INVERSIONS # In(1)-Df(1)ct: see In(1)ct-df # In(1)2-4-1-1 cytology: In(1)13E9-14;14C7-8. references: Kulkarni, Steinlauf, and Hall, 1988, Genetics 118: 267-85. # In(1)3C165g cytology: In(1)12D;19A. references: Gersh, 1967, Genetics 56: 309-19. # In(1)9A3 cytology: In(1)8E;16F. origin: Induced with ethyleneimine. references: Lim and Snyder, 1968, Mutat. Res. 6: 129-37. In(1)24: see YSX.YL, In(1)24LA2R in section on X-Y COMBINATIONS In(1)26: see YSX.YL, In(1)26 in section on X-Y COMBINATIONS # In(1)62b12 cytology: In(1)3B1;12F2-3. references: Judd, Shen, and Kaufman, 1972, Genetics 71: 139- 56. Young and Judd, 1978, Genetics 88: 723-42. # In(1)65: Inversion (1) 65 cytology: In(1)2C4-8;10A1-2. origin: X ray induced simultaneously with, but separated from, T(1;3)65 in y. references: Lindsley, Edington, and Von Halle, 1960, Genetics 45: 1649-70. Voelker, Greenleaf, Gyurkovics, Wisely, Huang and Searles, 1984, Genetics 107: 279-84. genetics: Inseparable from y. About 1% nondisjunction and 21.8% recombination in In(1)65/+ female; 25.9% nondisjunction and 19.7% recombination in In(1)65/+/Y female (Grell, 1962, Genetics 47: 1737-54). # In(1)78b cytology: In(1)3A2-3;3C3-5. origin: X ray induced in faswb chromosome. discoverer: Keppy. references: Welshons and Welshons, 1985, Genetics 110: 465-77. genetics: Male viable. Suppresses the faswb position effect but shows no mutant phenotype as a hemizygote, homozygote, or heterozygote with Df(1)w67k30. Distal break near z; proximal break between w and N. # In(1)94-2A cytology: In(1)1F-2A;5E-6A (Lindsley). origin: Derived by recombination from C(1)94-2A. discoverer: Rosenfeld. references: CP627. genetics: Leads to partial stabilization of tandem ring com- pound X chromosome. Recoverable in derivative single ring, R(1)9-4. Exists in three interchangeable configurations in C(1)TR (e.g., Novitski and Braver, 1954, Genetics 39: 197- 209). # In(1)123 cytology: In(1)9E1;20F. discoverer: Nash. genetics: Deficient for ras. #*In(1)272-13 cytology: In(1)1A6-B1;11A7-8;11F2-12A1;18A4-B1. new order: 1A1 - 1A6|12A1 - 18A4|11A7 - 1B1|11A8 - 11F2|18B1 - 20. origin: X ray induced. discoverer: Demerec, 1940. synonym: In(1)l-272-13; Tp(1;1)l-272-13. references: Sutton, 1943, Genetics 28: 213. genetics: Mutant for sc but not ac or svr. Male lethal. #*In(1)303-1 cytology: In(1)2B13-15;7B1-3;9D1-3. new order: 1 - 2B13|9D1 - 7B3|2B15 - 7B1|9D3 - 20. origin: X ray induced. discoverer: Demerec. synonym: Tp(1;1)303-1. references: Hoover, 1938, Z. Indukt. Abstamm. Vererbungsl. 74: 420-34 (fig.). genetics: Nearly lethal. #*In(1)481 cytology: In(1)12E-F;14B. origin: X ray induced simultaneously with Df(1)bb481. references: Lindsley, Edington, and Von Halle, 1960, Genetics 45: 1649-70. # In(1)601 cytology: In(1)2B;16A1-2. origin: X ray induced. synonym: In(1)Br. references: Brosseau, 1967, DIS 42: 38. genetics: Associated with Br601. Homozygous viable and fertile with eyes 1/2 to 2/3 normal size and resembling L. # In(1)1625 cytology: In(1)3E2-3;20F; includes nucleolus organizer. references: Vyse and Nash, 1969, Genet. Res. 13: 281-87. Nash and Vyse, 1977, Can. J. Genet. Cytol. 19: 637-44; genetics: Homozygous viable but with "weak" bristles when grown on yeast-sucrose or casein with RNA. Lethal when grown on casein medium alone. # In(1)A discoverer male inversion cytology origin or ref ( lethal? _________________________________________________________________________ In(1)A1 16D;18D spont 5 In(1)A14 3B1-2;4E1 X ray 3 + In(1)A74 1A7-8;1B8-9 X ray 3 + (at 1B8-9) In(1)A78 | 11A1-2;20A X ray 2,3 + (at 11A1-2) In(1)A82 / 12C6;14A8 X ray 1, 3 + In(1)A96 18F-19A;19B1-2 X ray 2, 3 + In(1)A97 | 10E1-2;11A1-2 X ray 3 + (at 11A1-2) In(1)A99 7C;9A3 + 6A1-2;19C-D X ray 3 In(1)A99b ` 1D3-E1;19D-E X ray 4 In(1)A101 see Tp(1;1)A101 In(1)A141 11C3-4;19F1-2 X ray 3 + ( 1 = Craymer and Roy, 1980, DIS 55: 200-04; 2 = Konrad, Goral- ski, and Mahowald; 3 = Lefevre; 4 = Stone; 5 = Trench, 1981, DIS 56: 30. | Allele of l(1)11Aa. / Induced with Df(1)A82 = Df(1)4D5-6;4E3, but separable from it. ` Viability, fertility, and egg hatch good. # In(1)AB cytology: In(1)9F;13F1-10. discoverer: Bodeman. references: Stone and Thomas, 1935, Genetica 17: 170-84. genetics: Primary nondisjunction 0.5%, secondary 29.3%; recom- bination 18.2% in In(1)AB/+ and 26.3% in In(1)AB/+/Y female (Grell, 1962, Genetics 47: 1737-54). Stone and Thomas (1935) obtained 14.3% recombination in In(1)AB/+. # In(1)ac3: Inversion (1) achaete cytology: In(1)1B2-3;1B14-C1. origin: X ray induced. discoverer: Dubinin, 1929. synonym: In(1)sc10. references: 1930, Zh. Eksperim. Biol. 6: 300-24. 1932, J. Genet. 25: 163-81. 1933, J. Genet. 27: 447. Campuzano, Carramolino, Cabrera, Ruiz-Gomez, Villares, Boronat, and Modolell, 1985, Cell 40: 327-38. Villares and Cabrera, 1987, Cell 50: 415-24. genetics: Associated with ac3. molecular biology: Breakpoint at DNA coordinate 58.8 or 59.6 (Campuzano et al., 1985). # In(1)AC2: Inversion (1) Adelaide Carpenter cytology: In(1)9D5-E1;13B5-6. origin: Spontaneous. discoverer: A. Carpenter. # In(1)AM cytology: In(1)8C17-D1;16E2-3 (Hoover). discoverer: Mackensen. references: Stone and Thomas, 1935, Genetica 17: 170-84. Hoover, 1938, Z. Indukt. Abstamm. Vererbungsl. 74: 420-34 (fig.). genetics: Homozygous female sterile and therefore inversion used as an X chromosome balancer. Inversion departs slightly from wild-type phenotype in that eyes are rounded and slightly bulging. Total recombination 3.8% in In(1)AM/+ (Stone and Thomas, 1935). # In(1)At: Inversion (1) Attenuated cytology: In(1)16A4-5;18C4-6;20A2-3 superimposed on In(1)1B3- 4;20FL1B2-3;20FR + In(1)4D7-E1;11F2-4. new order: 1A - 1B3|20F - 20A3|16A5 - 18C4|20A2 - 18C6| 16A4 - 11F4|4E1 - 11F2|4D7 - 1B3|20F. origin: X ray induced in In(1)scS1Lsc8R + In(1)dl-49. discoverer: Valencia and Valencia, 1949. synonym: Tp(1;1)At. references: 1949, DIS 23: 64. genetics: Associated with At. Male and homozygous female viable and fertile. #*In(1)B263-5: Inversion (1) Bar cytology: In(1)15F9-16A1;16A7-B1;17A3-4. Left break occurs between repeated regions associated with Dp(1;1)B = Dp(1;1)15F9-16A1;16A7-B1 (Kaufmann and Sutton). new order: 1 - 16A7|17A3 - 16A1|17A4 - 20. origin: X ray induced in B. discoverer: Demerec, 33k. references: Sutton, 1943, Genetics 28: 97-107. genetics: B reversed; lethal; un, vb, f, lh, and oso not affected. #*In(1)B263-24 cytology: In(1)10C2-D1;12D2-E1;15F9-16A1;16A7-B1; right break- point between first and second segments of BiBi triplication. new order: 1 - 10C2|16A7 - 12E1|10D1 - 12D2| 16A1 - 16A7|16A1 - 20. origin: X ray induced in Dp(1;1)BiBi = Dp(1;1)15F9-16A1;16A7- B1. discoverer: Demerec, 34a. synonym: Tp(1;1)B263-24. references: Sutton, 1943, Genetics 28: 97-107. genetics: Reversal of BiBi to wild type; un, vb, f, lh, and os not affected. Male lethal. #*In(1)B263-47 cytology: In(1)16A2-4;20A2-3. origin: X ray induced. discoverer: Demerec, 38d. references: Sutton, 1943, Genetics 28: 97-107. genetics: Position effect at B. # In(1)BM1: Inversion (1) Bar of Muller cytology: In(1)16A2-5;20D-F (Lefevre). origin: X ray induced. discoverer: Muller, 34e. references: 1935, DIS 3: 29. genetics: Position effect at B. In(1)BM1/0 males are bb and variegate for pdf (Schalet, 1969, DIS 44: 87). Primary non- disjunction 0.4 and secondary 18.5%; recombination 32% in In(1)BM1/+ and 35.4% in In(1)BM1/+/Y female (Grell, 1962, Genetics 47: 1737-54). Males reared at 18 show diffuse polytene X. (Lakhotia and Mishra, 1983, Indian J. Exp. Biol. 20: 643-51). # In(1)BM2 cytology: In(1)16A2-5;20F (Sutton, 1943, Genetics 28: 97-107). origin: X ray induced. discoverer: Muller, 34e. references: 1935, DIS 3: 29. genetics: Position effect at B. #*In(1)Brv2: Inversion (1) Bar-reversed cytology: In(1)3F8-4A1;16A2-4; right break in right section of Dp(1;1)B = Dp(1;1)15F9-16A1;16A7-B1. new order: 1 - 3F8|16A2 - 16A1|16A7 - 4A1|16A4 - 20. origin: X ray induced in Dp(1;1)B. discoverer: Bishop, 1940. references: Sutton, 1943, Genetics 28: 100. genetics: Reversal of B. #*In(1)Brv3 cytology: In(1)15F9-16A1;16A7-B1;20A5-F; right break between segments of Dp(1;1)B = Dp(1;1)15F9-16A1;16A7-B1. new order: 1 - 16A7|20A5 - 16A1|20F. origin: X ray induced in B. discoverer: Bishop, 1940. references: Sutton, 1943, Genetics 28: 100. genetics: B reversion. # In(1)B1-4 cytology: In(1)1A7-8;1F3-4. origin: Induced by I-R interaction. references: Pallison, 1981, Mol. Gen. Genet. 183: 123-29. genetics: Male lethal. Deficient for y and ac. # In(1)bbDf: Inversion (1) bobbed-Deficiency cytology: In(1)4D2-3;20F; deficiency in 20F; two-thirds normal length at metaphase. new order: 1 - 4D2|20F - 4D3|20F. origin: X ray induced. discoverer: Sivertzev-Dobzhansky and Dobzhansky, 31b. references: 1933, Genetics 18: 173-92. Sturtevant and Beadle, 1936, Genetics 21: 554-604. genetics: Right breakpoint between rb and rg. Deficient for bb. In(1)bbDf/+ female produces about 2% exceptional sons from 4-strand double exchange within inverted segment. Secon- dary exceptions about 13%. # In(1)bbDfLClR: Inversion (1) bobbed-Deficiency Left Cl-Right cytology: In(1)4D2-3;20FL4A5-B1;17A6-B1R; duplicated for 4B1-D2 and 17B1-20F. origin: Recombinant containing left end of In(1)bbDf and right end of In(1)Cl. references: Sturtevant and Beadle, 1936, Genetics 21: 554-604. genetics: Duplicated for bi, rb, fu, and car but not ec, rg, f, os, or bb. Survives as small male with less convex outer wing margins than normal and usually one or more notches at wing tips; sterile, has collapsed testes. Heterozygous female fer- tile, has slightly narrowed wings. # In(1)bbDfLy4R: Inversion (1) bobbed-Deficiency Left yellow-4 Right cytology: In(1)4D2-3;20FL1A8-B1;18A3-4R; duplicated for 1B1-4D2 and 18A4-20F. origin: Recombinant containing left end of In(1)bbDf and right end of In(1)y4. references: Sturtevant and Beadle, 1936, Genetics 21: 554-604. genetics: Duplicated for ac through rb and fu through car. Heterozygous female has stubby posterior verticals and disar- ranged scutellars; outer wing margin less convex than normal; fair viability and fertility. Enhances expression of hetero- zygous B. Male lethal. # In(1)br103: Inversion (1) broad cytology: In(1)2B3-4;3C1 (or 3C2-3). origin: Induced by ethyl methanesulfonate. references: Belyaeva, Aizenzon, Kiss, Gorelova, Pak, Umbetova, Kramers, and Zhimulev, 1982, DIS 58: 184-90. genetics: Break in 2B3-4 associated with lethal effect. #*In(1)Br: Inversion (1) Bridged origin: X ray induced. discoverer: Muller, 27l3. references: 1935, DIS 3: 29. genetics: Associated with dominant mutant, Br. Crossing over suppressed to right of v, about normal to left. # In(1)C10 - In(1)C212 inversion cytology origin discoverer ref ( _______________________________________________________________ In(1)C10 3A;5E EMS 1 *In(1)C18 | 3F;17A1-6 X ray Roberts, 1964 2 In(1)C88 / 5E4-7;20 X ray Lefevre In(1)C99 / 2E3;20 X ray Lefevre In(1)C146 | 1F;14A X ray Roberts, 1965 2 In(1)C171 / 3C5;20A X ray Lefevre In(1)C206 `- 8F;11A;16A X ray Roberts, 1965 2 In(1)C212 see T(1;2)C212 ( 1 = Lim and Snyder, 1968, Mutat. Res. 6: 129-37; 2 = Roberts, 1970, Genetics 65: 429-48. | Eliminates sc-f recombination. Male fertile. / Male lethal. ` 1 - 8F|16A1 - 11A1|8F - 11A|16A - 20. - Eleven percent recombination between sc and f. Male lethal. # In(1)CA32 cytology: In(1)4F1-2;6A. origin: / ray induced. discoverer: Ashburner. genetics: Associated with osp201. # In(1)ci-x: Inversion (1) cubitus cytology: In(1)1A;20F. origin: Spontaneous. references: Muller, 1934, DIS 2: 90. Brosseau, 1969, DIS 44: 45. genetics: Homozygous viable and fertile. Associated with yci- x, an extreme y allele. Enhances ci. # In(1)Cl: Inversion (1) Cl cytology: In(1)4A5-B1;17A6-B1 (Hoover, 1938, Z. Indukt. Abstamm. Vererbungsl. 74: 429). origin: Spontaneous in a sc t2 v sl B chromosome. discoverer: Muller, 20j. references: 1928, Genetics 13: 279-357. Gershenson, 1935, J. Genet. 30: 115-25. Sturtevant and Beadle, 1936, Genetics 21: 554-604. genetics: Left break between ec and bi; right break between os and fu; l(1)C associated with left break (Muller). About 0.35% primary and 37% secondary exceptions. Total recombina- tion about 1%. other information: In(1)Cl, sc l(1)C t2 v sl B is the ClB chro- mosome, described in the section on balancers. # In(1)ClLbbDfR: Inversion (1) Cl-Left bobbed-Deficiency Right cytology: In(1)4A5-B1;17A6-B1L4D2-3;20FR; deficient for 4B1-D2 and 17B1-20F. origin: Recombinant containing left end of In(1)Cl and right end of In(1)bbDf. references: Sturtevant and Beadle, 1936, Genetics 21: 554-604. genetics: Deficient for bi, rb, fu, car, and bb but not ec, rg, f, or os. Both bi and fu lethal when heterozygous for In(1)ClLbbDfR. Heterozygous female extreme Minute [M(1)18C], with abnormal wing shape; ovaries normal but female sterile. Male lethal. # In(1)ClLy4R: Inversion (1) Cl-Left yellow-4 Right cytology: In(1)4A5-B1;17A6-B1L1A8-B1;18A3-4R; duplicated for 1B1-4A5, deficient for 17B1-18A3. origin: Recombinant containing left end of In(1)Cl and right end of In(1)y4. references: Sturtevant and Beadle, 1936, Genetics 21: 554-604. genetics: Duplicated for ac through ec; deficient for fu but not f, vb, os, or car. Heterozygous female has irregular acrostichal rows and wings smaller and with less-convex poste- rior margin than normal. Enhances expression of heterozygous B. Male lethal. # In(1)cm-df: Inversion (1) carmine-deficiency cytology: In(1)3D;6D + Df(1)6D;6F. origin: Derived from an unstable X carrying a lethal (Uc- 1lJD15). synonym: Df(1)cm-In. references: Johnson-Schlitz and Lim, 1987, Genetics 115: 701- 09. Lim, 1988, Proc. Nat. Acad. Sci. USA 85: 9153-57. genetics: Deficient for cm. Produces N deficiencies at high rate. molecular biology: Chromosome carries five hobo transposing elements (Lim, 1988). # In(1)ct: Inversion (1) cut origin: X ray induced. genetics: All male lethal except for In(1)ct43aH1 and In(1)ctJ7 (semilethal). In(1)ct3a2 and In(1)ctJ7 give extreme ct in combination with ct6. inversion cytology ref ( ________________________________________________ *In(1)ct3a2 7B;20 2, 3 *In(1)ct3b1 3A4-B1;7B2-5 2 *In(1)ct12a2 4E2-3;7B2-4 1 *In(1)ct13a1 7B2-3;19-20 2 *In(1)ct14a3 7B2-3;20 2 *In(1)ct14b2 3D2-5;7B2-4 2 In(1)ct43aH1 4B1-4;7B4-C1 + 7 10D5-6;20F *In(1)ct268-13 | 2E3-F1;2F2-3;7B2-3; 4, 5 7B4-5;19A4-5;19A6-B1 superimposed on R(1)1A3-4;19F-20A1 (2F1-2,7B3-4,19A5-6 missing) *In(1)ct268-18 / 7B2-3;7B4-5;11D8-9 5 (7B3-4 missing) *In(1)ct268-20 ` 6F11-7A1;7B3;10B11-12 5 (7A1-B5 missing) *In(1)ct268-27 3D6-E1;7B3-5 5 *In(1)ctJ7 7B3-4;7D22 6 *In(1)ctJ12 7B3-4;7D4 6 *In(1)ctJ13 5A;7B3-4 6 ( 1 = De Frank; 2 = Hannah-Alava; 3 = Hannah-Alava, 1971, Mol. Gen. Genet. 113: 191-203; 4 = Hoover, 1937, Genetics 22: 634-40; 5 = Hoover, 1938, Z. Indukt. Abstamm. Verer- bungsl. 74: 420-34; 6 = Lefevre and Johnson, 1973, Genetics 74: 633-46; 7 = Valencia, 1966, DIS 41: 58. | New order: |1A1 - 2E3|7B2 -2F3 |19A4 - 7B5 |19B1 - 20.20 - 20A1|. / New order: 1A - 7B2|11D8 -7B5|11D9 - 20. ` New order: 1A - 6F11|10B11 -7B6|10B12 - 20. # In(1)ct78 cytology: In(1)6A1-B1;6F1-2;7C1-2;19A1-4; contains reversed repeat of 6F2 to 7C1. new order: 1A1 - 6A1|19A1 - 6F2|6F2 - 7C1| 6F1 - 6B1|19A4 - 20. origin: Derived from unstable X chromosome with an easily mobilized gypsy element at ct. references: Lim, 1979, Genetics 93: 681-701. genetics: Unstable. # In(1)ct-df: Inversion (1) cut-deficiency cytology: In(1)3D;6F + Df(1)6F;7C. origin: Derived from an unstable X carrying a lethal (Uc- 1lJD15). synonym: In-Df(1)ct. references: Johnson-Schlitz and Lim, 1987, Genetics 115: 701- 09. genetics: Deficient for ct. # In(1)D1: Inversion (1) from deoxycytidine cytology: In(1)13B;16A. origin: Induced by tritiated deoxycytidine. discoverer: Kaplan, 1965. references: 1966, DIS 41: 59. genetics: Male lethal. # In(1)D30 cytology: In(1)14C6-D1;15E-F. synonym: In(1)lD30. references: Ganetzky, 1984, Genetics 108: 897-911. genetics: Distal break associated with l(1)14Dc1. # In(1)dl-49: Inversion (1) delta-49 cytology: In(1)4D7-E1;11F2-4 [Painter; Hoover, 1938, Z. Indukt. Abstamm. Vererbungsl. 74: 420-34 (fig.)]. discoverer: Muller, 26k. references: Muller and Stone, 1930, Anat. Record 47: 393-94. Stone and Thomas, 1935, Genetica 17: 170-84. Sturtevant and Beadle, 1936, Genetics 21: 554-604. genetics: Left break between rb and cv; right between wy and g. Measures of recombination vary from 5.5% (Grell, 1962, Genet- ics 47: 1737-54) to about 15% (Sturtevant and Beadle, 1936); secondary exceptions from 33% (Grell, 1962) to 44% (Sturtevant and Beadle, 1936). other information: Used as a balancer either with markers y Hw m2 g4 or y w lzs with Hw and lzs sterilizing homozygous female. # In(1)dm75e: Inversion (1) diminutive cytology: In(1)3E;5E + Df(1)3C11;3E4. origin: X ray induced. discoverer: Lefevre. references: Craymer and Roy, 1980, DIS 55: 200-04. genetics: Deficient for dm. # In(1)dorvar2: Inversion (1) deep orange cytology: In(1)2A4-B1;12F-13F. new order: 1A - 2A4|12F - 2B1|13F - 20. origin: / ray induced. references: Belyaeva, Aizenzon, Kiss, Gorelova, Pak, Umbetova, Kramers, and Zhimulev, 1982, DIS 58: 184-90. genetics: Inversion males lethal with Dp(1;f)18 or Dp(1;f)112, viable and normal with Dp(1;f)101, y59bY(2), or y2Y67g24.2. Females heterozygous for BRC mutants, dor, or hfw show strong position effect. # In(1)dorvar7 cytology: In(1)2B5-6;20 + additional rearrangements between X and 2. origin: / ray induced. references: Belyaeva, Aizenzon, Kiss, Gorelova, Pak, Umbetova, Kramers, and Zhimulev, 1982, DIS 58: 184-90. genetics: Females heterozygous with hfw, dor, BRC mutants, and sta but not l(1)2Bk or l(1)2Bl show strong position effect. # In(1)drp: Inversion (1) droop wings cytology: In(1)12B;20B. origin: Spontaneous from hi. discoverer: Ives, 48f. synonym: In(1)hi1; Inversion (1) droop. references: 1949, DIS 23: 58. genetics: Associated with mutant droop wings. Male viable. #*In(1)dta: Inversion (1) delta wing cytology: In(1)6B2-3;15E7-F2. origin: Induced by triethylenemelamine. discoverer: Fahmy, 1953. references: 1958, DIS 32: 69. genetics: Associated with dta. Female sterile. # In(1)EC238 cytology: In(1)3D5-6;4C1. origin: Induced by ethyl methanesulfonate. discoverer: Lefevre. genetics: Male lethal. Allele of dm. # In(1)elav4 cytology: In(1)1A7;1B8. synonym: In(1)elavG3. references: Campos, Rosen, and White, 1986, Genetics 113: s27. # In(1)EN: Inversion (1) Entire cytology: In(1)1A;20F;20F. At prophase, distal end carries a single heterochromatic segment about equal in size to chromo- some 4; proximally, it carries a very short heterochromatic segment and as a second arm two larger heterochromatic seg- ments (Lindsley). new order: 20 - 1A|20C - 20F.20. Tentative. origin: Spontaneous opening out of R(1)1, y. discoverer: Novitski. references: 1949, DIS 23: 94-95. Lindsley, 1958. Z. Indukt. Abstamm. Vererbungsl. 89: 103-22. Lindsley and Novitski, 1959, Genetics 44: 187-96. genetics: Entire chromosome, including the lethally mutable loci distal to y, inverted. Carries mutant alleles of bb at each end, which acting together produce bb+ phenotype. Male viable and fertile. # In(1)EN2 cytology: In(1)1A3-4;19F-20A;20F. Inferred from origin. new order: 20 - 1A3|20A - 20F.20. Tentative. origin: Spontaneous opening of R(1)2, y+. discoverer: Muller. references: 1956, DIS 30: 140-41. genetics: Entire chromosome inverted like In(1)EN but carries y+ rather than y. #*In(1)EN2B: Inversion (1) Entire 2 of Bender cytology: In(1)1A3-4;19F-20A;20F. Inferred from origin. new order: 20 - 1A3|20A - 20F.20F. Tentative. origin: Spontaneous opening of R(1)2, y v. discoverer: M. A. Bender, 55e6. references: 1955, DIS 29: 69. #*In(1)exr: Inversion (1) extra venation cytology: In(1)12E8-10;15D1-3. origin: Induced by triethylenemelamine. discoverer: Fahmy, 1952. references: 1958, DIS 32: 70. genetics: Affects exr. # In(1)f67a: Inversion (1) forked cytology: In(1)12E;18B + In(1)15E;20. origin: X ray induced. synonym: Tp(1;1)f67a. references: Becker, 1968, DIS 43: 59. genetics: Mutant for f. Homo- and hemizygous viable. # In(1)f257-4 cytology: In(1)15F2-16A1;16D2-E1. origin: X ray induced. discoverer: Demerec, 33j. genetics: f affected. # In(1)FM3: Inversion (1) First Multiple cytology: In(1)3E-F;16A-B;19F-20F; superimposed on In(1)1B2- 3;20F + In(1)4D7-E1;11F2-4. new order: 1A - 1B2|20F|16B - 19F|3F - 4D7| 11F2 - 4E1|11F4 - 16A|3E - 1B3|20F. origin: X ray induced in In(1)sc8 + In(1)dl-49, y31d sc8 dm B. discoverer: R. F. Grell, 1954. references: Mislove and Lewis, 1954, DIS 28: 77. genetics: Mutant for two lethals, one allelic to l(1)1Ac and therefore covered by y+Y and the other covered by BSY; both In(1)FM3/y+Y/BSY and In(1)FM3/BSY y+ males survive. The treated chromosome carried y31d, but In(1)FM3/y variegates for yellow bristles. other information: Used as a first chromosome balancer, described as FM3 in the section on balancers. # In(1)FM4 cytology: In(1)3C;4E-F superimposed on In(1)1B2-3;20F + In(1)4D7-E1;11F2-4. new order: 1A - 1B2|20F - 11F4|4E|3C - 4D7| 11F2 - 4F|3C - 1B3|20F. origin: X ray induced in In(1)sc8 + In(1)dl-49, y31d sc8 dm B. discoverer: R. F. Grell, 1954. references: Mislove and Lewis, 1954, DIS 28: 77. other information: Used as a first chromosome balancer, described as FM4 in the section on balancers. # In(1)FM6 cytology: In(1)15D-E;20F superimposed on In(1)1B2-3;20F + In(1)3C;4E-F + In(1)4D7-E1;11F2-4. new order: 1A - 1B2|20F|15E - 20F|15D - 11F4|4E| 3C - 4D7|11F2 - 4F|3C - 1B3|20F. origin: X ray induced in In(1)FM4, y31d sc8 dm B. discoverer: R. F. Grell, 55i. references: Grell and Lewis, 1956, DIS 30: 70. other information: Used as first chromosome balancer, described as FM6 in the section on balancers. # In(1)FM7 cytology: In(1)1B2-3;20F + In(1)4D7-E1;11F2-4 + In(1)15D- E;20A-E. Salivaries of females heterozygous with In(1)sc8 In(1)dl-49 show complete synapsis, with the delta-49 region homozygous and an inversion loop from 15D-E to the chromo- center. new order: 1A1-1B2|20F-20A|15D-20A|15D-11F4|4E1-11F2|4D7-1B3|20F. origin: Crossing over in FM6/In(1)sc8 In(1)dl-49 female. synonym: FM7a. references: Merriam, 1968, DIS 43: 64. 1969, DIS 44: 101. other information: Used as a first chromosome balancer, described as FM7 in the section on balancers. # In(1)FM7LENR origin: Single exchange between y+YSX., In(1)FM7 and X.YLBS, In(1)EN to yield YSX.YL, In(1)FM7LENR in which the euchromatin from the X terminus through sc is replaced by YS. discoverer: Craymer. synonym: y+YSX.YLBS, In(1)FM7LENR. references: 1974, DIS 51: 21. genetics: Males and homozygous females viable and fertile. Carries y+, y, vOf,and BS. # In(1)g17: Inversion (1) garnet cytology: In(1)12B10;19F superimposed on In(1)1B3-4;20FL1B2- 3;20FR + In(1)4D7-E1;11F2-4. new order: 1A - 1B3|20F - 19F|12B10 - 19F| 12B10 - 11F4|4E1 - 11F2|4D7 - 1B3|20F. origin: X ray induced in In(1)scS1Lsc8R + In(1)dl-49. discoverer: Muller, Valencia, and Valencia, 1946-53. references: Valencia, 1966, DIS 41: 58. genetics: Associated with g17. # In(1)gw: Inversion (1) garnet-wild cytology: Breakpoints unknown. origin: X ray induced. discoverer: Muller. references: 1946, DIS 20: 67. Chovnick, 1958, DIS 32: 88. 1961, Genetics 46: 493-507 (fig.). genetics: Associated with gw. # In(1)gX: Inversion (1) garnet from X irradiation cytology: In(1)12;19-20. origin: X ray induced. discoverer: Muller. references: 1946, DIS 20: 67. genetics: Mutant for g. # In(1)GA106 cytology: In(1)2B6;20F. origin: X ray induced. discoverer: Lefevre. genetics: Male lethal. Mutant for br. # In(1)GE origin: X ray induced. discoverer: Lefevre. genetics: Male lethal. inversion cytology genetics ________________________________________________ In(1)GE224 3A;20F l(1)3Ac83 In(1)GE228 3B1;20A l(1)3Ba24 In(1)GE246 ( 2A-B;3D5-6 l(1)3Da2 In(1)GE257 3B3;20F l(1)3Ba25 ( Complex. # In(1)GEM224: see T(1;2)GEM64 # In(1)GJ4 cytology: In(1)1B6-7;3C1-2. references: Gelbart, 1971, Ph.D. Thesis, Univ. of Wisconsin. genetics: Associated with Dp(1;1)GJ4. # In(1)GJ5 cytology: In(1)1B;10A. references: Gelbart, 1971, Ph.D. Thesis, Univ. of Wisconsin. genetics: Associated with Dp(1;1)GJ5. # In(1)Grz+: Inversion (1) Green cytology: In(1)3C;12B-C. origin: X ray induced. references: Green, 1967, Biol. Zentralbl. 86: 211-20. genetics: Eye color wild type. # In(1)HA46 cytology: In(1)7B1-2;8C-D. origin: X ray induced. references: Lefevre and Leeds, 1983, Genetics 104: s45-46. genetics: Male lethal, but strong ct over ct6. Viable with ctl or Df(1)RF19, showing strong kf2 phenotype. # In(1)HC origin: X ray induced. discoverer: Lefevre. genetics: Male lethal. inversion cytology lethal at genetics ___________________________________________________ In(1)HC146 11A1-2;12A 11A1-2, 12A l(1)11Aa7 In(1)HC206 1E1-2;2A1-2 2A1-2 l(1)2Ae4 In(1)HC207 2C3;7B1 2C3 In(1)HC293 6E1;7F1-2 7F1-2 #*In(1)hi: Inversion (1) high origin: Spontaneous in hi. discoverer: Ives. references: Hinton, Ives, and Evans, 1952, Evolution 6: 19-28. genetics: Male lethal. inversion cytology ___________________________ *In(1)hi2 1F;20 *In(1)hi3 4D;20 *In(1)hi4 4C;20 *In(1)hi5 1F;20 *In(1)hi7 12E;20 *In(1)hi8 3C;20 *In(1)hi9 8F;20 *In(1)hi10 4E2-3;8A1-2 *In(1)hi11 (| 5C;7E;20A-F *In(1)hi12 1C3;20 *In(1)hi13 4E;20 ( Synonym: Tp(1;1)hi11. | New order: 1 - 5C|7E - 20A|7E - 5C|20A-F. # In(1)hi1: see In(1)drp #*In(1)Hv: Inversion (1) Hooked veins cytology: Breakpoints unknown. discoverer: Tanaka, 35a4. references: 1937, DIS 8: 11. genetics: Associated with Hv. # In(1)Hw2: Inversion (1) Hairy wing cytology: In(1)1A2-3;1A8-B1;1B2-3. new order: 1A1 - 1A2|1B2 - 1A3|1B1 - 20. origin: Spontaneous derivative of Dp(1;1)Hw = Dp(1;1)1A8- B1;1B2-3. discoverer: Nichols-Skoog, 35a9. genetics: Associated with Hw2. # In(1)Hw49C cytology: In(1)1B;2B3-4. references: Belyaeva, Protopopov, Baricheva, Semeshin, Izquierdo, and Zhimulev, 1987, Chromosoma 95: 295-310. genetics: Inversion has weak br effect. molecular biology: Right break within BRC at coordinate 115 kb (Sampedro, Galceran, and Izquierdo, 1989, Mol. Cell. Biol. 9: 3588-91). # In(1)IW1: Inversion (1) Inoue Watanabe cytology: In(1)5A;16E. origin: Spontaneous in natural population in Japan. references: Inoue and Watanabe, 1969, Jpn. J. Genet. 54: 69- 82. # In(1)IW2 cytology: In(1)5E;10C. origin: Spontaneous in a natural population in Japan. references: Inoue and Watanabe, 1969, Jpn. J. Genet. 54: 69- 82. # In(1)JA9 cytology: In(1)7A3;20F. origin: X ray induced. discoverer: Lefevre. references: Nicklas and Cline, 1983, Genetics 103: 619-31. genetics: Male lethal. Associated with l(1)7Aa2. # In(1)JA11 cytology: In(1)7B3-4;7E5. origin: X ray induced. discoverer: Lefevre. # In(1)JC origin: X ray induced. discoverer: Lefevre. genetics: Male lethal. inversion cytology genetics ________________________________________ In(1)JC31 1E5;3A1-2 l(1)3Ac88 In(1)JC43 see T(1;4)JC43 In(1)JC46 3A4;4E l(1)3Ac89 In(1)JC111 2C3;9A2-3 l(1)2Cb7 #*In(1)K2: Inversion (1) of Krivshenko cytology: In(1)6A;9A-B. origin: Spontaneous. discoverer: Krivshenko, 54c24. references: 1956, DIS 30: 75. genetics: Homozygous viable. # In(1)l3Ac27: Inversion (1) lethal cytology: In(1)3A3-4;6B2-3. origin: X ray induced. discoverer: Judd, 62g31. synonym: In(1)g31. references: Judd, Shen, and Kaufman, 1972, Genetics 71: 139- 56. genetics: Associated with l(1)3Ac27. # In(1)l3Ba1 cytology: In(1)3B1;12F2-3. origin: X ray induced. discoverer: Judd, 62b12. genetics: Associated with l(1)3Ba1. # *In(1)l-272-13: see In(1)272-13 # In(1)l-D30: see In(1)D30 # In(1)l-v: Inversion (1) lethal variegated origin: X ray induced. references: Lindsley, Edington, and Von Halle, 1960, Genetics 45: 1649-70. genetics: Variegated Y-suppressed lethal; male fertile. inversion cytology _____________________________ In(1)l-v59 3-4;20F In(1)l-v132 4E;20F In(1)l-v139 3C6-7;XR het *In(1)l-v146 5-6;20F In(1)l-v227 1-2;20F In(1)l-v231 ( 1C-D;20F ( Dimitri and Pisano, 1989, Genetics 122: 793-800. # In(1)Lu1: Inversion (1) Luning cytology: Breakpoints in proximal half of the X. references: Luning, Lake, and Linde, 1984, Hereditas 100: 247-57. genetics: Homozygous females show low frequency of primary non- disjunction. Heterozygous females show five-fold increase in primary nondisjunction and excess of XO exceptional male offspring. Recombination enhanced outside the inversion and in region of distal break in homozygous females (Lake and Cederberg, 1984, Hereditas 101: 79-84). # In(1)Lu2 cytology: In(1)3E;4C. discoverer: Luning. #*In(1)lz: Inversion (1) lozenge origin: X ray induced. discoverer: Green and Green. references: 1956, Z. Indukt. Abstamm. Vererbungsl. 87: 708-21. genetics: Mutant for spectacled-like alleles of lz. inversion cytology ( ________________________ *In(1)lz1 8D;20F *In(1)lz2 8D;20F *In(1)lz3 4D;8D *In(1)lz4 8A2-B1;8D *In(1)lz5 8D;18F2-19A1 *In(1)lz6 8D;9B12-C1 *In(1)lz7 8D;20F ( Hannah. #*In(1)lzsB: Inversion (1) lozenge- spectacled of Bishop cytology: In(1)8;20 (Green). origin: X ray induced. discoverer: Bishop. references: Oliver, 1947, Texas Univ. Publ. 4720: 167-84. genetics: Associated with lzsB. #*In(1)lzA cytology: In(1)3E;3F;9E;9F-10A; inferred from Mackensen's fig- ure; bands in 3E-F and 9E-F missing. new order: 1 - 3E|9E - 3F|10A1 - 20. synonym: Df(1)Del lz a. references: Mackensen, 1935, J. Hered. 26: 163-74 (fig.). genetics: Mutant or deficient for v but not lz or ras. No clue to reason for lz appearing in name. # In(1)m38c: Inversion (1) miniature cytology: In(1)10E1-2;13B (Craymer). origin: X ray induced. discoverer: Griffin, 1938. # In(1)mK: Inversion (1) miniature of Krivshenko cytology: In(1)10E4-5;20F. In mitotic chromosomes, right breakpoint is near juncture of heterochromatic elements hC and hD to the left of the NO but to the right of right breakpoint of In(1)sc4 (Cooper, 1959, Chromosoma 10: 535-88). origin: X ray induced. discoverer: Krivshenko, 55l3. synonym: In1(1)K. references: 1956, DIS 30: 75. Wargent, 1971, DIS 47: 91. Wargent and Hartman-Goldstein, 1974, Heredity 33: 317-26. Hartman-Goldstein and Wargent, 1975, Chromosoma 52: 349-62. genetics: Variegated for m; variegation increased in strain carrying In(2LR)RevB (Wargent and Hartman-Goldstein, 1974) as is heterochromatization of the mK chromosome in this strain (Hartman-Goldstein and Wargent, 1975). # In(1)M20 cytology: In(1)2B9-11;3C4-6. origin: Induced by methyl methanesulfonate. references: Lim and Snyder, 1974, Genet. Res. 24: 1-10. Belyaeva, Aizenzon, Kiss, Gorelova, Pak, Umbetova, Kramers, and Zhimulev, 1982, DIS 58: 184-90. genetics: Carries l(1)3Ae22. # In(1)mei269 cytology: In(1)3A-B;9E. references: Baker and Carpenter, 1972, Genetics 71: 255-86. genetics: Associated with mei-269. Suppresses nearly all recombination between y and v. # In(1)Mg: Inversion (1) Mglinetz references: Mglinetz, 1968, Genetika (Moscow) 4(8): 81-86. inversion cytology origin ( _______________________________ In(1)Mg83 5C;8F 1 In(1)Mg91 1C;4B 1 In(1)Mg92 8F;11E 1 In(1)Mg93 4D;20 2 In(1)Mg94 14B;16A 2 In(1)Mg95 12A;20 2 In(1)Mg96 2D;14F 2 ( 1 = / ray induced; 2 = Induced by 32P feeding. # In(1)MKS: Inversion (1) Medvedeva Kupert Savvateeva origin: X ray induced. references: Medvedeva, Kupert, and Savvateeva, 1985, DIS 61: 214. genetics: Male lethal. inversion cytology ______________________ In(1)MKS45 9A;18A In(1)MKS47 9A1;20E-F In(1)MKS78 14B;20C-D # In(1)Mud: Inversion (1) Muddled cytology: In(1)3C3-4;5A6-B1. discoverer: Grell. genetics: Associated with dominant mutant, Mud. # In(1)N: Inversion (1) Notch molecular biology: Lesions identified on physical map of N (Artavanis-Tsakonas et al., 1983, 1984; Grimwade et al., 1985). 3C7 breakpoint of In(1)N76b8 chosen as coordinate 0. inversion cytology origin ref ( genetics ________________________________________________________________________________ In(1)N66h26 3C1-2;3C7-8 mutable w| 1, 2, 3, 4, 5, 6, 7 w N rst+ vt+ In(1)N76b8 3C7-8;3C9-10 / ray 1, 2, 3, 6 N In(1)N77c17 / 1D2-E1;3C7-9 X ray 1, 2 N In(1)N809 3C6-7;3C7-9 revertant 3 In(1)N81k6 ` 3C6-9;13A12-B2 X ray 1, 3 N In(1)N81k10 3C5-9;20A3-F X ray 2, 3 N In(1)N81l1 3C5-9;20A3-F X ray 2, 3 N In(1)N81l5 3C5-9;20A3-F X ray 2, 3 N In(1)N81l9 3C3-D3;20A3-F X ray 2, 3 N ( 1 = Artavanis-Tsakonas, Muskavitch, and Yedvobnick, 1983, Proc. Nat. Acad. Sci. USA 80: 1977-81; 2 = Artavanis- Tsakonas, Grimwade, Harrison, Markopoulou, Muskavitch, Schlasinger-Bryant, Wharton, and Yedvobnick, 1984, Dev. Biol. 4: 233-54. 3 = Grimwade, Muskavitch, Welshons, Yed- vobnick, and Artavanis-Tsakonas, 1985, Dev. Biol. 107: 503-19; 4 = Keppy and Welshons, 1980, Chromosoma 76: 191-200; 5 = Welshons, 1974, Genetics 76: 775-94; 6 = Welshons and Keppy, 1981, Mol. Gen. Genet. 181: 319-24; 7 = Welshons and Welshons, 1985, Genetics 110: 465-77. | Discoverer: Green (1967, Genetics 56: 467-82). Stable N but can regain mutability (N -> N+) by reinversion (Welshons and Keppy, 1981; Welshons and Welshons, 1985). Highly mut- able FB elements thought to be cause of the instability (Grimwade et al., 1985). / Discoverer, cytology: Welshons. ` Discoverer: Muskavitch; cytology: Welshons. #*In(1)N218 cytology: In(1)3C;20; position of right breakpoint with respect to centromere of ring not determined. origin: X ray induced in R(1)2. discoverer: Barigozzi. references: 1942, Rev. Biol. (Perugia) 34: 59-72. genetics: Variegates for w and ec but not pn or cv. Seems to carry intermediate allele of N. # In(1)N264 origin: X ray induced. inversion cytology ref ( genetics ___________________________________________________________________________ *In(1)N264-7 | 3C6-7;3C8-9;8C5-7; 1 rst+ fa--spl- dm+ 3C7-8 missing (Hoover) *In(1)N264-48 / 1B6-7;1B10-11;3C7-8; 1 rst+ fa- dm+ 1B7-10 missing (Hoover) *In(1)N264-52 3C3-5;20B2-C1 1 variegates for rst-bi, not for w or peb *In(1)N264-57 3C9-11;20F 2 rst fa+ N dm+ (Hoover) *In(1)N264-71 3C6-7;20D-F (Sutton) 2 rst+ N dm+ *In(1)N264-84 3C6-7;20A-F (Sutton) 2 variegates for fa-dm, not for rst or bi *In(1)N264-108 ` 3C3-5;3E7-8;20A4-5; 1 w+ spl- ec+ 3C5-E7 missing *In(1)N264-112 3C6-7;3F5-6 (Sutton) 1 w+ dm+ ec+ *In(1)N264-116 2C8-10;3C7-9 (Sutton) 3 pn+ w+ rst+ dm+ ( 1 = Demerec; 2 = Demerec, 1941, Proc. Int. Congr. Genet. 7th, pp. 99-103. | new order: 1 - 3C6|8C5 - 3C9|8C7 - 20. / new order: 1 - 1B6|3C7 - 1B11|3C8 - 20. ` new order: 1 - 3C3|20A4 - 3E8|20A5 - 20F. # In(1)NM7 cytology: In(1)10B-C;20. references: Reuter, Hoffman, and Wolff, 1983, Biol. Zentralbl. 102: 281-98. # In(1)NP: Inversion (1) Notch from 32P cytology: In(1)3C;8E (Darby). origin: Induced by 32P. discoverer: Bateman, 1950. references: 1950, DIS 24: 55. 1951, DIS 25: 77. # In(1)N66 cytology: In(1)7A7-8;11A3-5. discoverer: Lefevre. references: Kulkarni and Hall, 1987, Genetics 115: 461-75. genetics: Fails to complement cac. # In(1)N83 cytology: In(1)7F10;9A4. origin: Lefevre. genetics: Mutant for gg6. #*In(1)Nel-A: Inversion (1) of Nel cytology: In(1)12A;18D. origin: Spontaneous. discoverer: Nel. #*In(1)Nel-B cytology: In(1)11A;12F. origin: Spontaneous. discoverer: Nel. #*In(1)ney: Inversion (1) narrow eye cytology: In(1)10A;16D. origin: X ray induced. discoverer: Becker, 1950. references: 1952, DIS 26: 69. genetics: Associated with ney. # In(1)oc: Inversion (1) ocelliless cytology: In(1)7F1-2;8A1-2. origin: X ray induced. discoverer: Bedichek, 30c15. references: Spradling, Waring, and Mahowald, 1979, Cell 16: 609-16. Spradling and Mahowald, 1981, Cell 27: 203-09. genetics: Mutant for oc. Homozygous females sterile, but sterility may not be due to mutation at oc since ocl/oc females are fertile (Lefevre). Cp36 and Cp38 are included within and 1-3 kb from the distal breakpoint of the inversion. Synthesis of chorion proteins s36-1 and s36-2 much reduced in homozygotes (Spradling et al., 1979). Abnormal ultrastructure of chorion described by Johnson and King (1974, J. Insect Mor- phol. Embryol. 3: 385-95). molecular biology: Sequences containing both breakpoints as well as adjacent sequences cloned. Inversion shows drasti- cally altered pattern of differential replication of sequences surrounding 7F1-2; the 40 kb of DNA lying distal to the 7F breakpoint do not amplify as in the normal X; the remaining 50 kb, now adjacent to 8A, show somewhat reduced amplification. Sequences proximal to the 8A breakpoint do amplify in In(1)oc-containing follicle cells. Region 7F seems to contain a replication origin stimulated to additional rounds of repli- cation. # In(1)ombH31: Inversion (1) optomotor blind cytology: In(1)4C4-7;12D2-E1. origin: Induced by ethyl methanesulfonate. references: Heisenberg, Wonneberger, and Gotz, 1978, J. Comp. Physiol. 124: 287-96. Blondeau and Heisenberg, 1982, J. Comp. Physiol. 145: 321-29. Heisenberg, 1982. genetics: Associated with omb1, a mutant showing an optic lobe defect producing abnormal tracking behavior in homozygotes and in flies heterozygous with Df(1)RC40. # In(1)ovo5: Inversion (1) ovo cytology: In(1)4E1-2;5A1-6. discoverer: Oliver. synonym: In(1)ovoD1rG5. genetics: Mutant for ovo. # In(1)paralk4: Inversion (1) paralytic cytology: In(1)13E9-14;14C7-8. references: J.C. Hall. genetics: Mutant for para. # In(1)pdf: Inversion (1) podfoot cytology: In(1)16B;19F-20A. origin: X ray induced. discoverer: Welshons, 57h6. references: 1960, DIS 34: 54. genetics: Associated with pdf. # In(1)pn: Inversion (1) prune origin: X ray induced. references: Ilyina, Sorokin, Belyaeva, and Zhimulev, 1980, DIS 55: 205. genetics: Mutant for pn. inversion cytology ___________________________ In(1)pn1 see Tp(1;2)pn1 In(1)pn36 see Tp(3;1)pn36 In(1)pn45 2D1-2;20A # In(1)PS: Inversion (1) Paik Sung origin: Naturally occurring inversions in Korea. references: Paik and Sung, 1980, DIS 45: 120. inversion cytology ____________________ In(1)PS1 1D;3F In(1)PS2 8C;18B In(1)PS3 10B;12B In(1)PS4 13F;16E #*In(1)Pub: Inversion (1) Pub discoverer: P. Farnsworth. references: Lefevre, 1954, DIS 28: 75. genetics: Associated with Pub. Called inversion because of reduction in crossing over; less than 1% combination with spl and about 10% with B. # In(1)r70b: Inversion (1) rudimentary cytology: In(1)7B;15A1-2. origin: X ray induced. discoverer: Lefevre. references: Rawls and Porter, 1979, Genetics 93: 143-61. genetics: Associated with r70b, a non-complementing r allele. # In(1)rhd origin: Induced by hybrid dysgenesis. genetics: Mutant for r. inversion cytology ________________________ In(1)rhd1-2 11A1;15A1 In(1)rhd1-3 7F1-3;15A1 In(1)rhd1-4 5D1;15A1 In(1)rhd2-1 7E1-2;15A1 in(1)rhd5-2 9F4;15A1 #*In(1)rK: Inversion (1) rudimentary of Krivshenko cytology: Proximal break in heterochromatin. discoverer: Krivshenko. references: Agol, 1936, DIS 5: 7. genetics: Mutant for r. # In(1)RA35 cytology: In(1)6E;7F1. discoverer: Lefevre. references: King, Mohler, Riley, Storto, and Nicolazzo, 1986, Dev. Genet. 7: 1-20. # In(1)rbD1: Inversion (1) ruby cytology: In(1)4C6-8;20B-C. origin: X ray induced. references: Banga, Bloomquist, Brodberg, Pye, Larrivee, Mason, Boyd, and Pak, 1986, Chromosoma 93: 341-46. genetics: Mutant for rb. Male lethal. # In(1)RB10-18 cytology: In(1)10F;18D. origin: Hybrid dysgenesis from RB18 (chromosome with a 2.0 kb BamHI - EcoRI fragment carrying tra+ inserted in X at 18D). references: McKeown, Belote, and Baker, 1987, Cell 48: 489-99. genetics: Carries tra+, making tra female flies with the inver- sion fully female in phenotype and fertility. # In(1)RF19: see Df(1)RF19 # In(1)RF19: see T(1;2)RF19 # In(1)RF24 cytology: In(1)13A6;19E. origin: X ray induced. discoverer: Lefevre. genetics: Male lethal. #*In(1)rg7: Inversion (1) rugose cytology: In(1)4E;7A (J.I. Valencia). origin: X ray induced. discoverer: Cantor, 46d20. genetics: Mutant for rg. #*In(1)rgP cytology: In(1)3C;4E (Darby). origin: Induced by 32P. discoverer: Bateman. references: 1951, DIS 25: 77-78. genetics: Mutant for rg. # In(1)rst3: Inversion (1) roughest cytology: In(1)3C3-4;20F. Right breakpoint about one-fourth the distance between the heterochromatic-euchromatic junction and the centromere, approximately between heterochromatic seg- ments hC and hD (Cooper, 1959, Chromosoma 10: 535-88). origin: X ray induced. discoverer: Gruneberg, 33l16. references: 1935, DIS 3: 27. 1935, J. Genet. 31: 163-84 (fig.). 1937, J. Genet. 34: 169-89. Spofford, 1969, Genetics 62: 555-71. genetics: Left breakpoint between w and rst; right breakpoint to the left of bb [Emmens, 1937, J. Genet. 34: 191-202 (fig.); Kaufmann, 1942, Genetics 27: 537-49 (fig.)]. Variegates for rst with extent of mutant eye tissue decreased by Su(var) (Spofford, 1969); in X/O male variegates for w (Gersh, 1963, DIS 37: 81). Precise reinversions of In(1)rst3 accompanied by reversion of phenotype reported to occur spon- taneously (Gruneberg, 1935) and after X irradiation of oocytes (Novitski, 1961, Genetics 46: 711-17) but not after irradia- tion of sperm (Kaufmann, 1942). #*In(1)rstl: Inversion (1) roughestlike cytology: Breakpoints unknown. origin: X ray induced. discoverer: Oliver, 29d3. references: 1935, DIS 3: 28. genetics: Associated with rstl. # In(1)S: Inversion (1) of Sinitskaya cytology: In(1)6F;10F10-11A1 (Brosseau, 1967). origin: X ray induced simultaneously with In(1)scS1. discoverer: Sinitskaya. references: Muller and Prokofyeva, 1934, Dokl. Akad. Nauk SSSR, n.s. 4: 74-83. Slizynski, 1948, DIS 22: 77. Brosseau, 1967, DIS 42: 41. other information: In(1)scS1 + In(1)S used as crossover suppressors in certain balancers, e.g., Basc. # In(1)S39 cytology: In(1)1D1-2;1E1. genetics: Mutant for su(wa). # In(1)sc1 cytology: In(1)1B3-4;6D8. genetics: Mutant for sc. # In(1)sc4: Inversion (1) scute cytology: In(1)1B3-4;20F. In mitotic chromosomes, the right break is to the right of and near the euchromatic- heterochromatic juncture in the heterochromatic segment h26 as defined by Gatti and Pimpinelli. origin: X ray induced in a y chromosome. discoverer: Agol, 1928. references: 1929, Zh. Eksp. Biol. Med. 5: 86-101. 1931, Genetics 16: 254-66. Serebrovsky and Dubinin, 1930, J. Hered. 21: 259-65. Sturtevant and Beadle, 1936, Genetics 21: 554-604. Muller and Raffel, 1940, Genetics 25: 541-83. Schalet, Lefevre, and Singer, 1970, DIS 45: 165. Schalet and Lefevre, 1976, The Genetics and Biology of Droso- phila (Ashburner and Novitski, eds.). Academic Press, Lon- don, New York, San Francisco, Vol 1b, pp. 847-902. Campuzano, Carramolino, Cabrera, Ruiz-Gomez, Villares, Boronat, and Modolell, 1985, Cell 40: 327-38. genetics: Mutant at sc; also carries y. Left break placed to the right of the ( subdivision of the sc locus and to the left of l(1)sc and the | subdivision (Garcia-Bellido, 1979, Genet- ics 91: 491-520). Right break in the proximal heterochroma- tin between su(f) and bb (Schalet et al., 1970). Proximal heterochromatin carries the ABO-X to CR region as well as the NO (Yedvobnick, Krider, and Levine, 1980, Genetics 95: 661- 72). Maternal and zygotic interactions between abo and In(1)sc4 (Malva, Labella, Manzi, Salzano, Lavorgna, De Ponti, and Graziani, 1985, Genetics 111: 487-94). In(1)sc4/+ female produces about 6% exceptional males from 4-strand double exchange. Secondary exceptions about 4%. molecular biology: Left breakpoint between DNA coordinates +24.0 and +25.8 (Campuzano et al., 1985). 0 is an arbitrarily chosen EcoRI site in the sc| segment of ASC; positive values to the left (Carramolino, Ruiz-Gomez, Guererro, Campuzano, and Modolell, 1982, EMBO J. 1: 1185-92). Molecular map of y and sc inversion breakpoints (after Campuzano, Carramolino, Cabrera, Ruiz-Gomez, Villares, Boronat, and Modolell, 1985, Cell 40: 327-38 and Gonzalez, Romani, Cubas, Mondolell, and Campuzano, 1989, EMBO J. 8: 3553-62). # In(1)sc4Lsc8R: Inversion (1) scute-4 Left scute-8 Right cytology: In(1)1B3-4;20FL1B2-3;20FR; duplication for 1B3; mitotic chromosomes deficient for the proximal portion of h26 through the distal portion of h32 according to Gatti and Pim- pinelli. About 0.6 the length of a normal X at metaphase. origin: Recombinant containing left end of In(1)sc4 and right end of In(1)sc8. discoverer: Gershenson. synonym: Df(1)bb-G. references: 1933, J. Genet. 28: 297-313. 1933, Biol. Zh. (Moscow) 2: 145-59, 419-24. Peacock, 1965, Genetics 51: 573-83. Ritossa and Spiegelman, 1965, Proc. Nat. Acad. Sci. USA 53: 739-45. Tartof, 1971, Science 171: 294-97. Malva, Graziani, Boncinelli, Polito, and Ritossa, 1972, Nature (London), New Biol. 239: 135-37. Tartof, 1973, Genetics 73: 613-34. Parry and Sandler, 1974, Genetics 77: 735-39. Peacock, Miklos, and Goodchild, 1975, Genetics 79: 613-34. Procunier and Tartof, 1978, Genetics 88: 67-79. genetics: Duplicated for the sc locus, carrying both sc4 and sc8; deficient for ABO-X, CR and all the ribosomal RNA- complementary DNA at the bb locus of a normal X (Ritossa and Spiegelman, 1965; Tartof, 1971). In(1)sc4sc8/Ybb+ males and heterozygous In(1)sc4sc8 females have one NO (on the Y and on the normal X) and show a bb+ phenotype. In(1)sc4sc8/Ybb- males and XO males carrying In(1)sc4sc8 are lethal. Magnifi- cation or increase in rDNA multiplicity may take place in In(1)sc4sc8/Ybb males, changing their phenotype from bb to bb+ (Tartof, 1971, 1973; Malva et al., 1972). In(1)sc4sc8/Y males frequently show correlated meiotic drive and nondisjunction (Peacock, 1965; Peacock et al., 1975), resulting in the recovery of more nullo than In(1)sc4sc8/Y gametes and more sc4sc8 than Y gametes. Distorted ratios result from sperm dysfunction which is proportional to the chromosome content of the nucleus (McKee, 1984, Genetics 106: 403-22). The extent of these meiotic irregularities is dependent on Y chromosome(s) present (Peacock et al., 1965) and the tempera- ture at which meiosis occurs (Zimmering, 1963, Genetics 48: 133-38). In(1)sc4Lsc8R/T(Y;A) and In(1)sc4Lsc8R/mal+Y males sterile (McKee and Lindsley, 1987, Genetics 116: 399-407). # In(1)sc4Lsc9R: Inversion (1) scute-4 Left scute-9 Right cytology: In(1)1B3-4;20FL1B3-4;18C1R. Duplicated for 18C1-20. origin: Recombinant containing left end of In(1)sc4 and right end of In(1)sc9. discoverer: Muller. references: 1935, Genetics 17: 237-52. Garcia-Bellido and Santamaria, 1978, Genetics 88: 469-86. Garcia-Bellido, 1979, Genetics 91: 491-520. genetics: Deficient for l(1)sc. Mutant for Hw. Duplicated for loci to right of 18C1. Male lethal but viable in presence of Dp(1;2)sc19 = Dp(1;2)1B1-2;1B4-7;25-26. Only affects larval nervous system (Villares and Cabrera, 1987, Cell 50: 415-24). # In(1)sc4LscL8R: Inversion (1) scute-4 Left scute of Levy 8 Right cytology: In(1)1B3-4;20FL1B3-4;20FR. Mitotic chromosomes defi- cient for the proximal part of h26 through h30 (Gatti and Pim- pinelli). origin: Recombinant containing left end of In(1)sc4 and right end of In(1)scL8. references: Muller, Raffel, Gershenson, and Prokofyeva- Belgovskaya, 1937, Genetics 22: 87-93. genetics: Deficient for bb and the NO. # In(1)sc4LscS1R: Inversion (1) scute-4 Left scute of Sinitskaya 1 Right cytology: In(1)1B3-4;20FL1B3-4;20FR; deficient for the proximal part of h26 through the majority of h32 (Gatti and Pim- pinelli). X at metaphase. origin: Recombinant containing left end of In(1)sc4 and right end of In(1)scS1. references: Muller, Raffel, Gershenson, and Prokofyeva- Belgovskaya, 1937, Genetics 22: 87-93. genetics: Deficient for bb. Behavior in meiosis of the male like that of In(1)sc4Lsc8R. # In(1)sc4LscV2R cytology: In(1)1B3-4;20FL1B2-3;20FR. Deficient for the proxi- mal part of h26 through the distal half of h29 (Gatti and Pim- pinelli). origin: Single recombinant between In(1)sc4Lsc8R and In(1)scV1. discoverer: Lindsley. genetics: X-Y disjunction normal; In(1)sc4LscV2R/T(Y;A) and In(1)sc4LscV2R/mal+Y males fertile (McKee and Lindsley, 1987, Genetics 116: 399-407). Carries sufficient ribosomal cistrons to support survival and bb+ phenotype of XO male. Duplicated for sc ( region. # In(1)sc4Ly3PR: Inversion (1) scute-4 Left yellow-3P Right cytology: In(1)1B3-4;20FL1A;20FR; duplicated for 1B1-3. origin: Recombinant containing left end of In(1)sc4 and right end of In(1)y3P. references: Garcia-Bellido, 1979, Genetics 91: 491-520. genetics: Fully viable, ac+ and sc+ with weak Hw phenotype. # In(1)sc4Ly4R: Inversion (1) scute-4 Left yellow-4 Right cytology: In(1)1B3-4;20FL1A8-B1;18A3-4R; duplicated for 1B1-3 and 18A4-20F. origin: Recombinant containing left end of In(1)sc4 and right end of In(1)y4. references: Sturtevant and Beadle, 1936, Genetics 21: 554-604. genetics: Duplicated for the loci of ac, sc, car, and M(1)18C; carries y1 distally and the y locus interrupted by In(1)y4 proximally. Both male and female look normal. # In(1)sc7 cytology: In(1)1B3-4;6D8 (Lefevre). origin: X ray induced in a wa chromosome. discoverer: Dubinin, 1929. references: 1930, Zh. Eksp. Biol. Med. 6: 300-24. Serebrovsky and Dubinin, 1930, J. Hered. 21: 259-65. Dubinin, 1933, J. Genet. 27: 443-64. Sturtevant and Beadle, 1936, Genetics 21: 554-604. Garcia-Bellido, 1979, Genetics 91: 491-520. Campuzano, Carramolino, Cabrera, Ruiz-Gomez, Villares, Boronat, and Modolell, 1985, Cell 40: 327-38. genetics: Mutant for sc. Normal disjunction and 33% recombina- tion in In(1)sc7/+ female, 26% secondary nondisjunction and 27% recombination in In(1)sc7/+/Y female (Grell, 1962, Genet- ics 47: 1737-54). wa removable from the inversion by double crossing over in triploid. molecular biology: Left breakpoint between DNA coordinates -1.8 and -5.9 (Campuzano et al., 1985). 0 is an arbitrarily chosen EcoRI site in the sc| segment of ASC; positive values to the left (Carramolino, Ruiz-Gomez, Guererro, Campuzano, and Modolell, 1982, EMBO J. 1: 1185-92). # In(1)sc8 cytology: In(1)1B2-3;20F. Mitotic chromosomes show break in proximal heterochromatin extremely close to the centromere in proximal part of h32 (Gatti and Pimpinelli). NO near left end of X. origin: X ray induced. discoverer: Sidorov, 1929. references: 1931, Zh. Exper. Biol. Med. 7: 28-40. 1936, Biol. Zentralbl. 5: 1-26. Noujdin, 1935, Zool. Zh. 14: 317-52. Patterson and Stone, 1935, Genetics 20: 172-78. Sturtevant and Beadle, 1936, Genetics 21: 554-604. Baker, 1971, Proc. Nat. Acad. Sci. USA 68: 2472-76. Garcia-Bellido, 1979, Genetics 91: 491-520. Campuzano, Carramolino, Cabrera, Ruiz-Gomez, Villares, Boronat, and Modolell, 1985, Cell 40: 327-38. genetics: Weak mutant for sc and shows a Hw effect; variegates for ac, y, and probably l(1)1Ac (Hess, 1962, Verh. Dtsch. Zool. Ges., Zool. Anz., Suppl. 26: 87-92) in X/O male. Left break between ac and sc because induced deficiencies for the terminal uninverted portion of In(1)sc8 are deficient for y and ac but not sc8 (Patterson and Stone, 1935) and because In(1)sc8Lsc4R is deficient for sc (Sturtevant and Beadle, 1936); [i.e., for the ( subdivision of the sc locus (Garcia- Bellido)]. Right break between bb and centromere because deficiencies for terminal genes are frequently deficient for bb (Patterson, 1933, Genetics 18: 32-52) as is In(1)sc4Lsc8R (Gershenson, 1933, J. Genet. 28: 297-313; Sturtevant and Bea- dle, 1936). In(1)sc8/+ female produces about 3% exceptional sons from 4-strand double crossing over within the inversion and about 8.7% recombination. In(1)sc8/+/Y female produces 19% secondary nondisjunction and 12% recombination (Sturtevant and Beadle, 1936; Grell, 1962, Genetics 47: 1737-54). In(1)sc8/0 partially male lethal (Baker, 1971; Johnson, Harger, and Holm, 1979, Genetics 92: s54-55); variegates for y; ac enhanced. molecular biology: Left breakpoint between DNA coordinates 46.8 and 47.9 (Campuzano et al., 1985). 0 is an arbitrarily chosen EcoRI site in the sc| segment of ASC; positive values to the left (Carramolino, Ruiz-Gomez, Guererro, Campuzano, and Modolell, 1982, EMBO J. 1: 1185-92). # In(1)sc8LENR: Inversion (1) scute-8 Left Entire Right cytology: In(1)1B2-3;20FL1A;20;20FR. origin: Recombinant containing left end of In(1)sc8 and right end of In(1)EN. references: Lindsley, 1958, Z. Indukt. Abstamm. Vererbungsl. 89: 103-22. genetics: Carries l(1)1A+ alleles, y+ (or y31d), and ac+ distally and l(1)1A+ alleles, y, and ac+ proximally on long arm plus heterochromatic short arm of In(1)EN. Carries bb+ in distal heterochromatin derived from In(1)sc8 and a mild allele of bb in proximal heterochromatin derived from In(1)EN. # In(1)sc8Lsc4R: Inversion (1) scute-8 Left scute-4 Right cytology: In(1)1B2-3;20FL1B3-4;20FR; deficient for 1B3 and duplicated for proximal portion of h26 through majority of h32. About 1.4 times the length of a normal X at metaphase. origin: Recombinant containing left end of In(1)sc8 and right end of In(1)sc4. references: Sturtevant and Beadle, 1936, Genetics 21: 554-604. Garcia-Bellido, and Santamaria, 1978, Genetics 88: 469-86. Garcia-Bellido, 1979, Genetics 91: 491-520. genetics: Deficient for ( subset of sc locus; duplicated for bb+ and the NO. Homozygous female lethal; In(1)sc8Lsc4R/+ female often has crippled legs. Male survives rarely and is extreme sc and slight ac (Garcia-Bellido, 1979). Remains immobile after hatching. # In(1)sc8Lsc9R cytology: In(1)1B2-3;20FL1B3-4;18C1R. origin: Recombinant containing left end of In(1)sc8 and right end of In(1)sc9. references: Garcia-Bellido and Santamaria, 1978, Genetics 88: 469-86. Garcia-Bellido, 1979, Genetics 91: 491-520. genetics: Male lethal. Deficient for ( subset of sc locus and l(1)sc; duplicated for loci to right of 18C1. Mutant for Hw. # In(1)sc8LscL8R: Inversion (1) scute-8 Left scute of Levy 8 Right cytology: In(1)1B2-3;20FL1B3-4;20FR; deficient for 1B3; mitotic chromosomes duplicated for h31 through majority of h32 (Gatti and Pimpinelli). origin: Recombinant containing left end of In(1)sc8 and right end of In(1)scL8. references: Muller, Raffel, Gershenson, and Prokofyeva- Belgovskaya, 1937, Genetics 22: 87-93. genetics: Duplicated for the majority of the ( subset of the sc locus. # In(1)sc8LscS1R: Inversion (1) scute-8 Left scute of Sinitskaya 1 Right cytology: In(1)1B2-3;20FL1B3-4;20B-D1R; deficient for 1B3. origin: Recombinant containing left end of In(1)sc8 and right end of In(1)scS1. genetics: Deficient for the majority of the ( subset of the sc locus. A few extreme sc males survive. # In(1)sc8Ly3PR: Inversion (1) scute-8 Left yellow-3 of Patterson Right cytology: In(1)1B2-3;20FL1A;20FR; duplicated for 1A-B2. origin: Recombinant containing left end of In(1)sc8 and right end of In(1)y3P. references: Muller, 1935, J. Hered. 26: 469-78. Garcia-Bellido, 1979, Genetics 91: 491-520. genetics: Duplicated for y and ac loci; shows variable Hw phenotype in the mesopleura (Garcia-Bellido, 1979). Not defi- cient for bb. Male viable. # In(1)sc8Ly4R: Inversion (1) scute-8 Left yellow-4 Right cytology: In(1)1B2-3;20FL1A8-B1;18A3-4R; duplicated for 1B1-2 and 18A4-20F. origin: Recombinant containing left end of In(1)sc8 and right end of In(1)y4. references: Sturtevant and Beadle, 1936, Genetics 21: 554-604. genetics: Duplicated for ac, car, M(1)18C, and bb. Both male and female survive and show Hw effect of In(1)sc8. # In(1)sc9 cytology: In(1)1B3-4;18C1 (Lefevre). origin: X ray induced. discoverer: Levit, 1929. references: 1930, Wilhelm Roux's Arch. Entwicklungsmech. Organ. 122: 770-83. Norton and Valencia, 1965, DIS 40: 40. Garcia-Bellido, 1979, Genetics 91: 491-520. Campuzano, Carramolino, Cabrera, Ruiz-Gomez, Villares, Boronat, and Modolell, 1985, Cell 40: 327-38. genetics: Mutant for sc. Left break to right of the ( region of the sc locus and l(1)sc; inferred from observation that In(1)sc4Lsc9R is lethal in male unless Dp(1;2)sc19 is present (Muller, 1935). Right break right of sby, smd, and coc and left of car, as shown by the deficiency for sby, smd, and coc of In(1)y4Lsc9R (Norton and Valencia, 1965). molecular biology: Breakpoint between DNA coordinates +5.6 and +4.7 (Campuzano et al., 1985). 0 is an arbitrarily chosen EcoRI site in the sc| segment of ASC; positive values to the left (Carramolino, Ruiz-Gomez, Guererro, Campuzano, and Modolell, 1982, EMBO J. 1: 1185-92). # In(1)sc10: see In(1)ac3 # In(1)sc29 cytology: In(1)1B;13A2-5 (Raffel). discoverer: Agol, 1930. references: Campuzano, Carramolino, Cabrera, Ruiz-Gomez, Vil- lares, Boronat, and Modolell, 1985, Cell 40: 327-38. genetics: Mutant at sc. Left break to right of l(1)sc (Muller). molecular biology: Breakpoint between DNA coordinates -6.1 and -6.4 (Campuzano et al., 1985). 0 is an arbitrarily chosen EcoRI site in the sc| segment of ASC; positive values to the left (Carramolino, Ruiz-Gomez, Guererro, Campuzano, and Modolell, 1982, EMBO J. 1: 1185-92). #*In(1)sc52c origin: Spontaneous. discoverer: Green, 52c. references: 1952, DIS 26: 63. genetics: Mutant for sc and su(s) [i.e., su(s)52c]. Inversion inferred from failure of sc52c to recombine with ras or v. #*In(1)sc90 cytology: In(1)1B4-7;1D2-E1; inferred from Goldat's fig. 2. origin: X ray induced derivative of sc6. discoverer: Goldat. references: 1936, Biol. Zentralbl. 5: 803-12. genetics: Mutant for sc. # In(1)sc260-14 cytology: In(1)1B2-3;11D3-8. origin: X ray induced. discoverer: Sutton, 39b. references: 1943, Genetics 28: 210-17. Campuzano, Carramolino, Cabrera, Ruiz-Gomez, Villares, Boronat, and Modolell, 1985, Cell 40: 327-38. genetics: Mutant for sc but not y, ac, or svr. molecular biology: Breakpoint between DNA coordinates +17.6 and +16.4 (Campuzano et al., 1985). 0 is an arbitrarily chosen EcoRI site in the sc| segment of ASC; positive values to the left (Carramolino, Ruiz-Gomez, Guererro, Campuzano, and Modolell, 1982, EMBO J. 1: 1185-92). # In(1)sc260-22 cytology: In(1)1B2-3;1E2-3. origin: X ray induced. discoverer: Sutton, 39f. references: 1943, Genetics 28: 210-17. Campuzano, Carramolino, Cabrera, Ruiz-Gomez, Villares, Boronat, and Modolell, 1985, Cell 40: 327-38. genetics: Mutant for sc but not y, ac, or svr. molecular biology: Breakpoint between DNA coordinates -10.9 and -11.5 (Campuzano et al., 1985). 0 is an arbitrarily chosen EcoRI site in the sc| segment of ASC; positive values to the left (Carramolino, Ruiz-Gomez, Guererro, Campuzano, and Modolell, 1982, EMBO J. 1: 1185-92). #*In(1)scA: Inversion (1) scute of Agol discoverer: Agol. references: 1936, DIS 5: 7. genetics: Mutant for sc; semilethal. Genetically, appears to extend from sc to near r (54.5). # In(1)scJ1: Inversion (1) scute of Jacobs-Muller cytology: In(1)1A4-5;1B4-5. discoverer: Jacobs-Muller. references: Muller, 1932, Proc. Intern. Congr. Genet. 6th., Vol. 1: 225. Muller, Prokofyeva, and Raffel, 1935, Nature (London) 135: 253-55. genetics: Mutant for sc and l(1)1Ac. # In(1)scL8: Inversion (1) scute of Levy cytology: In(1)1B3-4;20F; inferred from genetic data. In mitotic chromosomes, right break is between h30 and h31 of Gatti and Pimpinelli. NO near left end of X. discoverer: Levy, 1932. references: Muller, Raffel, Gershenson, and Prokofyeva- Belgovskaya, 1937, Genetics 22: 87-93. Muller and Raffel, 1938, Genetics 23: 160. Raffel and Muller, 1940, Genetics 25: 541-83. Baker, 1971, Proc. Nat. Acad. Sci. USA 68: 2472-76. Garcia-Bellido, 1979, Genetics 91: 491-520. Johnson, Harger, and Holm, 1979, Genetics 92: s54-55. Campuzano, Carramolino, Cabrera, Ruiz-Gomez, Villares, Boronat, and Modolell, 1985, Cell 40: 327-38. genetics: Mutant for sc. Left break in ( segment of the sc locus. Right break to right of bb because In(1)sc4LscL8R deficient for bb (Muller et al., 1937). Homozygous females sterile (Pucket and Snyder, 1973) In(1)scL8/0 almost com- pletely male lethal (Baker, 1971; Pucket and Snyder, 1973, Genetics 74: s221) but cell viable in gynandromorphs [Pyati, 1976, Genetika (Moscow) 12: 75-81]. Lethality of XO males believed to be due to position-effect inactivation of the ribosomal cistrons and other genes affecting viability (Baker, 1971); maternal effect suppression of this lethality reported (Johnson et al., 1979). molecular biology: Breakpoint between DNA coordinates +30.9 and +28.8 (Campuzano et al., 1985). 0 is an arbitrarily chosen EcoRI site in the sc| segment of ASC; positive values to the left (Carramolino, Ruiz-Gomez, Guererro, Campuzano, and Modolell, 1982, EMBO J. 1: 1185-92). # In(1)scL8Lsc4R: Inversion (1) scute of Levy 8 Left scute-4 Right cytology: In(1)1B3-4;20FL1B3-4;20FR. Mitotic chromosomes duplicated for proximal half of h26 through h30 of Gatti and Pimpinelli. origin: Recombinant containing left end of In(1)scL8 and right end of In(1)sc4. references: Muller, Raffel, Gershenson, and Prokofyeva- Belgovskaya, 1937, Genetics 22: 87-93. genetics: Duplicated for bb and the NO. # In(1)scL8Lsc8R: Inversion (1) scute of Levy 8 Left scute-8 Right cytology: In(1)1B3-4;20FL1B2-3;20FR; duplicated for 1B3 and mitotic chromosomes, deficient for h31 and majority of h32 (Gatti and Pimpinelli). origin: Recombinant containing left end of In(1)scL8 and right end of In(1)sc8. references: Muller, Raffel, Gershenson, and Prokofyeva- Belgovskaya, 1937, Genetics 22: 87-93. genetics: Duplicated for ( segment of the sc locus but not bb. Survives as X/0 male and homozygous female. # In(1)scL8Lsc9R cytology: In(1)1B3-4;20FL1B3-4;18C1R. origin: Recombinant containing left end of In(1)scL8 and right end of In(1)sc9. references: Garcia-Bellido, 1979, Genetics 91: 491-520. genetics: Male lethal. Deficient for l(1)scl; duplicated for loci to right of 18C1. Mutant for Hw. molecular biology: Deficient for 23.2 kilobases of DNA in sc region: coordinates 5.6 to 28.8 (Campuzano, Carramolino, Cabrera, Ruiz-Gomez, Villares, Boronat, and Modolell, 1985, Cell 40: 327-38). 0 is an arbitrarily chosen EcoRI site in the sc| segment of ASC; positive values to the left (Carramol- ino, Ruiz-Gomez, Guererro, Campuzano, and Modolell, 1982, EMBO J. 1: 1185-92). # In(1)scL8LscS1R: Inversion (1) scute of Levy 8 Left scute of Sinitskaya 1 Right cytology: In(1)1B3-4;20FL1B3-4;20FR; mitotic chromosome defi- cient for h31 and majority of h32 (Gatti and Pimpinelli). origin: Recombinant containing left end of In(1)scL8 and right end of In(1)scS1. references: Muller, Raffel, Gershenson, and Prokofyeva- Belgovskaya, 1937, Genetics 22: 87-93. genetics: Homozygous viable and fertile; does not affect expression of variegation of bwA. # In(1)scS1: Inversion (1) scute of Sinitskaya cytology: In(1)1B3-4;20F; inferred from genetic identity of left break with that of In(1)sc4 and of right break with that of In(1)sc8. In mitotic chromosomes, right break is in proxi- mal end of h32 of Gatti and Pimpinelli. origin: X ray induced simultaneously with In(1)S. discoverer: Sinitskaya, 34c. references: Muller and Prokofyeva, 1934, Dolk. Akad. Nauk SSSR 4: 74-83. Muller and Raffel, 1938, Genetics 23: 160. Raffel and Muller, 1940, Genetics 25: 541-83. Crew and Lamy, 1940, J. Genet. 39: 273-83. Baker, 1971, Proc. Nat. Acad. Sci. USA 68: 2472-76. Nix, 1973, Biochem, Genet. 10: 1-12. Garcia-Bellido, 1979, Genetics 91: 491-520. Johnson, Harger, and Holm, 1979, Genetics 92: s54-55. Campuzano, Carramolino, Cabrera, Ruiz-Gomez, Villares, Boronat, and Modolell, 1985, Cell 40: 327-38. genetics: Mutant for sc. Left break between the ( segment of sc and l(1)sc. Right break to right of bb (Muller, Raffel, Gershenson, and Prokofyeva-Belgovskaya, 1937, Genetics 22: 87-93). Homozygous female sterile (Pucket and Snyder, 1973, Genetics 74: s221). In(1)scS1/0 almost completely male lethal (Baker, 1971; Pucket and Snyder, 1973), the adult sur- vivors extreme scute and almost immotile, with reduction in rRNA (Nix, 1973). In gynandromorphs, however, In(1)scS1/0 cells viable [Pyati, 1976, Genetika (Moscow) 12: 75-81]. molecular biology: Breakpoint between DNA coordinates +28.2 and +26.9 (Campuzano et al., 1985). 0 is an arbitrarily chosen EcoRI site in the sc| segment of ASC; positive values to the left (Carramolino, Ruiz-Gomez, Guererro, Campuzano, and Modolell, 1982, EMBO J. 1: 1185-92). # In(1)scS1Lsc4R: Inversion (1) scute of Sinitskaya 1 Left scute-4 Right cytology: In(1)1B3-4;20FL1B3-4;20FR; duplicated for h26 through the majority of h32 (Gatti and Pimpinelli). About 1.4 times the length of a normal X at metaphase. origin: Recombinant containing left end of In(1)scS1 and right end of In(1)sc4. references: Ritossa and Spiegelmann, 1965, Proc. Nat. Acad. Sci. USA 53: 737-45. Krider and Plaut, 1972, J. Cell. Biol. 11: 675-83. Yedvobnick, Krider, and Levine, 1980, Genetics 95: 661-72. genetics: Duplicated for ABO-X, CR, bb+ and the NO. (Krider and Plaut, 1972; Yedvobnick et al., 1980). Viable in XO males. abo females heterozygous for In(1)scS1Lsc4R produce XO offspring that do not show disproportionate replication of rDNA (Yedvobnick et al., 1980). Carries twice the normal amount of DNA that is complementary to Drosophila ribosomal RNA (Ritossa and Spiegelmann, 1965). # In(1)scS1Lsc8R: Inversion (1) scute of Sinitskaya 1 Left scute-8 Right cytology: In(1)1B3-4;20FL1B2-3;20FR; duplicated for 1B3. origin: Recombinant containing left end of In(1)scS1 and right end of In(1)sc8. genetics: Duplicated for sc(. # In(1)scS1Lsc9R cytology: In(1)1B3-4;20FL1B3-4;18C1R. origin: Recombinant containing left end of In(1)scS1 and right end of In(1)sc9. references: Garcia-Bellido, 1979, Genetics 91: 491-520. genetics: Male lethal. Deficient for l(1)sc; duplicated for loci to right of 18C1. Mutant for Hw. # In(1)scS1LscL8R: Inversion (1) scute of Sinitskaya 1 Left scute of Levy 8 Right cytology: In(1)1B3-4;20FL1B3-4;20FR; chromosomes duplicated for h31 plus majority of h32 (Gatti and Pimpinelli). origin: Recombinant containing left end of In(1)scS1 and right end of In(1)scL8. references: Muller, Raffel, Gershenson, and Prokofyeva- Belgovskaya, 1937, Genetics 22: 87-93. # In(1)scSJ cytology: In(1)1B3-4;2E3. origin: X ray induced. references: Rowan, 1968, DIS 43: 61. genetics: Male lethal. Associated with scSJ. # In(1)scV2 cytology: In(1)1B2-3;20F. Proximal breakpoint in hetero- chromatic segment h29 (Gatti and Pimpinelli). origin: / ray induced. discoverer: J.I. Valencia, 23h46. references: Muller and Valencia, 1947, DIS 21: 70. Cooper, 1959, Chromosoma 10: 535-88. Lindsley, Appels, and Hilliker, 1982, DIS 58: 99-100. Campuzano, Carramolino, Cabrera, Ruiz-Gomez, Villares, Boronat, and Modolell, 1985, Cell 40: 327-38. genetics: Mutant for ac-sc. Left break between ac and sc and right break in the middle of the region containing the ribo- somal cistrons as indicated by in situ hybridization and by the survival as XO males of both In(1)sc4LscV2R and In(1)scV2Lsc8R (bb+ in phenotype) (Lindsley et al., 1982). XO males semi-lethal (Baker, 1971, Proc. Nat. Acad. Sci. USA 68: 2472-76; Johnson, Harger, and Holm, 1979, Genetics 92: s54). molecular biology: Breakpoint between DNA coordinates +55.7 and +54.3 (Campuzano et al., 1985). 0 is an arbitrarily chosen EcoRI site in the sc| segment of ASC; positive values to the left (Carramolino, Ruiz-Gomez, Guererro, Campuzano, and Modolell, 1982, EMBO J. 1: 1185-92). # In(1)scV2Lsc8R cytology: In(1)1B2-3;20FL1B2-3;20FR. origin: Single recombinant between In(1)scV2 and In(1)sc4Lsc8R. discoverer: Lindsley. genetics: X-Y disjunction normal; In(1)scV2Lsc8R/T(Y;A) and In(1)scV2Lsc8R/mal+Y males fertile (McKee and Lindsley, 1987, Genetics 116: 399-407). Carries sufficient ribosomal cistrons to support survival and bb+ phenotype of In(1)scV2Lsc8R/we bbl females. #*In(1)sd2: Inversion (1) scalloped origin: X ray induced. discoverer: Panshin, 33g7. references: 1935, DIS 3: 28. genetics: Mutant for sd. Crossing over inhibited. # In(1)sd58d origin: / ray induced. discoverer: Ives, 58d14. references: 1961, DIS 35: 46. Simpson, Lawrence, and Maschat, 1981, Dev. Biol. 84: 206-11. genetics: Mutant for sd. Not a translocation genetically; reduces recombination between ras and f by 80%. # In(1)sdx: Inversion (1) spreadex origin: X ray induced. discoverer: Muller. references: 1965, DIS 40: 35. genetics: Associated with sdx. # In(1)Si: Inversion (1) Simmons origin: Selected as sex-linked recessive lethals from P-M dys- genic crosses. references: Simmons, Raymond, Culbert, and Laverty, 1984, Genetics 107: 49-63. location of inversion cytology lethal ( __________________________________________ In(1)Si1 2B;14D1-2;19D1-2 14B13-15A9 In(1)Si2 11A2-6;14D1-2 19A1-20E In(1)Si3 14C7-D1;19C2-D1 14B13-15A9 In(1)Si4 14C7-D1;19C2-D1 14B13-15A9 In(1)Si5 14C8-D2;19C2-6 In(1)Si6 14D;19C 14B13-15A9 In(1)Si7 14D;19C 14B13-15A9 In(1)Si8 14D;19C 14B13-15A9 In(1)Si9 14D1-2;19A-D 14B13-15A9 In(1)Si10 14D1-2;19C2-5 14B13-15A9 In(1)Si11 14D1-2;19C-E 14B13-15A9 In(1)Si12 14D2-3;19C 14B13-15A9 In(1)Si13 14D2-E1;18F2-5 19A1-20E ( Determined by deficiency testing against Df(1)r75c = Df(1)14B13;15A9 and Df(1)mal3 = Df(1)19A1-2;20E-F. # In(1)SMG: Inversion (1) Semenova Mglinetz Glotoff origin: / ray induced. references: Semenova, Mglinetz, and Glotoff, 1970, Genetika (Moscow) 6(4): 165-69. inversion cytology ______________________ In(1)SMG1 2B;5C In(1)SMG2 1A;3C In(1)SMG3 ( 4;17B ( Includes deficiency ? # In(1)St: Inversion (1) Stalker origin: Naturally occurring inversions. references: Stalker, 1976, Genetics 82: 323-47. inversion cytology ______________________ In(1)St-A 12A;18F In(1)St-B 6D;11A In(1)St-C 15A;18B In(1)St-D ( 4D;17B ( Stalker, unpublished. #*In(1)stx: Inversion (1) streakex origin: X ray induced. discoverer: Muller, 26k30. references: 1935, DIS 3: 30. genetics: Associated with stx. # In(1)sx: Inversion (1) sexcombless cytology: In(1)11D4-6;14B8-9 + In(1)11E2-6;15E2-4. new order: 1 - 11D4|14B9 - 15E2|11E2 - 11D6| 14B8 - 11E6|15E4 - 20. origin: X ray induced. discoverer: Muller, 261. references: Mukherjee, 1963, DIS 38: 62 (fig.). Reinhardt and S'nchez, 1982, Wilhelm Roux's Arch. Dev. Biol. 191: 264-69. genetics: Associated with mutant sx, which is male sterile. # In(1)Sxl: Inversion (1) Sex lethal cytology: In(1)6F-7A;20. discoverer: Cline. genetics: Mutant for Sxl. #*In(1)Th1: Inversion (1) Thymidine cytology: In(1)12C;16C. origin: Induced by ingested H3-thymidine. discoverer: Kaplan. genetics: Male lethal. # In(1)Uc: Inversion (1) Unstable chromosome origin: Derived from unstable X chromosome (termed Uc) which contains a readily mobilized gypsy element at ct. references: Lim, 1979, Genetics 93: 681-701. Johnson-Schlitz and Lim, 1987, Genetics 115: 701-09. genetics: Unstable. inversion cytology ______________________________ In(1)Uc3C-6F 3C10-D1;6F1-2 In(1)Uc6D-10F 6D-E1;10F-11A1 In(1)Uc6F-7B 6F2-5;7B5-C1 In(1)Uc6F-7C 6F1-2;7C1-2 In(1)Uc6F-10F 6F1-2;10F-11A1 In(1)Uc6F-11B 6F1-2;11B4-7 In(1)Uc6F-12E 6F1-2;12E2-8 In(1)Uc7C-9A 7C1-4;9A1-4 In(1)Uc7C-10F 7C1-4;10F-11A1 # In(1)V: Inversion (1) Valencia origin: X ray induced. references: Valencia, 1970, DIS 45: 37. inversion cytology genetics _____________________________________________ In(1)V7-7 3C9-10;16C10;18B2-3 semilethal In(1)V7-12 5B;11A7 lethal In(1)V10-7 3A-B;16C lethal Y-suppressed lethal. # In(1)VA288 cytology: In(1)17E-F;19E. origin: Induced with ethyl methanesulfonate. discoverer: Lefevre. # In(1)vao: Inversion (1) varied outspread cytology: In(1)18C5-6;19E7-8. origin: Induced by triethylenemelamine. discoverer: Fahmy, 1953. references: 1959, DIS: 33: 94. genetics: Mutant for vao; variegated for an eye color, possibly car. Male sterile. # In(1)VE891 cytology: In(1)2B6-7;20A. origin: Induced with ethyl methanesulfonate. discoverer: Lefevre. genetics: Male lethal. #*In(1)w258-52: Inversion (1) white cytology: In(1)3C;8E11-F1 origin: X ray induced. discoverer: Demerec, 40a. genetics: Mutant for w and rst but not for spl, lz, dvr, or flp. # In(1)w-64d cytology: In(1)3B1-2;20F + Df(1)3B1-2;3C2-3 (Lefevre). origin: X ray induced. references: Lefevre, 1968, DIS 43: 62-63; 165. Kaufman, Shannon, Shen and Judd, 1975, Genetics 79: 265-82. genetics: Male lethal. When covered by Dp(1;3)wvco, males variegate for w and rst and show loss of bristles. Effect on bristles more extreme in XO males. Dp(1;3)wm49a also covers In(1)w-64d. molecular biology: Left breakpoint in a 1.6 kb restriction fragment at approximately 90 kilobases distal to the wa copia insertion (Bargiello and Young, 1984, Proc. Nat. Acad. Sci. USA 81: 2142-46; Pirrotta, Hadfield, and Pretorius, 1983, EMBO J. 2: 927-34). # In(1)w-68b15 - In(1)w-71a27.1 origin: X ray induced in In(1)z+64b9=In(1)3C1-2;12B8-9. references: Sorsa, Green, and Beerman, 1973, Nature (London), New Biol. 245: 34-37. inversion cytology new order genetics _______________________________________________________________________ In(1)w-68b15 3Cl;11F3;12B8 1A - 3C1|11F3 - 12B8| male viable; 11F2 - 3C1|12B9 - 20 zv w- In(1)w-70L26.3 4C;12A + 1A - 3B|12B|4C - 12A| male lethal; Df(1)3B;3C1 + 4C - 3C2|12B9 - 20 crm+ w- g+ Df(1)12A;12B8-9 In(1)w-70L26.8 3Cl;12B1;12B8 1A - 3C1|12B1 - 12B8| male viable; (reinversion) 12A10 - 3C2|12B9 - 20 zv w- In(1)w-71a9.3 1D1;3C1 1A - 1C5|3C1 - 1D1| male viable; 12B8 - 3C2|12B9 - 20 zv w- In(1)w-71a27.1 3Cl;11A1;12B8 1A - 3C1|11A1 -12B8| male viable 10F11 - 3C2|12B9 - 20 zv w- # In(1)wDZL-1 cytology: In(1)2F6;3C1-2. origin: In a wDZL/wDZL female. Presumed to be a rearrangement generated by wDZL. references: Bingham, 1980, Cold Spring Harbor Symp. Quant. Biol. 45(2): 519-25. genetics: In(1)wDZL-1/wDZL females have wild-type eye color. Viable and fertile in homo- and hemizygotes. # In(1)wDZL-3 cytology: In(1)3C1-2;3E3-7. origin: In a wDZL/wDZL female. Presumed to be a rearrangement generated by wDZL. references: Bingham, 1980, Cold Spring Harbor Symp. Quant. Biol. 45(2): 519-25. genetics: In(1)wDZL-3/wDZL females have wild-type eye color. Viable and fertile in homo- and hemizygotes. #*In(1)wG: Inversion (1) white of Goldschmidt cytology: In(1)3C;3D-E (Kodani). origin: X ray induced in In(1)yG = In(1)1A;1C3-4. discoverer: Goldschmidt. references: 1945, Univ. Calif. (Berkeley) Publ. Zool 49: 522. # In(1)wm4: Inversion (1) white-mottled cytology: In(1)3C1-2;20F (Lefevre, 1976). Right breakpoint in mitotic chromosomes is to the left of bb in region h28 (Gatti and Pimpinelli). Appels and Hilliker (1982, Genet. Res. 39: 149-56) place the breakpoint at the distal border of the rDNA sequences. origin: X ray induced. discoverer: Muller, 1929. references: 1930, J. Genet. 22: 299-334. Lefevre, 1976, The Genetics and Biology of Drosophila (Ash- burner and Novitski, eds.). Academic Press, London, New York, San Francisco, Vol. 1a, pp. 31-66. Spofford and De Salle, 1978, DIS 53: 204. Pirrotta, Hadfield, and Pretorius, 1983, EMBO. J. 2: 927-34. Tartof, Hobbs, and Jones, 1984, Cell 37: 869-78. genetics: Variegated for w. Left break to the left of w. molecular biology: Left (3C1-2) breakpoint at -24.5 kb in the restriction map of the w locus (0 point at site of the copia insertion in wa); right (20F) breakpoint near 5' end of a Type I mobile element (Tartof et al., 1984). other information: A strongly variegating line has been desig- nated In(1)wm4h (Reuter, Werner, and Hoffmann, 1982, Chromo- soma 85: 539-51; Reuter and Szidonya, 1983, Chromosome 88: 277-85). # In(1)wm4Lrst3R: Inversion (1) white-mottled 4 Left roughest-3 Right cytology: In(1)3C1-2;20FL3C3-4;20FR; deficient for 3C2-3. origin: Recombinant containing left end of In(1)wm4 and right end of In(1)rst3. references: Lefevre and Wilkins, 1966, Genetics 53: 175-87. Lefevre, 1968, DIS 43: 141. Lefevre and Green, 1972, Genetics 36: 391-412. genetics: Deficient for w; position effect on rst (Lefevre, 1968). Males lethal, with occasional w rst escapers at 29; lethality covered by Dp(1;2)51b. # In(1)wm4Lsc4R cytology: In(1)3C1-2;20FL1B3-4;20FR; carries distal hetero- chromatin of In(1)wm4 and proximal heterochromatin of In(1)sc4. origin: Recombinant containing left end of In(1)wm4 and right end of In(1)sc4. references: Yedvobnick, Krider, and Levine, 1980, Genetics 95: 667-721. genetics: Variegated for w; duplicated for the ABO-X to CR region and for l(1)sc through w; carries bb+. # In(1)wm4Lwm51bR cytology: In(1)3C1-2;20FL3C1-2;20FR. Right break just proximal to the NO. origin: Recombinant containing left end of In(1)wm4 and right end of In(1)wm51b. references: Appels and Hilliker, 1982, Genet. Res. 39: 149-56. genetics: Variegated for w. Carries ABO-X and CR; deficient for the majority, if not all, of the ribosomal cistrons. # In(1)wm4LwmJR: Inversion (1) white- mottled 4 Left white- mottled of Jonsson Right cytology: In(1)3C1-2;20FL3C2-3;20F;102CR deficient for 3C2 and for an undetermined portion, including the centromere, of the base of the X. new order: 1 - 3C1|20F - 3C3|102C - 101A. origin: Recombinant containing left end of In(1)wm4 and right end of In(1)wmJ, which is part of T(1;4)wmJ = T(1;4)3C2- 3;20F;102C. references: Lefevre, 1963, DIS 37: 49-50. Lefevre and Wilkins, 1966, Genetics 53: 175-87. genetics: Deficient for white; males viable and therefore not deficient for any lethal. Also deficient for proximal hetero- chromatin, including bb (XO lethal). # In(1)wm4rv origin: X ray induced in In(1)wm4. references: Tartof, Hobbs, and Jones, 1984, Cell 37: 869-78. genetics: Eyes w+ (even when revertants reared at 17). inversion cytology new order __________________________________________________________ In(1)wm4rv5 3C1-2;4A;20A 1A - 3C1|20 - 4A|3C2 - 4A|20 In(1)wm4rv6 1F;3C1-2;20A 1A - 1F|3C2 - 20|3C1 - 1F|20 In(1)wm4rv26 3C1-2;6B;20A 1A - 3C1|20 - 6B|3C2 - 6B|20 # In(1)wm51b cytology: In(1)3C1-2;20F; right break proximal to the NO (Gersh), at the junction between h29 and h30 (Gatti and Pim- pinelli). Appels and Hilliker (1982, Genet. Res. 39: 149-56) place the breakpoint at the proximal border of the rDNA sequences. origin: X ray induced. discoverer: Baker, 51b19. references: CP627. Spofford and De Salle, 1978, DIS 53: 204. Tartof, Hobbs, and Jones, 1984, Cell 37: 869-78. genetics: Variegated for w and rst. Recombinant carrying left end of In(1)wm51b and right end of the 4-centric element of T(1;4)wmJ = T(1;4)3C2-3;20F;102C is white eyed and male viable, indicating that In(1)wm51b, like In(1)wm4 = In(1)3C1- 2;20F, is broken between 3C1 and 2 (Gersh). molecular biology: Left (3C1-2) breakpoint is at -21 kb of the restriction map of the w locus (0 point at site of the copia insertion in wa); right (20F) breakpoint is at a mobile ele- ment (Tartof et al., 1984). # In(1)wm51bLwm4R cytology: In(1)3C1-2;20FL3C1-2;20FR. origin: Recombinant containing left end of In(1)wm51b and right end of In(1)wm4. references: Appels and Hilliker, 1982, Genet. Res. 39: 149-56. genetics: Variegated for w and rst. Carries ABO-X and CR; duplicated for the majority, if not all, of the ribosomal cis- trons. # In(1)wm53j cytology: In(1)1A;3C3-5;20;20F;20F. Inferred from origin. new order: 20 - 3C5|20F|1A - 3C3|20. Tentative. origin: X ray induced in In(1)EN = In(1)1A;20F;20F. discoverer: Bender, 53j. references: 1955, DIS 29: 69. genetics: Variegated for w. # In(1)wm54l cytology: In(1)3C3-5;20F. origin: Neutron induced. discoverer: Mickey, 54l3. references: 1963, DIS 38: 29. genetics: Variegated for w. # In(1)wm55b cytology: In(1)1A3-4;3C3-5;20;19F-20A1;20A1-F. Inferred from origin. Appears as a rod in metaphase. new order: 20F - 3C5|20A1|1A4 - 3C3|20F.20. Tentative. origin: X-ray-induced derivative of R(1)2 = R(1)1A3-4;20F opened in inverted order. discoverer: M. A. Bender, 55b28. references: 1955, DIS 29: 69. genetics: Variegated for w. # In(1)wmB: Inversion (1) white-mottled of Barnes cytology: In(1)3C2-3;20F. origin: X ray induced. discoverer: Barnes, 1965. references: Lefevre, 1968, DIS 43: 62-63. genetics: Variegated for w in both males and females as in In(1)wm4. Variegated for rst and vt in XO males. # In(1)wmJ: see T(1;4)wmJ # In(1)wmJLrst3R: Inversion (1) white- mottled of Jonsson Left roughest-3 Right cytology: In(1)3C2-3;20FL3C3-4;20FR; deficient for 3C3. origin: Recombinant carrying left end of In(1)wmJ, which is part of T(1;4)wmJ, and right end of In(1)rst3. references: Lefevre, 1963, DIS 37: 49-50. Lefevre and Wilkins, 1966, Genetics 53: 175-87. genetics: Male lethal. Variegated for w and rst. # In(1)wmMc: Inversion (1) white-mottled of McLean cytology: In(1)3C1-2;20F; inferred from genetic data. origin: X ray induced. discoverer: McLean. references: Muller, 1946, DIS 20: 68. Tartof, Hobbs, and Jones, 1984, Cell 37: 869-78. genetics: Variegates for w and rst. Complementary single recombinants between In(1)wm4 = In(1)3C1-2;20F and In(1)wmMc are viable, fertile, and bb+. Left breakpoints therefore identical and right breakpoints on the same side of bb. molecular biology: Left (3C1-2) breakpoint is at -21 kb in the restriction map of the w locus (0 point at site of the copia insertion in wa); right (20F) breakpoint near the 3' end of a Type I mobile element that is inserted in a ribosomal RNA gene (Tartof et al., 1984). # In(1)wvC: Inversion (1) white-variegated of Catcheside cytology: In(1)3C1-2;20F superimposed on R(1)1A3-4;20F. new order: |1A4-3C1|20F-3C2|20F|. Position of centromere indeterminate. origin: X ray induced in R(1)2. discoverer: Catcheside. references: Hinton, 1955, Genetics 40: 952-61. genetics: Variegates for w, rst, spl, and N but not y. X/Y male viability reduced; X/Y/Y male more viable. Characterized by variable degree of instability manifested by production of gynandromorphs, X/0 males, and dominant lethals. An extreme example gave 140 females, 106 gynandromorphs, 181 X/0 males, and 868 dominant lethals among 1295 putative ring/rod zygotes. Small ring-shaped duplications are generated infrequently (analysis by Hinton, 1955). Behavior of rod derivatives of In(1)wvC (Hinton, 1957, Genetics 42: 55-65) suggests genera- tion of dicentrics through sister-strand fusion rather than exchange. Fusion postulated to occur in heterochromatin of the 3C1|20F reunion point of In(1)wvC. Mitotic abnormalities in cleavage of In(1)wvC embryos described (Hinton, 1959, Genetics 44: 923-31). Chromosome tends to become stable in stocks. Viability and fertility correlated with stability. Widely used in mosaic analysis and fate mapping (e.g., Garcia-Bellido and Merriam, 1969, J. Exp. Zool. 170: 61-76). # In(1)ww cytology: In(1)3B2-C1;4B4-C1. origin: Spontaneous in a mutable z wzmz strain. references: Kalish, 1970, Mol. Gen. Genet. 107: 336-50. 1980, DIS 55: 206-07. genetics: Mutant for w. Reverts to wzmz with reinversion of In(1)ww. # In(1)y3P: Inversion (1) yellow-3 of Patterson cytology: In(1)1B1-2;20 (Muller and Prokofyeva, 1935) or In(1)1A8-B1;20F. Heterochromatic break proximal to h29. origin: X ray induced. discoverer: Patterson, 31e25. references: Muller, 1935, Genetica 17: 237-52. Muller and Prokofyeva, 1935, Proc. Nat. Acad. Sci. USA 21: 16-26. Sidorov, 1936, Biol. Zh. (Moscow) 5: 3-26. Garcia-Bellido, 1979, Genetics 91: 491-520. Carramolino, Ruiz-Gomez, Guerrero, Campuzano, and Modolell, 1982, EMBO J. 1: 1185-91. Biessmann, 1985, Proc. Nat. Acad. Sci. USA 82: 7369-73. Campuzano, Carramolino, Cabrera, Ruiz-Gomez, Villares, Boronat, and Modolell, 1985, Cell 40: 327-38. genetics: Variegated for y and, to a lesser extent, for Hw. Genetic breaks between l(1)1Ac and y and between bb and cen- tromere. Inversion slightly longer than In(1)sc8. molecular biology: The left breakpoint defines the distal limit of the y coding region. On the DNA map of Campuzano et al., 1985, this breakpoint is at +73 and on the DNA map of Biessmann, 1985, it lies between +36.5 and +38.3; in both maps, positive values are to the left of the origin. # In(1)y3PLsc4R cytology: In(1)1A;20L1B3-4;20FR. origin: Recombinant containing left end of In(1)y3P and right end of In(1)sc4. references: Garcia-Bellido and Santamaria, 1978, Genetics 88: 469-86. Garcia-Bellido, 1979, Genetics 91: 491-520. genetics: Male lethal. Carries Hw and the region covering l(1)sc. Deficient for y, ac, and the ( segment of sc. molecular biology: Deficiency includes coding sequences for transcripts T4, T5, and T6 (Campuzano, Carramolino, Ruiz- Gomez, Villares, Boronat, and Modolell, 1985, Cell 40: 327- 48). # In(1)y3PLsc8R: Inversion (1) yellow-3 of Patterson Left scute-8 Right cytology: In(1)1A;20L1B2-3;20FR; deficient for 1A-B2. origin: Recombinant containing left end of In(1)y3P and right end of In(1)sc8. references: Muller, 1935, J. Hered. 26: 469-78. Campuzano, Carramolino, Cabrera, Ruiz-Gomez, Villares, Boronat, and Modolell, 1985, Cell 40: 327-38. Chia, Howes, Martin, Meng, Moses, and Tsubota, 1986, EMBO J. 5: 3597-3605. genetics: Deficient for y and ac but not l(1)1Ac, sc, or bb. Male viable. molecular biology: Deletes sequences encoding transcripts T5 and T6. # In(1)y3PLsc9R cytology: In(1)1A;20L1B3-4;18C1R. origin: Recombinant containing left end of In(1)y3P and right end of In(1)sc9. references: Garcia-Bellido and Santamaria, 1978, Genetics 88: 469-86. Garcia-Bellido, 1979, Genetics 91: 491-520. genetics: Male lethal. Deficient for y, ac, sc(, and l(1)sc. Mutant for Hw. Duplicated for car-bb. # In(1)y3PLscS1R cytology: In(1)1A;20L1B3-4;20FR. origin: Recombinant containing left end of In(1)y3P and right end of In(1)scS1. references: Garcia-Bellido and Santamaria, 1978, Genetics 88: 469-86. Garcia-Bellido, 1979, Genetics 91: 491-520. genetics: Male lethal. Deficient for y, ac, and sc(; retains l(1)sc. Male spots in gynandromorphs deficient for ac and sc. # In(1)y4 cytology: In(1)1A8-B1;18A3-4 (Norton and Valencia, 1965, DIS 40: 40). origin: X ray induced. discoverer: Serebrovsky. references: Dubinin and Friesen, 1932, Biol. Zentralbl. 52: 147-62. Sturtevant and Beadle, 1936, Genetics 21: 554-604. Campuzano, Carramolino, Cabrera, Ruiz-Gomez, Villares, Boronat, and Modolell, 1985, Cell 40: 327-38. genetics: Mutant for y. Right break within the y locus (Biessmann, 1985, Proc. Nat. Acad. Sci. USA 82: 7369-73); left break between fu on left and sby, smd, and coc on right; shown by deficiency of In(1)y4Lsc9R for ac, sc(, l(1)sc, sby, smd, and coc but not l(1)1Ac or fu (Norton and Valencia, 1965). In(1)y4/+ female produces about 2% exceptional sons from 4-strand double exchange in the inverted regions; In(1)y4/+/Y female produces about 7% secondary exceptions (Sturtevant and Beadle, 1936). molecular biology: Left breakpoint between DNA coordinates 70.6 and 71.6 [to right of breakpoint of In(1)y3P (Campuzano et al., 1985)]. # In(1)y4Lsc4R: Inversion (1) yellow-4 Left scute-4 Right cytology: In(1)1A8-B1;18A3-4L1B3-4;20FR; deficient for 1B1-3 and 18A4 through the distal portion of h26. origin: Recombinant containing left end of In(1)y4 and right end of In(1)sc4. references: Sturtevant and Beadle, 1936, Genetics 21: 554-604. genetics: Deficient for ac, sc, car, and M(1)18C but not os or bb. Heterozygous female Minute and poorly viable but fertile. Male lethal. # In(1)y4Lsc8R: Inversion (1) yellow-4 Left scute-8 Right cytology: In(1)1A8-B1;18A3-4L1B2-3;20FR; deficient for 1B1-2 and 18A4 through the majority of h32. origin: Recombinant containing left end of In(1)y4 and right end of In(1)sc8. references: Sturtevant and Beadle, 1936, Genetics 21: 554-604. genetics: Deficient for ac, car, M(1)18C, and bb but not svr; carries the distal half of the y locus, y4. Heterozygous female Minute, fertile, and poorly viable. Male lethal. # In(1)y4Lsc9R: Inversion (1) yellow-4 Left scute-9 Right cytology: In(1)1A8-B1;18A3-4L1B2-3;18B8-9R; deficient for 1B1-2 and 18A4-B8. origin: Recombinant containing left end of In(1)y4 and right end of In(1)sc9. references: Norton and Valencia, 1965, DIS 40: 40. genetics: Deficient for ac, sc(, l(1)sc, sby, smd, and coc but not l(1)1Ac or fu-pph. Carries the distal half of the y locus. Male lethal. #*In(1)y5 cytology: In(1)1A-B;14D (Muller and Raffel). discoverer: Patterson. genetics: Mutant for y. Recessive lethal associated with right breakpoint. # In(1)y65f4 cytology: In(1)1B2-3;1C1. origin: X ray induced. references: Lefevre, 1968, Genetics 60: 196-97. 1970, DIS 45: 32. genetics: Phenotype y2-like, with bristles dark and body slightly darker than y2. Fertile in males and females. # In(1)yA: Inversion (1) yellow of Alexandrov references: Alexandrov, Ankina and Alexandrova, 1985, DIS 61: 212-13. inversion cytology origin ( genetics | ____________________________________________________ In(1)yA72d3 1B1-2;20A 2 y In(1)yA74b51 / 1B1-2;20D 1 yc4 In(1)yA74c166 1B4-9;9D 1 yc4 In(1)yA74e 1B1-2;20D 2 y In(1)yA76b94 1B1-2;16C8 2 ytd In(1)yA79b21 1B1-2;16D 2 y In(1)yA79d2 1B1-2;20A-B 2 y In(1)yA83fXL 1B1-2;20E-F 3 y ( 1 = caffeine and / rays; 2 = / rays; 3 = X rays. | Phenotype resembles allele indicated. / Additional rearrangements between X and 3. #*In(1)yG: Inversion (1) yellow of Goldschmidt cytology: In(1)1A;1C3-4 (Kodani). origin: Spontaneous. discoverer: Goldschmidt. synonym: In(1)ypx bl. genetics: Mutant for y. # In(1)yR10 cytology: In(1)1A5-B1;20. origin: X ray induced. references: Roberts, 1974, Mutat. Res. 22: 139-44. genetics: Phenotype dark yellow with dark hairs and darkish wing. Male viable and fertile. # In(1)yR20 cytology: In(1)1A6-8;1E2-3. origin: X ray induced. references: Roberts, 1974, Mutat. Res. 22: 139-44. genetics: Mutant for y, ac, and probably separate lethal. Males lethal with or without y+Y or l(1)1Ac+Y. # In(1)z+: Inversion (1) zeste wild origin: X ray induced. Recovered as z reversion in genotype ordinarily exhibiting z phenotype. inversion cytology ref ( ___________________________________________ In(1)z+1 3C1;3F5-6 1 In(1)z+2 3C1-2;7A 1 In(1)z+7G3 3C3-5;14B4-C1;20A3 2 In(1)z+8 3C1-3;20D-F 1 In(1)z+11E7 3C2-5;17C4-D1;20A3 2 In(1)z+28 2B-C;3C 1 In(1)z+30 3C1-2;5D 1 In(1)z+38 3C;10C-D 1 In(1)z+48 3C1-2;4D-5D 1 In(1)z+50 3C1-2;20B-C 1 In(1)z+51 1F3-4;3B4-C1;12B-D;20 1 ( 1 = Gelbart, 1971, Ph.D. Thesis, Univ. of Wisconsin; 2 = Gans, 1953, Bull. Biol. Fr. Belg., Suppl. 38: 1-90. # In(1)z+64b9 cytology: In(1)3C1-2;12B9-10; faint band to right of 3C1 con- sisting of leftmost border of 3C2 plus material from 12B9 (Sorsa, 1973). origin: X ray induced in z male carrying triplication of w. references: Green, 1967, Biol. Zentralbl. 86: 211-20. Arcos-Teran and Beerman, 1968, Chromosoma 25: 377-91. Sorsa, 1973, Cold Spring Harbor Symp. Quant. Biol. 38: 601- 08. Sorsa, Green, and Beerman, 1973, Nature (London), New Biol. 245: 34-37. genetics: Males fertile, with wild-type eye pigmentation. molecular biology: Molecular breakpoint localized approximately 10 kb to the right of the wa copia insert (Goldberg, Paro, and Gehring, 1982, EMBO. J. 1: 93-98). # In(1)ze(bx) cytology: In(1)3A;4F. origin: / ray induced. synonym: In(1)e(bx). references: Lewis, 1959, DIS 33: 96. Kaufman, Tasaki, and Suzuki, 1973, Genetics 75: 299-321. genetics: Associated with ze(bx). Homozygotes show slightly variegated eye color (Lewis, 1959); heterozygotes over z are z. molecular biology: Left breakpoint localized to a 4 kilobase BamHl fragment near the origin of a 160 kb walk (Gunaratne, Matsukhani, Lipari, Liou, Martindale, and Goldberg, 1986, Proc. Nat. Acad. Sci. USA 83: 701-05). #*In(1)z2: Inversion (1) zeste cytology: Dp(1;1)2C10-D1;4D2-4;18F-19A; duplicated for 2D1-4D2. new order: 1 - 4D2|18F - 2D1|19A - 20. origin: X ray induced. discoverer: Gans. references: 1953, Bull. Biol. Fr. Belg., Suppl. 38: 1-90. # In(1)ZP: Inversion (1) Zacharopoulou Pelecanos cytology: In(1)1A;3D. origin: Spontaneous in natural population in Greece. references: Zacharopoulou, 1974, DIS 51: 52-53. Zacharopoulou and Pelecanos, 1980, Genetica 54: 105-11. # In(1)ZWD: Inversion (1) Zeste White Disrupter origin: / ray induced. references: Smolik-Utlaut, and Gelbart, 1987, Genetics 116: 285-98. inversion cytology male phen. female phen. ________________________________________________________________________ In(1)ZWD2 3C1-2;10D w+ eyes w+ eyes In(1)ZWD3 3C1-2;3F w+ ec eyes brick red, ec eyes In(1)ZWD4 3C1-2;4E w+, rough eyes; sterile In(1)ZWD6 see T(1;3)ZWD6 In(1)ZWD7 3C1-2;3E w+ eyes mottled eyes In(1)ZWD8 3C;18F + Df(1)18F;20 lethal In(1)ZWD10 see Tp(1;3)ZWD10 # In1(1)K: see In(1)mK # In(1LR)l-v139: Inversion (1LR) lethal-variegated cytology: In(1LR)3C6-7. origin: X ray induced. discoverer: Lindsley, Edington, and Von Halle. references: 1960, Genetics 45: 1649-70. Gersh, 1965, Genetics 51: 477-80 (fig.). genetics: Variegated for w, rst, and a lethal; requires two Y chromosomes for survival; X/Y/Y male fertile. Recombinant carrying left end of the XP4D element of T(1;4)wm5 = T(1;4)3C3-4;101F1-2 and right end of In(1LR)l-v139 variegates for w but not for rst or the lethal. #*In(1LR)sc260-25: Inversion (1LR) scute cytology: In(1LR)1B2-3. origin: X ray induced. discoverer: Sutton, 39k. synonym: Tp(1;1)sc260-25. references: 1940, Genetics 25: 628-35 (fig.). genetics: Mutant for sc; variegates for y and ac but not svr. Genetic tests indicate loci of l(1)1Ac, y, and ac are located at the base of X to the right of bb. Sutton judged it to be a transposition of 1A1-B2 into the proximal heterochromatin, but since this requires three breaks with one to the left of 1A1, a pericentric inversion is deemed more probable. Recombina- tion between In(1LR)sc260-25 and a normal sequence yields Df(1)sc260-25 = Df(1)1B2-3 and Dp(1;1)sc260-25 = Dp(1;1)1B2-3. The deficiency is deficient for l(1)1Ac, y, and ac (Sutton, 1940). # In(1LR)scV1: Inversion (1LR) scute of Valencia cytology: In(1LR)1A8-C3; inferred from genetic results. origin: / ray induced. discoverer: J. I. Valencia, 46h23. synonym: Inp(1)scV1 (Inp symbolized a pericentric inversion). references: Muller and Valencia, 1947, DIS 21: 69-70. genetics: Mutant for ac and sc. A single exchange between In(1LR)scV1 and a normal X chromosome produces one recombinant with the left end of In(1LR)scV1 that is deficient for the tip of X, Df(1)scV1, and one with the right end of In(1LR)scV1 that is duplicated for the tip of X, Dp(1;1)scV1. Left break between ac and M(1)1B based on observation that Dp(1;1)scV1 is duplicated for ac, and Df(1)scV1 is deficient for ac but not M(1)1B. Right break in XR. Dp(1;1)scV1 carrying y in normal position and y+ in duplicated region provides an excellent marker system for right end of the X. # In(Y) origin: Induced in y+Y by X rays (Brosseau, 1960) or by / rays (M. Schwartz); and in BSYy+ by X rays. genetics: Male sterile; mutant sterility factors indicated in table below. Presence of inversions indicated by examination of prophase or metaphase figures. inversion cytology ref ( genetics _________________________________________________ In(YL)A49 4 kl-2- In(YL)B2 | h9;h15 1, 3 kl-5--kl-3- In(YL)B3 h1-2;h3 1, 3 kl-5- In(YL)D43 h2;h9 2 In(YL)G11 h7;h10 2 In(YL)S15 / h7;h11 3 kl-3--kl-1- In(YL)S16 ` h7;h10-11 + 3 kl-3--kl-2- h13;h17-18 In(YLS)A33 4 male sterile In(YLS)B1 h14-15;h19 1, 3 kl-1- In(YLS)S18 h10-11;h20 3 kl-2- In(YLS)S19 y+Xhj;h21-22 3 ks-1- In(YS)S17 h21;h25 3 ks-1--ks-2- ( 1 = Brosseau, 1960, Genetics 45: 257-74; 2 = Gatti; 3 = Gatti and Pimpinelli, 1983, Chromosoma 83: 349-73. 4 = Hazelrigg, Fornili, and Kaufman, 1982, Chromosoma 87: 535-59. | Chromosome includes Df(YL)B2 = Df(YL)h3;h8. / Mutant located proximal to inversion? ` Chromosome carries two inversions.