ovarian clones on phenotype of offspring (Perrimon, Engstrom, and Mahowald, 1984, Dev. Biol. 105: 404-14). l(1)dd4S recovered as a mutation on the pater- nal X in a cross of homozygous mei-9 females by normal males [isolated as l(1)08/20]. Ordinarily dies just prior to eclo- sion, but in dry cultures, both males and females eclose and have good viability, but are almost completely sterile. Wings are held up, some bristles on head and thorax (especially scu- tellars) are absent; abdomen mutant effects similar to those of bb. Females heterozygous for l(1)dd4S and a deficiency are almost completely lethal. cytology: Placed in 12A-C based on the failure of YPXDB166/XPYDB136 to complement the lethality of l(1)dd4S. Dp(1;Y)g+ covers lethal, sterile, and visible effects in males; Dp(1;f)LJ9 covers lethal effect, but only partially covers visible effects. # l(1)dd9 phenotype: Discs missing or degenerate; mitotic index of larval ganglion reduced; chromosomes unevenly condensed, appear fuzzy; sister chromatids often closely apposed; hetero- chromatic regions elongated; tetraploid cells and some chromo- some breakage seen (Gatti and Baker, 1989, Genes Dev. 3: 438-53). No maternal effect of homozygosis in ovarian clones on phenotype of offspring (Perrimon, Engstrom, and Mahowald, 1984, Dev. Biol. 105: 404-14). # l(1)dd10 phenotype: Discs missing or degenerate; mitotic index of larval ganglion cells three times that of controls; mitotic chromo- somes more highly condensed than normal; 30% of metaphases polyploid; chromosome fragmentation common; no anaphase fig- ures seen (Gatti and Baker, 1989, Genes Dev. 3: 438-53). Homozygous cells in ovary lethal (Perrimon, Engstrom, and Mahowald, 1984, Dev. Biol. 105: 404-14). # l(1)dd11 phenotype: Discs missing or degenerate; mitotic index of larval ganglion cells and chromosome condensation normal; 43.5% of metaphases polyploid; cells containing 500 to 1000 chromosomes encountered; some chromosome fragmentation seen (Gatti and Baker, 1989, Genes Dev. 3: 438-53). Homozygous cells in ovary lethal (Perrimon, Engstrom, and Mahowald, 1984, Dev. Biol. 105: 404-14). # l(1)dd12 phenotype: Discs missing or degenerate; mitotic index of larval ganglion cells reduced; chromosomes swollen and unevenly con- densed; few metaphases polyploid; no chromosome fragmentation seen (Gatti and Baker, 1989, Genes Dev. 3: 438-53). Homozy- gous cells in ovary lethal (Perrimon, Engstrom, and Mahowald, 1984, Dev. Biol. 105: 404-14). # l(1)dh1: lethal (1) discs heterogeneous location: 1-27.5. origin: Induced by ethyl methanesulfonate. synonym: l(1)d.het.-1. references: Kiss, Bencze, Fekete, Fodor, Gausz, Mar'y, Szabad, and Szidonya, 1976, Theor. Appl. Genet. 48: 217-26. phenotype: Pupal lethal; imaginal leg discs small, remaining imaginal discs normal in size and structure. # l(1)dh2 location: 1-57. origin: Induced by ethyl methanesulfonate. synonym: l(1)d.het.-2. references: Kiss, Bencze, Fekete, Fodor, Gausz, Mar'y, Szabad, and Szidonya, 1976, Theor. Appl. Genet. 48: 217-26. phenotype: Pupal lethal; leg discs degenerated; remaining ima- ginal discs of normal size and structure. Chromosomes in lar- val ganglion cells irregularly condensed, often displaying coiled and banded appearance; in addition, chromatid breaks and extremely hyperploid or tetraploid cells are frequently observed (Gatti, Pimpinelli, Bove, Baker, Smith, Carpenter, and Ripoll, Proc. Int. Cong. Genet. 15th, 1983, Vol. 3, pp. 193-204; Gatti and Baker, 1989, Genes Dev. 3: 438-53). # l(1)dn: lethal (1) discs normal A group of late larval and early pupal lethals in which the imaginal discs appear normal at the time that pupation nor- mally occurs. The ability of the discs of these mutants to differentiate in a normal hormonal mileau has been examined in both gynandromorphs and when transplanted into larvae that are then allowed to undergo metamorphosis. PHENOTYPE | genetic _______________ Mutant location synonym ref ( A B C _________________________________________________________________ l(1)dn1 1-0.1 npr1 1 _ .05 L l(1)d.norm.-1 l(1)dn2 1-1.4-11.9 l(1)d.norm.-2 1 _ 0 L l(1)dn3 1-4.1-10.6 l(1)d.norm.-3 1 - 0 L/P l(1)dn4 1-14.5 l(1)d.norm.-4 1 + .23 P l(1)dn5 l(1)d.norm.-5 1 + .11 L/P l(1)dn6 1-56 l(1)d.norm.-6 1 - 0 P l(1)dn7 1-57 l(1)d.norm.-7 1 - .60 P l(1)dn8 1-60 l(1)d.norm.-8 1 - .12 P l(1)dn11 1-26 l(1)d.norm.-11 2 _ 0 L l(1)dn12 / 1-0.2 npr1 2 + 0 L l(1)d.norm.-12 l(1)dn13 1-18.5 l(1)d.norm.-13 2 + 0 L/P l(1)dn14 l(1)d.norm.-14 2 + .08 P l(1)dn15 / 1-9.5 l(1)d.norm.-15 2 + P l(1)dn16 l(1)d.norm.-16 2 + P l(1)dn17 l(1)d.norm.-17 2 + P l(1)dn18 l(1)d.norm.-18 2 + P l(1)dn19 1-0.8 l(1)d.norm.-19 2 + P l(1)dn20 l(1)d.norm.-20 2 + P l(1)dn21 1-35.8 l(1)d.norm.-21 2 + P l(1)dn22 l(1)d.norm.-22 2 P l(1)dn23 l(1)d.norm.-23 2 + P l(1)dn24 1-0.3 l(1)d.norm.-24 2 + P l(1)dn25 / 1-22 l(1)d.norm.-25 2 + P l(1)dn26 1-56-58 l(1)d.norm.-26 2 + P l(1)dn27 1-41.9 l(1)d.norm.-27 2 + P l(1)dn28 1-61.9 l(1)d.norm.-28 2 _ .10 P ( 1 = Stewart, Murphy, and Fristrom, 1972, Dev. Biol. 27: 71-83; 2 = Kiss, Bencze, Fekete, Fodor, Gausz, Maroy, Szabad, and Szidonya, 1976, Theor. Appl. Genet. 48: 217- 226. | A = differentiation in transplants; B = survival of gynan- dromorphs; C = lethal phase (L = larval, P = pupal). / Cell division normal (Gatti and Baker, 1989, Genes Dev. 3: 438-53). # l(1)ds: lethal (1) discs small A group of late larval and early pupal lethals in which the imaginal discs appear normal in morphology, but smaller than their wild-type counterparts at approximately the same stage of development. The ability of the discs of these mutants to differentiate in a normal hormonal mileau has been examined both in gynandromorphs and when transplanted into larvae that are then allowed to undergo metamorphosis. PHENOTYPE | genetic _____________ Mutant location synonym ref ( A B C ______________________________________________________________ l(1)ds1 1-0.7 l(1)d.sml.-1 3 + 0.31 P l(1)ds21 1-32.2 l(1)d.sml.-2a 3 - 0.06 P l(1)ds22 1-22.8-32.5 l(1)d.sml.-2b 3 + 0.22 P l(1)ds3 1-42 l(1)d.sml.-3 3 + 1.30 P l(1)ds4 1-54 l(1)d.sml.-4 3 - 0 P l(1)ds5 1-63 l(1)d.sml.-5 3 - 0.14 P l(1)ds8 / 1-19.5 l(1)d.sml.-8 1 0 L l(1)ds9 / 1-56.9-57.1 l(1)d.sml.-9 1 _ L l(1)ds10 1-18.5 l(1)1-74 2 0 P l(1)ds11 1-26.3 l(1)1-43 2 0 P l(1)ds12 1-58.7 l(1)1-45 2 0 P l(1)ds13 1-66.4 l(1)1-48 2 0 P ( 1 = Kiss, Bencze, Fekete, Fodor, Gausz, Maroy, Szabad, and Szidonya, 1976, Theor. Appl. Genet. 48: 217-226; 2 = Kiss and Szabad, 1980, DIS 55: 75-76; 3 = Stewart, Murphy, and Fristrom, 1972, Dev. Biol. 27: 71-83. | A = differentiation in transplants; B = survival of gynan- dromorphs; C = lethal phase (L = larval, P = pupal). / Cell division normal (Gatti and Baker, 1989, Genes Dev. 3: 438-53). # l(1)ds10 phenotype: Discs small, folding rudimentary; ring gland normal size. # l(1)ds11 phenotype: Discs very small, no folding; ring gland small; pupariation accelerated by implantation of wild-type ring glands. # l(1)ds12 phenotype: Discs very small, no folding; ring gland small. # l(1)ds13 phenotype: Discs small, folding rudimentary; ring gland small. # l(1)E7ts location: 1-15.2 (1.5 units to the right of cv). origin: Induced by ethyl methanesulfonate. references: Suzuki, Piternick, Hayashi, Tarasoff, Baillie, and Erasmus, 1967, Proc. Nat. Acad. Sci. USA 57: 907-12. Tarasoff and Suzuki, 1970, Dev. Biol. 23: 492-509. phenotype: Males, but not homozygous females, able to develop at 29; females die as embryos or young larvae; males die as late pupae or young imagos. TSP of males lasts from midpupal into early adulthood. Females sensitive during first 40 hr as well as from 60-75 hr and again during pupation. Mutant females homozygous for tra respond to high temperature as do tra+ females. # l(1)E12: see l(1)5CDa # l(1)E25ts location: 1-15.5 (1.8 units to the right of cv). origin: Induced by ethyl methanesulfonate. references: Suzuki, Piternick, Hayashi, Tarasoff, Baillie, and Erasmus, 1967, Proc. Nat. Acad. Sci. USA 57: 907-12. Tarasoff and Suzuki, 1970, Dev. Biol. 23: 492-509. phenotype: Hatchability of eggs deposited by l(2)E25ts females inversely related to length of maternal exposure to 29; no hatch after 12-15 hr at 29. Heat effect reversible by cooling for the first few hours after ovoposition. Exposure of pater- nal male to restrictive temperatures without effect. Newly fertilized eggs placed at 29 produce larvae that arrest in second instar; later shift up causes later arrest. Lethal polyphasic. # l(1)E34ts location: 1-20.7 (7.0 units to the right of cv). origin: Induced by ethyl methanesulfonate. references: Suzuki, Piternick, Hayashi, Tarasoff, Baillie, and Erasmus, 1967, Proc. Nat. Acad. Sci. USA 57: 907-12. Tarasoff and Suzuki, 1970, Dev. Biol. 23: 492-509. phenotype: Late pupal lethal; flies raised at 29 form eye and bristle pigments and wings but fail to eclose. Rates of development heterogeneous. TSP begins at time of initiation of pupation. # l(1)EN: lethal (1) from Eugene Nonautonomous origin: X ray induced. references: Novitski, 1963, DIS 37: 53. phenotype: A series of sex-linked recessive lethals selected by virtue of the survival of hemizygous lethal-bearing cells in gynandromorphs. Free amino acid concentrations in lethal- bearing immature stages estimated by means of paper chromatog- raphy; differences from wild type reported (see also CP627). genetic lethal amino acid locus location phase phenotype ( comments ________________________________________________________________________________ l(1)EN1 1-46 L1-P ALA,tyr salivary glands and gastric ceca small; fat body missing in L3 l(1)EN2 1-0.3 L3-P GLN,glu,asp l(1)EN3 near car P GLN = l(1)19Fd; red-black pigmented areas on larval cuticle l(1)EN4 1-52 P-A GLN l(1)EN5 1-47 L1-L2 GLN l(1)EN6 1-63 E-P GLN larval fat bodies and Malpighian tubules reduced l(1)EN7 rearranged P GLN,tyr fat bodies beaded l(1)EN8 left of cv L2-L3 GLN,tyr fat bodies, Malpighian tubules, and salivary glands reduced; rare survivors have soft exoskeleton l(1)EN9 1-10 L3 GLN,tyr fat bodies, Malpighian tubules, and salivary glands reduced; larvae translucent; fluorescence accumulates in larval cuticle l(1)EN10 1-59 P-A GLN,tyr,pro = l(1)carot12 l(1)EN10a 1-50 P GLY l(1)EN11 1-43 L2-P PHE,tyr melanotic spots on some larvae and in pupae; odor of dying larvae urinous l(1)EN12 1-3 L3-P tyr surviving adults have soft exoskeleton with little pigmentation; almost translucent l(1)EN13 1-13.4 tyr l(1)EN14 rearranged L2-L3 tyr,pro fluorescence accumulates in larval cuticle. l(1)EN15 near car L3-P tyr,pro l(1)EN16 1-24 L1-P tyr,pro ( Upper-case symbols represent amino acids found in higher- than-normal concentrations; lower-case symbols represent amino acids found in lower-than-normal concentrations. # l(1)ERts: lethal (1) endoplasmic reticulum location: 1-18. origin: Induced by ethyl methanesulfonate. references: Fullilove and Woodruff, 1974, Dev. Biol. 38: 291- 307 (fig.). phenotype: Embryonic development arrested prior to gastrulation at 29; hatching delayed approximately two hr at 25 but development normal. Embryos produced by l(1)ERts females held at 29 arrested prior to gastrulation; this TSP lasts until 8 hr after fertilization. Hatching of eggs produced by such females delayed 2 hr at 21 compared with eggs from wild-type females. Second TSP occurs during the first three days of larval life; larvae developing at 29 arrest as fully-developed pupae which fail to eclose. Electron-microscope observations made on arrested embryos; show abnormal distributions of nuclei, cytoplasm, and yolk; rough endoplasmic reticulum abnormal. # l(1)ESHS: lethal (1) of Eeken, Sobels Hyland, and Schalet origin: MR induced. Recovered among the progeny of males whose fathers carried MR-h12 and who inherited from their mothers In(1)dl49, y w f (experiment 1/), y mei-9a mei-41D5 (experi- ments 2/ and D), or Berlin-K wild type (experiments 20/, 24/, 28/, and 32/) X chromosomes. P-element sequence inserts detected by in situ hybridization to polytene X chromosomes in those mutants whose acquisition numbers are followed by an asterisk, but not in those followed by double asterisks. references: Eeken, Sobels, Hyland, and Schalet, 1985, Mutat. Res. 150: 261-75. cytology: Lethals in regions covered by X duplications; sub- jected to more or less complete deficiency mapping, but com- plementation mapping with respect to previously mapped lethal mutations not generally done. Those few shown not to comple- ment known lethal mutations are listed with the appropriate loci; the remainder are arranged below in relation to the duplications and deficiencies against which they were tested and in their order along the chromosome. Allelism tests among l(1)ESHS mutants mapping to the same cytological interval not invariably performed; such allelism as discerned indicated by more than a single isolation designation for a locus. As allelism of l(1)ESHS mutants to known loci is determined, they will be removed from this list and appended to the allelic lists of said loci. Polytene analysis revealed no case of gross chromosome rearrangement. side breakpoint variant original designation ______________________________________________________________ right 1B9-10 Df(1)y74k24.1 1B9-E2 l(1)ESHS1 D2 1B9-E2 l(1)ESHS2 D1*, D52* left 1E1-2 Df(2)sta left 2A2 Df(1)HA18 2A2-4 l(1)ESHS3 2/6B2, 32/35B2*, D3* 2A2-4 l(1)ESHS4 D42 right 2A4 Df(1)HA18 right 2B3-4 Df(1)sta 2B3-12 l(1)ESHS5 32/10B* right 2B12 Df(1)A94 right 2B17 y2Y67g19.1 2B17-C2 l(1)ESHS6 2/1A1 2B17-C2 l(1)ESHS7 2/1D 2B17-C2 l(1)ESHS8 2/3B1 2B17-C2 l(1)ESHS9 28/80A 2B17-C2 l(1)ESHS10 32/18B4 2B17-C2 l(1)ESHS11 D17 left 2C2 Dp(1;3)wvco 2C2-D1 l(1)ESHS12 28/26A1 left 2D1 w+Y 2D1-2 l(1)ESHS13 1/2A4 2D1-3 l(1)ESHS14 2/16B1, 2/16B2 left 2D3 Df(1)Pgd-kz 2D3-F1 l(1)ESHS15 24/17B left 2E2-F1 Df(1)TEM304 right 3A3 Df(1)TEM304 2F5-3C5 l(1)ESHS16 1/12A 2F5-3C5 l(1)ESHS17 D14** right 3A1 Dp(1;f)R right 3C5 Dp(1;3)wvco 3C5-D4 l(1)ESHS18 1/8D 3C5-D4 l(1)ESHS19 D22 right 3D3-4 w+Y right 3E2-3 Df(1)N8 3E2-8 l(1)ESHS20 1/8B1 3E2-8 l(1)ESHS21 1/8B2 3E2-8 l(1)ESHS22 D12 3E2-8 l(1)ESHS23 D81** right 3E8 Dp(1;2)w+-ec+ left 6C Dp(1;3)sn13a 6C-7A3 *l(1)ESHS24 1/3B 6C-7A3 *l(1)ESHS25 2/3B2 6C-7A3 *l(1)ESHS26 D20 6C-7A3 l(1)ESHS27 D7, D8 6C-7A3 l(1)ESHS28 1/9C 6C-7A3 l(1)ESHS29 D77 6C-7A3 l(1)ESHS30 32/2B left 7A2-3 Df(1)ct-J4 7A2-8 l(1)ESHS31 D47 right 7A8 Dp(1;2)sn+72d left 7B2-4 Df(1)ct4b1 7B2-C1 l(1)ESHS32 24/52A1, 28/60A, 28/85A1 7B2-C1 l(1)ESHS33 28/99A1 right 7C1 Df(1)ct-J4 right 7C3 Df(1)ct4b1 7C3-D1 l(1)ESHS34 24/16B 7C3-D1 l(1)ESHS35 D6, D69 right 7C9-D1 Dp(1;3)sn13a left 7D1 Df(1)sn-c128 right 7D5-6 Df(1)sn-c128 7D5-10 l(1)ESHS36 D63 7D5-10 l(1)ESHS37 D67 left Df(1)D46 left 7D10 Df(1)RA2 left Df(1)D31 right Df(1)D46 7D10-8A5 l(1)ESHS38 D68 7D10-8A5 l(1)ESHS39 D75 right Df(1)D31 right 8A5 Dp(1;2)sn+72d left 9A2 Dp(1;2)v+75d 9A2-B2 l(1)ESHS40 28/7A4 left 9B1-2 Df(1)v-L15 left 9E1 Dp(1;2)v+63i 9E1-4 l(1)ESHS41 D45, D79 left 9E3-4 Dp(1;2)v+74c left 9F3 v+BS-Y 9F3-6 l(1)ESHS42 1/15B2 9F3-6 l(1)ESHS43 D70 left 9F5-6 Df(1)v-L4 left 10B3 Df(1)N71 10B3-C3 l(1)ESHS44 32/56A left 10C2-3 Df(1)m259-4 right 10E3-4 v+BS-Y 10E3-11A2 l(1)ESHS45 32/53B left 11A2 Df(1)HF368 11A2-7 l(1)ESHS46 24/39B, D25, D29 right 11A7 Dp(1;2)v+65b left 13F10 Dp(1;4)r+ 13F10-14B3 l(1)ESHS47 28/74A left 14B13 Dp(1;2)r+75c left 14B6 Df(1)r-D 14B13-15A4 l(1)ESHS48 D23 14B13-15A4 l(1)ESHS49 20/9A left 15A4 Dp(1;3)f+71b right 15A9 Dp(1;2)r+75c 15A9-16A2 l(1)ESHS50 24/47B1,2,3, 32/43B right 15A2 Df(1)r-D 15A9-16A2 l(1)ESHS51 32/16A right 16A2 Dp(1;4)r+ right 19E6-7 Df(1)16-3-35 19E6-8 l(1)ESHS52 D76, D83 right 19E7-8 Df(1)A118 left 19F1 Df(1)16-129 l(1)ESHS53 D44 right 19F6-20A1 Df(1)16-129 # l(1)fdg: see fdg #*l(1)ff: lethal (1) formalin food location: 1- (not located). origin: Induced by formaldehyde. discoverer: Auerbach. synonym: Lff11. references: Ede, 1956, Arch. Entwicklungsmech. Organ. 148: 416-36 (fig.). phenotype: Develops to late embryonic stage; at 22 hr (normal hatching time), shows vigorous muscular movements but is unable to break through vitelline membrane. Muscular activity persists several hours, but hatching does not occur; cell degeneration begins at about 25 hr. Differentiation abnormal in several ways: pharyngeal apparatus reduced and distorted; brain forms irregular mass; constriction forms behind head; segmentation distorted; body wall usually incomplete dorsally. RK2. # l(1)FM Several lethal mutations have been recorded in FM6 or FM7; they have not been further characterized. locus Bal synonym ref _________________________________________________________________ l(1)FMa FM6 l(1)69a (Liu and Lim, 1975, Genetics 79: 601- 11) l(1)FMb FM6 l(1)FMc FM7 l(1)TW-9 (Wieschaus, Nusslein-Volhard, and Jurgens, 1984, Roux's Arch. Dev. Biol. 193: 296-307) # l(1)HM: lethal (1) of Helen Mayo A series of cold-sensitive sex-linked recessive lethal muta- tions induced by ethyl methanesulfonate. Cold-sensitive lethals are defined as exhibiting >20% survival at 22 and none at 17, and cold-sensitive semilethals as exhibiting >30% sur- vival at 22 and <13% at 17 (Mayoh and Suzuki, 1973, Can. J. Genet. Cytol. 15: 237-54; Falke and Wright, 1975, Genetics 81: 655-82). mutant genetic female fertility ( locus location synonym 17 25 phenotype _____________________________________________________________________________ l(1)HM1 1-0.6 S S l(1)HM2 1-57 survival of females > males l(1)HM3 1-34 F sS l(1)HM4 1-55 F F l(1)HM5 1-63.8 l(1)carot14 S S l(1)HM6 1-63.8 l(1)carot14 S S l(1)HM7 1-0.4 F F l(1)HM8 1-23 F F wings upheld at 17 and 25 l(1)HM9 1-0 F F l(1)HM10 sS sS abdominal tumors; rarely blistered wings at 17 l(1)HM11 1-0 F F l(1)HM12 1-0 F F l(1)HM13 1-1.4 S S l(1)HM14 1-51 F F l(1)HM15 1-63.8 l(1)carot14 l(1)HM16 1-41.8 sno S F short fine bristles; abdominal etching l(1)HM17 F F l(1)HM18 1-61 F F l(1)HM19 eclosion of survivors delayed nine days l(1)HM20 1-57 S F short fine bristles; abdominal etching l(1)HM21 1-33 l(1)10Ac S F l(1)HM22 1-22 F F l(1)HM23 1-41.8 sno S F maternal effect lethal l(1)HM24 F F l(1)HM25 1-48 F F ( F = fertile; S = sterile; sS = semisterile, producing very few progeny. # l(1)J: lethal (1) of J'nos Szidonia Thirty-nine complementing heat-sensitive lethals which develop at 22 but not at 29. discoverer: Szidonia. references: Shellenbarger and Cross, 1979, Dev. Biol. 71: 308-22 (fig.). # l(1)J413 location: 1-between g and f. phenotype: Males raised at 22 become sterile and lack motile sperm after six days at 28. No postmeiotic cysts found in sterilized males. Basal third of testis contains debris; distal two-thirds accumulate primary spermatocytes. # l(1)J770 phenotype: Males raised at 22 survive but die when held at 28 following eclosion. # l(1)J1024 location: 1-19.3. phenotype: Males raised at 22 become sterile and lack motile sperm after six days at 28. Testicular contents disorganized in sterile males; dispersed but well-condensed sperm heads present. Thought to be blocked in spermatid elongation. # l(1)J1649 phenotype: Males raised at 22 survive but die when held at 28 following eclosion. # l(1)J1660 phenotype: Males raised at 22 fertile, but become sterile after eight days at 28; sterile males have motile sperm, which are not transmitted to females. # l(1)J1674 phenotype: Males raised at 22 fertile, but become sterile after eight days at 28; sterile males have motile sperm, which are not transmitted to females. # l(1)J1743 phenotype: Males raised at 22 survive but die when held at 28 following eclosion. # l(1)J1259: see Df(1)259 #*l(1)jl: lethal (1) jawless location: 1-14. origin: Ultraviolet induced. discoverer: McQuate, 1951. references: Oster, 1952, Heredity 6: 403-7. phenotype: Dies during first larval instar. Mouth parts poorly formed and sometimes absent. RK2. cytology: Salivary chromosomes normal (Valencia and McQuate, 1951, Genetics 36: 580). # l(1)L5: see RpII215 #*l(1)m: lethal (1) malignant location: 1- (not located). origin: Induced by mustard gas. synonym: l-mal. references: El Shatoury, 1955, Arch. Entwicklungsmech. Organ. 147: 496-522 (fig.). El Shatoury and Waddington, 1957, J. Embryol. Exp. Morphol. 5: 143-52 (fig.). phenotype: Cells originating from lymph glands in late third instar first spread to and cause destruction of imaginal buds and later may move along ventral nerve cord to attack poste- rior fat bodies and testes. The tumor cells eventually become melanotic after destruction of various healthy tissues. Death occurs in late larval or early pupal stages. RK2. # l(1)M A series of sex-linked recessive lethals induced by ethyl methanesulfonate by Bryant and Zornetzer (1973, Genetics 75: 623-37). They were characterized with respect to lethal stage and survival in gynandromorphs. Gynandromorphs __________________________________________ genetic lethal relative amount of phenotype of mutant location stage survival (%) male tissue (%) male tissue ___________________________________________________________________ l(1)M1 E 0 l(1)M3 L1 11 10 abnormal bristles l(1)M4 1-44 L1 28 42 + l(1)M5 L2 9 23 + l(1)M8 1-57 L1 9 15 cuticle incompletely tanned l(1)M9 1-37 L1 0 l(1)M11 1-56 EP 0 l(1)M16 1-57 L1 0 l(1)M19 E 0 l(1)M22 L2 0 l(1)M24 1-52 E-L1 22 16 + l(1)M25 1-46 LP 48 36 + l(1)M26 1-41 L1-3 31 11 + l(1)M36 1-41 L2 3 6 abnormal bristles l(1)M38 L3 82 44 + l(1)M39 1-39 L3 1 9 abnormal bristles l(1)M42 1-57 E 0 l(1)M46 1-12 EP 0 l(1)M47 1-11 EP 0 l(1)M52 1-44 LP 19 40 + l(1)M53 1-34 L1 24 21 + l(1)M54 1-15 L3-EP 0 l(1)M55 1-3 E 9 15 + l(1)M58 1-28 L1-2 12 24 abnormal bristles curled wings l(1)M60 L1 32 21 + l(1)M64 1-13 L2 41 42 + l(1)M66 1-35 E 0 l(1)M70 L3 24 26 abnormal bristles l(1)M75 L1 0 l(1)M77 13 14 + l(1)M82 1-27 EP 6 17 abnormal bristles l(1)M83 EP 0 l(1)M84 E 0 l(1)M96 0 # l(1)M41 location: 1-36.0. origin: Induced by methyl methanesulfonate. references: Lim, 1970, DIS 45: 73-74. other information: Putative spontaneous revertants reported by Lim. # l(1)Mb and l(1)Mc: lethal (1) Madrid A series of 89 ethyl-methanesulfonate-induced sex-linked recessive lethal mutations studied in genetic mosaics, both in gynandromorphs and epidermal clones (Ripoll, 1977, Genetics 86: 357-76). Epidermal phenotypes of subset in which male tissue had distinctive phenotype or in which gynandromorphs failed to survive described following table. genetic lethal relative viability epidermal mutant location stage of gynandromorphs clones _______________________________________________________________ l(1)Mb7 1-7 E 0.04 l(1)Mb8 1-60 E-L 0 lethal l(1)Mb15 1-30.1 L 0 l(1)Mb16 1-0.5 L 0 l(1)Mb22 1-39.7 L 0 l(1)Mb24 1-22.4 L 0 l(1)Mb26 1-26.8 E 0 lethal l(1)Mb28 1-15.5 P 0 l(1)Mb38 1-48.5 P 0.22 l(1)Mb46 1-56.4 L 0 lethal l(1)Mc1 P 1.63 l(1)Mc19 ( 1-44.4 E 0 lethal l(1)Mc23 1-43.5 L 0 l(1)Mc24 1-55.9 L 0 lethal l(1)Mc28 1-0 E-L 0 l(1)Mc32 1-32.4 E 0 l(1)Mc35 1-62 E-L 0 lethal l(1)Mc39 1-23.5 L 0.04 l(1)Mc51 1-27 P 0.18 l(1)Mc52 1->56 L 0 l(1)Mc56 1-25 L 0.19 ( Fails to complement g. # l(1)Mb7 phenotype: All bristles transparent, smaller than normal; glassy eyes; aristae almost branchless. # l(1)Mb16 phenotype: Bristles and trichomes normal. 30% of clones split into several spots of similar size, which together add up in area to the area of control spots. Split clones found only in spots induced more than 48 hr before puparium formation. # l(1)Mb24 phenotype: Bristles small and unpigmented; wing trichomes about half normal size. As a consequence of reduced cell size, the area occupied by a clone does not correspond to that expected for its number of cells. # l(1)Mb28 phenotype: Bristles of the wing margin small and unpigmented. Clones in the wing blade extremely elongated. Whereas control clones are 5-10 times longer than wide, with irregular bord- ers, clones of cells monozygous for the lethal are 30-50 times longer than wide, with smooth borders. This phenotype found only in clones induced more than 48 hr before puparium forma- tion. # l(1)Mb38 phenotype: External genitalia do not evaginate when male or mosaic; normal structures remain within the abdomen. Other structures, when male, evaginate normally. # l(1)Mc1 phenotype: Rounded wings, about one-third shorter than normal. Rough and bulgy eyes. # l(1)Mc28 phenotype: Bristles smaller than normal. Wing trichomes small; occasionally clones of cells without epidermal processes appear. Behaves as expected for a mutation decreasing mitotic rate. # l(1)Mc39 phenotype: Very thin bristles, shorter than normal; abdomen almost completely devoid of bristles. # l(1)Mc51 phenotype: Several (2-6) trichomes per cell in wing disc derivatives. Only 75% of the individual cells show this phenotype. # l(1)Mc56 phenotype: Wings coiled dorsally. # l(1)ml: lethal (1) melanomalike location: 1-10. origin: Ultraviolet induced. discoverer: McQuate, 1951. references: Oster, 1952, Heredity 6: 403-7. Oster and Sobels, 1956, Am. Nat. 90: 55-60. phenotype: Larvae die in third instar. At death, they have internal melanotic masses (usually one or two, sometimes as many as ten). RK2. cytology: Salivary chromosomes normal (Valencia and McQuate, 1951, Genetics 36: 580). #*l(1)mt: lethal (1) midget location: 1-2.5. origin: Ultraviolet induced. discoverer: McQuate, 1951. references: Oster, 1952, Heredity 6: 403-7. phenotype: Dies as undersized third-instar larva. RK2. cytology: Salivary chromosomes normal (Valencia and McQuate, 1951, Genetics 36: 580). # l(1)nc: lethal (1) nutritionally conditional Three mutants that are lethal on Burnett and Sang's defined casein medium (1963, J. Insect. Physiol. 9: 553-62) but can be rescued by addition of yeast extract to the medium. origin: Induced by ethyl methanesulfonate. references: Vyse and Nash, 1969, Genet. Res. 13: 281-87. Vyse and Sang, 1971, Genet. Res. 18: 117-21. genetic partial rescue locus location synonym by RNA __________________________________________________ l(1)nc1 1-21.7 l(1)1308 + l(1)nc2 ( l(1)1625 + *l(1)nc3 | 1-52.9 l(1)11523 - ( Associated with In(1)1625 = In(1)3F;20C. | Female sterile---probably a rudimentary allele. #*l(1)nd: lethal (1) no differentiation location: 1- (not located). origin: Induced by mustard gas. references: El Shatoury, 1955, Arch. Entwicklungsmech. Organ. 147: 523-38 (fig.). phenotype: Some or all imaginal buds fail to differentiate dur- ing larval third instar, apparently as a result of abnormal proliferation of imaginal disk mesoderm. Death in pupal or prepupal stage. RK2. #*l(1)ne: lethal (1) nonevaginated location: 1-0.1. origin: Induced by urethane. discoverer: Vogt, 1949. references: 1951, DIS 25: 76. Florschutz-de Waard and Faber, 1952, DIS 26: 99. Faber, Sobels, Florschutz-de Waard, and Oppenoorth, 1954, Z. Indukt. Abstamm. Vererbungsl. 86: 293-321 (fig.). phenotype: Lacks imaginal thoracic hypoderm. Cephalic complex and thoracic imaginal disks fail to evaginate. The unaffected abdominal hypoderm develops but ends anteriorly in a free edge that folds back on itself and forms a darkly-pigmented ring around the pupa. Genital disk capable of normal evagination but vasa deferentia do not connect to testes, which do not spiralize. Death occurs 3-5.5 days after prepuparium forma- tion. Pupae darker than normal with sticky, irregular surface and distinctly meandering tracheal trunks. RK2. #*l(1)nib: lethal (1) no imaginal buds location: 1- (not located). references: El Shatoury and Waddington, 1957, J. Embryol. Exp. Morphol. 5: 143-52 (fig.). phenotype: Dies in third larval instar. Imaginal buds small or absent. Excessive proliferation of stomach epithelium leads to occlusion of gut. Proliferations degenerate into melanotic masses. RK2. # l(1)P1: lethal (1) of Parkash location: 1-52. origin: Recovered from thymidine-fed flies. references: Parkash, 1969, DIS 44: 51. phenotype: l(1)P1 males completely lethal when reared at 16 and viable when reared at 26; lethal period at larval-pupal tran- sition. Homozygous females survive either temperature. # l(1)P2 location: 1-42.3. origin: Recovered from thymidine-fed flies. references: Parkash, 1971, DIS 46: 67. phenotype: Mutant males survive rearing at 16 but not 26. # l(1)P3 origin: Recovered from thymidine-fed flies. references: Parkash, 1971, DIS 46: 67. phenotype: Mutant males die when reared at 16 but survive rear- ing at 26 and are sterile. #*l(1)rr: lethal (1) ring gland rudimentary location: 1-0.3. origin: Ultraviolet induced. discoverer: McQuate, 1951. references: Oster, 1952, Heredity 6: 403-7. phenotype: Dies during third larval instar. Larvae live 15- 30 days but do not become giant. Ring gland abnormally small, probably causing failure to undergo third molt. RK2. cytology: Salivary chromosomes normal (Valencia and McQuate, 1951, Genetics 36: 580). #*l(1)S9 location: 1- (to the right of car). origin: Spontaneous. discoverer: Auerbach. references: Ede, 1956, Arch. Entwicklungsmech. Organ. 149: 256-66 (fig.). phenotype: Almost all embryos deformed at anterior end, where there is usually some undigested yolk. Death occurs in embryonic, larval, and pupal stages. Primary abnormality is distribution of cleavage nuclei, which causes blastoderm to be fragile at its anterior end. RK2. # l(1)sc: see ASC #*l(1)sd: lethal (1) scheiben defekt location: 1-17.9. origin: Induced by triethylenemelamine (CB. 1246). discoverer: M. J. Fahmy. references: Schnitter, 1961, Rev. Suisse Zool. 68: 345-418 (fig.). phenotype: Dies during transition from larva to prepupa. Some larvae form puparia but do not differentiate further. Pattern of damage complex; most severe defects found in certain imagi- nal disks. Several larval organs abnormal, especially the salivary glands. RK2. #*l(1)te: lethal (1) tracheae enlarged. location: 1-0.3. origin: Ultraviolet induced. discoverer: McQuate, 1951. references: Oster, 1952, Heredity 6: 403-7. phenotype: Dies during third larval instar. Main tracheal tubes greatly enlarged, sometimes lack functional posterior spiracles. RK2. cytology: Salivary chromosomes normal (Valencia and McQuate, 1951, Genetics 36: 580). #*l(1)tl: lethal (1) tracheae lacking location: 1-59. origin: Ultraviolet induced. discoverer: McQuate, 1951. references: Oster, 1952, Heredity 6: 403-7. phenotype: Dies during first larval instar. Main tracheal tubes absent, although small side branches present. RK2. cytology: Salivary chromosomes normal (Valencia and McQuate, 1951, Genetics 36: 580). #*l(1)tr: lethal (1) tracheae ramified location: 1-56. origin: Ultraviolet induced. discoverer: McQuate, 1951. references: Oster, 1952, Heredity 6: 403-7. phenotype: Dies during first larval instar. Main tracheal tubes thick and have numerous side branches. RK2. cytology: Salivary chromosomes normal (Valencia and McQuate, 1951, Genetics 36: 580). #*l(1)trs: lethal (1) tracheae stretched location: 1-8.0. origin: Ultraviolet induced. discoverer: McQuate, 1951. synonym: l(1)ts (preoccupied). references: Oster, 1952, Heredity 6: 403-7. phenotype: Dies during first larval instar. Larvae very large for this stage and all tracheal tubes very thin, suggesting that they grow more slowly than larvae and thus become stretched. RK2. cytology: Salivary gland chromosomes normal (Valencia and McQuate, 1951, Genetics 36: 580). #*l(1)ts: lethal (1) temperature sensitive location: 1-8. discoverer: Falbo and R'. references: 1945, DIS 19: 45, 57. phenotype: Inviable in cultures grown at 23 but shows more than 50% survival in cultures grown at 26.5. RK3. # l(1)ts1 location: 1-1.9. origin: Induced with ethyl methanesulfonate. references: Fausto-Sterling, Wiener, and Digan, 1979, J. Exp. Zool. 200: 199-210. phenotype: Maternal-effect lethal. Homozygous females raised or aged at 28 produce embryos that fail to develop (incomplete dorsal closure, abnormal midgut formation) regardless of zygotic genotype. Females raised at 18 produce viable embryos. Viable embryos placed at 28 die as late pupae and are insensitive to maternal genotype. TSP for maternal effect after stage 7 of oogenesis; pupal TSP lasts 2.5 days. # l(1)ts Lethals recovered as temperature-sensitive alleles by work- ers in several different laboratories. Some are mapped, and most have been scored for survival in patches of homozygous cuticular tissue. In general complementation tests among these lethals or between these lethals and other X-linked lethal mutations were not carried out. These names are tran- sitional and likely to be changed if any of the mutants is further characterized. genetic epidermal locus location origin synonym ref ( clones | __________________________________________________________________ l(1)ts13 / EMS 3 l(1)ts19 / EMS 3 l(1)ts66 ` rt. of f EMS 5, 6 *l(1)ts79 7 l(1)ts88 / EMS 3 l(1)ts108 / EMS 3 l(1)ts120 - 1-51.5 EMS 4 t.s. *l(1)ts136 EMS 7 l(1)ts155 cv-ct EMS l(1)5CD 5, 6 l(1)ts178 EMS 4 non t.s. l(1)ts340 1-28.3 EMS 7 l(1)ts398 1-38.9 EMS agn 5, 6 l(1)ts403 1-32.6 EMS sbr 1 t.s. l(1)ts445a 1-25.0 EMS 7 l(1)ts445b EMS 4 non t.s. l(1)ts480 1-54 EMS 1 t.s. l(1)ts504 ` 1-6.0 EMS 7 t.s. l(1)ts538 1-0.38 EMS 4 t.s. l(1)ts612 1-17.0 EMS 7 l(1)ts613 1-62.8 EMS 4 t.s. l(1)ts622 1-38.9 EMS agn 5, 6 l(1)ts639 EMS 4 non t.s. l(1)ts726 n 1-66.0 EMS su(f) 4 t.s. l(1)ts875 EMS 4 non t.s. l(1)ts958 1-7.25 EMS 7 l(1)ts967 - EMS 7 l(1)ts980 1-38.9 EMS agn 5, 6 l(1)ts982 1-26.0 EMS 7 l(1)ts996 EMS 1 non t.s. l(1)ts1006 / EMS 1, 3 t.s. l(1)ts10061251 EMS 1, 3 l(1)ts10061704 EMS 1, 3 l(1)ts10061843 EMS 1, 3 l(1)ts1064 EMS 4 non t.s. l(1)ts1075 EMS 4 non t.s. l(1)ts1081 EMS 4 t.s. l(1)ts1082 1-61.0 EMS 4 t.s. l(1)ts1107 EMS 4 t.s. l(1)ts1126 `- 1-16.6 EMS 7, 8 l(1)ts1137 EMS 4 non t.s. l(1)ts1233 EMS 4 t.s. l(1)ts1251 `- 1-43 EMS 1, 2 t.s. l(1)ts1299 EMS 4 non t.s. l(1)ts1343 EMS 4 non t.s. l(1)ts1415 EMS 4 t.s. l(1)ts1480 EMS 4 non t.s. l(1)ts1681 EMS 4 t.s. l(1)ts1704 1-46 EMS 1 non t.s. l(1)ts1808 EMS 4 t.s. l(1)ts1843 1-46 EMS 1 non t.s. l(1)ts1891 ` 1-52.9 EMS 4 t.s. l(1)ts1901 EMS 4 non t.s. l(1)ts2009 EMS 4 t.s. l(1)ts2320 / EMS 3 l(1)ts2641 / EMS 3 l(1)ts2864 / 1-35 EMS 1, 3 t.s. l(1)ts3733 1-38 EMS 1 t.s. l(1)ts3803 / 1-53 EMS 1, 3 t.s. l(1)ts3803UC259 EMS 1, 3 t.s. l(1)ts4931B / EMS 3 l(1)ts4975 1-49 EMS 1 t.s. l(1)ts5141 1-34 EMS 1 t.s. l(1)ts5569 / EMS 3 l(1)ts5697 / 1-55 EMS 1, 3 t.s. l(1)ts56972366 EMS 1, 3 t.s. l(1)ts56972588 EMS 1, 3 t.s. l(1)ts6225 1-20 EMS 1 non t.s. l(1)tsG1 i ICR170 9 l(1)tsG2 i ICR170 9 l(1)tsSD19 EMS 1 t.s. l(1)tsW1 ICR170 9 l(1)tsW2 ICR170 9 l(1)tsW3 ICR170 9 l(1)tsW4 ICR170 9 l(1)tsW5 ICR170 9 l(1)tsUC13 1-29 EMS 1 t.s. l(1)tsUC19 1-55 EMS 1 t.s. l(1)tsUC32 1-45 EMS 1 t.s. l(1)tsUC34 1-18 EMS 1 t.s. l(1)tsUC88 1-45 EMS 1 t.s. ( 1 = Arking, 1975, Genetics 80: 519-37; 2 = Arking, 1978, Genetics 88: s4-5; 3 = King and Mohler, 1975, Handbook of Genetics (R.C. King, ed.). Plenum Press, New York and Lon- don, Vol. 3, pp. 757-91; 4 = Russell, 1974, Dev. Biol. 40: 24-39; 5 = Savvateeva and Kamyshev, 1981, Pharmacol. Biochem. Behav. 14: 603-11; 6 = Savvateeva, Peresleny, Ivanushina, and Korochkin, 1985, Dev. Genet. 5: 157-72; 7 = Simpson and Schneiderman, 1975, Wilhelm Roux's Arch. Dev. Biol. 178: 247-75; 8 = Simpson and Schneiderman, 1976, Wilhelm Roux's Arch. Dev. Biol. 179: 215-36; 9 = Woodruff and Gander, 1974, Mut. Res. 25: 337-45. | t.s. indicates that the incidence of X-ray-induced sn clones in y/l(1)ts sn females compared to the recovery of y clones (Arking) or of y clones in y/l(1)ts/sn females compared to the recovery of sn clones (Russell) is significantly lower in flies raised at 29 than in those raised at 22; non t.s. indicates no significant difference. / Survivors at permissive temperature are female sterile. ` Phenotypes described more fully below. - l(1)ts120 and l(1)1891 not allelic. l(1)ts613 and l(1)1082 not allelic. n See su(f). - Survivors male sterile. i Cold sensitive. # l(1)ts66 phenotype: Selected as a temperature-sensitive lethal in the presence of theophylline; hypersensitive to theophylline at 29, but not at 25. Mutant males contain lower levels of cyclic nucleotide phosphodiesterase than wild type and normal levels of adenyl cyclase. Exhibit increased motor activity at 29; movements uncoordinated; flight and both phototaxis and geotaxis impaired. Unable to learn (Savvateeva and Kamyshev, 1981, Pharmacol. Biochem. Behav. 14: 603-11; Savvateeva, Peresleny, Ivanushina, and Korochkin, 1985, Dev. Genet. 5: 157-72). # l(1)ts504 phenotype: Temperature-sensitive pupal lethal. Heat pulses of one-to-three days duration applied during larval stages delay pupariation and cause duplications and deficiencies of imagi- nal structures in surviving adults. Similarly, rarely surviv- ing gynandromorphs exhibit duplicated and missing structures; heterozygous females from the same cross that are malformed interpreted as cryptic gynandromorphs in which the male tissue has died. Epidermal clones of homozygous tissue very reduced in number and size in the head and thorax, but do not differ from controls in the abdomen (Simpson and Schneiderman, 1975, Wilhelm Roux's Arch. Dev. Biol. 178: 247-75). # l(1)ts1126 phenotype: Temperature-sensitive, cell-autonomous lethal mutant. Exposure of first- and second-instar larvae to 29 retards growth and delays pupariation, but adults eventually formed are normal. Exposure of third-instar larvae to 29 does not delay pupariation, but results in the production of smaller-than-normal flies. Late third-instar pulses cause delayed eclosion, and absence of the black pigment band as well as reduced bristle number and size in the tergites of survivors. Homozygous clones substantially reduced in size in the wing by heat pulses during early instars and in tergites by pulses at the end of the larval stage. In gynandromorphs that pupate at normal times l(1)ts1126/0 compartments are smaller than normal; in gynandromorphs exhibiting delayed development, compartment sizes are normal [Simpson and Morata, 1980, Developmental Neurobiology of Drosophila (Siddiqi, Babu, Hall, and Hall, eds.). Plenum Press, New York and London, pp. 129-39]. All effects explained by a reduced rate of cell division in mutant cells (Simpson and Schneiderman, 1976, Wilhelm Roux's Arch. Dev. Biol. 179: 215-36). # l(1)ts1251 phenotype: A temperature-sensitive cell lethal; also a temperature-sensitive male sterile mutation. Larvae subjected to 29 during the latter part of the third larval instar pro- duce pharate adults that display duplicated or missing struc- tures or both typically resulting from cell death. Some 5% also exhibit transformation of the humeral disc into a hetero- typic structure consisting proximally of foreleg tissue (coxa through first tarsal segments on basis of chaetotaxy) and distally of antennal tissue, i.e., arista (Arking, 1978, Genetics 88: s4-5). #*l(1)TS-45: lethal (1) no. 45 of T. Shiomi location: 1-5.8. origin: X ray induced. discoverer: Shiomi, 52f. references: 1954, DIS 28: 78. Imaizumi and Shiomi, 1955, Arch. Biol. (Li`ge) 66: 483-87. phenotype: Dies before hatching. No visible morphological abnormality. Heterozygote of l(1)TS-45/Basc has average of 612 eye facets compared to only 402 in +/Basc. Accumulation of urea or carbamides in larvae of heterozygote; these com- pounds presumably tend to normalize the Bar phenotype. RK2. #*l(1)TS-56 location: 1-1.5. origin: X ray induced. discoverer: Shiomi, 52f. references: 1954, DIS 28: 78. phenotype: Lethal in late embryonic stage. Development of tra- cheae, other chitinized parts, and body segments abnormal. RK2. # l(1)TW: lethal (1) of Ted Wright A series of six ethyl-methanesulfonate-induced mutants that have reduced survival when raised at 17 compared with that when raised at 25; the differences in survival at the two temperatures vary substantially among replicate crosses. genetic lethal locus location synonym stage comments ______________________________________________________________________________ l(1)TW1 1-26.3 L female sterile at 16, few eggs l(1)TW2 1-41.8 sno l(1)TW3 1-2.5 P females fertile; ether sensitive l(1)TW4 1-48.4 LP females fertile; metathoracic legs abnormal l(1)TW5 1-63.8 l(1)carot14 LP females sterile; abnormal abdomen, indented wings at 16 l(1)TW6 1-37.1 nod8 E females sterile at 16, meiotic nondisjunction allele origin discoverer ref ( _______________________________________ l(1)TW1cs EMS Wright 1, 2 l(1)TW3cs EMS Wright 1, 2 l(1)TW4cs EMS Wright 1, 2 l(1)TW6cs EMS Wright 1, 2 ( 1 = Falke and Wright, 1975, Genetics 81: 655-82; 2 = Wright, 1973, Mol. Gen. Genet. 122: 101-18. # l(1)v: lethal (1) variegated origin: X ray induced. references: Lindsley, Edington, and Von Halle, 1960, Genetics 45: 1649-70. phenotype: A series of sex-linked recessive lethals that die as XO males but survive as XY males and homozygous females. All are associated with chromosome rearrangements with one break- point in the X chromosome and one in pericentric heterochroma- tin, of either the X or an autosome; interpreted as position- effect variegation of vital loci. In some cases the viability of XY males is further reduced by the known enhancers of variegation, Df(2R)M41A10 and Evar7. The lethals associated with reciprocal translocations are male sterile, owing to a failure of sperm head elongation. viability XY male enhanced by lethal XY XO fertility Df(2R)M41A10 Evar7 cytology _____________________________________________________________________________ l(1)v3 .74 0 sterile yes no T(1;3)4A;81 l(1)v11 ( .78 .04 fertile yes no T(1;4)15;101 l(1)v25 1.0 0 sterile T(1;2)19-20;40-41 *l(1)v47 | .41 0 Tp(2;1)8F-9B l(1)v59 / .63 0 fertile In(1)3-4;20F l(1)v75 .26 <.01 sterile no yes T(1;2)19-20;41 l(1)v129 .91 .26 sterile T(1;2)18B;41 l(1)v132 .83 <.01 fertile In(1)3-4;20F l(1)v135 .40 <.01 T(1;2)18-19;41 l(1)v139 ` 0 0 In(1LR)3C6-7 *l(1)v146 - .41 0 fertile yes yes In(1)5-6;20F l(1)v150 .15 0 sterile T(1;2)16-17;40 l(1)v163 .17 <.01 sterile T(1;3)17A-B;80-81 l(1)v216 .15 0 sterile yes no l(1)v219 1.0 0 sterile yes no T(1;2)10A;40 *l(1)v223 .41 0 sterile yes T(1;2)14F;41;50E l(1)v227 .48 0 fertile yes yes 1-2;20F l(1)v231 n 1.0 <.01 fertile In(1)1C-D;20F *l(1)v252 1.0 .02 sterile *l(1)v306 .78 0 fertile Tp(?1)1B-E l(1)v361 1.0 0 sterile T(1;3)19-20;80-81 l(1)v451 .63 .04 sterile + l(1)v453 1.0 0 sterile yes no T(1;3)12D;80-81 l(1)v454 .50 0 sterile yes yes T(1;2;3)12B;22-23;81 + T(2;4)44F;101F l(1)v455 - low 0 sterile yes yes T(1;3)3C;81 l(1)v459 i .78 0 fertile T(1;2;3)3D-F;XR;50;80-81 l(1)v463 .50 .18 sterile no yes T(1;3)19-20;81-82 ( Homozygous females have blistered wings and duplicated ante- rior scutellar and postalar bristles. | XY males have gg-like phenotype but with peripheral darken- ing of eye color. Associated with insertion of an unspeci- fied segment of heterochromatin into 8F-9B; linkage tests suggest chromosome-2 origin. / Homozygous females survive and have fewer and smaller bris- tles. ` XYY males viable and fertile; show strong variegation for w and rst. Recombinant carrying the left end of the XP4D ele- ment to T(1;4)wm5 and the right end of In(1LR)l-v139 is variegated for w but not for rst and is male viable. - Viability of XXY>XX; homozygous females frequently lacking dorsocentral bristles. Variegates for absence of external genitalia. n Surviving XO males have rough reduced eyes. - Variegates for w. i XY males have rough eyes and deformed wings and wing veins. #*l(1)w location: 1-66. discoverer: Schubel, 1934. references: 1934, Am. Nat. 68: 278-82. phenotype: Males survive; homozygous females die. RK3. other information: Probably a lethal allele of bb. #*l(1)X2: lethal (1) X ray induced location: 1- (near forked). origin: X ray induced. discoverer: Auerbach. references: Ede, 1956, Arch. Entwicklungsmech. Organ. 148: 437-51 (fig.). phenotype: Embryos die in advanced stage of development. They live beyond normal hatching time, move actively, but do not hatch. Embryo distorted; head material not involuted and pharyngeal material external; body wall has disarranged seg- mentation in medial region. Mutant disrupts mechanism con- trolling mitosis in early stages of gastrulation, occasionally as early as blastoderm formation. RK2. cytology: Salivary chromosomes normal. #*l(1)X10 location: 1-0.0 (near sc). origin: X ray induced. discoverer: Auerbach. references: Ede, 1956, Arch. Entwicklungsmech. Organ. 149: 247-58 (fig.). phenotype: Variation in expression of factors discontinuous. There are three types of lethal embryos; some may survive into larval stage. Type 1 stops development after formation of a cap of undifferentiated cells. Type 2 has limited differen- tiation, often the nervous tissue exclusively, but no organ formation. Type 3 survives beyond normal hatching time, has no gross abnormalities, but does not hatch. RK2. #*l(1)X20 location: 1- (near sc). origin: X ray induced. discoverer: Auerbach. references: Ede, 1956, Arch. Entwicklungsmech. Organ. 149: 101-14 (fig.). phenotype: Four types of defective embryos produced. Types 1 and 2 reach late stage of development and are alive at time larvae normally hatch. Type 1 has a complete nervous system but incomplete hypoderm. Type 2 has hypoderm but a deficient nervous system. Types 3 and 4 stop developing at early stages. Type 3 has no development beyond gastrulation, and type 4 forms no blastoderm. RK2. #*l(1)X27 location: 1-63.4. origin: X ray induced. discoverer: Auerbach. references: Ede, 1956, Arch. Entwicklungsmech. Organ. 149: 88-100 (fig.). phenotype: Embryos alive in a late stage of development at nor- mal hatching time but do not hatch. Degeneration begins at about 25 hr. Germ band irregular at beginning of gastrula- tion, apparently the result of defective ventral furrow forma- tion. Consequently, hindgut is open dorsally, nervous system irregularly developed, and ventral nerve cord interrupted in region of midgut. Other abnormalities from different causes are: (1) gut remains saclike, (2) ectoderm remains unseg- mented, and (3) musculature of body wall is underdeveloped. RK2. # l(1)Y A series of sex-linked recessive lethals induced by ethyl methanesulfonate by Bryant and Zornetzer (1973, Genetics 75: 623-37). They were characterized with respect to lethal stage and survival in gynandromorphs. Gynandromorphs _______________________________________________________ lethal relative amount of phenotype of mutant stage survival (%) male tissue (%) male tissue __________________________________________________________________________ l(1)Y8 L1 0 l(1)Y12 E 3 12 wings incompletely expanded l(1)Y80 E 20 21 + l(1)Y107 L1 2 15 abnormal bristles l(1)Y110 LP 6 17 degenerated ommatidia The following table refers to a number of series of sex- linked-lethal mutations induced or spontaneous, many of which were mapped genetically, and some of which were analysed cyto- logically. Virtually all have long since been discarded; they are cited here for completeness of the record (see also CP627). number genetic series of lethals mapping cytology origin ref ( _____________________________________________________________ l(1)291- 13 no yes spont 13 l(1)294- 4 yes yes X ray 13 l(1)296- 6 yes yes spont 13 l(1)302- 4 yes yes neutron 13 l(1)304- 4 yes yes X ray 13 l(1)DM 5 rough no X ray 7,8 l(1)GSB 51 yes no X ray 4 l(1)I 13 no no heat 10, 11 l(1)K 4 yes no 32P 5 l(1)LB 500 yes no various 1, 2 l(1)MA 50 few no spont 9 l(1)Q 64 yes no ICR170 3 l(1)R 71 yes no various 12 l(1)S 4 spont 6, 14 ( 1 = Belitz, 1954, Z. Indukt. Abstamm. Vererbungsl. 86: 173-84; 2 = Belitz, 1956, DIS 30: 104; 3 = Carlson, Sederoff, and Cogan, 1967, Genetics 55: 295-313; 4 = Gershenson, 1934, DIS 1: 54; 5 = King, 1950, DIS 24: 58; 6 = Morgan and Bridges, 1916, Carnegie Inst. Wash. Publ. No. 237: 64, 79; 7 = Moriwaki, Jpn.J. Zool., 5: 585-602; 8 = Moriwaki, 1940, DIS 13: 50; 9 = Muller and Altenburg, 1919, Proc. Soc. Exp. Biol. Med. 17: 10-14; 10 = Plough and Ives, 1934, DIS 1: 32; 11 = Plough and Ives, 1934, Genetics 20: 42-69; 12 = Rohrborn, 1959, Z. Vererbungsl. 90: 116-31; 13 = Slizynski, 1938, Genetics 23: 283-90; 14 = Stark, 1915, J. Exp. Zool. 19: 531-38. # l(2)21B Four lethally mutable loci, including GsI, which encodes glutamine synthetase I, based on twenty recessive lethal muta- tions recovered following various mutagenic treatments (Cag- gese, Caizzi, Bozzetti, Barsanti, and Ritossa, 1988, Biochem. Genet. 26: 571-84). genetic cytological locus location location included in excluded from synonym _______________________________________________________________ l(2)21Ba 2-{0} 21B2-5 Df(2L)PM1 Df(2L)PM44 l(2)21Bb 2-{0} 21B2-5 Df(2L)PM1 Df(2L)PM44 l(2)21Bc 2-0.1 21B3-6 Df(2L)PM45 Df(2L)PM1 GsI l(2)21Bd 2-{0} 21B4-6 Df(2L)TE75 Df(2L)PM45 allele origin synonym ______________________________ l(2)21Ba1 EMS l(2)M5 l(2)21Ba2 ENU l(2)R35 l(2)21Ba3 HD l(2)PM10 l(2)21Bb1 EMS l(2)M10 l(2)21Bb2 EMS l(2)M11 l(2)21Bb3 ENU l(2)R31 l(2)21Bb4 ENU l(2)R212 l(2)21Bb5 HD l(2)PM58 l(2)21Bb6 HD l(2)PM59 l(2)21Bb7 HD l(2)PM158 l(2)21Bd1 EMS l(2)M3 l(2)21Bd2 EMS l(2)M8 l(2)21Bd3 EMS l(2)M12 l(2)21Bd4 EMS l(2)C2